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| | CG2681 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (626 aa) |
| | fzr | Fizzy-related, isoform A; Fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. (478 aa) |
| | Prosbeta2R1 | Proteasome subunit beta; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process. (307 aa) |
| | APC7 | Anaphase Promoting Complex subunit 7 (APC7) encodes a protein that associates with the anaphase promoting complex/cyclosome (APC/C). It shows synergistic genetic interaction with the essential APC/C subunit encoded by Cdc23. The association of the product of APC7 and APC/C may be either transient or occurs only in certain forms of the APC/C complex. (615 aa) |
| | UbcE2H | Ubiquitin conjugating enzyme E2H (UbcE2H)encodes an E2 enzyme involved in protein ubiquitylation. It is involved in response to viral infection; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | APC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (775 aa) |
| | CG17754 | LP02641p. (654 aa) |
| | CG2111 | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (931 aa) |
| | CG9806 | Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: multicellular organism reproduction; peptide catabolic process; proteolysis. (911 aa) |
| | Prosalpha3 | Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (264 aa) |
| | ari-2 | Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates; Belongs to the RBR family. Ariadne subfamily. (509 aa) |
| | Prosbeta5R1 | Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (315 aa) |
| | mr | Morula (mr) encodes the APC2 subunit of the anaphase promoting complex (APC). mr strong alleles produce lethality, metaphase arrest and neuroblast polyploidy. mr weak alleles result in female sterility, affecting the endocycle in the nurse cells, as well as metaphase arrest in early embryonic mitoses; Belongs to the cullin family. (802 aa) |
| | snama | Something that sticks like glue (snama) encodes a protein required for cell proliferation and survival in the developing eye. It is involved in apoptosis. (1231 aa) |
| | CG3356 | LP03102p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination. (1122 aa) |
| | Psa | Puromycin sensitive aminopeptidase, isoform C; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (1075 aa) |
| | Patj | Patj (Patj) encodes a PDZ domain-protein that forms an apical protein complex with the products of crb and sdt. It plays supporting roles in apico-basal cell polarity and stability of adherens junction. It is also involved in retinal morphogenesis, maintenance, and planar cell polarity; Belongs to the Patj family. (871 aa) |
| | ida | Imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. (777 aa) |
| | Ubi-p63E | Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa) |
| | CG17030 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. (180 aa) |
| | Uba5 | Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity. (404 aa) |
| | CG2247 | LD23158p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; defense response to bacterium. (1048 aa) |
| | CG9941 | LP12254p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (789 aa) |
| | Fbxl4 | F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa) |
| | shtd | Shattered (shtd) encodes the largest subunit that forms the scaffold of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase. APC/C is active during mitosis and G1 phases of the cell cycle to mediates the degradation of cyclins and other key cell cycle regulators, which triggers the metaphase to anaphase transition and the exit from mitosis. (2030 aa) |
| | Prosalpha4 | Proteasome subunit alpha type-7-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (249 aa) |
| | Rpn1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (919 aa) |
| | Ltn1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family. (1747 aa) |
| | Rpn12 | 26S proteasome regulatory complex subunit p30; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (264 aa) |
| | sina | E3 ubiquitin-protein ligase sina; E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cel [...] (314 aa) |
| | dbo | Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth. (623 aa) |
| | elgi | Early girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. (315 aa) |
| | Prosbeta2 | Proteasome beta2 subunit (Prosbeta2) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (272 aa) |
| | vih | Ubiquitin-conjugating enzyme E2 C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Belongs to the ubiquitin-conjugating enzyme family. (178 aa) |
| | CG11658 | LD30288p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (351 aa) |
| | CG32085 | FI04525p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (666 aa) |
| | CG6071 | Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; peptide catabolic process. (962 aa) |
| | Ube3a | Ubiquitin protein ligase E3A (Ube3a) encodes the founding member of the HECT-type ubiquitin E3 ligase family of enzymes. It is involved in the final step of conjugation of ubiquitin to its target substrates. It regulates protein degradation by targeting modified proteins to the proteasome or by regulating the proteasome activity through ubiquitination of its subunits, which in turn affects many aspects of neuronal function, such as synaptic plasticity, long-term memory or dendritic development. (973 aa) |
| | CG5087 | RE40614p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination. (1078 aa) |
| | Cbl | Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa) |
| | Uev1A | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. (145 aa) |
| | Rpt6 | 26S proteasome regulatory subunit 8; Regulatory particle triple-A ATPase 6 (Rpt6) encodes a subunit of the proteasome, which is responsible for the ATP-dependent degradation of obsolete or damaged proteins. Rpt6 product belongs to the heterohexameric ring formed by triple-A ATPases that unfolds ubiquitinated target proteins before their degradation. (405 aa) |
| | CG1812 | LD33804p. (616 aa) |
| | CG17068 | LP10161p; It is involved in the biological process described with: neurogenesis. (694 aa) |
| | Su(dx) | E3 ubiquitin-protein ligase Su(dx); E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation. (949 aa) |
| | Charon | LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway. (524 aa) |
| | Nle | Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family. (488 aa) |
| | park | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa) |
| | Rpn10 | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. (396 aa) |
| | Mkrn1 | Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa) |
| | CG7148 | GH10766p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (454 aa) |
| | CG11247 | FI01120p; Zinc ion binding; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of gene expression. (522 aa) |
| | Rpn5 | Regulatory particle non-ATPase 5; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process. (502 aa) |
| | dgrn | Degringolade, isoform A; Degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. (319 aa) |
| | Prosbeta7 | Proteasome subunit beta type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (268 aa) |
| | Prosbeta2R2 | Proteasome beta2 subunit-related 2; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (322 aa) |
| | Ubc6 | Ubiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK ; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | Skp2 | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. (559 aa) |
| | Rpn11 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. (308 aa) |
| | Fbw5 | F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway. (656 aa) |
| | Rchy1 | Ring finger and CHY zinc finger domain containing 1, isoform A; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; negative regulation of gliogenesis; protein ubiquitination. (433 aa) |
| | CG11070 | BcDNA.LD34475; Ubiquitin-ubiquitin ligase activity. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; protein polyubiquitination. (993 aa) |
| | poe | Protein purity of essence; Has a role in growth of the perineurial glial layer of the larval peripheral nerve. May have a role in male fertility and eye development or function. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (5322 aa) |
| | CG13088 | AT02038p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (401 aa) |
| | RpS27A | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] (156 aa) |
| | STUB1 | Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. (289 aa) |
| | Ufd4 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (2727 aa) |
| | abo | Abnormal oocyte (abo) encodes a negative regulator of histone transcription genes by its binding to their regulatory regions. abo mutations cause a maternal-effect lethality that can be rescued by specific regions of heterochromatin during early embryogenesis. (539 aa) |
| | CG6724 | Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (420 aa) |
| | fzy | FI02843p; Fizzy (fzy) encodes WD40 domain protein required for the full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) in mitosis and meiosis. The product of fzy functions to target substrates for destruction and drive metaphase and anaphase transition. (526 aa) |
| | kel | Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals. (1477 aa) |
| | mib2 | Mind bomb 2 (mib2) encodes a protein required for regulating synaptic plasticity and memory formation and maintaining muscle integrity. (1049 aa) |
| | Cdc23 | Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (678 aa) |
| | CG2617 | RE60872p; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (274 aa) |
| | Ubc84D | Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (153 aa) |
| | Ufl1 | E3 UFM1-protein ligase 1 homolog; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (782 aa) |
| | Iru | E3 ubiquitin-protein ligase Iruka; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex. By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing. (380 aa) |
| | Prosbeta3 | Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (205 aa) |
| | Prosalpha2 | Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (234 aa) |
| | CG5961 | LD45245p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (442 aa) |
| | CG8774 | Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (942 aa) |
| | CG32473 | FI18373p1; Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (1025 aa) |
| | CG9588 | 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). (220 aa) |
| | eff | Ubiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes. (147 aa) |
| | CG6752 | AT01875p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process. (1332 aa) |
| | Fbxl7 | F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. (772 aa) |
| | Keap1 | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa) |
| | CG5823 | HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination. (283 aa) |
| | Prosalpha4T1 | Proteasome subunit alpha type-7-1A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (249 aa) |
| | EloB | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. (118 aa) |
| | CG5849 | Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (968 aa) |
| | CG31343 | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (961 aa) |
| | CG31198 | Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (940 aa) |
| | Rpn7 | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (389 aa) |
| | CG4813 | LD46938p; Zinc ion binding; metal ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination. (398 aa) |
| | Cdc16 | Cell division cycle 16 (Cdc16) encodes an essential subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (718 aa) |
| | Rpt5 | Regulatory particle triple-A ATPase 5 (Rpt5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (428 aa) |
| | Rpn9 | 26S proteasome regulatory complex subunit p39A; Structural molecule activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process. (382 aa) |
| | CG10254 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. (1398 aa) |
| | CG10011 | ANK_REP_REGION domain-containing protein. (2119 aa) |
| | SP1029 | Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (932 aa) |
| | Cul5 | FI20194p1; Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction; Belongs to the cullin family. (852 aa) |
| | CG2218 | FI06144p; Ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; ubiquitin protein ligase binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; protein polyubiquitination. (486 aa) |
| | stops | Slow termination of phototransduction, isoform A; It is involved in the biological process described with: intracellular signal transduction; deactivation of rhodopsin mediated signaling; sensory perception of sound. (521 aa) |
| | Cul2 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. (753 aa) |
| | Fem-1 | Protein fem-1 homolog B; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. (702 aa) |
| | EloC | Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. (117 aa) |
| | Atg7 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa) |
| | nopo | No poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa) |
| | POSH | Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway. (838 aa) |
| | Prosalpha5 | Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (244 aa) |
| | APC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC10 family. (195 aa) |
| | Prosbeta1 | Proteasome subunit beta; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process. (224 aa) |
| | Rpn6 | 26S proteasome non-ATPase regulatory subunit 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core. (439 aa) |
| | Uba3 | Nedd8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. (450 aa) |
| | CG13344 | Uncharacterized protein, isoform A; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: positive regulation of NF-kappaB transcription factor activity; protein ubiquitination. (374 aa) |
| | TppII | Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys- polypeptide only at high concentration. Does not cleave Ala-Phe-Pro- polypeptide nor Pro-Leu-Gly-polypeptide; Belongs to the peptidase S8 family. (1441 aa) |
| | CG17019 | Uncharacterized protein, isoform A; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein K48-linked ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. (700 aa) |
| | PI31 | Proteasome inhibitor PI31 subunit; Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (270 aa) |
| | Vhl | Protein Vhl; Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation. (178 aa) |
| | Fbl6 | F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa) |
| | Prosbeta5 | Proteasome beta5 subunit (Prosbeta5) encodes an endopeptidase subunit of the of the 26S proteasome; Belongs to the peptidase T1B family. (282 aa) |
| | Uba1 | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. (1191 aa) |
| | Cul1 | Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa) |
| | CG30382 | Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (244 aa) |
| | Rpt1 | 26S proteasome regulatory complex subunit p48B; Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. (433 aa) |
| | Ubc10 | Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...] (154 aa) |
| | Prosalpha7 | Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (253 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | CG33969 | RE11703p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (410 aa) |
| | SkpA | SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa) |
| | CG40045 | RE63412p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the ubiquitin-conjugating enzyme family. (168 aa) |
| | CG9003 | Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to endoplasmic reticulum stress. (651 aa) |
| | CG3502 | Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (912 aa) |
| | CG8773 | Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: dsRNA transport; peptide catabolic process; proteolysis. (994 aa) |
| | wech | Wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link. (832 aa) |
| | CG7656 | FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family. (319 aa) |
| | Nedd4 | E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa) |
| | HERC2 | Probable E3 ubiquitin-protein ligase HERC2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (4912 aa) |
| | ctrip | Circadian trip (ctrip) encodes a HECT ubiquitin ligase that regulates the levels and circadian oscillations of the transcriptional activator encoded by Clk. It plays a role in the control of rest-activity rhythms. (3140 aa) |
| | sinah | Probable E3 ubiquitin-protein ligase sinah; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for [...] (351 aa) |
| | Cul3 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. (934 aa) |
| | Roc2 | Regulator of cullins 2 (Roc2) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul5 and recruits ubiquitin-charged E2 to the CRL5 E3 ubiquitin ligase complex, which functions during oogenesis. (113 aa) |
| | Rpn3 | Probable 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (494 aa) |
| | CG33144 | Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (1102 aa) |
| | CG42797 | FI18049p1; Ubiquitin protein ligase activity. (1426 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra. Belongs to the TRIM/RBCC family. (740 aa) |
| | mahj | Mahjong (mahj) encodes a protein involved in regulation of cell cycle, proliferation and cellular fitness. Epithelial cells lacking mahj function are out competed by their wild type neighbors; Belongs to the VPRBP/DCAF1 family. (1544 aa) |
| | CG32369 | Uncharacterized protein, isoform A; Zinc ion binding. (1066 aa) |
| | Rpt4 | Regulatory particle triple-A ATPase 4 (Rpt4) encodes the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. It localizes to the nucleolus and participates in regulating rRNA transcription. It physically interacts with the tumor suppressor encoded by BHD. (397 aa) |
| | ben | Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. (151 aa) |
| | Roc1a | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa) |
| | gus | Gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance. (279 aa) |
| | CG11360 | LD09246p1; Ubiquitin protein ligase activity; RNA binding; zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (628 aa) |
| | Herc4 | HECT and RLD domain containing E3 ubiquitin ligase 4 (Herc4) encodes a HECT-type E3 ubiquity ligase that is involved in the host defense against Gram-positive bacteria mediated by Toll pathway. (1062 aa) |
| | REG | Proteasome regulator dREG; REG (REG) encodes an endopeptidase regulator involved in the regulation of the mitotic G1/S transition and proteasomal protein catabolism. (245 aa) |
| | CG33981 | Uncharacterized protein, isoform C; It is involved in the biological process described with: protein K11-linked ubiquitination. (112 aa) |
| | lute | Lute, isoform D; Lute (lute) encodes a protein involved in neurogenesis. (735 aa) |
| | dnr1 | Defense repressor 1, isoform B; Defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. (696 aa) |
| | Rpn8 | 26S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. (358 aa) |
| | FBgn0028372 | Isopeptidase-T-3, isoform C. (561 aa) |
| | Ppa | Partner of paired, isoform B; Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. (562 aa) |
| | Rpn2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1029 aa) |
| | Hakai | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. (473 aa) |
| | UbcE2M | Nedd8-conjugating enzyme UbcE2M; Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP- BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full- length ci stability and hedgehog signaling. (181 aa) |
| | CG31445 | Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (927 aa) |
| | Smurf | E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (1061 aa) |
| | Cdc27 | Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1. (900 aa) |
| | lmgA | Putative APC11 anaphase-promoting complex subunit; Lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by Apc2, it forms the minimal ubiquitin ligase module of the APC/C. (85 aa) |
| | Ubc2 | Ubiquitin-conjugating enzyme E2-24 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (232 aa) |
| | FBXO11 | F-box protein 11 (FBXO11) encodes a subunit of a SCF-like E3 ubiquitin ligase involved in gene silencing mediated by both siRNAs and miRNAs.s. (1182 aa) |
| | CG4238 | Uncharacterized protein, isoform D; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity. (977 aa) |
| | RpL40 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | CG3104 | GH07239p; Cytoskeletal anchor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport. (321 aa) |
| | Prosbeta4 | Proteasome beta4 subunit (Prosbeta4) encodes a protein involved in proteasomal degradation; Belongs to the peptidase T1B family. (201 aa) |
| | CG1440 | Uncharacterized protein, isoform D; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: homocysteine catabolic process; response to toxic substance; proteolysis. (551 aa) |
| | CG7220 | RH10776p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; protein monoubiquitination; protein polyubiquitination. (190 aa) |
| | Ubc7 | Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of innate immune response; protein polyubiquitination; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process; defense response to Gram-negative bacterium. (167 aa) |
| | Prosbeta5R2 | Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (279 aa) |
| | CG12096 | 26S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome. (506 aa) |
| | HUWE1 | Uncharacterized protein, isoform H; Ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; dsRNA transport. (5151 aa) |
| | CG14435 | Uncharacterized protein, isoform A; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (303 aa) |
| | Prosalpha4T2 | Proteasome subunit alpha type-7-1B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (252 aa) |
| | Prosalpha6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (279 aa) |
| | CG5440 | Uncharacterized protein, isoform B; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family. (169 aa) |
| | CG42335 | Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (924 aa) |
| | CG15803 | Uncharacterized protein, isoform C; Protein C-terminus binding. (880 aa) |
| | Ubc4 | Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (199 aa) |
| | Ubi-p5E | Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa) |
| | Rpt2 | 26S proteasome regulatory subunit 4; Regulatory particle triple-A ATPase 2 (Rpt2) encodes one of six ATPases that form the base of the regulatory 19S cap of the proteasome. The Rpt2 product is involved in the recognition of specific substrates destined for degradation, such as those involved in Notch signalling pathway. (439 aa) |
| | CG8188 | Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (209 aa) |
| | Ubr1 | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family. (1824 aa) |
| | Rpt3 | Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa) |
| | CG2924 | LD28546p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination. (397 aa) |
| | CG31233 | Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis. (952 aa) |
| | nompC | No mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ. (1761 aa) |
| | unk | Unkempt (unk) encodes a highly conserved protein with roles in mRNA binding and ubiquitination. Together with the product of hdc, it acts downstream of the product of Mtor to regulate photoreceptor differentiation during eye development. (673 aa) |
| | CG46339 | Uncharacterized protein, isoform D; Peptide binding; aminopeptidase activity; zinc ion binding; metalloaminopeptidase activity. (1194 aa) |
| | CG11951 | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (924 aa) |
| | CG7653 | Uncharacterized protein; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: proteolysis; peptide catabolic process. (710 aa) |
