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| | CG15531 | FA_desaturase domain-containing protein; Iron ion binding; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: unsaturated fatty acid biosynthetic process; oxidation-reduction process; Belongs to the fatty acid desaturase type 1 family. (334 aa) |
| | PIG-C | Phosphatidylinositol glycan anchor biosynthesis class C (PIG-C) encodes a subunit of GPI-GlcNAc transferase, which catalyzes the first reaction in the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor. (312 aa) |
| | EMC4 | ER membrane protein complex subunit 4; Belongs to the EMC4 family. (166 aa) |
| | RpS26 | 40S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa) |
| | Cds | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] (447 aa) |
| | CG9747 | GH07782p; Iron ion binding; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: unsaturated fatty acid biosynthetic process; oxidation-reduction process; Belongs to the fatty acid desaturase type 1 family. (461 aa) |
| | CG4960 | Receptor expression-enhancing protein; It is involved in the biological process described with: endoplasmic reticulum tubular network organization; regulation of intracellular transport. (174 aa) |
| | Stt3A | Catalytic subunit 3A of the oligosaccharyltransferase complex, isoform A; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (713 aa) |
| | Sec61alpha | Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. (476 aa) |
| | CG32039 | Uncharacterized protein, isoform A. (82 aa) |
| | CG13887 | LP10861p; It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; intracellular protein transport. (228 aa) |
| | Sting | Sting, isoform B; cyclic-di-GMP binding; cyclic-GMP-AMP binding. (343 aa) |
| | CG6527 | GEO13014p1; FFAT motif binding. It is involved in the biological process described with: endoplasmic reticulum membrane organization; endoplasmic reticulum-plasma membrane tethering. (166 aa) |
| | CG7218 | Protein TAPT1 homolog; It is involved in the biological process described with: positive regulation of cilium assembly; maintenance of protein localization in endoplasmic reticulum. (676 aa) |
| | PIG-Z | GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly (By similarity). (696 aa) |
| | Pld3 | GM01519p; Catalytic activity. (494 aa) |
| | CG3328 | Uncharacterized protein, isoform C; Sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (1423 aa) |
| | l(1)G0320 | Lethal (1) G0320, isoform A. (302 aa) |
| | Vap33 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. (269 aa) |
| | Sec61gamma | Protein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa) |
| | PIG-Q | Phosphatidylinositol glycan anchor biosynthesis class Q (PIG-Q) encodes a protein required for the biosynthesis of glycosylphosphatidylinositol, which is a component for anchoring eukaryotic proteins to membranes. (481 aa) |
| | Spase25 | Signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (199 aa) |
| | PIG-A | Phosphatidylinositol glycan anchor biosynthesis class A, isoform A; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (479 aa) |
| | CG6870 | GEO08203p1; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (137 aa) |
| | CG34194 | FI16908p1. (104 aa) |
| | EMC1 | ER Membrane protein Complex 1 (EMC1) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (915 aa) |
| | CG9855 | FI03672p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (382 aa) |
| | CG34293 | MIP14036p. (84 aa) |
| | PIG-X | Phosphatidylinositol glycan anchor biosynthesis class X, isoform C; It is involved in the biological process described with: GPI anchor biosynthetic process. (243 aa) |
| | CG1941 | RE04845p; O-acyltransferase activity; diacylglycerol O-acyltransferase activity. It is involved in the biological process described with: lipid metabolic process; triglyceride biosynthetic process. (352 aa) |
| | PIG-S | Phosphatidylinositol glycan anchor biosynthesis class S (PIG-S) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (536 aa) |
| | PIG-V | GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere; Belongs to the PIGV family. (449 aa) |
| | cni | Protein cornichon; Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo. (144 aa) |
| | EMC2B | GH23451p. (282 aa) |
| | CG2065 | RH23455p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa) |
| | CG2070 | LP06328p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa) |
| | CG30495 | Uncharacterized protein, isoform B; NADP-retinol dehydrogenase activity. (331 aa) |
| | ste24c | Ste24c prenyl protease type I (ste24c) encodes a protein that, along with the products of ste24a and ste24b, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24c plays an essential role in the male germline; Belongs to the peptidase M48A family. (456 aa) |
| | CG14671 | GEO12035p1; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (155 aa) |
| | CG30156 | AT29763p; Hsp70 protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; cellular response to misfolded protein; ubiquitin-dependent ERAD pathway. (358 aa) |
| | CG31522 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (392 aa) |
| | CG31523 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (354 aa) |
| | tw | Protein O-mannosyl-transferase 2; Twisted (tw) encodes a protein that transfers a mannose to the Ser/Thr residues of dystroglycan, via forming an heterodimer with the product of rt. Its roles include myogenesis, muscle architecture and cell adhesion. (765 aa) |
| | PIG-H | Phosphatidylinositol glycan anchor biosynthesis class H, isoform A; It is involved in the biological process described with: GPI anchor biosynthetic process. (221 aa) |
| | alt | Aluminum tubes, isoform G. (874 aa) |
| | Der-1 | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. (245 aa) |
| | Calr | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (406 aa) |
| | bif | Bifocal, isoform F; Bifocal (bif) encodes an actin and microtubule binding protein involved in axon guidance and regulation of axon extension. (1305 aa) |
| | Vti1b | Vesicle transport through interaction with t-SNAREs 1b, isoform A; SNAP receptor activity; SNARE binding. (122 aa) |
| | SrpRbeta | Signal recognition particle receptor beta (SrpRbeta) encodes a protein that contributes to cuticle secretion by epidermal cells. (244 aa) |
| | Alg11 | ALG11, alpha-1,2-mannosyltransferase, isoform A; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide-lipid intermediate biosynthetic process. (475 aa) |
| | SelT | Thioredoxin reductase-like selenoprotein T homolog CG3887; Probably has thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. SELT subfamily. (198 aa) |
| | CG9662 | Putative oligosaccharyltransferase complex subunit CG9662; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic retic [...] (149 aa) |
| | CG33303 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (458 aa) |
| | crc | Cryptocephal, isoform A; Cryptocephal (crc) encodes a protein that belongs to a member of the CREB/ATF family of basic-leucine zipper transcription factors. It serves as an coactivator of the product EcR of to promote expression the molting peptide hormone encoded by ETH. It also acts as an unfolded protein response transcription factor to regulate glycolytic genes in response to ER stress. (381 aa) |
| | CG3842 | GH10714p; NADP-retinol dehydrogenase activity. (406 aa) |
| | CG30389 | Uncharacterized protein, isoform E; Microtubule binding; actin filament binding. It is involved in the biological process described with: neuronal signal transduction; chemotaxis. (1037 aa) |
| | sip3 | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] (626 aa) |
| | Mctp | Multiple C2 and transmembrane domain-containing protein; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. (982 aa) |
| | Hrd3 | HMG-coA reductase degradation 3, isoform A; It is involved in the biological process described with: ubiquitin-dependent ERAD pathway. (819 aa) |
| | Xport-B | Exit protein of rhodopsin and TRP B, isoform A; It is involved in the biological process described with: protein localization to rhabdomere. (113 aa) |
| | CG16781 | Uncharacterized protein, isoform B; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (386 aa) |
| | Sec22 | Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family. (213 aa) |
| | GramD1B | GRAM domain containing 1B, isoform E. (1249 aa) |
| | Esyt2 | Extended synaptotagmin-like protein 2 (Esyt2) encodes a member of the Synaptotagmin family that localizes to the endoplasmic reticculum (ER). In axonal ER of motorneurons, it may be involved in coordinating intracellular calcium dynamics and constitutive membrane trafficking. (853 aa) |
| | CG8112 | O-acyltransferase activity; cholesterol O-acyltransferase activity. It is involved in the biological process described with: cholesterol homeostasis; cholesterol metabolic process; cholesterol esterification. (559 aa) |
| | sll | Slalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (465 aa) |
| | Spase22-23 | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (179 aa) |
| | RyR | Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa) |
| | ReepA | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. (716 aa) |
| | hob | Hobbit, isoform B; It is involved in the biological process described with: positive regulation of intracellular transport. (2300 aa) |
| | CG31690 | Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (859 aa) |
| | Rtnl1 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. (607 aa) |
| | CG5342 | PigN domain-containing protein; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (837 aa) |
| | SppL | Signal peptide peptidase-like, isoform D; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: membrane protein proteolysis; signal peptide processing. (422 aa) |
| | Dpm2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (81 aa) |
| | EMC10 | Uncharacterized protein, isoform C. (227 aa) |
| | CG42359 | GH27195p; It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly; positive regulation of innate immune response; defense response to Gram-negative bacterium. (132 aa) |
| | CG9592 | IP08778p; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (152 aa) |
| | GCS1 | Glucosidase 1, isoform B; Mannosyl-oligosaccharide glucosidase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide metabolic process. (849 aa) |
| | THADA | Thyroid adenoma-associated protein homolog; Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior. (1746 aa) |
| | shams | IP22168p; Shams (shams) encodes a xylosyltransferase involved in protein O-linked glycosylation and Notch signalling regulation. (362 aa) |
| | meigo | Solute carrier family 35 member B1 homolog; Medial glomeruli (meigo) encodes an evolutionarily conserved, multi-membrane pass protein that is mainly localized at the endoplasmic reticulum. meigo genetically interacts with Ephrin in dendrite targeting of olfactory projection neurons. (338 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | Elo68beta | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (269 aa) |
| | CG41106 | MIP26267p; It is involved in the biological process described with: positive regulation of protein dephosphorylation. (123 aa) |
| | CG17883 | RE60063p; GTPase activator activity; Rab GTPase binding. It is involved in the biological process described with: regulation of GTPase activity; endoplasmic reticulum to Golgi vesicle-mediated transport. (378 aa) |
| | mol | Moladietz, isoform A; Protein binding. It is involved in the biological process described with: protein localization; protein transport; long-term memory; response to oxidative stress. (474 aa) |
| | Vkor | Vitamin-K epoxide reductase (Vkor) encodes an enzyme that converts Vitamin-K 2,3-epoxide back to the active form of Vitamin-K by de-epoxidation. (152 aa) |
| | Dpm3 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (94 aa) |
| | CG33774 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (40 aa) |
| | CG3566 | Uncharacterized protein, isoform B; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (117 aa) |
| | rho-5 | Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. (1429 aa) |
| | OstDelta | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (634 aa) |
| | CG1946 | IP08359p; O-acyltransferase activity; diacylglycerol O-acyltransferase activity. It is involved in the biological process described with: triglyceride biosynthetic process; lipid metabolic process. (349 aa) |
| | CG2064 | Uncharacterized protein; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa) |
| | CG30491 | AT09608p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | PIG-G | Phosphatidylinositol glycan anchor biosynthesis class G; CP2 mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (927 aa) |
| | CG8237 | LD27256p. (325 aa) |
| | PIG-N | Phosphatidylinositol glycan anchor biosynthesis class N; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (894 aa) |
| | CG1371 | Uncharacterized protein; Carbohydrate binding. (1199 aa) |
| | CG30008 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (266 aa) |
| | CG8860 | Protein transport protein Sec61 gamma-1 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa) |
| | Spt-I | Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process. (468 aa) |
| | bbc | Bb in a boxcar, isoform B; Diacylglycerol cholinephosphotransferase activity; ethanolaminephosphotransferase activity; phosphotransferase activity, for other substituted phosphate groups. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (417 aa) |
| | Sec61beta | Sec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy. (100 aa) |
| | EMC7 | DUF2012 domain-containing protein; Carbohydrate binding. (245 aa) |
| | CG8311 | Uncharacterized protein; Dolichol kinase activity. It is involved in the biological process described with: dolichyl monophosphate biosynthetic process. (503 aa) |
| | ste24b | Ste24b prenyl protease type I (ste24b) encodes a protein that, along with the products of ste24a and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24b plays an essential role in the male germline; Belongs to the peptidase M48A family. (447 aa) |
| | ste24a | Prenyl protease type I (ste24a) encodes a protein that, along with the products of ste24b and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases; Belongs to the peptidase M48A family. (451 aa) |
| | PIG-O | Phosphatidylinositol glycan anchor biosynthesis class O; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (1077 aa) |
| | CG18609 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (263 aa) |
| | CG17821 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (262 aa) |
| | CG15111 | FI04476p; Acylglycerol lipase activity; lysophospholipase activity. It is involved in the biological process described with: monoacylglycerol catabolic process; phosphatidylserine catabolic process. (411 aa) |
| | CG13426 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity; protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (105 aa) |
| | Fmo-2 | Flavin-containing monooxygenase 2 (Fmo-2) encodes a monooxygenase involved in oxidation-reduction metabolism. (429 aa) |
| | PGAP3 | Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling. (330 aa) |
| | SCAP | SREBP cleavage activating protein; Sterol binding. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; protein processing; SREBP signaling pathway. (1276 aa) |
| | nero | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control; Belongs to the deoxyhypusine hydroxylase family. (302 aa) |
| | CG9743 | RH14937p; Iron ion binding; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: unsaturated fatty acid biosynthetic process; oxidation-reduction process; Belongs to the fatty acid desaturase type 1 family. (420 aa) |
| | Cnx99A | Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para. (605 aa) |
| | Spase12 | Signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (98 aa) |
| | Alg13 | Glyco_tran_28_C domain-containing protein; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (171 aa) |
| | CG14511 | IP10585p; Transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity; UDP-xylose transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport. (322 aa) |
| | superdeath | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (999 aa) |
| | CG13978 | PigN domain-containing protein; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (898 aa) |
| | CG17991 | AT21004p; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination. (294 aa) |
| | PIG-P | Phosphatidylinositol glycan anchor biosynthesis class P; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (158 aa) |
| | CG10425 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. (336 aa) |
| | Alg9 | Mannosyltransferase activity; alpha-1,2-mannosyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation. (623 aa) |
| | EMC6 | Uncharacterized protein; It is involved in the biological process described with: autophagosome assembly. (113 aa) |
| | Stt3B | Catalytic subunit 3B of the oligosaccharyltransferase complex; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (774 aa) |
| | atl | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. (541 aa) |
| | CG5510 | RE50040p; Mannose binding. It is involved in the biological process described with: Golgi organization; endoplasmic reticulum organization; endoplasmic reticulum to Golgi vesicle-mediated transport. (329 aa) |
| | CG31141 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (253 aa) |
| | Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. (920 aa) |
| | CG13829 | Uncharacterized protein; It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (211 aa) |
| | CG6660 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. It is involved in the biological process described with: sphingolipid biosynthetic process; very long-chain fatty acid biosynthetic process; fatty acid elongation, saturated fatty acid; fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, monounsaturated fatty acid. (272 aa) |
| | wfs1 | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging. (853 aa) |
| | CG4907 | PigN domain-containing protein; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (919 aa) |
| | CG5326 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (277 aa) |
| | sit | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (295 aa) |
| | CG33110 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (337 aa) |
| | bond | James bond (bond) encodes a member of the Elov1 family of enzymes that function as very long chain fatty acid elongases. It contributes to sperm generation and the production of the male sex pheromone CH503 in the ejaculatory bulb. (322 aa) |
| | Xport-A | Exit protein of rhodopsin and TRP A (Xport-A) encodes a TRP channel chaperone. It mediates the transport to the plasma membrane of the products of ninaE and trp. (116 aa) |
| | CG5823 | HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination. (283 aa) |
| | EMC2A | LD10670p. (282 aa) |
| | Der-2 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (261 aa) |
| | CG3061 | RH07106p; Hsp70 protein binding. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; chaperone cofactor-dependent protein refolding; cellular response to misfolded protein. (370 aa) |
| | CG8630 | RE43130p; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: lipid metabolic process; oxidation-reduction process; Belongs to the fatty acid desaturase type 1 family. (408 aa) |
| | Desat1 | Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. (383 aa) |
| | Desat2 | Fatty acid desaturase 2; stearoyl-CoA 9-desaturase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; unsaturated fatty acid biosynthetic process; Belongs to the fatty acid desaturase type 1 family. (361 aa) |
| | CG6790 | PigN domain-containing protein; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (897 aa) |
| | CG16904 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (262 aa) |
| | CG9459 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (265 aa) |
| | CG9458 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (264 aa) |
| | eloF | Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis. (257 aa) |
| | CG8534 | Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (265 aa) |
| | Alg12 | Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation; Belongs to the glycosyltransferase 22 family. (678 aa) |
| | ATP6AP2 | ATPase H(+)-transporting accessory protein 2 C-terminal fragment; Multifunctional protein which functions as transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump. As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan. Also mediates Wnt/beta-cat signaling through interaction with fz/fz2. Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal sys [...] (320 aa) |
| | ELOVL | Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. (329 aa) |
| | twr | Signal peptidase complex catalytic subunit SEC11; Serine-type peptidase activity; peptidase activity. It is involved in the biological process described with: signal peptide processing. (185 aa) |
| | Ufl1 | E3 UFM1-protein ligase 1 homolog; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (782 aa) |
| | CG10029 | MIP10555p; Protein disulfide isomerase activity; peptide disulfide oxidoreductase activity. It is involved in the biological process described with: protein folding; cell redox homeostasis. (410 aa) |
| | Dpm1 | Probable dolichol-phosphate mannosyltransferase; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; Belongs to the glycosyltransferase 2 family. (241 aa) |
| | CG33116 | FI05338p; Phosphotransferase activity, for other substituted phosphate groups; ethanolaminephosphotransferase activity. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (427 aa) |
| | CG10470 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (183 aa) |
| | EMC5 | GEO07313p1; Inorganic cation transmembrane transporter activity. (109 aa) |
| | mdy | O-acyltransferase; Midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults. (565 aa) |
| | lace | Lace, isoform A; Lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis. (597 aa) |
| | Hacd2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (371 aa) |
| | Alg7 | GH19029p; phospho-N-acetylmuramoyl-pentapeptide-transferase activity; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; dolichyl diphosphate biosynthetic process. (409 aa) |
| | Hacd1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (245 aa) |
| | CG6230 | Cation-transporting ATPase; Ion transmembrane transporter activity, phosphorylative mechanism; nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1225 aa) |
| | EMC3 | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (247 aa) |
| | gny | Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Involved in cuticle differentiation. (475 aa) |
| | CG4972 | Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family. (561 aa) |
| | Trp1 | Translocation protein 1, isoform B; Protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (428 aa) |
| | jp | Junctophilin, isoform A; Junctophilin (jp) belongs to a gene family encoding proteins anchored to the endoplasmic reticulum through a transmembrane region. The product of jp contributes to the formation and maintenance of junctional membrane complexes. It serves as a physical bridge between the plasma membrane and the endoplasmic reticulum in excitable cells, allowing the functional crosstalk between ion channels. It is necessary for calcium signalling in muscle contraction and neuronal communication. (1054 aa) |
| | Dad1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (112 aa) |
| | PIG-U | Phosphatidylinositol glycan anchor biosynthesis class U (PIG-U) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (426 aa) |
| | wol | Dolichyl-phosphate beta-glucosyltransferase; Required for normal production of N-glycosylated proteins in the endoplasmic reticulum (ER). Required for embryonic segmentation, dorsal-ventral patterning and gastrulation. Required for chitin orientation and shaping of the apical and lateral plasma membranes of epidermal cells during cuticle differentiation. Also required for correctly shaping apical membrane topology of the epithelia of other organs such as the midgut and the hindgut. (326 aa) |
| | Ostgamma | Oligosaccharide transferase gamma subunit (Ostgamma) encodes a subunit of the oligosaccharyltransferase complex involved in cell migration and cellular encapsulation response. (330 aa) |
| | CG7149 | GH11618p; Ethanolaminephosphotransferase activity; phosphotransferase activity, for other substituted phosphate groups. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (415 aa) |
| | CG9175 | FI09914p; GTPase activator activity; Sar guanyl-nucleotide exchange factor activity; GTPase binding. It is involved in the biological process described with: cell morphogenesis; regulation of COPII vesicle coating; protein secretion. (445 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | jagn | Jagunal (jagn) encodes a conserved protein that is located in the endoplasmic reticulum membrane. It contributes to oocyte growth by organizing the endoplasmic reticulum. It is also involved in bristle growth. (197 aa) |
| | ORMDL | ORM1-like protein; Negative regulator of sphingolipid synthesis. (154 aa) |
| | Hpd | 4-hydroxyphenylpyruvate dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; tyrosine catabolic process. (380 aa) |
| | CG5969 | Vacuolar ATPase assembly integral membrane protein VMA21 homolog; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (105 aa) |
| | Spp | Signal peptide peptidase; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: signal peptide processing; cellular response to unfolded protein; membrane protein proteolysis. (389 aa) |
| | CG15880 | Uncharacterized protein; It is involved in the biological process described with: GPI anchor biosynthetic process. (263 aa) |
| | PGAP2 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. (255 aa) |
| | ninaA | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family. (237 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | Tango14 | Transport and golgi organization 14, isoform A; Dehydrodolichyl diphosphate synthase activity. It is involved in the biological process described with: dolichol biosynthetic process; protein secretion; protein glycosylation; angiogenesis. (278 aa) |
| | CG4341 | Protein O-mannosyl-transferase TMTC2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (938 aa) |
| | cnir | Cornichon related; It is involved in the biological process described with: vesicle-mediated transport. (157 aa) |
| | Dd | CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). Belongs to t [...] (243 aa) |
| | CG10674 | Protein Asterix. (108 aa) |
| | Fitm | Fat storage-inducing transmembrane protein; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing. (480 aa) |
| | Membrin | Probable Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa) |
| | Sras | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family. (302 aa) |
| | SMSr | Sphingomyelin synthase-related 1; Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory [...] (600 aa) |
| | Sec63 | Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa) |
| | fan | Farinelli (fan) encodes an important protein for sperm development that interacts with the product of Osbp. (218 aa) |
| | ergic53 | Ergic53, isoform A; Mannose binding. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; endoplasmic reticulum organization; Golgi organization. (512 aa) |
| | Use1 | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion. (250 aa) |
| | ghi | Ghiberti (ghi) encodes a protein homologous to the mammalian small regulatory subunit of serine palmitoyltransferase. Mutations in ghi affect the first steps of sphingolipids biosynthesis and disrupt meiotic cytokinesis of males. (81 aa) |
| | CG8009 | Nuclear envelope phosphatase-regulatory subunit 1 homolog; May form with the serine/threonine protein phosphatase l(1)G0269 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (By similarity). (131 aa) |
| | CG32069 | GEO12001p1; It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport. (80 aa) |
| | Elo68alpha | Elongation of very long chain fatty acids protein; Elongase 68alpha (Elo68alpha) encodes a transmembrane fatty acid elongase, elongating Delta9 unsaturated LCFAs (C14 and C16) to Delta11 LCFAs (C16 and C18), that is involved in the synthesis of the male pheromone cis-vaccenyl acetate. (262 aa) |
| | Ufd1-like | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (316 aa) |
| | wls | Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa) |
| | Alg10 | Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG10 glucosyltransferase family. (449 aa) |
| | Fad2 | Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones. (355 aa) |
| | CG7573 | LP11230p; Metalloendopeptidase activity. It is involved in the biological process described with: CAAX-box protein processing. (477 aa) |
| | rt | Protein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa) |
| | CG7011 | GH25868p; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; endoplasmic reticulum to Golgi vesicle-mediated transport. (373 aa) |
| | Baldspot | Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis. (316 aa) |
| | kud | Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...] (78 aa) |
| | Papst2 | PAPS transporter 2 (Papst2) encodes the second transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and localizes in the cis-cisterna of the Golgi and the ER. It transfers PAPS from cytosol into the lumen of Golgi and ER. The product of Papst2 contributes to the sulfation of glycans and proteins, and is suggested to regulate several signaling pathways (Hh, Dpp, Wingless) mediated by glycosaminoglycans in development; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (396 aa) |
| | PIG-F | Phosphatidylinositol glycan anchor biosynthesis class F; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (236 aa) |
| | SREBP | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. (1113 aa) |
| | CG7990 | Post-GPI attachment to proteins factor 2-like; It is involved in the biological process described with: GPI anchor biosynthetic process. (325 aa) |
| | por | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of Wnt proteins is required for efficient binding to frizzled receptors (By similarity). Also facilitates the glycosylation of Wnt family members, including wg and Wnt5. The cotranslational disulfide bond formation of wg competes with the N-glycosylation. Porc stimulates the post-translational N- glycosyla [...] (525 aa) |
| | stas | Transmembrane protein 41 homolog; Required in cholinergic neurons, but not in motor neurons, for normal neurotransmitter release by motor neurons. Involved in muscle growth; Belongs to the TMEM41 family. (320 aa) |
| | CG15814 | FI05221p; Ubiquitin protein ligase activity; metal ion binding; zinc ion binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; ubiquitin-dependent ERAD pathway. (321 aa) |
| | Cnx14D | Calnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. (639 aa) |
| | CG9911 | LD41494p; Protein disulfide isomerase activity. It is involved in the biological process described with: cell redox homeostasis. (412 aa) |
| | CG7872 | DnaJ homolog subfamily C member 25 homolog; It is involved in the biological process described with: protein folding. (333 aa) |
| | Alg14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (191 aa) |
| | CG11162 | Fatty acid hydroxylase domain-containing protein; C-4 methylsterol oxidase activity; oxidoreductase activity; iron ion binding. It is involved in the biological process described with: sterol biosynthetic process; oxidation-reduction process; Belongs to the sterol desaturase family. (278 aa) |
| | CG1998 | RE26969p; Iron ion binding; oxidoreductase activity; C-4 methylsterol oxidase activity. It is involved in the biological process described with: sterol biosynthetic process; oxidation-reduction process; Belongs to the sterol desaturase family. (406 aa) |
| | CG32641 | annotation not available (132 aa) |
| | CG32640 | J domain-containing protein. (132 aa) |
| | CG1924 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. (570 aa) |
| | CG1840 | LD12750p; It is involved in the biological process described with: calcium ion transport; endoplasmic reticulum calcium ion homeostasis. (118 aa) |
| | SelG | Selenoprotein G (SelG) encodes a type III Golgi apparatus transmembrane protein. It is implicated in the release of Ca[2+] from the endoplasmic reticulum to the cytosol by regulating the expression of genes participating in the inositol 1,4,5-tris-phosphate pathway. (110 aa) |
| | SrpRalpha | Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis. (614 aa) |
| | Ero1L | Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. (483 aa) |
| | PIG-B | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly (By similarity). Belongs to the glycosyltransferase 22 family. PIGB subfamily. (561 aa) |
| | CG1317 | FI03626p; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway. (988 aa) |
| | Sac1 | Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance. (592 aa) |
| | Vti1a | Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. (230 aa) |
| | SERCA | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa) |
| | Xxylt | UDP-xylosyltransferase activity. It is involved in the biological process described with: protein O-linked glycosylation; negative regulation of Notch signaling pathway. (458 aa) |
| | Fmo-1 | N,N-dimethylaniline monooxygenase activity; monooxygenase activity; NADP binding; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process. (416 aa) |
| | CG3500 | FI08011p; COPII adaptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport. (198 aa) |
| | EMC8-9 | ER Membrane protein Complex 8-9 (EMC8-9) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (203 aa) |
| | GlcT | Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development. (440 aa) |
| | Tango11 | Transport and Golgi organization protein 11; May play a role in mitochondrial and peroxisomal fission. Belongs to the Tango11 family. (277 aa) |
| | CG30284 | AT22714p. (353 aa) |
| | Ost48 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (449 aa) |
| | Erk7 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. (916 aa) |
| | CG10761 | AT07234p; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (323 aa) |
| | PIG-T | Phosphatidylinositol glycan anchor biosynthesis class T; GPI-anchor transamidase activity. It is involved in the biological process described with: attachment of GPI anchor to protein. (633 aa) |
| | sws | Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family. (1425 aa) |
| | xit | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Functions in developmental processes such as germband extension, the apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis prior to gastrulation. Involved in the glycosylation and intracellular distribution of shg ( [...] (511 aa) |
| | Efr | UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (352 aa) |
| | CG3149 | Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family. (556 aa) |
| | GAA1 | Glycosylphosphatidylinositol anchor attachment 1 (GAA1) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (674 aa) |
| | Seipin | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa) |
| | PIG-K | Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (355 aa) |
| | TRAM | Translocating chain-associated membrane protein; It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane, translocation; Belongs to the TRAM family. (368 aa) |
