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| | U2af50 | U2 small nuclear riboprotein auxiliary factor 50 (U2af50) encodes the large subunit of the heterodimeric complex U2AF. U2AF binds to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site early in spliceosome assembly. (427 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | B52 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (355 aa) |
| | sm | Smooth, isoform T; Smooth (sm) encodes an RNA binding, heterogeneous nuclear ribonucleoprotein involved in axon guidance, mRNA processing, chemosensation, determination of lifespan and feeding behavior. (552 aa) |
| | Ref2 | RNA and export factor binding protein 2, isoform A; mRNA binding; nucleic acid binding. (220 aa) |
| | shep | Alan shepard (shep) encodes an evolutionarily conserved RNA/DNA binding protein that regulates alternative splicing and gypsy insulator activities. It regulates neural development during the embryonic and larval stages, and neuronal remodeling during metamorphosis. (590 aa) |
| | btz | Barentsz, isoform D; Barentsz (btz) encodes a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. It is required for the posterior localization of osk mRNA. (806 aa) |
| | mbf1 | Multiprotein bridging factor 1 (mbf1) encodes a transcriptional co-activator that bridges between sequence-specific transcriptional regulators and the product of Tbp. Under stress, the product of mbf1 in the cytoplasm can translocate into the nucleus and serve as a co-activator to induce stress-reponse genes. (188 aa) |
| | Rbp9 | RNA-binding protein 9, isoform J; RNA-binding protein 9 (Rbp9) encodes a putative RNA binding protein involved in the establishment of the blood-brain barrier and control of germ cell proliferation. (684 aa) |
| | cpo | Couch potato (cpo) is most strongly expressed in nuclei of the central and peripheral nervous systems and the ring gland, where its product may regulate gene transcription to control complex neurological and neuroendocrine functions. It is required for normal synaptic transmission, climate adaptation, olfaction, diapause and behavioral responses. (962 aa) |
| | bru3 | Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. (422 aa) |
| | Sxl | Protein sex-lethal; Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex- determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific [...] (722 aa) |
| | CG4887 | FI21118p1; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1004 aa) |
| | swm | Zinc finger protein swm; Negatively regulates Hedgehog (hh) protein signal in wing development. Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells. (1063 aa) |
| | snRNP-U1-70K | Small ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome. (448 aa) |
| | qkr54B | Quaking related 54B, isoform E; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (617 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | eRF1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (447 aa) |
| | bol | Protein boule; RNA-binding protein that plays a central role in spermatogenesis. Required for meiotic entry and germline differentiation, at the transition between G2 and M phases of meiosis I. Acts by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. Essential for translation of twine (twe) mRNA. Required for the expression of various genes such as CG6784, CG17210, CG15841 scpr-B, scpr-C, and rho-6; Belongs to the RRM DAZ family. (233 aa) |
| | CG10466 | Uncharacterized protein, isoform A; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (154 aa) |
| | mRpS7 | 28S ribosomal protein S7, mitochondrial; Structural constituent of ribosome; rRNA binding; mRNA binding. It is involved in the biological process described with: mitochondrial translation; translation; ribosomal small subunit assembly; Belongs to the universal ribosomal protein uS7 family. (218 aa) |
| | Top2 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I. During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles. May have a role in chromatin [...] (1447 aa) |
| | Sf3b1 | Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome. (1340 aa) |
| | tral | Trailer hitch (tral) encodes a protein required for oocyte dorsoventral patterning via actin and microtubule cytoskeleton organization. (657 aa) |
| | cocoon | AT09813p; RNA binding; mRNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding. It is involved in the biological process described with: regulation of RNA metabolic process. (318 aa) |
| | apt | Apontic, isoform F; Apontic (apt) encodes a DNA-binding protein that acts as a transcriptional regulator and can function in translational repression. It plays roles in cell migration, cell fate specification, and morphogenesis via STAT signaling pathway inhibition. (499 aa) |
| | Rox8 | Rox8, isoform D; Rox8 (Rox8) encodes a protein involved in the regulation of alternative mRNA splicing. (470 aa) |
| | roq | Roquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (819 aa) |
| | U2af38 | U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. (264 aa) |
| | Rsf1 | RNA-binding protein Rsf1; May control important aspects of development. (200 aa) |
| | msi | Musashi, isoform B; Musashi (msi) encodes an RNA binding protein that binds to the 3' UTR region of target mRNAs, including ttk and sima, thus it positively regulates neural differentiation and negatively regulates the HIF pathway. It contributes to cell fate determination, as well as cellular response to normoxic/hypoxic conditions. (634 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | mRpL12 | Mitochondrial ribosomal protein L12 (mRpL12) encodes a protein required for Cyclin D/Cdk4-driven cell growth. (182 aa) |
| | CG3335 | Uncharacterized protein; Helicase activity; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA cis splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (918 aa) |
| | Slbp | Histone RNA hairpin-binding protein; Stem-loop binding protein (Slbp) encodes a protein that plays an essential role in 3' end processing of histone pre-mRNAs into mature histone mRNAs by recruiting the product of snRNA:U7 to the pre-mRNA. (276 aa) |
| | CG11726 | IP09423p; Nucleic acid binding; mRNA binding. (291 aa) |
| | yps | Ypsilon schachtel, isoform A; Nucleic acid binding; protein binding; mRNA binding. It is involved in the biological process described with: oogenesis; mRNA splicing, via spliceosome; regulation of gene expression. (352 aa) |
| | eIF2beta | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family. (312 aa) |
| | CG10948 | Uncharacterized protein, isoform C; Nucleic acid binding; mRNA binding; disulfide oxidoreductase activity. It is involved in the biological process described with: ultradian rhythm. (804 aa) |
| | Vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...] (399 aa) |
| | D | Dichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development. (382 aa) |
| | CG9705 | Cold shock domain-containing protein CG9705; mRNA 3'-UTR binding. It is involved in the biological process described with: regulation of mRNA stability; dendrite morphogenesis. (143 aa) |
| | Edc3 | Enhancer of mRNA-decapping protein 3; In the process of mRNA degradation, may play a role in mRNA decapping. (680 aa) |
| | CG3808 | RRM domain-containing protein; Nucleic acid binding; RNA methyltransferase activity; mRNA binding. It is involved in the biological process described with: RNA processing; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (615 aa) |
| | CG14230 | Probable RNA-binding protein CG14230; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome. (580 aa) |
| | CG18259 | FI13061p; Nucleic acid binding. (474 aa) |
| | CG6961 | LD35981p; mRNA binding; nucleic acid binding. (474 aa) |
| | DENR | Density-regulated protein homolog; Regulates translation as part of a complex with MCTS1. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR. (189 aa) |
| | nonA | Protein no-on-transient A; Required for normal vision and courtship behavior in Drosophila. (742 aa) |
| | caz | Cabeza (caz) encodes a chromatin binding protein involved in locomotion, synaptic growth at the neuromuscular junction and eye development. (399 aa) |
| | CG1316 | RE70333p; Nucleic acid binding; mRNA binding. (470 aa) |
| | Ythdc1 | YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. Acts by acting as a reader of m6A methylation. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. (721 aa) |
| | Larp4B | La-related protein Larp4B; Probable RNA binding protein. Negatively regulates myc at the protein level, via an unknown mechanism, and may therefore have a role in growth. Has no effect on myc mRNA levels. (1531 aa) |
| | CG7879 | FI22004p1; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of RNA splicing; regulation of alternative mRNA splicing, via spliceosome. (985 aa) |
| | CG3594 | FI01540p; Nucleic acid binding; mRNA binding. (250 aa) |
| | CG4806 | LD27920p; RNA binding; mRNA binding. (657 aa) |
| | Pof | Protein painting of fourth; Probable RNA-binding protein that specifically binds to the fourth chromosome and may bind an RNA that spreads the fourth chromosome. May be a reminiscence of X chromosome dosage compensation of ancestral Drosophila species in which the X and the fourth chromosomes are one single chromosome. (495 aa) |
| | ytr | Yantar, isoform A; Yantar (ytr) encodes a conserved arginine-rich protein involved in alternative splicing and hemocyte differentiation. (194 aa) |
| | DCP1 | Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing. (372 aa) |
| | Upf3 | Upf3, isoform B; Upf3 (Upf3) encodes a protein that regulates targets of the nonsense-mediated mRNA decay pathway. This pathway participates in homeostatic gene expression regulation and plays a quality control role in the elimination of mRNAs with premature termination codons. The product of Upf3 is involved in cell cycle progression and general developmental rate. (492 aa) |
| | RpS26 | 40S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa) |
| | eIF3a | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1140 aa) |
| | vas | ATP-dependent RNA helicase vasa; Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells. Belongs to the D [...] (661 aa) |
| | orb2 | Translational regulator orb2; Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'- UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid- like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Isoform A is required for initial memory acquisition and, following subsequent late dopaminerg [...] (769 aa) |
| | Hrb98DE | Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate. (365 aa) |
| | Rb97D | Ribonucleoprotein RB97D; Required for spermatogenesis. Could be required to process a specific transcript essential for spermatogenesis. (471 aa) |
| | bam | Bag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway. (442 aa) |
| | Ythdf | YTH domain-containing family protein; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability. (700 aa) |
| | CG5808 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (653 aa) |
| | Saf-B | Scaffold attachment factor B, isoform B; mRNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of mRNA processing; regulation of transcription by RNA polymerase II; regulation of alternative mRNA splicing, via spliceosome. (928 aa) |
| | Nab2 | Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. (1004 aa) |
| | Irp-1A | Iron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa) |
| | nonA-l | NonA-like, isoform A; Poly-pyrimidine tract binding; mRNA binding; transcription regulatory region sequence-specific DNA binding; nucleic acid binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; mRNA splicing, via spliceosome. (630 aa) |
| | Tis11 | Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets. (436 aa) |
| | ps | Pasilla, isoform R; Pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology. (780 aa) |
| | Hrb87F | Heterogeneous nuclear ribonucleoprotein at 87F (Hrb87F) encodes a hnRNP-A family RNA-binding protein, involved in gene expression and RNA processing. It is an essential component of the nucleoplasmic omega speckles and necessary for telomere maintenance. Hrb87F null mutants show defects in development, female fertility and stress tolerance. (385 aa) |
| | orb | Oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. (915 aa) |
| | Syp | Syncrip, isoform J; Syncrip (Syp) encodes an RNA-binding protein that regulates the localization and translation of mRNAs involved in multiple processes. It is required for synapse morphology and synaptic transmission at the neuromuscular junction as well as being involved in oocyte axis specification and control of neuronal cell fates in the mushroom body. (761 aa) |
| | NAT1 | NAT1, isoform D; NAT1 (NAT1) encodes a protein involved in chaeta development. (1488 aa) |
| | CG31156 | LD12377p; Structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: nucleobase-containing compound metabolic process; translation. (948 aa) |
| | CG6937 | RRM domain-containing protein; mRNA binding; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (356 aa) |
| | CG6015 | LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (576 aa) |
| | eIF3g2 | Eukaryotic translation initiation factor 3 subunit G-2; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (273 aa) |
| | Regnase-1 | LD08718p; Endoribonuclease activity; mRNA binding; metal ion binding. It is involved in the biological process described with: RNA phosphodiester bond hydrolysis, endonucleolytic. (540 aa) |
| | nos | Protein nanos; Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal. Acts by forming a complex with pum and brat that regulates translation and mRNA stability. The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Controls posterior development. Rescuing factor for the abdominal defect of posterior group mutants. The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein. (401 aa) |
| | CG7706 | FHA domain-containing protein; mRNA binding. (726 aa) |
| | CstF64 | Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa) |
| | Cbp20 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa) |
| | SF1 | Splicing factor 1, isoform A; Zinc ion binding; pre-mRNA branch point binding; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (787 aa) |
| | RpS5b | 40S ribosomal protein S5b; rRNA binding; structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the universal ribosomal protein uS7 family. (230 aa) |
| | sqd | RNA-binding protein squid; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues. (344 aa) |
| | CG14506 | Uncharacterized protein, isoform B; Nucleic acid binding; mRNA binding. (404 aa) |
| | how | Protein held out wings; Required for integrin-mediated cell-adhesion in wing blade. Vital role in steroid regulation of muscle development and to control heart rate. Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. (418 aa) |
| | brat | Brain tumor protein; A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation. Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. During neuroblast division, segregates asymmetrically and inhibits s [...] (1061 aa) |
| | CG44249 | RRM domain-containing protein; mRNA binding; nucleic acid binding; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: DNA metabolic process; DNA catabolic process, exonucleolytic; mRNA splicing, via spliceosome; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (407 aa) |
| | CG14414 | Uncharacterized protein, isoform E; mRNA binding; RNA binding. (213 aa) |
| | qkr58E-2 | Quaking related 58E-2, isoform A; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (416 aa) |
| | qkr58E-3 | Quaking related 58E-3 (qkr58E-3) encodes an RNA binding protein that contributes to mRNA splicing and apoptosis. (317 aa) |
| | ssx | Sister-of-Sex-lethal, isoform D; RNA binding; mRNA binding. It is involved in the biological process described with: defense response to bacterium; posttranscriptional gene silencing; regulation of RNA splicing. (485 aa) |
| | CG4119 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (998 aa) |
| | RpL24 | 60S ribosomal protein L24; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; assembly of large subunit precursor of preribosome; translation; ribosomal large subunit assembly; Belongs to the eukaryotic ribosomal protein eL24 family. (155 aa) |
| | CG10384 | IP21806p; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (492 aa) |
| | RpS5a | Ribosomal protein S5a (RpS5a) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS7 family. (228 aa) |
| | eIF4H1 | Nucleic acid binding; translation initiation factor activity; mRNA binding. It is involved in the biological process described with: translational initiation. (388 aa) |
| | CG34354 | Uncharacterized protein, isoform F; Nucleic acid binding; mRNA binding. (550 aa) |
| | eIF4G2 | Eukaryotic translation initiation factor 4G2 (eIF4G2) encodes an eIF4G homolog involved in regulation of translation initiation within male germ cells. It is required for spermatogenesis. (2072 aa) |
| | Dp1 | Dodeca-satellite-binding protein 1 (Dp1) encodes a single-stranded nucleic acid binding protein that belongs to the vigilin protein family. It binds to target mRNAs and enhances their translation. (1301 aa) |
| | CG7564 | LD04387p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome. (420 aa) |
| | nsr | Novel spermatogenesis regulator, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; posttranscriptional regulation of gene expression; sperm axoneme assembly; sperm individualization. (340 aa) |
| | Achl | Achilles, isoform A; Achilles (Achl) is a clock-controlled gene that is expressed in a rhythmic manner in the brain. It regulates wing development and expression of antimicrobial peptides. (867 aa) |
| | Unr | Upstream of N-ras (Unr) encodes an RNA binding protein that functions as an RNA chaperone and translation regulator. It performs opposing, sex-specific, roles in X-chromosome dosage compensation by regulating lncRNA:roX2 RNA conformation in males and msl-2 mRNA translation in females. (1057 aa) |
| | rin | Rasputin, isoform B; Rasputin (rin) encodes an RNA-binding protein that regulates gene expression. It is involved in eye development and the dorsal/ventral axis specification of the ovary. (690 aa) |
| | cup | Protein cup; Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localizat [...] (1117 aa) |
| | Rbp4 | RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. (428 aa) |
| | CG14718 | GH13594p; mRNA binding; transcription coregulator activity; RNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. (446 aa) |
| | Rbp1 | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. (144 aa) |
| | rump | Rumpelstiltskin, isoform A; Rumpelstiltskin (rump) encodes the Drosophila hnRNP M homolog. It binds to nos and osk mRNAs and plays a role in mRNA localization to the germ plasm by diffusion/entrapment during late stages of oogenesis. It also binds to exonic splicing enhancers on pre-mRNA targets, implicating it as a splicing factor. (632 aa) |
| | RnpS1 | RNA-binding protein S1 (RnpS1) encodes a protein involved in RNA splicing and regulation of DNA transposition. (374 aa) |
| | osk | Maternal effect protein oskar; Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole. (606 aa) |
| | SLIRP2 | SRA stem-loop interacting RNA binding protein 2; Protein binding; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA processing; regulation of RNA metabolic process. (91 aa) |
| | CG7483 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. Has a role in oskar mRNA localization at the posterior pole of the developing oocyte. (399 aa) |
| | bcd | Homeotic protein bicoid; Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. (494 aa) |
| | Ref1 | RNA and export factor binding protein 1; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (266 aa) |
| | La | La protein homolog; May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development. (390 aa) |
| | bsf | Bicoid stability factor (bsf) encodes a member of the family of proteins containing the pentatricopeptide motif, an RNA binding domain. It is found in the cytoplasm, where it functions in mRNA stability and post-transcriptional control of gene expression, and in mitochondria, where it has multiple roles in gene expression. It acts at many stages of development, and is required for progression through oogenesis and viability. (1412 aa) |
| | CG12288 | Uncharacterized protein; mRNA binding; nucleic acid binding. (435 aa) |
| | BicC | Protein bicaudal C; RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression. (905 aa) |
| | vig | Vasa intronic gene (vig) encodes a protein involved in RNA interference and heterochromatin organization. (490 aa) |
| | me31B | ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa) |
| | Srp54 | LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (513 aa) |
| | Su(var)205 | Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. (206 aa) |
| | Mettl14 | N6-adenosine-methyltransferase non-catalytic subunit; Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA- binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and pro [...] (397 aa) |
| | x16 | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. (258 aa) |
| | CG14641 | LD46870p; pre-mRNA binding; mRNA binding; metal ion binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (418 aa) |
| | srl | Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding. (1067 aa) |
| | CG2931 | RE50009p; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome. (302 aa) |
| | RpL13A | Ribosomal protein L13A (RpL13A) encodes a component of the large ribosomal subunit, and thus involved in mRNA translation. Mutations in genes encoding ribosomal proteins affect fertility, viability and other Drosophila phenotypes, described as Minute; Belongs to the universal ribosomal protein uL13 family. (205 aa) |
| | Rm62 | ATP-dependent RNA helicase p62; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation (By similarity). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner. (719 aa) |
| | CG7414 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (638 aa) |
| | barc | Barricade, isoform A; RNA binding; U2 snRNP binding; mRNA binding. It is involved in the biological process described with: positive regulation of RNA splicing; regulation of neurogenesis; mRNA splicing, via spliceosome. (556 aa) |
| | Mkrn1 | Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa) |
| | spen | Protein split ends; Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins. (5560 aa) |
| | CG11454 | RRM domain-containing protein; mRNA binding; single-stranded RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (238 aa) |
| | CG4896 | Uncharacterized protein, isoform D; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (949 aa) |
| | Secp43 | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. (336 aa) |
| | CG3294 | Uncharacterized protein, isoform A; pre-mRNA 3'-splice site binding; metal ion binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; wound healing. (456 aa) |
| | SLIRP1 | SRA stem-loop interacting RNA binding protein 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA processing; regulation of RNA metabolic process. (90 aa) |
| | peng | Protein penguin; mRNA binding. It is involved in the biological process described with: regulation of translation; apposition of dorsal and ventral imaginal disc-derived wing surfaces. (737 aa) |
| | lin-28 | Protein lin-28 homolog; mRNA binding; zinc ion binding; mRNA 3'-UTR binding; Belongs to the lin-28 family. (195 aa) |
| | Sf3b6 | Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the in [...] (121 aa) |
| | lark | RNA-binding protein lark; Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development. (352 aa) |
| | Cpsf6 | Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa) |
| | Sbp2 | SECIS-binding protein 2 (Sbp2) encodes an RNA stem-loop binding protein involved in selenocysteine incorporation at a stop codon (UGA) during translation. (313 aa) |
| | Nelf-E | Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing. Belongs to the RRM NELF-E family. (280 aa) |
| | thoc5 | THO complex subunit 5; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC5 family. (616 aa) |
| | LS2 | U2 snRNP auxiliary factor large subunit; Large Subunit 2 (LS2) encodes an RNA binding protein that regulates both RNA splicing and gene silencing; Belongs to the splicing factor SR family. (449 aa) |
| | CNBP | CCHC-type zinc finger protein CG3800; mRNA binding; single-stranded RNA binding; translation regulator activity; zinc ion binding. It is involved in the biological process described with: positive regulation of cytoplasmic translation. (165 aa) |
| | CG3927 | KH domain-containing protein; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (270 aa) |
| | qkr58E-1 | Quaking related 58E-1, isoform A; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (396 aa) |
| | CG4021 | KH domain-containing protein; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (319 aa) |
| | CG9346 | Uncharacterized protein; RNA binding; mRNA binding. It is involved in the biological process described with: RNA processing. (957 aa) |
| | RpS14b | mRNA 5'-UTR binding; structural constituent of ribosome; small ribosomal subunit rRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation; ribosomal small subunit assembly; translation. (151 aa) |
| | RpS14a | 40S ribosomal protein S14a; Small ribosomal subunit rRNA binding; structural constituent of ribosome; mRNA 5'-UTR binding. It is involved in the biological process described with: cytoplasmic translation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation; ribosomal small subunit assembly; Belongs to the universal ribosomal protein uS11 family. (151 aa) |
| | CG3198 | RH42690p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome; positive regulation of gene expression. (438 aa) |
| | swa | Protein swallow; Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis. (548 aa) |
| | Spx | Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (347 aa) |
| | Shmt | Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa) |
| | RpL35 | Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation. (123 aa) |
| | Rnp4F | RNA-binding protein 4F (Rnp4F) encodes an essential evolutionarily-conserved RNA-binding protein. Rnp4F gene expression is post-transcriptionally regulated by interaction with a stable stem-loop structure in the 5'-UTR of the mRNA with trans-acting factors. (941 aa) |
| | snf | U1 small nuclear ribonucleoprotein A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing; Belongs to the RRM U1 A/B'' family. (216 aa) |
| | Cbp80 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs [...] (800 aa) |
| | eIF3g1 | Eukaryotic translation initiation factor 3 subunit G-1; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (269 aa) |
| | Lrpprc2 | Leucine-rich pentatricopeptide repeat containing 2 (Lrpprc2) encodes an RNA-binding protein that forms a complex with the product of SLIRP2. It localizes to the mitochondrial matrix where it functions to coordinate mitochondrial translation. (1072 aa) |
| | CG14628 | EG:BACR42I17.12 protein; mRNA binding; nucleic acid binding. (141 aa) |
| | CG7903 | Uncharacterized protein, isoform A; Nucleic acid binding; mRNA binding. (384 aa) |
| | eIF4H2 | Translation initiation factor activity; nucleic acid binding; mRNA binding. It is involved in the biological process described with: translational initiation. (459 aa) |
| | mod | DNA-binding protein modulo; Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development. It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories. (542 aa) |
| | rig | Rigor mortis (rig) encodes a component of the cytoplasmic U snRNP body and a member of the SMN-Gemins complex. It is required in the motor system for viability and motor behaviour. It also works as a nuclear receptor interacting protein required for ecdysone signalling during larval development. (1235 aa) |
| | Spt5 | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] (1078 aa) |
| | pAbp | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] (634 aa) |
| | stau | Maternal effect protein staufen; RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis. In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior- posterior patterning of the developing embryo. Association with osk or bcd at their respective poles, appears to promote the formation and stabilization o [...] (1026 aa) |
| | Dcr-2 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa) |
| | eIF3b | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (690 aa) |
| | cyp33 | Peptidyl-prolyl cis-trans isomerase E; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity); Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (300 aa) |
| | NiPp1 | Nuclear inhibitor of Protein phosphatase 1 (NiPp1) encodes a PP1 phosphatase inhibitor involved in axon guidance. (383 aa) |
| | Psi | P-element somatic inhibitor (Psi) encodes a protein that has dual roles in RNA processing and transcriptional regulation. It is required for activating Myc transcription. (797 aa) |
| | clu | Clueless (clu) encodes a cytoplasmic ribonucleoprotein that is required for mitochondrial function. It functions in part with protein complexes at the outer mitochondrial membrane, such as the ribosome, the translocase complex TOM and the mitophagy proteins encoded by park and Pink1. Loss of clu causes mitochondrial oxidative damage, decreased ATP and lethality. (1448 aa) |
| | fus | RNA-binding protein fusilli; mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator. (967 aa) |
| | Arc1 | Activity-regulated cytoskeleton associated protein 1; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles. Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation. Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction. May play a role in energy balance: required for regulation of body fat b [...] (254 aa) |
| | tsu | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte. Belongs to the RBM8A family. (165 aa) |
| | Pabp2 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, [...] (224 aa) |
| | nito | RNA-binding protein spenito; RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs. M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, may act by binding target RNAs and recruiting the WMM complex. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physi [...] (793 aa) |
| | 4E-T | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. (1010 aa) |
| | mRpL13 | 39S ribosomal protein L13, mitochondrial; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: negative regulation of translation; mitochondrial translation; translation; Belongs to the universal ribosomal protein uL13 family. (178 aa) |
| | TBPH | TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa) |
| | Caper | Caper, isoform A; Caper (Caper) encodes an RNA-binding protein involved in regulation of alternative mRNA splicing. (594 aa) |
| | mRpS11 | Mitochondrial ribosomal protein S11; mRNA 5'-UTR binding; structural constituent of ribosome; small ribosomal subunit rRNA binding. It is involved in the biological process described with: ribosomal small subunit assembly; translation; mitochondrial translation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (200 aa) |
| | glo | Glorund, isoform A; Glorund (glo) encodes a hnRNP F/H family RNA-binding protein that binds directly to nos mRNA and regulates its translation during late stages of oogenesis. The functions of the product of glo include nurse cell nuclear chromatin organization, axis patterning as well as being required for viability to adulthood. (586 aa) |
| | tra2 | Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] (264 aa) |
| | Pur-alpha | Purine-rich binding protein-alpha (Pur-alpha) encodes a DNA- and RNA-binding protein involved in the regulation of transcription and cell-cycle. In the cytoplasm it is found in motile RNPs, indicating a role in RNA localization. (275 aa) |
| | Cpsf160 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa) |
| | otu | Protein ovarian tumor locus; Essential for female fertility; germ cell division and differentiation. (853 aa) |
| | HnRNP-K | Heterogeneous nuclear ribonucleoprotein K (HnRNP-K) encodes a member of the hnRNP family of DNA/RNA binding proteins. It localizes, along with other hnRNPs, in nucleoplasmic omega speckles. It is involved in gene regulation, post-transcriptional RNA processing and RNA transport. (502 aa) |
| | PIP4K | Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size. (404 aa) |
| | CG34334 | SD20656p; mRNA binding; nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; RNA splicing. (708 aa) |
| | eIF4G1 | Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. (1919 aa) |
| | CG4266 | Uncharacterized protein, isoform B; mRNA binding; nucleic acid binding. (1306 aa) |
| | CG7907 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. (753 aa) |
| | Rbp6 | RNA-binding protein 6 (Rbp6) encodes a paralog of the RNA-binding protein encoded by msi. In contrast to msi, Rbp6 mutants are viable and fertile, with only a slight delay in eclosion. The product of Rbp6 may have roles in response to fungal infection and aggressive behavior. (499 aa) |
| | CG17168 | RE68879p; RNA binding; mRNA binding. It is involved in the biological process described with: production of miRNAs involved in gene silencing by miRNA. (421 aa) |
| | egl | Egalitarian, isoform B; Egalitarian (egl) encodes an RNA binding protein that links specific mRNAs to the minus end-directed microtubule motor, cytoplasmic dynein-1. (1004 aa) |
| | hang | Hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. (2223 aa) |
| | smg | Smaug (smg) encodes the founding member of the SMAUG family of sequence-specific RNA-binding proteins. During the maternal-to-zygotic transition in early embryos, the smg product inhibits the translation and induces the degradation of hundreds of maternal mRNAs by recruitment of the CCR4-NOT deadenylase complex, thereby controlling embryonic patterning, activation of zygotic transcription, and early embryonic cell cycles. (1109 aa) |
| | CG42360 | RNase_Zc3h12a domain-containing protein. (496 aa) |
| | CG6967 | Uncharacterized protein, isoform C; RNA binding. It is involved in the biological process described with: posttranscriptional gene silencing by RNA. (764 aa) |
| | CG31368 | Uncharacterized protein, isoform D; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1486 aa) |
| | larp | La-related protein 1; RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation. (1673 aa) |
| | tho2 | Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. (1642 aa) |
| | Pcf11 | Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation. (1953 aa) |
| | Rbp1-like | Rbp1-like, isoform B; Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism. (247 aa) |
| | SF2 | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. (255 aa) |
| | bru2 | Bruno 2, isoform E; RNA binding; mRNA binding. It is involved in the biological process described with: negative regulation of translation; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome. (893 aa) |
| | mub | Mushroom-body expressed, isoform K; Mushroom-body expressed (mub) encodes a protein involved in thermosensory behavior and regulation of alternative mRNA splicing. (573 aa) |
| | Rbfox1 | RNA-binding Fox protein 1 (Rbfox1) encodes RNA-binding proteins that bind to (U)GCAUG elements. Nuclear isoforms of the product of Rbfox1 regulate tissue specific alternative splicing, while cytoplasmic isoforms regulate mRNA translation. It functions in a number of processes, including germline cyst development. (962 aa) |
| | Imp | IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs. (638 aa) |
| | CG4612 | LD36772p; poly(U) RNA binding; mRNA 3'-UTR binding; mRNA binding; poly(A) binding; RNA binding. It is involved in the biological process described with: long-term memory; positive regulation of translation. (307 aa) |
| | Marf1 | Meiosis regulator and mRNA stability factor 1, isoform D; mRNA binding involved in posttranscriptional gene silencing; CCR4-NOT complex binding. It is involved in the biological process described with: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; posttranscriptional gene silencing. (1305 aa) |
| | SC35 | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (195 aa) |
| | su(f) | Suppressor of forked (su(f)) is an essential gene that encodes a protein involved in mRNA 3'-end processing (the nuclear cleavage/polyadenylation reaction) and alternative poly(A) site utilization. su(f) product accumulates in dividing cells where it is required for mitosis progression. (765 aa) |
| | heph | Hephaestus, isoform Y; Hephaestus (heph) encodes a nucleo-cytoplasmic shuttling protein that regulates osk mRNA translation. It is involved in spermatid individualization and Notch signalling regulation. (898 aa) |
| | fne | Found in neurons (fne) encodes an RNA binding protein that works as a post-transcriptional regulator. It is present in the cytoplasm of all neurons. Lack of fne produces fusion of the mushroom body beta-lobes and altered male courtship behaviour. (356 aa) |
| | Hrb27C | Heterogeneous nuclear ribonucleoprotein 27C; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. (421 aa) |
| | elav | Protein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa) |
