STRINGSTRING
mkg-p mkg-p MTPAP MTPAP Ssu72 Ssu72 Wdr33 Wdr33 Sym Sym Fip1 Fip1 bsf bsf Cpsf73 Cpsf73 nos nos Cpsf100 Cpsf100 Suv3 Suv3 cbc cbc Pabp2 Pabp2 Cpsf160 Cpsf160 CG4266 CG4266 PNPase PNPase Pcf11 Pcf11 Gld2 Gld2 hrg hrg orb orb wisp wisp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mkg-pMonkey king protein, isoform A; RNA uridylyltransferase activity; nucleotidyltransferase activity. It is involved in the biological process described with: mRNA processing; pre-miRNA processing; RNA 3' uridylation. (659 aa)
MTPAPPoly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. (612 aa)
Ssu72Ssu72 CTD phosphatase (Ssu72) encodes an RNA polymerase II C-terminal domain (CTD) phosphatase. Its phosphatase activity is important for RNAPII transcription and termination and for gene looping. It may also be involved in the regulation of sister chromatid cohesion. (195 aa)
Wdr33WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa)
SymSymplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa)
Fip1Factor interacting with poly(A) polymerase 1; Myosin binding. It is involved in the biological process described with: mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; pre-mRNA cleavage required for polyadenylation; mRNA 3'-end processing by stem-loop binding and cleavage. (701 aa)
bsfBicoid stability factor (bsf) encodes a member of the family of proteins containing the pentatricopeptide motif, an RNA binding domain. It is found in the cytoplasm, where it functions in mRNA stability and post-transcriptional control of gene expression, and in mitochondria, where it has multiple roles in gene expression. It acts at many stages of development, and is required for progression through oogenesis and viability. (1412 aa)
Cpsf73Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa)
nosProtein nanos; Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal. Acts by forming a complex with pum and brat that regulates translation and mRNA stability. The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Controls posterior development. Rescuing factor for the abdominal defect of posterior group mutants. The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein. (401 aa)
Cpsf100Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa)
Suv3ATP-dependent RNA helicase SUV3 homolog, mitochondrial; Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts. (763 aa)
cbcProtein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (423 aa)
Pabp2Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, [...] (224 aa)
Cpsf160Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa)
CG4266Uncharacterized protein, isoform B; mRNA binding; nucleic acid binding. (1306 aa)
PNPasePolynucleotide phosphorylase (PNPase) encodes an enzyme involved in the regulation of mitochondrial mRNA stability. (771 aa)
Pcf11Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation. (1953 aa)
Gld2GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory. (1364 aa)
hrgHiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb. (827 aa)
orbOo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. (915 aa)
wispPoly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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