STRINGSTRING
trr trr Hira Hira ocm ocm CTCF CTCF Pc Pc Snr1 Snr1 Su(var)205 Su(var)205 esc esc D1 D1 E(var)3-9 E(var)3-9 Scm Scm Su(var)3-7 Su(var)3-7 Ravus Ravus Ace Ace PR-Set7 PR-Set7 trx trx Hsc70-4 Hsc70-4 mor mor mod(mdg4) mod(mdg4) p38a p38a Spt5 Spt5 Rho1 Rho1 Iswi Iswi nec nec osa osa Parp Parp gpp gpp ash1 ash1 Pcl Pcl Asx Asx E(z) E(z) Alh Alh Ada3 Ada3 barr barr wapl wapl Kr-h1 Kr-h1 E2f1 E2f1 Psc Psc vas vas
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trrHistone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...] (2431 aa)
HiraProtein HIRA homolog; Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4. Belongs to the WD repeat HIR1 family. (1047 aa)
ocmOver compensating males, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II activating transcription factor binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; dosage compensation; larval lymph gland hemopoiesis; cell fate specification; negative regulation of transcription by RNA polymerase II. (2175 aa)
CTCFGH14774p; CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture. (818 aa)
PcPolycomb group protein Pc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specif [...] (390 aa)
Snr1Snf5-related 1 (Snr1) encodes a core component of the ATP-dependent SWI/SNF chromatin-remodeling complex (Brahma complex). It functions as a tumor suppressor and is required for maintaining normal endosomal trafficking-mediated signaling cascades; Belongs to the SNF5 family. (370 aa)
Su(var)205Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. (206 aa)
escPolycomb protein esc; Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitme [...] (425 aa)
D1D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. (355 aa)
E(var)3-9Enhancer of variegation 3-9; Nucleic acid binding; zinc ion binding. It is involved in the biological process described with: regulation of gene expression; chromatin maintenance. (588 aa)
ScmPolycomb protein Scm; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility; Belongs to the SCM family. (877 aa)
Su(var)3-7Suppressor of variegation 3-7 (Su(var)3-7) encodes a protein associated with heterochromatin. Increasing the amount of the product of Su(var)3-7 triggers heterochromatin expansion and epigenetic gene silencing. (1250 aa)
RavusFI14740p; DNA binding. (359 aa)
AceAcetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. (649 aa)
PR-Set7Histone-lysine N-methyltransferase PR-Set7; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis; Belongs to the class V-like SAM-binding methyltransferase superfa [...] (691 aa)
trxHistone-lysine N-methyltransferase trithorax; Histone methyltransferase that trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. (3726 aa)
Hsc70-4Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa)
morBrahma associated protein 155 kDa; Moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex. (1209 aa)
mod(mdg4)Modifier of mdg4; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independe [...] (610 aa)
p38aP38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. (366 aa)
Spt5Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] (1078 aa)
Rho1Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa)
IswiChromatin-remodeling complex ATPase chain Iswi; Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. (1027 aa)
necGH10112p; Necrotic (nec) encodes a hemolymphatic Serpin that negatively regulates a serine protease involved in the immune activation of the Toll pathway. It is thought to function at the level or upstream of the serine protease encoded by psh. (476 aa)
osaTrithorax group protein osa; Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. Thi [...] (2716 aa)
ParpPoly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. (994 aa)
gppHistone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity. (2137 aa)
ash1Histone-lysine N-methyltransferase ash1; Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active. Belongs to t [...] (2226 aa)
PclPolycomb protein Pcl; Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitme [...] (1043 aa)
AsxPolycomb protein Asx; Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non- catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act b [...] (1670 aa)
E(z)Histone-lysine N-methyltransferase E(z); Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting [...] (765 aa)
AlhAlhambra, isoform P; Alhambra (Alh) encodes a zinc finger/leucine zipper nuclear protein. It is required in the nervous system for maintaining eve expression and normal growth. It is also involved in muscle development and male courtship behavior. (1717 aa)
Ada3Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. (588 aa)
barrCondensin complex subunit 2; Barren (barr) encodes a chromatin binding protein involved in chromatin condensation. It regulates Malpighian tubule development and epithelial morphogenesis. (735 aa)
waplWings apart-like (wapl) encodes a protein that interacts with the product of pds5 to form the releasin complex that enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. It also influences gene activation and silencing through interactions with cohesin. (1741 aa)
Kr-h1Kruppel homolog 1 (Kr-h1) encodes a transcriptional regulator involved in axon pathfinding, neurite and axon remodeling as well as pupal photoreceptor maturation. In all cases, the function of the product of Kr-h1 is linked to that of the 20-hydroxyecdysone hormone. (845 aa)
E2f1Transcription factor E2f1; Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg; Belongs to the E2F/DP family. (821 aa)
PscPolycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] (1601 aa)
vasATP-dependent RNA helicase vasa; Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells. Belongs to the D [...] (661 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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