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| | CG8549 | Uncharacterized protein, isoform A; It is involved in the biological process described with: mature ribosome assembly. (252 aa) |
| | Prat2 | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (547 aa) |
| | Vps8 | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. (1229 aa) |
| | vn | Vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. (623 aa) |
| | lin-28 | Protein lin-28 homolog; mRNA binding; zinc ion binding; mRNA 3'-UTR binding; Belongs to the lin-28 family. (195 aa) |
| | Tps1 | Trehalose-6-phosphate synthase 1 (Tps1) encodes the trehalose synthesis enzyme with an N-terminal trehalose-6-phosphate (T6P) synthase domain that catalyzes the production of T6P using glucose-6-phosphate and UDP-glucose. Its C-terminal T6P phosphatase domain dephosphorylates T6P to generate trehalose. (809 aa) |
| | ft | Cadherin-related tumor suppressor; Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor. Also required for planar cell polarity of wing hairs. Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface. Involved in regulation of eye imagin [...] (5147 aa) |
| | Elba2 | Early boundary activity protein 2; The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba2 can act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression. (381 aa) |
| | dpp | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] (588 aa) |
| | al | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. (408 aa) |
| | ex | Protein expanded; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signa [...] (1427 aa) |
| | smo | Protein smoothened; Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which a [...] (1036 aa) |
| | Scox | Synthesis of cytochrome c oxidase (Scox) encodes a protein involved in cytochrome complex assembly and regulation of ATP biosynthesis. (251 aa) |
| | CG9536 | LD47671p; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein glycosylation. (450 aa) |
| | Nuf2 | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. (395 aa) |
| | wg | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa) |
| | Cdk1 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. (297 aa) |
| | CCT4 | T-complex protein 1 subunit delta; Unfolded protein binding; ATP binding. It is involved in the biological process described with: protein folding. (533 aa) |
| | kuz | Kuzbanian, isoform A; Kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. (1238 aa) |
| | rk | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. (1360 aa) |
| | Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) |
| | amos | Basic helix-loop-helix transcription factor amos; Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz). (198 aa) |
| | Hr38 | Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae; Belongs to the nuclear hormone receptor family. NR4 subfamily. (1078 aa) |
| | Antp | Homeotic protein antennapedia; Antennapedia (Antp) is the distal-most member of the Antennapedia complex; one of two Hox gene complexes. Antp encodes a sequence-specific homeodomain transcription factor, which is part of a developmental regulatory system that specifies segmental identity in the pro- and mesothorax. In adults Antp loss of function is associated with a transformation of leg into antenna while ectopic expression in the head is associated with antenna to leg and eye to wing transformations. (378 aa) |
| | ato | Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (312 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (544 aa) |
| | dmt | Dalmatian (dmt) encodes a nuclear protein that localizes to centromeric heterochromatin and other polytene chromosome bands. It is required to block expression of rpr and hid during the radiation resistant stage of embryonic development, when cells become irreversibly committed to cell fate. (857 aa) |
| | Scm | Polycomb protein Scm; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility; Belongs to the SCM family. (877 aa) |
| | Ras85D | Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa) |
| | CG31406 | AT10048p; It is involved in the biological process described with: notum morphogenesis. (249 aa) |
| | hth | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] (487 aa) |
| | wkd | TBC1 domain family member whacked; Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of [...] (363 aa) |
| | aurA | Aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. (411 aa) |
| | Sbf | SET domain binding factor, isoform A. (1993 aa) |
| | prd1 | Pruning defect 1, isoform A; Rab GTPase binding. (1354 aa) |
| | Cyfip | Cytoplasmic FMR1-interacting protein; Specifically Rac1-associated protein 1 (Sra-1) encodes an essential protein that is a component of the WAVE actin nucleator complex. It controls actin cytoskeleton remodeling and interacts with the products of Fmr1 and Rac1. It controls morphogenesis and synapse organization. (1291 aa) |
| | Cp190 | Centrosome-associated zinc finger protein CP190; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the [...] (1096 aa) |
| | CCT3 | T-complex protein 1 subunit gamma; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (544 aa) |
| | Ubx | Homeotic protein ultrabithorax; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor; Belongs to the Antp homeobox family. (389 aa) |
| | abd-A | Homeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...] (590 aa) |
| | Dl | Neurogenic locus protein delta; Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. (833 aa) |
| | Ino80 | Chromatin-remodeling ATPase INO80; INO80 complex subunit (Ino80) encodes a component of the INO80 chromatin remodelling complex that interacts with Polycomb and Trithorax group proteins. It is involved in the regulation of homeotic gene expression and regression of ecdysone dependent transcription; Belongs to the SNF2/RAD54 helicase family. (1638 aa) |
| | CG5412 | Esterase CG5412; It is involved in the biological process described with: response to retinoic acid; Belongs to the LovG family. (279 aa) |
| | H | Protein hairless; Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate. (1077 aa) |
| | Sep2 | Septin-2; Involved in cytokinesis. (419 aa) |
| | TFAM | Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA. (284 aa) |
| | CG17278 | SD04019p; CG17278 encodes a secreted Kazal-type serine protease whose expression is induced by bacterial infection. RNAi results in lethality and wing adhesion defects. (80 aa) |
| | mod(mdg4) | Modifier of mdg4; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independe [...] (610 aa) |
| | Burs | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. (173 aa) |
| | CCT1 | T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (557 aa) |
| | Dcr-1 | Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa) |
| | TfIIA-S | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers. Forms a complex with Moonshiner/CG12721 and Trf2 which recruit transcriptional machinery to heterochromatin to initiate the bidirectional transcription [...] (106 aa) |
| | Nab2 | Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. (1004 aa) |
| | ash2 | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] (556 aa) |
| | FBgn0002734 | Enhancer of split mdelta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm. (173 aa) |
| | Exo84 | Exocyst 84, isoform B; Exocyst 84 (Exo84) encodes an exocyst component involved in epithelial polarity. It mediates the apical localization of the transmembrane protein encoded by crb. (672 aa) |
| | bigmax | GM14426p; Bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by Mondo, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance. (254 aa) |
| | Hrb98DE | Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate. (365 aa) |
| | WASp | WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis. (527 aa) |
| | AdoR | Adenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation. (774 aa) |
| | Rpt6R | Regulatory particle triple-A ATPase 6-related; Hydrolase activity; TBP-class protein binding; ATP binding; ATPase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of RNA polymerase II transcription preinitiation complex assembly; modulation of chemical synaptic transmission; Belongs to the AAA ATPase family. (399 aa) |
| | wts | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] (1105 aa) |
| | Chchd3 | Coiled-coil-helix-coiled-coil-helix domain containing 3 (Chchd3) encodes a mitochondrial inner membrane protein that is required for mitochondrial fusion. Loss of Chchd3 leads to inactivation of Hippo activity, decreased tissue growth, cell proliferation defects, oxidative stress and JNK pathway activation. (223 aa) |
| | pasha | Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing. (642 aa) |
| | mod | DNA-binding protein modulo; Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development. It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories. (542 aa) |
| | sxc | Super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing. (1059 aa) |
| | Rab2 | Rab2, isoform A; Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. (213 aa) |
| | Rho1 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa) |
| | clu | Clueless (clu) encodes a cytoplasmic ribonucleoprotein that is required for mitochondrial function. It functions in part with protein complexes at the outer mitochondrial membrane, such as the ribosome, the translocase complex TOM and the mitophagy proteins encoded by park and Pink1. Loss of clu causes mitochondrial oxidative damage, decreased ATP and lethality. (1448 aa) |
| | Impbeta11 | Ran GTPase binding. It is involved in the biological process described with: protein import into nucleus. (1075 aa) |
| | CCT5 | Chaperonin containing TCP1 subunit 5 (CCT5) encodes a component of the TCP-1 ring complex (TRiC) chaperonin. It is involved in myofibril organization maintenance, cardiac physiological rhythm and lifespan determination. (542 aa) |
| | PI31 | Proteasome inhibitor PI31 subunit; Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (270 aa) |
| | RNaseZ | Ribonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa) |
| | CCT8 | Chaperonin containing TCP1 subunit 8; Unfolded protein binding; ATP binding. It is involved in the biological process described with: protein folding. (546 aa) |
| | drosha | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa) |
| | lgs | Protein BCL9 homolog; Legless (lgs) encodes a conserved transcriptional cofactor of the product of arm that is essential for the transcription of Wingless target genes. It contributes to growth regulation, cell survival and developmental patterning. (1469 aa) |
| | toy | Twin of eyeless (toy) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to formation of the central nervous system. (543 aa) |
| | pho | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] (520 aa) |
| | Wnt4 | Protein Wnt-4; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis. (539 aa) |
| | sv | Shaven, isoform A; Shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye. (844 aa) |
| | chb | CLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...] (1491 aa) |
| | fab1 | Putative 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome- related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing. (1809 aa) |
| | TBPH | TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa) |
| | salm | Homeotic protein spalt-major; Spalt major (salm) encodes a zinc finger transcriptional repressor. It mediates most dpp functions during development of the central part of the wing through regulation of the products of kni and ara. The product of salm is required for cell specification during the development of the nervous system, muscle, eye or trachea. (1365 aa) |
| | vari | Varicose, isoform B; Varicose (vari) encodes a protein involved in tracheal system development and septate junction assembly; Belongs to the MAGUK family. (636 aa) |
| | Ca-alpha1D | Voltage-dependent calcium channel type D subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Encodes a dihydropyridine- and diltiazem- sensitive current in larval body wall muscle. Vital for embryonic development; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2552 aa) |
| | gro | Groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. (730 aa) |
| | capt | Adenylyl cyclase-associated protein; Capulet (capt) encodes a conserved actin binding protein that functions across eukaryotes to negatively regulate actin filament assembly. Different types of actin filament formation are differentially affected by the loss of capt. (783 aa) |
| | Top1 | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unb [...] (974 aa) |
| | Eip74EF | Ecdysone-induced protein 74EF (Eip74EF) encodes a transcription factor that responds to different concentrations of 20-hydroxyecdysone. It contributes to puparium formation and autophagy; Belongs to the ETS family. (883 aa) |
| | tefu | Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...] (2767 aa) |
| | Mnn1 | Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like. (763 aa) |
| | Snap25 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. (212 aa) |
| | nub | Protein nubbin; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins. Belongs to the POU transcription factor family. Class-2 subfamily. (961 aa) |
| | pan | Protein pangolin, isoform J; Pangolin (pan) encodes an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to the product of gro) and activator (when bound to the product of arm) to promote cell fate specification. (1192 aa) |
| | wmd | Wing morphogenesis defect (wmd) encodes an essential WD-repeat protein that is required for wing development and motor behavior. (328 aa) |
| | Taf4 | Transcription initiation factor TFIID subunit 4; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May function as a coactivator by serving as a site of protein-protein contact between activators like Sp1 (or btd) and TFIID complex. (1088 aa) |
| | Kap3 | Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. (1038 aa) |
| | Shaw | Shaker cognate w (Shaw) encodes a voltage-gated potassium channel (Kv3.1) that mediates a non-inactivating potassium current open at resting membrane potential. It is important for controlling excitability of motor neurons and clock neurons. It regulates circadian rhythms and is in a pathway with the product of qsm and Na[+] K[+] Ca[2+] Co-transporter. (619 aa) |
| | lqfR | Liquid facets-Related (lqfR) encodes a Golgi protein involved in cell proliferation and oogenesis. (1415 aa) |
| | Csk | C-terminal Src kinase (Csk) encodes a cytoplasmic tyrosine kinase that acts as a tumor suppressor through Src pathway inibition as well as a mediator of the activity of the product of Egfr. (1052 aa) |
| | mtgo | Miles to go, isoform E. (2064 aa) |
| | Dll | Homeotic protein distal-less; Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin. (347 aa) |
| | Eb1 | Eb1, isoform F; Eb1 (Eb1) encodes a microtubule end-binding protein that contributes to organization of the microtubule cytoskeleton. It is involved in chromosome segregation, wound healing and flight behavior. (297 aa) |
| | hyx | Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. (538 aa) |
| | Trf2 | TATA box binding protein-related factor 2 (Trf2) encodes a core promoter recognition factor that mediates gene transcription. It contributes to spiracle morphogenesis, pupal development and salivary gland cell death. (1715 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | jar | Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (1268 aa) |
| | jb | Jean-baptiste; It is involved in the biological process described with: pupation. (152 aa) |
| | CG42638 | Cation channel activity. (652 aa) |
| | EcR | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa) |
| | Pka-R1 | Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa) |
| | nej | Nejire, isoform C; Nejire (nej) encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including the histone encoded by His3 on K18, K27, and H4 on K8. By regulating gene expression, the product of nej has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning. (3282 aa) |
| | gpp | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity. (2137 aa) |
| | d | Dachs, isoform E; Dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1426 aa) |
| | pros | Homeobox protein prospero; Homeodomain protein that controls neuronal identity. As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd. Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems. Regulates asymmetric stem cell self- renewal together with brat. (1835 aa) |
| | msps | Protein mini spindles; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte micr [...] (2082 aa) |
| | Cam | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa) |
| | Imp | IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs. (638 aa) |
| | jvl | Javelin-like, isoform D; Javelin-like (jvl) encodes a microtubule associated protein whose roles include actin and microtubule organization during oocyte development and bristle growth. (1315 aa) |
| | ash1 | Histone-lysine N-methyltransferase ash1; Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active. Belongs to t [...] (2226 aa) |
| | Dap160 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. (1190 aa) |
| | nbs | Nibrin; Nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. (818 aa) |
| | l(2)gd1 | Coiled-coil and C2 domain-containing protein 1-like; Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling; Belongs to the CC2D1 family. (834 aa) |
| | l(2)gl | Lethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development. (1161 aa) |
| | mtd | Mustard, isoform V; Mustard (mtd) encodes an ecdysone-regulated late puff protein. A isoform including only the C-terminal with a TLDc domain enters the nucleus. This isoform increases intestinal stem cell division and suppresses expression of the antimicrobial peptide encoded by DptA at the transcriptional level, independent of IMD pathway signaling. (1344 aa) |
| | Eip75B | Ecdysone-induced protein 75B (Eip75B) encodes a nuclear receptor that interacts with the receptor encoded by Hr3. The product of Eip75B regulates feeding behavior, fat deposition, and developmental timing in response to nitric oxide (NO) signaling. It also acts downstream from NO in the nervous system, where it controls neuronal remodeling. (1412 aa) |
| | east | Enhanced adult sensory threshold (east) encodes a ubiquitous protein localized to an extrachromosomal domain of the nucleus. It is involved in chemosensory behavior, chromosome segregation during cell division, cell survival and muscle development. (2342 aa) |
| | ben | Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. (151 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | scrib | Protein lap4; Scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. (2585 aa) |
| | vib | Vibrator, isoform B; Vibrator (vib) is an essential gene that encodes a conserved phosphatidylinositol transfer protein. The vib protein is enriched at the cleavage furrow and it is required for cytokinesis. (273 aa) |
| | sd | Scalloped, isoform Q; Scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification. (625 aa) |
| | CG43666 | Uncharacterized protein. (284 aa) |
| | Spc105R | Spc105-related, isoform B; Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore. (1960 aa) |
| | ush | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] (1212 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | Socs36E | Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. (737 aa) |
| | sbb | Scribbler, isoform J; Scribbler (sbb) encodes a transcriptional co-regulator that acts mainly as a co-repressor. It interacts physically and genetically with the product of Gug and is used by the repressor encoded by tll in early embryos. It regulates larval behavior, photoreceptor axon target choice, and functions downstream of Hedgehog signaling. (2330 aa) |
| | bon | Bonus, isoform C; Bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. (1207 aa) |
| | wit | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] (913 aa) |
| | brm | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] (1658 aa) |
| | Dab | Disabled (Dab) encodes an adaptor protein that is a core component of the Abl tyrosine kinase signaling pathway. It associates with transmembrane receptors including those encoded by N and Appl. It is involved in axon patterning, embryo morphogenesis and trafficking in endocytosis, exocytosis and Golgi organization. (2360 aa) |
| | sky | GTPase-activating protein skywalker; GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads [...] (607 aa) |
| | Spps | Sp1-like factor for pairing sensitive-silencing (Spps) encodes a zinc-finger protein in the Sp1/KLF family. It binds to Polycomb response elements, and is required for the recruitment of Polycomb group proteins to some of them. (985 aa) |
| | Atf3 | Activating transcription factor 3; Transcription factor which binds to the cAMP response element (CRE). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut. Required for the expression of odorant receptors Or43b and Or47b ; Belongs to the bZIP family. ATF subfamily. (688 aa) |
| | br | Broad-complex core protein isoform 6; Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (1011 aa) |
| | Mef2 | Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family. (606 aa) |
| | bi | Optomotor-blind protein; Bifid (bi) encodes a T-box transcription factor that controls cell proliferation, viability and cell migration. It contributes to the development of several tissues such as brain, eyes and wings. In wing development it is activated by the product of dpp and to a lesser extent by Wg signaling. (1023 aa) |
| | wek | Zinc finger protein weckle; Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination. (470 aa) |
| | Mps1 | Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. (672 aa) |
| | simj | Simjang, isoform E; Simjang (simj) encodes a component of the NURD complex, which couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. The product of simj is involded in cardiogenesis and habituation. (937 aa) |
| | Myc | Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | B4 | B4, isoform A; B4 (B4) encodes a protein involved in imaginal disc development. (1107 aa) |
| | Edem1 | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as "ER-Associated Degradation"; Belongs to the glycosyl hydrolase 47 family. (1004 aa) |
| | Dhc64C | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. (4661 aa) |
| | G9a | G9a, isoform B; G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory. (1657 aa) |
| | Acsl | Acyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa) |
| | endos | Endosulfine, isoform A; Endosulfine (endos) encodes a protein that, after its phosphorylation by the kinase encoded by gwl, inhibits the phosphatase encoded by tws. This inhibition is important for the entry of cells into M phase during the cell cycle. (119 aa) |
| | Smurf | E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (1061 aa) |
| | dsf | Dissatisfaction, isoform A; Dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation. (691 aa) |
| | exd | Homeobox protein extradenticle; Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system. (376 aa) |
| | Cdc27 | Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1. (900 aa) |
| | lmgA | Putative APC11 anaphase-promoting complex subunit; Lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by Apc2, it forms the minimal ubiquitin ligase module of the APC/C. (85 aa) |
| | TfAP-2 | Transcription factor AP-2 (TfAP-2) encodes a transcription factor with essential roles in leg, proboscis, and central nervous system development. It mediates Notch signaling in the developing tarsus. (471 aa) |
| | Glut1 | Glucose transporter 1 (Glut1) encodes a transmembrane protein that transports glucose but not galactose. (1440 aa) |
| | Tasp1 | Taspase 1 (Tasp1) encodes a threonine-type endopeptidase involved in spermatogenesis and the defense response to Gram-negative bacteria. (365 aa) |
| | usp | Protein ultraspiracle; Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post- embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene; Belongs to the nuclear hormone receptor family. NR2 subfamily. (508 aa) |
| | HisRS | Histidyl-tRNA synthetase, isoform D; histidine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: histidyl-tRNA aminoacylation; mitochondrial translation. (564 aa) |
| | E(z) | Histone-lysine N-methyltransferase E(z); Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting [...] (765 aa) |
| | e(y)3 | Enhancer of yellow 3 (e(y)3) encodes a nuclear protein required for embryogenesis and oogenesis. It participates in gene activation in euchromatin as a component of both the SWI/SNF chromatin remodeling complex and the TFIID transcription coactivator. It also contributes to gene silencing in pericentric heterochromatin and is also a coactivator in the JAK/STAT pathway. (2012 aa) |
| | cic | Putative transcription factor capicua; Transcriptional repressor required for the specification of numerous cell types during embryonic development. Required for terminal patterning of early embryos. May associate with gro to repress tll and hkb, restricting their expression to embryonic terminal poles where they initiate correct development of head and tail structures. Required for dorsoventral patterning of oocytes and early embryos. Cooperates with dl to repress zen and other dorsal specific genes within the embryo and promotes expression of the ventralizing factor pip in ovarian fo [...] (2150 aa) |
| | beta-Spec | Beta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. (2308 aa) |
| | ATP7 | ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa) |
| | CtBP | C-terminal-binding protein; Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (481 aa) |
| | Pak | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. (840 aa) |
| | stg | M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity. (479 aa) |
| | Atg17 | Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa) |
| | coro | Coronin; Actin filament binding. It is involved in the biological process described with: defense response to fungus; actin filament organization; adult somatic muscle development; Belongs to the WD repeat coronin family. (535 aa) |
| | Acn | Acinus, isoform A; Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy. (739 aa) |
| | CG13366 | FI18193p1. (1094 aa) |
| | hyd | E3 ubiquitin-protein ligase hyd; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk. (2887 aa) |
| | EMC1 | ER Membrane protein Complex 1 (EMC1) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (915 aa) |
| | eyg | Eyegone, isoform A; Eyegone (eyg) encodes a Pax family transcription factor that acts as a transcriptional repressor. In eye development, the product of eyg promotes cell proliferation in the larval eye disc through activation of Jak/STAT pathway. It also plays both positive and negative roles in head vortex development. (670 aa) |
| | Smox | Mothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa) |
| | tweek | Tweek, isoform J; Tweek (tweek) encodes a protein involved in the endocytosis of synaptic vesicles. (5150 aa) |
| | cnk | Connector enhancer of KSR protein CNK; Enzyme regulator activity; MAP-kinase scaffold activity; receptor tyrosine kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding. (1557 aa) |
| | jhamt | Juvenile hormone acid O-methyltransferase; O-methyltransferase that transfers a methyl group from S- adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis. Also able to methylate farnesoate to methyl farnesoate. (297 aa) |
| | Swip-1 | EF-hand domain-containing protein D2 homolog; Swiprosin-1 (Swip-1) encodes a calcium binding protein, expressed in fusion competent myoblasts and macrophages of the embryo. (217 aa) |
| | Ubqn | Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. (547 aa) |
| | Vap33 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. (269 aa) |
| | bs | Serum response factor homolog; Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea. (449 aa) |
| | Fas2 | Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa) |
| | NimB5 | Nimrod B5, isoform A; It is involved in the biological process described with: defense response to bacterium. (315 aa) |
| | ND-B17 | NADH dehydrogenase (Ubiquinone) B17 subunit, isoform A; NADH dehydrogenase activity. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone. (167 aa) |
| | Cyp303a1 | Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (503 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | Shawn | Shawn, isoform B; Shawn (Shawn) encodes a mitochondrial carrier involved in metal homeostasis; Belongs to the mitochondrial carrier (TC 2.A.29) family. (387 aa) |
| | Ser | Protein serrate; Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues. (1407 aa) |
| | Nsf2 | Vesicle-fusing ATPase 2; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity). (752 aa) |
| | flfl | Serine/threonine-protein phosphatase 4 regulatory subunit 3; Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required fo [...] (980 aa) |
| | LanB2 | Laminin B2 (LanB2) encodes a subunit of laminin, a heterotrimeric protein found in the extracellular matrix (ECM) and a major component of the basal lamina. Laminins interact with a variety of cell surface molecules such as integrin receptors and other secreted ECM components. It contributes to ECM organization, tissue adhesion, cell motility and developmental patterning. (1639 aa) |
| | tws | Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment. (499 aa) |
| | mtm | Myotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. (619 aa) |
| | Zyx | Zyx102.44 isoform; Zyxin (Zyx) encodes an actin cytoskeleton regulator found at cell-matrix junctions and cell-cell adherens junctions. Its roles include mechanotransduction and regulation of the Hippo signaling pathway. (585 aa) |
| | Gdi | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa) |
| | inv | Homeobox protein invected; Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification. Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis. Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule. (576 aa) |
| | raptor | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. (1621 aa) |
| | MAN1 | Inner nuclear membrane protein Man1; Inner nuclear membrane protein. Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ). Appears to be required for pupal development and consequently transition to the adult stage. During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote. (650 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | MetRS-m | Methionine--tRNA ligase, mitochondrial; ATP binding; methionine-tRNA ligase activity. It is involved in the biological process described with: methionyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa) |
| | Hr3 | Hormone receptor 3 (Hr3) encodes a protein induced directly by 20-hydroxyecdysone as a delayed-early response. It is required for tracheal air filling and ventral nerve cord condensation in embryos, for developmental progression through early metamorphosis, and in the prothoracic gland for ecdysteroid biosynthesis. (871 aa) |
| | Gld | Glucose dehydrogenase [FAD, quinone] short protein; Glucose dehydrogenase (Gld) encodes a dehydrogenase that belongs to the GMC oxidoreductase family. The product of Gld is essential for the enzymatic modification of the puparium wall that enables the newly developed adult fly to eclose. Gld is also highly expressed in the male and female reproductive tract and its product modulates sperm storage and utilization. (625 aa) |
| | nmo | Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (439 aa) |
| | Scr | Homeotic protein Sex combs reduced; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required [...] (508 aa) |
| | ctp | Dynein light chain 1, cytoplasmic; Cut up (ctp) encodes the 8 kDa (LC8/DLC1) subunit of the cytoplasmic Dynein, as well as the Myosin V. It homodimerizes and binds to a variety of proteins. It is involved in both dynein-dependent and independent functions such as cell viability, axonal guidance, spermatid growth and individualization, and regulation of spermatogonial divisions; Belongs to the dynein light chain family. (267 aa) |
| | tna | Tonalli, isoform B; Tonalli (tna) is an essential gene that encodes several isoforms, including Tna-A, which physically associates with subunits of the Brahma chromatin remodeling complex and is involved in transcriptional activation. (1186 aa) |
| | sc | Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation. (345 aa) |
| | Pex5 | Peroxin 5, isoform A; Peroxisome matrix targeting signal-1 binding. It is involved in the biological process described with: protein import into peroxisome matrix, docking; response to anesthetic; peroxisome organization. (614 aa) |
| | ph-d | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. (1537 aa) |
| | egh | Beta-1,4-mannosyltransferase egh; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system; Belongs to the glycosyltransferase 2 family. (457 aa) |
| | N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) |
| | Rala | Ras-related protein Ral-a; Ras-like protein A (Rala) encodes a GTPase that regulates Notch, Jak/Stat and JNK signalling pathways. (201 aa) |
| | MCTS1 | Malignant T-cell-amplified sequence 1 homolog; Regulates translation as part of a complex with DENR. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR. Belongs to the MCTS1 family. (182 aa) |
| | kdn | Probable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family. (522 aa) |
| | CG3918 | LD15209p; Nucleic acid binding; zinc ion binding. (321 aa) |
| | schlank | Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. (400 aa) |
| | Nf-YC | Nuclear factor Y-box C (Nf-YC) encodes a transcription factor involved in axon guidance. (601 aa) |
| | spidey | RH59310p; Spidey (spidey) encodes a member of the short chain dehydrogenase/reductase family. It regulates oenocyte growth and maturation, as well as the metabolism of ecdysteroids and cuticular hydrocarbons; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa) |
| | Trxr-1 | Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (596 aa) |
| | Moe | Moesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa) |
| | Lim1 | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. (505 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. (535 aa) |
| | mxc | Multi sex combs (mxc) encodes a Cylin E/Cdk2 substrate and molecular scaffold that is necessary for assembly of the histone locus body, which is a nuclear body associated with replication dependent histone gene clusters that contains factors necessary for the transcription and processing of histone mRNA. (1837 aa) |
| | Lpt | Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. (1482 aa) |
| | SERCA | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa) |
| | Ssrp | FACT complex subunit Ssrp1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (723 aa) |
| | betaTub60D | Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (454 aa) |
| | Eps-15 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. (1253 aa) |
| | hfp | Poly(U)-binding-splicing factor half pint; Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq. Belongs to the RRM half pint family. (637 aa) |
| | CG2021 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | ecd | Ecdysoneless (ecd) encodes a protein that physically interacts with several components of the U5 snRPN pre-mRNA splicing complex. Its loss result in intron retention within spok, accounting for ecdysone deficiency of some ecd mutants; Belongs to the ECD family. (684 aa) |
| | Drsl4 | Drosomycin-like 4 (Drsl4) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. (71 aa) |
| | sty | Protein sprouty; Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells. (589 aa) |
| | Ack | Activated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa) |
| | C901 | RT07140p1; Notch binding. It is involved in the biological process described with: cell communication. (559 aa) |
| | sesB | ADP,ATP carrier protein; Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. (312 aa) |
| | Ant2 | Adenine nucleotide translocase 2, isoform A; ATP:ADP antiporter activity. It is involved in the biological process described with: ATP transport; transmembrane transport; ADP transport; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) |
| | dsh | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa) |
| | hop | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. (1177 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | Usp7 | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1129 aa) |
| | comt | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. (745 aa) |
| | jub | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. (728 aa) |
| | l(1)G0007 | Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation. (1222 aa) |
| | CCT6 | Chaperonin containing TCP1 subunit 6; ATP binding; unfolded protein binding. It is involved in the biological process described with: mitotic cell cycle; protein folding; centriole replication. (533 aa) |
| | sing | Singles bar (sing) encodes a small multipass transmembrane protein that is required for muscle fusion in embryonic and adult stages. It is needed for progression beyond the pre-fusion complex stage of myoblast fusion, possibly by delivering fusion machinery components by vesicle fusion. (176 aa) |
| | DENR | Density-regulated protein homolog; Regulates translation as part of a complex with MCTS1. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR. (189 aa) |
| | fu | Serine/threonine-protein kinase fused; Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. (805 aa) |
| | Rip11 | Rab11 interacting protein (Rip11) encodes a protein that belongs to Rab11 family interacting proteins (FIP family). It binds only to the GTP bound form of the product of Rab11, thus acting as its effector. It regulates Rhodopsin transport and cytokinesis. (832 aa) |
| | dome | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. (1282 aa) |
| | nkd | Protein naked cuticle; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification. Belongs to the NKD family. (928 aa) |
| | rpr | Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1. (65 aa) |
| | dlp | Dally-like, isoform A; Dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg; Belongs to the glypican family. (765 aa) |
| | CG6650 | LD24362p; ADP-specific glucokinase activity. It is involved in the biological process described with: carbohydrate metabolic process. (501 aa) |
| | vih | Ubiquitin-conjugating enzyme E2 C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Belongs to the ubiquitin-conjugating enzyme family. (178 aa) |
| | Gcn5 | Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. (813 aa) |
| | Smyd4-2 | SET and MYND domain containing, class 4, member 2 (Smyd4-2) encodes a histone deacetylase involved in photoreceptor development, eclosion, and gene expression regulation. (663 aa) |
| | wls | Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa) |
| | Dronc | Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. (450 aa) |
| | aay | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (270 aa) |
| | Nf-YA | Nuclear factor Y-box A (Nf-YA) encodes a subunit of the nuclear transcription factor Y (NF-Y), also known as the CCAAT motif-binding factor (CBF). It is involved in eye and thorax development via gene expression regulation. (399 aa) |
| | Arp3 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline. (418 aa) |
| | lark | RNA-binding protein lark; Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development. (352 aa) |
| | CTCF | GH14774p; CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture. (818 aa) |
