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Tsen34 Tsen34 Tsen54 Tsen54 CG33057 CG33057 RtcB RtcB CG31249 CG31249 Archease Archease cbc cbc RNaseZ RNaseZ Tsen15 Tsen15 Tsen2 Tsen2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Tsen34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (276 aa)
Tsen54tRNA_int_end_N2 domain-containing protein; It is involved in the biological process described with: tRNA-type intron splice site recognition and cleavage. (383 aa)
CG33057GH08776p; tRNA 2'-phosphotransferase activity. It is involved in the biological process described with: tRNA processing; tRNA splicing, via endonucleolytic cleavage and ligation. (212 aa)
RtcBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs; Belongs to the RtcB family. (506 aa)
CG31249RE59232p. (250 aa)
ArcheaseProtein archease-like; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (CG9987). (156 aa)
cbcProtein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (423 aa)
RNaseZRibonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa)
Tsen15Uncharacterized protein, isoform A; tRNA-intron endonuclease activity. It is involved in the biological process described with: tRNA splicing, via endonucleolytic cleavage and ligation. (170 aa)
Tsen2Uncharacterized protein; tRNA-intron endonuclease activity; nucleic acid binding. It is involved in the biological process described with: tRNA-type intron splice site recognition and cleavage. (233 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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