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y y crm crm Stoml2 Stoml2 tsr tsr sbr sbr dsh dsh RpII215 RpII215 dmrt11E dmrt11E OdsH OdsH CG32117 CG32117 rt rt ERR ERR Mst77F Mst77F park park PAPLA1 PAPLA1 Rcd-1r Rcd-1r Aldh Aldh Rbp4 Rbp4 CG17083 CG17083 shps shps CG17669 CG17669 knon knon U2A U2A porin porin mt:CoII mt:CoII CHES-1-like CHES-1-like Haspin Haspin Cap-H2 Cap-H2 Mst36Fb Mst36Fb Mst36Fa Mst36Fa Fmr1 Fmr1 hts hts su(Hw) su(Hw) dsx dsx Tektin-A Tektin-A SCaMC SCaMC Tudor-SN Tudor-SN bur bur kl-5 kl-5 PRY PRY ttm50 ttm50 Cby Cby
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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yYellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts; Belongs to the major royal jelly protein family. (541 aa)
crmProtein cramped; Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV); Belongs to the cramped family. (982 aa)
Stoml2Stomatin like 2, isoform A. (366 aa)
tsrCofilin/actin-depolymerizing factor homolog; Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation. Promotes cell motility during ovary development and oogenesis. During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles. Also required for border cell migration during oogenesis. During border cell migration, required for actin tu [...] (148 aa)
sbrNuclear RNA export factor 1; Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm. (672 aa)
dshSegment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa)
RpII215DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1887 aa)
dmrt11Edoublesex-Mab related 11E (dmrt11E) encodes a transcription factor-like protein containing a highly conserved DNA-binding DM domain that plays a critical role in sex determination and spermatogenesis. (377 aa)
OdsHOds-site homeobox (OdsH) encodes a protein involved in male sterility. (382 aa)
CG32117FI08063p. (215 aa)
rtProtein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa)
ERREstrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages. (496 aa)
Mst77FHistone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I. (215 aa)
parkParkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa)
PAPLA1Phosphatidic Acid Phospholipase A1 (PAPLA1) encodes a protein required for the endoplasmic reticulum to Golgi trafficking of a family of G-protein coupled receptors. (2016 aa)
Rcd-1rRcd-1 related; It is involved in the biological process described with: negative regulation of translation; spermatogenesis; mRNA catabolic process; reproductive process. (290 aa)
AldhAldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. (520 aa)
Rbp4RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. (428 aa)
CG17083AT03545p. (550 aa)
shpsAT01267p; Oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process. (477 aa)
CG17669Dynein assembly factor 3, axonemal homolog; Required for the assembly of axonemal inner and outer dynein arms; Belongs to the DNAAF3 family. (540 aa)
knonKnotted onions; Proton transmembrane transporter activity. It is involved in the biological process described with: Nebenkern assembly; ATP synthesis coupled proton transport. (734 aa)
U2AProbable U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome (By similarity). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity). In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26. Belongs to the U2 small nuclear ribonucleoprotein A family. (265 aa)
porinVoltage-dependent anion-selective channel; Porin (porin) encodes a beta-barrel channel protein localized in the outer membrane of mitochondria that conducts translocation of various ions and metabolites between cytoplasm and mitochondria. It plays roles in mitochondria dynamics and mitophagy, and is ubiquitinated by the E3 ligases encoded by park and Mul1. (282 aa)
mt:CoIICytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (228 aa)
CHES-1-likeCheckpoint suppressor 1-like (CHES-1-like) encodes a transcription factor that regulates the division of cardiac progenitor cells and dpp transcription in testis. (1268 aa)
HaspinPutative serine/threonine-protein kinase haspin homolog; Histone kinase activity (H3-T3 specific); ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; mitotic cell cycle; protein phosphorylation. (566 aa)
Cap-H2Chromosome associated protein H2 (Cap-H2) encodes a condensin protein involved in chromatin organization and chromosome segregation. (960 aa)
Mst36FbMale-specific transcript 36Fb; It is involved in the biological process described with: spermatogenesis. (470 aa)
Mst36FaMale-specific transcript 36Fa; It is involved in the biological process described with: spermatogenesis. (498 aa)
Fmr1Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa)
htsHu li tai shao (hts) encodes an adducin homolog that is associated with the plasma membrane cytoskeleton, fusome and oocyte ring canals. It has essential functions in muscle, nerve and other tissues, and is required for fertility in males and females; Belongs to the aldolase class II family. Adducin subfamily. (1833 aa)
su(Hw)Protein suppressor of hairy wing; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fibe [...] (941 aa)
dsxProtein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (572 aa)
Tektin-ATektin A, isoform A; It is involved in the biological process described with: cilium movement involved in cell motility; cilium assembly. (585 aa)
SCaMCShort Calcium-binding Mitochondrial Carrier (SCaMC) encodes a mitochondrial carrier family protein with calcium-binding motifs. SCaMC transcripts are strongly detected in the corpora allata, suggesting its potential role in juvenile hormone biosynthesis. (583 aa)
Tudor-SNStaphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. (926 aa)
burBurgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. (683 aa)
kl-5Male fertility factor kl5; ATP binding; microtubule motor activity. It is involved in the biological process described with: microtubule-based movement. (4559 aa)
PRYPolycystin-related Y protein. (1247 aa)
ttm50Mitochondrial import inner membrane translocase subunit TIM50-C; Tiny tim 50 (ttm50) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. It plays active roles in regulating metabolic levels for modulation of growth in development. (428 aa)
CbyChibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation. (132 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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