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| | CG7530 | LD44720p; Signaling receptor activity. (351 aa) |
| | Crz | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa) |
| | Ace | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. (649 aa) |
| | HisCl1 | Histamine-gated chloride channel subunit 1 (HisCl1) encodes an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (426 aa) |
| | mura | Murashka, isoform C; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: long-term memory; protein ubiquitination; behavioral response to ethanol. (1173 aa) |
| | puc | Puckered, isoform A; Puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. (476 aa) |
| | Antp | Homeotic protein antennapedia; Antennapedia (Antp) is the distal-most member of the Antennapedia complex; one of two Hox gene complexes. Antp encodes a sequence-specific homeodomain transcription factor, which is part of a developmental regulatory system that specifies segmental identity in the pro- and mesothorax. In adults Antp loss of function is associated with a transformation of leg into antenna while ectopic expression in the head is associated with antenna to leg and eye to wing transformations. (378 aa) |
| | alpha-Est7 | alpha-Esterase-7 (alpha-Est7) encodes a carboxylic ester hydrolase involved in insecticide tolerance, lipid metabolism and lifespan control; Belongs to the type-B carboxylesterase/lipase family. (572 aa) |
| | lok | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. (476 aa) |
| | spi | Protein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination. (234 aa) |
| | Catsup | Protein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (449 aa) |
| | Syx5 | Syntaxin-5; Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis. (467 aa) |
| | Ku80 | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. (699 aa) |
| | ZnT35C | Zinc transporter 35C (ZnT35C) encodes a protein involved in cellular and organismal zinc efflux that plays a major role in the detoxification of zinc excess. ZnT35C is a target of the metal-responsive transcription factor encoded by MTF-1. (472 aa) |
| | Sirt1 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa) |
| | Nos | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. (1349 aa) |
| | nAChRalpha6 | Nicotinic Acetylcholine Receptor alpha6 (nAChRalpha6) encodes a postsynaptic receptor involved in cation transport, synaptic transmission, muscle homeostasis and sensitivity to insecticides. (523 aa) |
| | IP3K1 | Kinase; Inositol 1,4,5-triphosphate kinase 1 (IP3K1) encodes a protein involved in response to oxidative stress; Belongs to the inositol phosphokinase (IPK) family. (441 aa) |
| | Trx-2 | Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. (106 aa) |
| | Akap200 | A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...] (837 aa) |
| | SLC5A11 | Sodium/solute co-transporter-like 5A11 (SLC5A11) encodes a protein involved in behavioral response to nutrient; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (600 aa) |
| | Uro | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (352 aa) |
| | 5-HT2A | 5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. (930 aa) |
| | Orco | Odorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa) |
| | kra | Krasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2beta. It is involved in axon guidance, long-term memory, and alcohol addiction. (422 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | Psn | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa) |
| | Tspo | Translocator protein (Tspo) encodes a protein localized in the outer mitochondrial membrane that is thought to be involved in various pathways, including steroid and heme biosynthesis, apoptosis, protein import, cell proliferation and differentiation and also has been proposed to participate in the formation of the mitochondrial permeability transition pore. (185 aa) |
| | aru | Arouser, isoform A; Arouser (aru) encodes an SH3 adaptor protein that interacts with Egfr and PI3K pathways. Its roles include regulation of synapse number, memory formation and ethanol sedation sensitivity. (805 aa) |
| | Thor | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa) |
| | tank | Tank, isoform A; Tank (tank) encodes the homolog of tumor suppressor EI24/PIG8. It regulates ethanol sedation sensitivity. (497 aa) |
| | bves | Bves, isoform A; cAMP binding. (414 aa) |
| | sgl | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (476 aa) |
| | GstO1 | Glutathione S-transferase omega class; Glutathione S transferase O1 (GstO1) encodes a transferase involved in glutathione metabolism; Belongs to the GST superfamily. (254 aa) |
| | Doc3 | Dorsocross3 (Doc3) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives. (424 aa) |
| | Tat | Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (461 aa) |
| | aay | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (270 aa) |
| | Dronc | Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. (450 aa) |
| | Ilp2 | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa) |
| | hid | Cell death protein hid; Activator of apoptosis, with grim and rpr, that acts on the effector Dredd. Seems to act genetically upstream of baculoviral anti-apoptotic p35. Blocks Diap2 from binding and inactivating the effector caspase Drice. (410 aa) |
| | Cat | Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. (506 aa) |
| | Pfrx | 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form; ATP binding; 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity. It is involved in the biological process described with: glycolytic process; fructose metabolic process; fructose 2,6-bisphosphate metabolic process; carbohydrate phosphorylation. (716 aa) |
| | sun | Protein stunted; Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels. (61 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | RpII215 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1887 aa) |
| | tipE | Protein tipE; Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality. (452 aa) |
| | mth | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (522 aa) |
| | SiaT | Beta-galactoside alpha-2,6-sialyltransferase; Sialyltransferase (SiaT) encodes an enzyme that functions in the sialylation pathway. It is required to produce sialylated glycans, which are important for nervous system function. It contributes to lifespan, locomotor abnormalities, response to heat and neuromuscular junction development; Belongs to the glycosyltransferase 29 family. (474 aa) |
| | DCP1 | Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing. (372 aa) |
| | tsr | Cofilin/actin-depolymerizing factor homolog; Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation. Promotes cell motility during ovary development and oogenesis. During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles. Also required for border cell migration during oogenesis. During border cell migration, required for actin tu [...] (148 aa) |
| | bw | Brown (bw) encodes a member of the traffic ATPase (or ABC) family of membrane transporters. It is believed to heterodimerize with the product of w. bw and w are necessary to import guanine, a precursor for the red pteridine pigments, into pigment cells of the eyes, Malpighian tubules and testis sheath. (675 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | CG10527 | Uncharacterized protein. (296 aa) |
| | fh | Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family. (190 aa) |
| | Usp30 | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. (558 aa) |
| | Shmt | Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa) |
| | TrxT | Thioredoxin-T; Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline. (157 aa) |
| | w | White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker. (687 aa) |
| | Ilp6 | Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa) |
| | mus81 | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. (426 aa) |
| | Ilp5 | Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. (108 aa) |
| | dj-1beta | Protein dj-1beta; Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor. Does not play a role in methylglyoxal detoxification. Plays a role in mitochondrial function together with Pink1. In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN- phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels. (187 aa) |
| | CG11699 | CG11699-RA protein. (146 aa) |
| | Hsp27 | Heat shock protein 27 (Hsp27) encodes a member of the ATP-independent, small heat shock protein family. It contributes to regulation of eye morphology, polyglutamine toxicity, lifespan and starvation tolerance. (213 aa) |
| | Hsp26 | Heat shock protein 26 (Hsp26) encodes a protein involved in protein folding. It contributes to lifespan determination and the response to cold and heat. (208 aa) |
| | Aprt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | Cyp12d1-p | Probable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa) |
| | ple | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. (579 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | sni | Sniffer, isoform A; Sniffer (sni) encodes a homodimeric carbonyl reductase that belongs to the SDR superfamily of proteins. It catalyzes the reduction of the lipid derived aldehyde 4-oxononenal. It contributes to protection against oxidative stress-induced neurodegeneration and prevention of apoptosis by removal of damaged cardiolipin; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | mars | Mars (mars) encodes a microtubule-associated protein that shuttles between the mitotic spindle and the nucleus. It is required for mitotic spindle attachment to the centrosome; Belongs to the SAPAP family. (921 aa) |
| | na | Narrow abdomen, isoform F; Narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. (2233 aa) |
| | Met | Methoprene-tolerant, isoform A; Methoprene-tolerant (Met) encodes bHLH-PAS domain transcription factor paralogous to gce. It is a receptor for the sesquiterpenoid juvenile hormone. (716 aa) |
| | Marf | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (814 aa) |
| | sei | Putative potassium channel subunit homolog; Seizure (sei) encodes a protein involved in sound perception. (855 aa) |
| | nonC | Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1. (3218 aa) |
| | Jwa | PRA1 family protein; It is involved in the biological process described with: response to ethanol. (249 aa) |
| | ics | Icarus, isoform A; Icarus (ics) encodes RSU1 (Ras suppressor 1), an adapter protein that participates in integrin-dependent processes by interacting with the integrin effector protein encoded by stck. (283 aa) |
| | ktub | Protein king tubby; Functions in regulating protein trafficking, retinal maintenance and lipid storage. Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA- mediated endocytosis of the rhodopsin ninaE (Rh1). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC. Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base. Plays a role [...] (469 aa) |
| | Bx | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. (424 aa) |
| | Gclc | Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine; Belongs to the glutamate--cysteine ligase type 3 family. (717 aa) |
| | Cyp6g1 | Cytochrome P450 6g1; Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones. (524 aa) |
| | CG1461 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (501 aa) |
| | Irc | Immune-regulated catalase (Irc) encodes a catalase involved in oxidant detoxification. (697 aa) |
| | Drp1 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | Bacc | Bacchus; Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA. (152 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | Calr | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (406 aa) |
| | Rdl | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. (608 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Diap1 | Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...] (438 aa) |
| | Spn27A | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] (447 aa) |
| | S6k | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa) |
| | Pdk1 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa) |
| | Gbs-70E | Protein phosphatase 1 regulatory subunit; Glycogen binding subunit 70E (Gbs-70E) is one of the glycogen binding subunits of protein phosphatase 1 (Pp1) that interacts with all of the known Pp1 catalytic subunits (encoded by Pp1-87B, flw, Pp1alpha-96A, and Pp1-13C). The product of Gbs-70E is involved in the regulation of glycogen metabolism, and plays a role in the egg development. (384 aa) |
| | apt | Apontic, isoform F; Apontic (apt) encodes a DNA-binding protein that acts as a transcriptional regulator and can function in translational repression. It plays roles in cell migration, cell fate specification, and morphogenesis via STAT signaling pathway inhibition. (499 aa) |
| | Rac1 | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa) |
| | para | Sodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily. (2145 aa) |
| | br | Broad-complex core protein isoform 6; Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (1011 aa) |
| | nAChRalpha1 | Acetylcholine receptor subunit alpha-like 1; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (597 aa) |
| | Dop1R2 | Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa) |
| | slo | Calcium-activated potassium channel slowpoke; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob [...] (1217 aa) |
| | NaCP60E | Na channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses; Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily. (2896 aa) |
| | mbf1 | Multiprotein bridging factor 1 (mbf1) encodes a transcriptional co-activator that bridges between sequence-specific transcriptional regulators and the product of Tbp. Under stress, the product of mbf1 in the cytoplasm can translocate into the nucleus and serve as a co-activator to induce stress-reponse genes. (188 aa) |
| | HtrA2 | Serine protease HTRA2, mitochondrial, short; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th. (422 aa) |
| | NLaz | Neural lazarillo, isoform B; Neural Lazarillo (NLaz) encodes an extracellular lipid binding protein of the Lipocalin family. It is regulated by JNK signaling and negatively regulates the IIS pathway. It contributes to longevity, stress resistance, and behavior. (245 aa) |
| | Cdc42 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa) |
| | unc-13 | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa) |
| | NPFR | Neuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] (489 aa) |
| | CG17734 | Uncharacterized protein, isoform C; It is involved in the biological process described with: mitochondrial respirasome assembly; behavioral response to ethanol. (106 aa) |
| | foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) |
| | DCP2 | Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly. (792 aa) |
| | Sin3A | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. (2066 aa) |
| | RyR | Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa) |
| | Mco1 | Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown. (959 aa) |
| | gce | Germ cell-expressed bHLH-PAS (gce) encodes a bHLH-PAS domain transcription factor paralogous to the product of Met. It is a receptor for the sesquiterpenoid juvenile hormone. (959 aa) |
| | Pka-R1 | Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: behavioral response to ethanol; phosphatidic acid biosynthetic process. (271 aa) |
| | nAChRalpha7 | Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. (564 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | Pten | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa) |
| | Duox | Dual oxidase; Plays a role in innate immunity limiting microbial proliferation in the gut. Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection. May generate antimicrobial oxidative burst through its peroxidase-like domain. (1537 aa) |
| | Doa | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa) |
| | RhoGAP18B | Rho GTPase activating protein at 18B (RhoGAP18B) encodes a protein that can act as a GTPase activating protein for several Rho GTPase and is involved in the regulation of actin dynamics. (1317 aa) |
| | hang | Hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. (2223 aa) |
| | CHKov1 | CHK domain ov1. (410 aa) |
| | MTF-1 | Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal. (1006 aa) |
| | Mt2 | Methyltransferase 2 (Mt2) encodes a (cytosine-5) tRNA methyltransferase. The modification protects tRNAs against endonucleolytic cleavage and contributes to stress resistance, protein translation and small RNA-mediated gene regulation; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (345 aa) |
| | stmA | Protein EFR3 homolog cmp44E; An essential gene required for embryogenesis; required for cell viability; Belongs to the EFR3 family. (834 aa) |
| | Prx5 | Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis. (190 aa) |
| | Adh | Alcohol dehydrogenase (Adh) encodes an alcohol and acetaldehyde dehydrogenase involved in alcohol and acetaldehyde metabolism. (256 aa) |
| | Syn | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa) |
| | DopEcR | Dopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. (322 aa) |
| | r | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. (2224 aa) |
| | Sh | Potassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...] (655 aa) |
| | Atpalpha | Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1041 aa) |
| | Cyp12d1-d | Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa) |
| | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B; Foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. (1088 aa) |
| | zfh2 | Zn finger homeodomain 2 (zfh2) encodes a putative transcription factor. Its roles include specification of cell fates and promotion of apoptosis during CNS development, and proximal-distal patterning during wing and leg imaginal disc development. (3005 aa) |
| | hig | Hikaru genki (hig) encodes a secretory matrix protein localized to the synaptic clefts of cholinergic synapses. It is required for the accumulation of acetylcholine receptor subunits on the postsynaptic membranes. (958 aa) |
| | Pka-R2 | cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain. (377 aa) |
| | Cyp6g2 | Probable cytochrome P450 6g2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides; Belongs to the cytochrome P450 family. (519 aa) |
| | vg | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] (453 aa) |
| | DJ-1alpha | Protein DJ-1alpha; Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor. Does not play a role in methylglyoxal detoxification (By similarity). (217 aa) |
| | Cp1 | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. (371 aa) |
| | Opa1 | Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (972 aa) |
| | Arf51F | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation. (175 aa) |
| | scb | Integrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...] (1115 aa) |
| | Jhe | Carboxylic ester hydrolase; Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior; Belongs to the type-B carboxylesterase/lipase family. (579 aa) |
| | Rho1 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa) |
| | inaC | Protein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa) |
| | Dcr-2 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa) |
| | hppy | Happyhour, isoform A; Happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. (1218 aa) |
| | Trap1 | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. (691 aa) |
| | Zip42C.1 | Zinc/iron regulated transporter-related protein 42C.1 (Zip42C.1) encodes a plasma membrane resident zinc transporter belonging to the Zinc-Iron Permease family. It works together with the products of Zip42C.2 and Zip89B in dietary zinc absorption. (352 aa) |
| | Cyp6a2 | Cytochrome P450 6a2; Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones. (506 aa) |
| | mle | Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. (1293 aa) |
| | Tpi | Triose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production. (348 aa) |
| | AdoR | Adenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation. (774 aa) |
| | Drice | Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family. (339 aa) |
| | superdeath | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (999 aa) |
| | Pkc98E | Protein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn. (739 aa) |
| | ssh | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. (1193 aa) |
| | Hr96 | Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. (723 aa) |
| | nAChRbeta2 | Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. (519 aa) |
| | nAChRalpha2 | Acetylcholine receptor subunit alpha-like 2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (576 aa) |
| | Hsp68 | Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. (635 aa) |
| | p53 | P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. (495 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | TotA | Protein Turandot A; A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response. Belongs to the Turandot family. (129 aa) |
| | ort | Ora transientless (ort) encodes an ionotropic histamine-gated chloride channel required for vision. It is essential in the first-order interneurons to receive histaminergic inputs from the photoreceptors. In the central brain the product of ort modulates preference and tolerance for high and low temperature; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (485 aa) |
| | Mekk1 | Mekk1, isoform B; Mekk1 (Mekk1) encodes a MAP kinase kinase kinase that regulates the stress response. It is required for resistance to several stresses, notably osmotic shock, and for the regulation of the activity of the product of Duox. (1571 aa) |
| | VAChT | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa) |
| | Zip89B | Zinc/iron regulated transporter-related protein 89B (Zip89B) encodes a protein involved in zinc detoxification and zinc transmembrane import. (495 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
