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| | Rab35 | Rab35, isoform A; Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system. (201 aa) |
| | Vps11 | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. (830 aa) |
| | AMPKalpha | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. (582 aa) |
| | dor | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route. Required for the biogenesis of eye pigment granules. Required to maintain normal levels of rush, which functions in endosome formation [...] (1002 aa) |
| | Vps26 | Vacuolar protein sorting-associated protein 26; Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis. Belongs to the VPS26 family. (478 aa) |
| | Ocrl | Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. (850 aa) |
| | CG3191 | GH16463p; Phosphatidylinositol bisphosphate binding. (309 aa) |
| | N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) |
| | VhaAC39-1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | CG3309 | LD41638p; Rab guanyl-nucleotide exchange factor activity. (634 aa) |
| | Snx27 | LD13361p; Phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: intracellular protein transport; retrograde transport, endosome to plasma membrane; signal transduction. (531 aa) |
| | Rab18 | GH11193p; Protein binding; GTPase activity; GTP binding. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport; lipid droplet organization. (197 aa) |
| | CG3823 | GH10083p; Phosphatidylinositol bisphosphate binding. (295 aa) |
| | Ykt6 | YKT6 v-SNARE; Protein-cysteine S-palmitoyltransferase activity; SNAP receptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; Belongs to the synaptobrevin family. (199 aa) |
| | AP-1gamma | Adaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking. (982 aa) |
| | RabX2 | CG2885; GTP binding; GTPase activity. (195 aa) |
| | Rab9D | Rab at 9D; GTPase activity; GTP binding. (197 aa) |
| | Rab9E | Rab at 9E; GTPase activity; GTP binding. (197 aa) |
| | Rab9Db | Rab at 9Db; GTP binding; GTPase activity. (197 aa) |
| | shg | DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa) |
| | Rbpn-5 | Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. (647 aa) |
| | Sara | Zinc finger FYVE domain-containing protein; Smad anchor for receptor activation (Sara) encodes an endosomal protein involved in asymmetric stem cell division, intestinal stem cell homeostasis and stem cell fate determination. (1343 aa) |
| | Vps35 | Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles. (822 aa) |
| | Pi3K59F | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa) |
| | RabX1 | Rab-related GTP-binding protein Chrowded; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. (261 aa) |
| | Vti1a | Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. (230 aa) |
| | ru | Roughoid/rhomboid-3; Roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye; Belongs to the peptidase S54 family. (341 aa) |
| | Vta1 | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. (316 aa) |
| | CG1275 | LD36721p; Oxidoreductase activity; ferric-chelate reductase activity; metal ion binding. (340 aa) |
| | CG32485 | GH16843p; Rab GTPase binding; phosphatidylinositol transfer activity. (222 aa) |
| | Ccz1 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. (485 aa) |
| | CG33514 | LP22879p; Phosphatidylinositol bisphosphate binding. (311 aa) |
| | Rab9Fb | Rab at 9Fb; GTPase activity; GTP binding. (214 aa) |
| | Rab9Fa | Rab at 9Fa; GTP binding; GTPase activity. (197 aa) |
| | Rab40 | Rab40, isoform B; GTP binding; GTPase activity. It is involved in the biological process described with: protein localization to plasma membrane; vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport. (265 aa) |
| | g | AP-3 complex subunit delta; Garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color. (1034 aa) |
| | Scamp | Secretory carrier-associated membrane protein; It is involved in the biological process described with: neuromuscular synaptic transmission; synaptic vesicle exocytosis; protein transport; long-term memory. (343 aa) |
| | Mvb12 | Multivesicular body subunit 12, isoform A; Ubiquitin binding. It is involved in the biological process described with: virus maturation; viral budding; receptor catabolic process; endosome to lysosome transport via multivesicular body sorting pathway; regulation of epidermal growth factor receptor signaling pathway. (352 aa) |
| | CG32225 | Uncharacterized protein; It is involved in the biological process described with: establishment of protein localization to organelle. (295 aa) |
| | CG14184 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. (180 aa) |
| | Rab8 | Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. (207 aa) |
| | Trpml | Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa) |
| | serp | Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length. (541 aa) |
| | Ndfip | Nedd4 family interacting protein (Ndfip) encodes a protein that interacts with the ubiquitin ligases encoded by Nedd4 and Su(dx) and regulates Notch signaling. (267 aa) |
| | TSG101 | Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles. (408 aa) |
| | Trs20 | Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Involved in dsRNA uptake. (139 aa) |
| | mop | Myopic (mop) encodes an endocytic protein that is required for normal Egfr signaling and for the progression of the product of Egfr through the endocytic pathway. It also controls the endosomal localization and signaling activity of the product of yki. (1833 aa) |
| | Vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...] (399 aa) |
| | Tsf2 | Transferrin 2 (Tsf2) encodes a protein that requires binding with iron for protein function. It is localised at the paracellular septate junctions in epithelial tissues and is required for junction assembly. Tsf2 mutants show overelongated tracheal tubes. (819 aa) |
| | CG10657 | LD40136p; Phosphatidylinositol bisphosphate binding. (334 aa) |
| | Pi3K68D | Phosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway; Belongs to the PI3/PI4-kinase family. (1876 aa) |
| | wls | Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa) |
| | CG6707 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (266 aa) |
| | SH3PX1 | Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family. (565 aa) |
| | CG3529 | GH05942p; It is involved in the biological process described with: intracellular protein transport. (543 aa) |
| | Culd | CUB and LDLa domain (Culd) encodes a photoreceptor-cell enriched transmembrane protein. It localizes to endocytic vesicles and is required for endocytic trafficking of the products of ninaE and trpl. (965 aa) |
| | Ist1 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. (417 aa) |
| | Vps8 | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. (1229 aa) |
| | CG32407 | Uncharacterized protein, isoform A. (241 aa) |
| | Cralbp | Cellular retinaldehyde binding protein; Phosphatidylinositol bisphosphate binding; retinal binding. (324 aa) |
| | Membrin | Probable Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa) |
| | CHMP2B | Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation. (212 aa) |
| | Rab10 | LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. (204 aa) |
| | Mon1 | Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes. (528 aa) |
| | FIG4 | FIG4 phosphoinositide 5-phosphatase; Phosphoric ester hydrolase activity. It is involved in the biological process described with: larval locomotory behavior; regulation of lysosome size; compound eye morphogenesis. (858 aa) |
| | Snx1 | Sorting nexin 1, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol binding. It is involved in the biological process described with: intracellular protein transport; endocytosis; retrograde transport, endosome to Golgi; early endosome to Golgi transport. (458 aa) |
| | Sec5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa) |
| | CG15399 | Uncharacterized protein; GTPase activity. (242 aa) |
| | Snx21 | LD12265p; Phosphatidylinositol binding. It is involved in the biological process described with: protein transport. (326 aa) |
| | Rab5 | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. (219 aa) |
| | TBC1D23 | Uncharacterized protein; GTPase activator activity. It is involved in the biological process described with: positive regulation of intracellular transport; retrograde transport, endosome to Golgi; regulation of GTPase activity. (689 aa) |
| | Vps29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | Psn | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa) |
| | CG5498 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. (448 aa) |
| | Syx7 | Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. (282 aa) |
| | Arf79F | ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa) |
| | Rab23 | RH23273p; Rab23 (Rab23) encodes a member of the Rab family of small GTPases known to be involved in vesicle transport processes. It cooperates with the product of in and the core group of planar cell polarity genes. It contributes to restricting actin accumulation and thus, prehair initiation to a single site within each wing cell, and to regulate the number and orientation of hairs on the leg and the abdominal cuticle. In addition, it regulates the trafficking of the ligand encoded by hh in the germline stem cell niche. (268 aa) |
| | spartin | Protein spartin; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival. (553 aa) |
| | tkv | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (575 aa) |
| | Vps52 | Vacuolar protein sorting 52; Rab GTPase binding; syntaxin binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; lysosomal transport; Golgi to vacuole transport; endocytic recycling. (662 aa) |
| | ifc | Sphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa) |
| | IPIP | Uncharacterized protein, isoform A; Protein homodimerization activity. It is involved in the biological process described with: endosome organization; receptor recycling; retrograde transport, endosome to Golgi. (296 aa) |
| | Rab30 | Rab30, isoform A; Rab30 (Rab30) encodes a JNK transcriptional target. It is involved in JNK-mediated processes such as dorsal closure, embryonic head involution and thorax closure. (223 aa) |
| | wg | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa) |
| | CG6739 | FI24007p1. (787 aa) |
| | Rbsn-5 | Rabenosyn-5 (Rbsn-5) encodes a Rab5-binding effector that controls entry of endocytosed cargo into the early endosome. (505 aa) |
| | Trs23 | Trafficking protein particle complex subunit; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle-mediated transport; Golgi vesicle transport; Belongs to the TRAPP small subunits family. (219 aa) |
| | Snx17 | LD15323p; Phosphatidylinositol binding. It is involved in the biological process described with: retrograde transport, endosome to plasma membrane; intracellular protein transport. (490 aa) |
| | Wdfy2 | WD repeat and FYVE domain containing 2, isoform A; Protein kinase binding; metal ion binding. (408 aa) |
| | TBC1D16 | TBC1 domain family member 16; Rab GTPase binding; GTPase activator activity. It is involved in the biological process described with: intracellular protein transport; regulation of GTPase activity; activation of GTPase activity. (702 aa) |
| | Stam | Signal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. (689 aa) |
| | PLCXD | Uncharacterized protein, isoform A; Glycosylphosphatidylinositol diacylglycerol-lyase activity; phosphoric diester hydrolase activity. It is involved in the biological process described with: glycerophospholipid metabolic process. (482 aa) |
| | Uvrag | UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. (696 aa) |
| | CG31729 | ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; phospholipid translocation; endocytosis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1256 aa) |
| | CG16957 | IP06960p; Heme binding; Belongs to the cytochrome b5 family. (192 aa) |
| | Rab14 | Rab14, isoform B; Rab14 (Rab14) encodes a protein involved in phagocytosis, phagolysosome assembly and phagosome acidification. (239 aa) |
| | EMC5 | GEO07313p1; Inorganic cation transmembrane transporter activity. (109 aa) |
| | hook | Protein hook; Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down- regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity. (679 aa) |
| | Rab9 | RE17845p; Rab9 (Rab9) encodes a member of the Rab subfamily of small GTPases associated with late endosomes. It promotes membrane budding and retrograde recycling of endocytosed materials to the Golgi apparatus. Its roles include recycling of tracheal luminal proteins and tracheal tube length control. (256 aa) |
| | CG10237 | LD41874p; Phosphatidylinositol bisphosphate binding. (324 aa) |
| | CG10026 | SD01558p; Phosphatidylinositol bisphosphate binding. (299 aa) |
| | brun | Protein brunelleschi; Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells. (1320 aa) |
| | gzl | Godzilla E3 ubiquitin protein ligase (gzl) encodes a protein that ubiquitylates the SNARE protein encoded by Syb. It also promotes apico-basal transcytosis of the product of wg in the wing imaginal disc. (536 aa) |
| | CG10435 | LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. (495 aa) |
| | CG8202 | VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. (942 aa) |
| | Vps16A | Vacuolar protein sorting 16A (Vps16A) encodes a subunit of a heterohexameric tethering complex known as homotypic fusion and protein sorting (HOPS). HOPS roles include promoting the fusion of late endosomes, autophagosomes, biosynthetic vesicles, and lysosomes, and the biogenesis of lysosome-related eye pigment granules. The product of Vps16A is also part of miniCORVET (class C core vacuole/endosome tethering), a tethering complex involved in endosome maturation in nephrocytes and blood cells. (833 aa) |
| | Vps15 | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa) |
| | Vps45 | Vacuolar protein sorting 45 (Vps45) encodes an SM protein that is activated by the product of Rab5 and binds to the product of Rbsn-5 to control entry of endocytosed cargo into the early endosome; Belongs to the STXBP/unc-18/SEC1 family. (574 aa) |
| | Sbf | SET domain binding factor, isoform A. (1993 aa) |
| | prd1 | Pruning defect 1, isoform A; Rab GTPase binding. (1354 aa) |
| | Snx3 | Sorting nexin 3 (Snx3) encodes a protein involved in the secretion of the morphogen encoded by wg. It regulates the retromer-dependent recycling of the transmembrane cargo encoded by wls. (167 aa) |
| | Past1 | Putative Achaete Scute Target 1 (Past1) encodes a protein that associates predominantly with the plasma membrane and genetically interacts with N. It contributes to endocytosis, male sterility, temperature sensitivity, life span and differentiation of photoreceptors R1/R6/R7 and cone cells; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | Vha55 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (490 aa) |
| | CG5608 | FI07645p; It is involved in the biological process described with: phosphatidylinositol biosynthetic process; positive regulation of kinase activity. (687 aa) |
| | Lkb1 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. (567 aa) |
| | Trs33 | TRAPP subunit 33; It is involved in the biological process described with: regulation of GTPase activity; vesicle-mediated transport; Golgi vesicle transport; endoplasmic reticulum to Golgi vesicle-mediated transport. (152 aa) |
| | SIDL | Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Has a role in one of the several mechanisms underlying dendritic localization of Shal channels. (1145 aa) |
| | ema | Protein CLEC16A homolog; Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways. Required for endosome trafficking and maturation. Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes. In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy. Essential for the recruitment of lva-positive Golgi elements to autophagosomes. Likely to function by promoting membrane traffic from [...] (1067 aa) |
| | CG7523 | Uncharacterized protein. (260 aa) |
| | Dl | Neurogenic locus protein delta; Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. (833 aa) |
| | ninaE | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa) |
| | Rab11 | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa) |
| | Sec15 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (766 aa) |
| | lsn | Vacuolar-sorting protein SNF8; Larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization. (254 aa) |
| | VhaAC39-2 | Probable V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | CG10300 | CRAL-TRIO domain-containing protein; Phosphatidylinositol bisphosphate binding. (311 aa) |
| | Rab7 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. (207 aa) |
| | CG6607 | AT25567p; Rab GTPase binding. It is involved in the biological process described with: Rab protein signal transduction. (406 aa) |
| | RabX4 | RabX4; GTPase activity; GTP binding. (213 aa) |
| | Vps33B | Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes; Belongs to the STXBP/unc-18/SEC1 family. (640 aa) |
| | Vps2 | Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. (256 aa) |
| | ALiX | ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis. (836 aa) |
| | Vha100-1 | Vacuolar H[+] ATPase 100kD subunit 1 (Vha100-1) encodes a subunit of the V0 domain of V-ATPase, which acidifies autophagosomes and lysosomes in neurons. The product of Vha100-1 is involved in autophagosome maturation, tracheal branching and eye development. (855 aa) |
| | Vps16B | Vacuolar protein sorting 16B (Vps16B) encodes a protein that, together with its binding partner encoded by Vps33B, forms a distinct complex necessary for fusions between phagosomes and lysosomes. (447 aa) |
| | Bet5 | Trafficking protein particle complex subunit; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: Golgi vesicle transport; vesicle-mediated transport; endoplasmic reticulum to Golgi vesicle-mediated transport; Belongs to the TRAPP small subunits family. (145 aa) |
| | spdo | FI04474p; Sanpodo (spdo) encodes a four-pass transmembrane domain containing protein that interacts with both the product of numb and the Notch signaling pathway to enable precursor cells to divide asymmetrically to produce daughter cells of distinct fates. Its roles include cell fate specification in the nervous system, mesoderm, and endoderm. (565 aa) |
| | Sap-r | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. (953 aa) |
| | Lamp1 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. (318 aa) |
| | FAM21 | WASH complex subunit 2; Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. Belongs to the FAM21 family. (1469 aa) |
| | CG13442 | FI20425p1; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination; protein polyubiquitination. (425 aa) |
| | Vps51 | Vacuolar protein sorting-associated protein 51 homolog; May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans- Golgi network (TGN); Belongs to the VPS51 family. (740 aa) |
| | Rab4 | Rab4, isoform A; Rab4 (Rab4) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The product of Rab4 controls endocytic recycling and regulates synapse organization and neurotransmission in the nervous system. It also contributes to the sorting of cell adhesion molecules during epithelial morphogenesis and immune-mediators during the innate immune response. (213 aa) |
| | HPS4 | Hermansky-Pudlak Syndrome 4 (HPS4) encodes a tethering factor that regulates gene silencing by small RNAs via endosomal trafficking. (858 aa) |
| | Vps50 | Vacuolar protein sorting 50; It is involved in the biological process described with: endocytic recycling; retrograde transport, endosome to Golgi. (966 aa) |
| | Snx16 | Sorting nexin 16 (Snx16) encodes a protein that regulates synaptic growth at the neuromuscular junction. (407 aa) |
| | Tsf3 | Transferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (714 aa) |
| | Arf51F | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation. (175 aa) |
| | Trs31 | Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (194 aa) |
| | Sans | Scaffold protein containing ankyrin repeats and SAM domain (Sans) encodes a putative scaffolding protein containing three ankyrin repeats and a sterile alpha motif domain. (516 aa) |
| | ClC-b | Chloride channel-b (ClC-b) encodes a chloride transmembrane transporter involved in phagocytosis. (813 aa) |
| | fdl | Probable beta-hexosaminidase fdl; Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing. Belongs to the glycosyl hydrolase 20 family. (673 aa) |
| | CG9067 | Uncharacterized protein; It is involved in the biological process described with: Golgi vesicle transport; endoplasmic reticulum to Golgi vesicle-mediated transport. (138 aa) |
| | Rab3 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. (220 aa) |
| | CG12926 | FI02944p; Phosphatidylinositol bisphosphate binding. (313 aa) |
| | CG1902 | SD04017p; Phosphatidylinositol bisphosphate binding. (312 aa) |
| | CG30339 | RE54230p; Phosphatidylinositol bisphosphate binding. (308 aa) |
| | Rme-8 | Receptor mediated endocytosis 8 (Rme-8) encodes a protein involved in the regulation of border follicle cell migration and the endocytosis of the receptor encoded by N. (2408 aa) |
| | shrb | GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling. (226 aa) |
| | Vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be invo [...] (174 aa) |
| | fab1 | Putative 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome- related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing. (1809 aa) |
| | spin | Protein spinster; Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage. Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (630 aa) |
| | Vsp37A | Vacuolar protein sorting 37A, isoform A; It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane. (200 aa) |
| | Hrs | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (760 aa) |
| | Bet3 | Trafficking protein particle complex subunit; Blocked early in transport 3 (Bet3) encodes a protein involved in dsRNA transport; Belongs to the TRAPP small subunits family. BET3 subfamily. (178 aa) |
| | Rab32 | Rab32, isoform B; Rab32 (Rab32) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in eye development, autophagy and lipid storage. (686 aa) |
| | lqf | Liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways. (831 aa) |
| | Pi4KIIalpha | Pi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. (710 aa) |
| | CG33965 | RT07682p; Phosphatidylinositol bisphosphate binding. (317 aa) |
| | CG33966 | CRAL-TRIO domain-containing protein; Phosphatidylinositol bisphosphate binding. (310 aa) |
| | hh | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa) |
| | PIP4K | Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size. (404 aa) |
| | Whamy | WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion. (630 aa) |
| | Fas3 | Fasciclin-3; Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system. (577 aa) |
| | LpR2 | Lipophorin receptor 2 (LpR2) encodes a transmembrane receptor. A subset of LpR2-encoded isoforms are involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. (1064 aa) |
| | CG10301 | RT07778p; Phosphatidylinositol bisphosphate binding. (306 aa) |
| | Nhe3 | Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: regulation of intracellular pH; potassium ion transmembrane transport; sodium ion import across plasma membrane; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa) |
| | dsb | Debris buster (dsb) encodes a double-span transmembrane protein of the CD36 family residing in late endosomes and lysosomes. It is required for late stage phagosome maturation; Belongs to the CD36 family. (615 aa) |
| | sona | Sol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth. (1102 aa) |
| | lqfR | Liquid facets-Related (lqfR) encodes a Golgi protein involved in cell proliferation and oogenesis. (1415 aa) |
| | CG5189 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. (125 aa) |
| | Rab21 | Rab21, isoform C; GTP binding; GTPase activity; phosphatidylinositol 3-kinase catalytic subunit binding; protein binding. It is involved in the biological process described with: Rab protein signal transduction; intracellular protein transport; vesicle-mediated transport; positive regulation of autophagosome maturation; cortical actin cytoskeleton organization. (222 aa) |
| | gol | Goliath (gol) encodes an E3 ubiquitin ligase, whose cellular substrates are unknown. During embyrogenesis gol is expressed in fusion-competence myoblasts of the somatic and visceral mesoderm. (601 aa) |
| | Pten | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa) |
| | mon2 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes. (1684 aa) |
| | LpR1 | Lipophorin receptor 1, isoform K; Lipophorin receptor 1 (LpR1) encodes a transmembrane receptor that regulates immune response by mediating clearance of the protein encoded by nec from the hemolymph. Some of the LpR1-encoded isoforms are also involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. (1076 aa) |
| | Strump | WASH complex subunit homolog 5; Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail. (1191 aa) |
| | CG42638 | Cation channel activity. (652 aa) |
| | CG8270 | Mic1 domain-containing protein; It is involved in the biological process described with: regulation of autophagy. (642 aa) |
| | Vps37B | Vacuolar protein sorting 37B, isoform A; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane; endosome transport via multivesicular body sorting pathway. (214 aa) |
| | CG6051 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. (989 aa) |
| | Start1 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. (583 aa) |
| | CG5110 | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. (124 aa) |
| | Snx6 | Sorting nexin 6, isoform B; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; phagosome-lysosome fusion involved in apoptotic cell clearance. (455 aa) |
| | dbr | Debra, isoform B; Debra (dbr) encodes a transcriptional coactivator of various transcription factors, including the products of ci and dl. It contributes to developmental patterning, long-term memory, and cellular proliferation. (1007 aa) |
| | nuf | Nuclear fallout, isoform J; Nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes. (541 aa) |
| | uif | Uninflatable, isoform C; Uninflatable (uif) encodes a single pass transmembrane protein that localizes to the apical plasma membrane in epithelial cells. It is required for embryonic tracheal maturation and tracheal growth in the larva. (3589 aa) |
| | Rab39 | Rab39, isoform A; GTPase activity; protein binding; GTP binding. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport. (218 aa) |
| | Vps20 | Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis. (212 aa) |
| | CG4080 | LD02310p; Zinc ion binding; MHC protein binding; ubiquitin protein ligase activity. It is involved in the biological process described with: immune response; protein polyubiquitination; antigen processing and presentation of peptide antigen via MHC class II. (617 aa) |
| | CG4250 | Uncharacterized protein, isoform B. (134 aa) |
| | Vps13 | Vacuolar protein sorting-associated protein 13; Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system. May function as part of a lysosomal degradation pathway. (3321 aa) |
| | Vps28 | Vacuolar protein sorting 28 (Vps28) encodes a member of the ESCRT-I complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. (210 aa) |
| | Khc-73 | Kinesin heavy chain 73 (Khc-73) encodes a member of the Kinesin-3 family of microtubule-based transport motors. It facilitates endosomal transport during interphase and modulates cortical polarity during asymmetric neuroblast cell division; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1957 aa) |
| | Mvl | Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa) |
| | CG15099 | Protein dopey-1 homolog; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family. (2683 aa) |
| | wit | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] (913 aa) |
| | CG14977 | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. (164 aa) |
| | Tl | Protein toll; Receptor for the cleaved activated form of spz, spaetzle C- 106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by [...] (1117 aa) |
| | CG6923 | Uncharacterized protein, isoform D; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (1265 aa) |
| | CG13784 | Uncharacterized protein, isoform F; It is involved in the biological process described with: phospholipid translocation; retrograde transport, endosome to Golgi. (969 aa) |
| | Osi23 | Osiris 23; It is involved in the biological process described with: cuticle development. (255 aa) |
| | car | Vacuolar protein sorting-associated protein 33A; Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. (639 aa) |
| | CG2224 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. (420 aa) |
| | nSyb | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa) |
| | Rubicon | Uncharacterized protein, isoform A; Phosphatidylinositol phosphate binding. It is involved in the biological process described with: negative regulation of autophagy. (827 aa) |
| | Rab26 | Ras-related protein Rab-26; Participates in exocrine secretion. (410 aa) |
| | Rab19 | Rab-related protein 3; GTP binding; GTPase activity; GTPase activator activity; protein binding. It is involved in the biological process described with: enteroendocrine cell differentiation; intracellular protein transport; Rab protein signal transduction; vesicle-mediated transport; regulation of cell differentiation involved in tissue homeostasis. (219 aa) |
| | asrij | OCIA domain-containing protein 1; Asrij (asrij) encodes a conserved ovarian carcinoma immunoreactive antigen domain-containing endosomal protein that maintains stemness. It positively regulates JAK/STAT signalling and negatively regulates the Notch pathway. It interacts with the GTP-bound form of the product of Arf79F to regulate hematopoiesis and immunity; Belongs to the OCIAD1 family. (258 aa) |
| | comm | Protein commissureless 1; Commissureless (comm) product regulates the cell surface localization of Robo axon guidance receptors by intercepting them in the ER/Golgi during exocytosis or removing them from the surface by endocytosis. comm is required for formation of the CNS axon scaffold and synaptogenesis. (370 aa) |
| | Vps60 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] (226 aa) |
| | rho | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa) |
| | CG14812 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. (100 aa) |
| | ClC-c | Chloride channel-c (ClC-c) encodes an intracellular chloride transporter that is involved in endosomal lumen acidification. (893 aa) |
| | Cln3 | Battenin. (422 aa) |
| | path | Proton-coupled amino acid transporter-like protein pathetic; Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in a cell- autonomous manner for dendrite growth in neurons with large dendrite arbors. (471 aa) |
| | RhoGAP68F | Rho GTPase activating protein at 68F (RhoGAP68F) encodes a GTPase activating protein acting upon small Rho-family GTPases involved in epithelial morphogenesis. It localizes to Rab4 recycling endosomes, forms a complex with the product of Rab4 and modulates the transport of Rab4 recycling endosomes back to the cell surface. (476 aa) |
| | Vti1b | Vesicle transport through interaction with t-SNAREs 1b, isoform A; SNAP receptor activity; SNARE binding. (122 aa) |
| | ed | Echinoid, isoform A; Echinoid (ed) encodes a cell adhesion molecule of adherens junctions that mediate cell adhesion/recognition. It participates in multiple signaling pathways including Egfr, Notch and Hippo during organogenesis. It is also required in multiple steps of dorsal closure during embryogenesis. (1332 aa) |
| | Nct | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (699 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | CG7956 | Uncharacterized protein, isoform F; Phosphatidylinositol-4-phosphate phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; regulation of endocytic recycling. (1142 aa) |
| | Synd | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa) |
| | aph-1 | Gamma-secretase subunit Aph-1; Anterior pharynx defective 1 (aph-1) encodes a scaffolding subunit of the gamma-secretase complex together with the products of Psn, Nct and pen-2. It is involved in several Notch related processes such as differentiation, cellular organization and developmental patterning via gamma-secretase proteolitic function. (238 aa) |
| | SWIP | WASH complex subunit 4; Strumpellin and WASH-interacting protein (SWIP) encodes a protein that is part of the multi-subunit WASH regulatory complex (SHRC) to activate Arp2/3-mediated actin nucleation in a context-dependent manner. The product of SWIP, along with the SHRC, has been found to play a role in actin architecture and ooplasmic streaming during oogenesis, in endosome recycling, and in integrin-mediated cell spreading of hemocytes. (1102 aa) |
| | rush | Pleckstrin homology domain-containing family F member 1 homolog; Functions in the regulation of endosome morphology and late endosome formation. Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes. Important for localization of Gdi to the endosomal membranes. May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and [...] (316 aa) |
| | wash | WASH complex subunit 1; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migrat [...] (499 aa) |
| | pen-2 | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. (101 aa) |
| | PICK1 | Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding. (577 aa) |
| | CG3091 | RH61816p; Phosphatidylinositol bisphosphate binding. (303 aa) |
| | Vps4 | Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. (442 aa) |
| | wus | Wurst, isoform A; Wurst (wus) encodes a transmembrane protein essential for clathrin-mediated endocytosis. It recruits the product of Hsc70-4 and clathrin to the apical cell membrane of epithelial cells. The endocytosis mediated by the product of wus is required for size determination and lumen clearance of the airways. (406 aa) |
| | Crag | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] (1671 aa) |
| | Nost | Nostrin, isoform H; Nostrin (Nost) encodes a lipid binding protein involved in epithelial cell differentiation, plasma membrane tubulation and adherens junction organization. (1330 aa) |
| | c11.1 | C11.1, isoform A. (1742 aa) |
| | CG31636 | FI18525p1; Phosphatidylinositol bisphosphate binding. (313 aa) |
| | lt | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. (841 aa) |
| | CG8134 | GH09650p; It is involved in the biological process described with: vesicle cytoskeletal trafficking. (345 aa) |
| | nwk | Protein nervous wreck; Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation. Required for normal structure and function of synapses at the neuromuscular junction. Plays a role in synaptic vesicle trafficking. Required for the release of a normal number of synaptic vesicles per action potential. (1075 aa) |
| | CG2663 | Uncharacterized protein, isoform A; Phosphatidylinositol bisphosphate binding. (308 aa) |
| | CG11178 | LD19061p; It is involved in the biological process described with: cell migration. (707 aa) |
| | Chmp1 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. (203 aa) |
| | CG4074 | IP10134p. (295 aa) |
| | hemo | Hemotin; Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3- 3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing. (88 aa) |
| | CG43345 | LD39232p1; Catalytic activity. (493 aa) |
| | CG30423 | RH04491p; Signaling receptor binding. It is involved in the biological process described with: negative regulation of receptor signaling pathway via JAK-STAT; late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface. (126 aa) |
| | Tsf1 | Transferrin 1 (Tsf1) encodes an iron binding protein induced during the immune response. Iron sequestration is a classical host defense mechanism to combat bacterial infection. (641 aa) |
| | Vamp7 | Vesicle-associated membrane protein 7 (Vamp7) encodes an R type SNARE protein. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Syx17 and Snap29. It localizes to endosomes in a Rab21 and Sbf dependent manner; Belongs to the synaptobrevin family. (218 aa) |
| | pHCl-2 | pH-sensitive chloride channel 2 (pHCl-2) encodes a channel involved in chloride transmembrane transport and renal water transport regulation; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (526 aa) |
| | Vps24 | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. (223 aa) |
| | upd2 | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. (406 aa) |
| | CG33096 | Uncharacterized protein, isoform H; Palmitoyl-(protein) hydrolase activity. It is involved in the biological process described with: protein depalmitoylation. (349 aa) |
