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| | Wdr33 | WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa) |
| | Sym | Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa) |
| | noi | Splicing factor 3A subunit 3; Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility; Belongs to the SF3A3 family. (503 aa) |
| | CG2931 | RE50009p; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome. (302 aa) |
| | lost | LD30155p; Lost (lost) encodes a protein that interacts with the RNA-binding protein encoded by rump for posterior localization of mRNAs by diffusion/entrapment during late stages of oogenesis. The identification of the product of lost in various RNP complexes suggests a broad role in RNA metabolism. (545 aa) |
| | Fip1 | Factor interacting with poly(A) polymerase 1; Myosin binding. It is involved in the biological process described with: mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; pre-mRNA cleavage required for polyadenylation; mRNA 3'-end processing by stem-loop binding and cleavage. (701 aa) |
| | Rm62 | ATP-dependent RNA helicase p62; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation (By similarity). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner. (719 aa) |
| | barc | Barricade, isoform A; RNA binding; U2 snRNP binding; mRNA binding. It is involved in the biological process described with: positive regulation of RNA splicing; regulation of neurogenesis; mRNA splicing, via spliceosome. (556 aa) |
| | kin17 | FI03293p; Double-stranded DNA binding. It is involved in the biological process described with: DNA replication; mRNA splicing, via spliceosome; cellular response to DNA damage stimulus. (390 aa) |
| | Clp | Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa) |
| | CG4896 | Uncharacterized protein, isoform D; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (949 aa) |
| | CG31922 | zf-U1 domain-containing protein; Zinc ion binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (139 aa) |
| | Cwc25 | LD47748p; It is involved in the biological process described with: mRNA splicing, via spliceosome. (521 aa) |
| | Prp40 | LD24714p; RNA binding. It is involved in the biological process described with: mRNA cis splicing, via spliceosome; mRNA splicing, via spliceosome. (806 aa) |
| | Secp43 | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. (336 aa) |
| | Dim1 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | CG3225 | LD11291p; RNA binding; helicase activity. It is involved in the biological process described with: mRNA splicing, via spliceosome. (678 aa) |
| | CG3294 | Uncharacterized protein, isoform A; pre-mRNA 3'-splice site binding; metal ion binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; wound healing. (456 aa) |
| | CG6610 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family. (91 aa) |
| | Sf3b6 | Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the in [...] (121 aa) |
| | lark | RNA-binding protein lark; Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development. (352 aa) |
| | Neos | Neosin, isoform A; Nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (371 aa) |
| | Cpsf6 | Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa) |
| | ldbr | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (534 aa) |
| | CG3335 | Uncharacterized protein; Helicase activity; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA cis splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (918 aa) |
| | CG10907 | RE08109p; Peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; protein folding; mRNA splicing, via spliceosome. (502 aa) |
| | yps | Ypsilon schachtel, isoform A; Nucleic acid binding; protein binding; mRNA binding. It is involved in the biological process described with: oogenesis; mRNA splicing, via spliceosome; regulation of gene expression. (352 aa) |
| | CG10418 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | SmD1 | Small ribonucleoprotein particle protein SmD1 (SmD1) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (124 aa) |
| | Sf3a2 | Splicing factor 3a subunit 2; RNA binding; zinc ion binding. It is involved in the biological process described with: positive regulation of gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome. (264 aa) |
| | Srrm1 | FI04407p; SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl. (954 aa) |
| | CG8833 | G patch domain-containing protein 1 homolog; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA processing; Belongs to the GPATCH1 family. (952 aa) |
| | Tdrd3 | Tudor domain containing 3; RNA binding. It is involved in the biological process described with: mRNA processing. (836 aa) |
| | Prp31 | Pre-mRNA processing factor 31 (Prp31) encodes a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development. (501 aa) |
| | l(3)72Ab | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2142 aa) |
| | tra | Female-specific protein transformer; Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males. (197 aa) |
| | U4-U6-60K | U4-U6 small nuclear riboprotein factor 60K; U4 snRNA binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (553 aa) |
| | Pep | Zinc finger protein on ecdysone puffs; May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci. (716 aa) |
| | Gem2 | Protein Gemin2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. (245 aa) |
| | Prp3 | Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing. (598 aa) |
| | Ssu72 | Ssu72 CTD phosphatase (Ssu72) encodes an RNA polymerase II C-terminal domain (CTD) phosphatase. Its phosphatase activity is important for RNAPII transcription and termination and for gene looping. It may also be involved in the regulation of sister chromatid cohesion. (195 aa) |
| | Usp39 | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. (494 aa) |
| | CG6179 | Nitric oxide synthase-interacting protein homolog; Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity; Belongs to the NOSIP family. (307 aa) |
| | SNRPG | Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly. Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). (76 aa) |
| | nonA | Protein no-on-transient A; Required for normal vision and courtship behavior in Drosophila. (742 aa) |
| | caz | Cabeza (caz) encodes a chromatin binding protein involved in locomotion, synaptic growth at the neuromuscular junction and eye development. (399 aa) |
| | CG8565 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. (790 aa) |
| | CG9213 | CWF19-like protein 2 homolog; It is involved in the biological process described with: mRNA splicing, via spliceosome; Belongs to the CWF19 family. (687 aa) |
| | CG6227 | LD41277p; ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (1224 aa) |
| | CG5877 | Uncharacterized protein, isoform A; It is involved in the biological process described with: mRNA splicing, via spliceosome; heterochromatin assembly by small RNA; RNA interference. (984 aa) |
| | mRNA-cap | Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (649 aa) |
| | l(1)G0007 | Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation. (1222 aa) |
| | CG15747 | FI21110p1; It is involved in the biological process described with: mRNA splicing, via spliceosome. (387 aa) |
| | CG1622 | FI05227p; It is involved in the biological process described with: mRNA splicing, via spliceosome. (398 aa) |
| | Tango4 | Transport and golgi organization 4; It is involved in the biological process described with: mRNA splicing, via spliceosome; protein secretion; Golgi organization. (482 aa) |
| | l(1)10Bb | L(1)10Bb protein; It is involved in the biological process described with: mRNA splicing, via spliceosome. (144 aa) |
| | CG11586 | MIP29039p; Zinc ion binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (194 aa) |
| | Ythdc1 | YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. Acts by acting as a reader of m6A methylation. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. (721 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (790 aa) |
| | CG9018 | Uncharacterized protein, isoform A; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing. (375 aa) |
| | ecd | Ecdysoneless (ecd) encodes a protein that physically interacts with several components of the U5 snRPN pre-mRNA splicing complex. Its loss result in intron retention within spok, accounting for ecdysone deficiency of some ecd mutants; Belongs to the ECD family. (684 aa) |
| | CG13807 | IP04067p; RNA binding. It is involved in the biological process described with: RNA 5'-cap (guanine-N7)-methylation. (170 aa) |
| | Mfap1 | Microfibrillar-associated protein 1; Required for pre-mRNA splicing. (478 aa) |
| | CG2021 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | hfp | Poly(U)-binding-splicing factor half pint; Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq. Belongs to the RRM half pint family. (637 aa) |
| | Sf3b3 | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing [...] (1227 aa) |
| | Cdc5 | Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (814 aa) |
| | Cypl | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (176 aa) |
| | thoc7 | THO complex protein 7; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC7 family. (288 aa) |
| | snama | Something that sticks like glue (snama) encodes a protein required for cell proliferation and survival in the developing eye. It is involved in apoptosis. (1231 aa) |
| | ytr | Yantar, isoform A; Yantar (ytr) encodes a conserved arginine-rich protein involved in alternative splicing and hemocyte differentiation. (194 aa) |
| | LS2 | U2 snRNP auxiliary factor large subunit; Large Subunit 2 (LS2) encodes an RNA binding protein that regulates both RNA splicing and gene silencing; Belongs to the splicing factor SR family. (449 aa) |
| | qkr58E-1 | Quaking related 58E-1, isoform A; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (396 aa) |
| | mago | Protein mago nashi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton. (147 aa) |
| | CG9344 | RE43665p; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (79 aa) |
| | c12.1 | Protein CWC15 homolog; Involved in pre-mRNA splicing. (259 aa) |
| | Es2 | Splicing factor ESS-2 homolog; It is involved in the biological process described with: nervous system development; mRNA splicing, via spliceosome. (501 aa) |
| | CG3198 | RH42690p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome; positive regulation of gene expression. (438 aa) |
| | Spx | Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (347 aa) |
| | CG17764 | Uncharacterized protein; It is involved in the biological process described with: mRNA splicing, via spliceosome. (272 aa) |
| | Rnp4F | RNA-binding protein 4F (Rnp4F) encodes an essential evolutionarily-conserved RNA-binding protein. Rnp4F gene expression is post-transcriptionally regulated by interaction with a stable stem-loop structure in the 5'-UTR of the mRNA with trans-acting factors. (941 aa) |
| | snf | U1 small nuclear ribonucleoprotein A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing; Belongs to the RRM U1 A/B'' family. (216 aa) |
| | Cbp80 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs [...] (800 aa) |
| | CG2685 | EG:100G10.1 protein; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome. (552 aa) |
| | crn | Crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis; Belongs to the crooked-neck family. (702 aa) |
| | MTPAP | Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. (612 aa) |
| | su(w[a]) | Protein suppressor of white apricot; Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). Regulates its own expression at the level of RNA processing. (963 aa) |
| | mdlc | CG4973 protein; Midlife crisis (mdlc) encodes a nuclear protein that is required for maintaining neuronal differentiation. (357 aa) |
| | CG6015 | LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (576 aa) |
| | LSm3 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (103 aa) |
| | Mettl3 | N6-adenosine-methyltransferase MT-A70-like protein; Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy [...] (608 aa) |
| | CG5986 | LD03179p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (232 aa) |
| | CG13625 | GH07383p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (647 aa) |
| | CG5808 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (653 aa) |
| | PQBP1 | Poly-glutamine tract binding protein 1 (PQBP1) encodes a component of nuclear speckles and cytoplasmic stress granules. It is involved in RNA transcription, RNA splicing, and possibly in protein translation. (231 aa) |
| | CG6066 | NKAP family protein CG6066; Chromatin binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; Notch signaling pathway; negative regulation of transcription, DNA-templated; Belongs to the NKAP family. (463 aa) |
| | CG4849 | LD28793p; U5 snRNA binding; GTP binding; GTPase activity; translation elongation factor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; translational elongation; positive regulation of gene expression. (975 aa) |
| | BCAS2 | LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling. (278 aa) |
| | Moca-cyp | Moca-cyp, isoform A; Moca-cyp (Moca-cyp) encodes a peptidyl-prolyl cis-trans isomerase. (970 aa) |
| | CG1646 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. (1066 aa) |
| | Cpsf100 | Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa) |
| | Slbp | Histone RNA hairpin-binding protein; Stem-loop binding protein (Slbp) encodes a protein that plays an essential role in 3' end processing of histone pre-mRNAs into mature histone mRNAs by recruiting the product of snRNA:U7 to the pre-mRNA. (276 aa) |
| | Slu7 | Pre-mRNA-splicing factor Slu7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (574 aa) |
| | CstF50 | Cleavage stimulation factor 50 kD subunit. (424 aa) |
| | mod | DNA-binding protein modulo; Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development. It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories. (542 aa) |
| | Ars2 | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family. (943 aa) |
| | CG17266 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (183 aa) |
| | ubl | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa) |
| | rig | Rigor mortis (rig) encodes a component of the cytoplasmic U snRNP body and a member of the SMN-Gemins complex. It is required in the motor system for viability and motor behaviour. It also works as a nuclear receptor interacting protein required for ecdysone signalling during larval development. (1235 aa) |
| | CG15084 | Coiled-coil domain-containing protein 130 homolog; It is involved in the biological process described with: RNA splicing; Belongs to the CWC16 family. (316 aa) |
| | Prp19 | Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. (505 aa) |
| | pAbp | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] (634 aa) |
| | icln | Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...] (215 aa) |
| | cyp33 | Peptidyl-prolyl cis-trans isomerase E; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity); Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (300 aa) |
| | Psi | P-element somatic inhibitor (Psi) encodes a protein that has dual roles in RNA processing and transcriptional regulation. It is required for activating Myc transcription. (797 aa) |
| | CG7747 | LD20635p; Ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; mRNA splicing, via spliceosome; protein folding; protein polyubiquitination. (517 aa) |
| | CG8435 | LD32459p; It is involved in the biological process described with: RNA splicing. (333 aa) |
| | CG11808 | GH08125p; It is involved in the biological process described with: mRNA splicing, via spliceosome. (219 aa) |
| | pea | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces. (1242 aa) |
| | fand | Pre-mRNA-splicing factor syf1 homolog; Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of it [...] (883 aa) |
| | CG6220 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. (359 aa) |
| | CG6209 | Uncharacterized protein; It is involved in the biological process described with: mRNA splicing, via spliceosome. (607 aa) |
| | cbc | Protein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (423 aa) |
| | FLASH | FLICE-associated huge protein (FLASH) encodes a metazoan-specific protein that plays an essential role in 3' end processing of replication-dependent histone pre-mRNAs. It localizes to histone locus bodies, which are microscopically detectable nuclear foci that form in the vicinity of histone gene clusters. (844 aa) |
| | spt4 | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By simi [...] (116 aa) |
| | SmD3 | Small ribonucleoprotein particle protein SmD3 (SmD3) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. The product of SmD3 also has a function in germline specification, as it is required for localization of the product of osk to the posterior pole of the oocyte. (151 aa) |
| | SmF | Small ribonucleoprotein particle protein SmF (SmF) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmE and SNRPG. (88 aa) |
| | Prp8 | pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome. (2396 aa) |
| | CG7741 | CWF19-like protein 1 homolog; RNA lariat debranching enzyme activator activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; Belongs to the CWF19 family. (545 aa) |
| | CG12343 | Pre-mRNA-splicing factor Syf2; Involved in pre-mRNA splicing as component of the spliceosome. (226 aa) |
| | Lsm10 | Lsm10 (Lsm10) encodes a core component of the U7 snRNP complex, which functions in 3' end processing of the non-polyadenylated, replication-dependent histone mRNAs. The product of Lsm10 is part of the heptameric Sm ring complex that binds directly to U7 snRNA. It replaces the protein encoded by SmD1 in the canonical heptameric Sm protein ring that binds spliceosomal snRNAs. (141 aa) |
| | RNaseZ | Ribonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa) |
| | Cdc2rk | Cdc2-related kinase (Cdc2rk) encodes a kinase that might be involved in cell cycle regulation; Belongs to the protein kinase superfamily. (387 aa) |
| | Lsm11 | FI05704p; Lsm11 (Lsm11) encodes one of the seven proteins that form a heptameric Sm ring in the U7 snRNP, which is a key factor involved in 3' end processing of histone pre-mRNAs. It interacts with the product of FLASH. The two interacting proteins form a biochemical platform that recruits a number of polyadenylation subunits to the U7 snRNP, including the products of Sym, Cpsf100, Cpsf73 and CstF64. (256 aa) |
| | tsu | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte. Belongs to the RBM8A family. (165 aa) |
| | Prp38 | Pre-mRNA-splicing factor 38; Required for pre-mRNA splicing; Belongs to the PRP38 family. (330 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1241 aa) |
| | Pabp2 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, [...] (224 aa) |
| | nito | RNA-binding protein spenito; RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs. M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, may act by binding target RNAs and recruiting the WMM complex. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physi [...] (793 aa) |
| | U2A | Probable U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome (By similarity). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity). In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26. Belongs to the U2 small nuclear ribonucleoprotein A family. (265 aa) |
| | Dhx15 | DEAH-box helicase 15, isoform A; RNA helicase activity; RNA binding; ATP binding. It is involved in the biological process described with: positive regulation of p38MAPK cascade; mRNA splicing, via spliceosome. (729 aa) |
| | aft | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve. (700 aa) |
| | CG6686 | RE11167p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; positive regulation of gene expression; maturation of 5S rRNA. (970 aa) |
| | Caper | Caper, isoform A; Caper (Caper) encodes an RNA-binding protein involved in regulation of alternative mRNA splicing. (594 aa) |
| | tra2 | Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] (264 aa) |
| | Cpsf160 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa) |
| | CG17768 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. (154 aa) |
| | Spf45 | RNA binding motif protein 17; Spf45 (Spf45) encodes a bi-functional protein with roles in both splicing and DNA repair. (403 aa) |
| | CG34334 | SD20656p; mRNA binding; nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; RNA splicing. (708 aa) |
| | CG4266 | Uncharacterized protein, isoform B; mRNA binding; nucleic acid binding. (1306 aa) |
| | Pnn | Pinin, isoform B; It is involved in the biological process described with: mRNA splicing, via spliceosome; cell adhesion. (307 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | CG7907 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. (753 aa) |
| | CG17454 | LD28068p; RNA binding. It is involved in the biological process described with: mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (243 aa) |
| | hyx | Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. (538 aa) |
| | PNPase | Polynucleotide phosphorylase (PNPase) encodes an enzyme involved in the regulation of mitochondrial mRNA stability. (771 aa) |
| | CG30122 | Uncharacterized protein, isoform C; It is involved in the biological process described with: mRNA splicing, via spliceosome. (1272 aa) |
| | CG31368 | Uncharacterized protein, isoform D; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1486 aa) |
| | tho2 | Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. (1642 aa) |
| | exu | Maternal protein exuperantia; Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA. (532 aa) |
| | Pcf11 | Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation. (1953 aa) |
| | CG42724 | Uncharacterized protein, isoform C; RNA polymerase binding; transcription coregulator activity. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1123 aa) |
| | Srrm234 | Uncharacterized protein, isoform F; It is involved in the biological process described with: mRNA splicing, via spliceosome; alternative mRNA splicing, via spliceosome. (1655 aa) |
| | CG1677 | MIP35121p1; Metal ion binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1000 aa) |
| | Rbp1-like | Rbp1-like, isoform B; Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism. (247 aa) |
| | SmB | Small ribonucleoprotein particle protein SmB (SmB) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD3. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing; Belongs to the snRNP SmB/SmN family. (199 aa) |
| | Smu1 | Smu1 spliceosomal factor (Smu1) encodes a spliceosomal protein required for normal neuromuscular junction development and function. It functions together with the product of beag. Both proteins can regulate synaptic levels of the product of Fas2. (509 aa) |
| | SF2 | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. (255 aa) |
| | bru2 | Bruno 2, isoform E; RNA binding; mRNA binding. It is involved in the biological process described with: negative regulation of translation; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome. (893 aa) |
| | Imp | IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs. (638 aa) |
| | SC35 | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (195 aa) |
| | su(f) | Suppressor of forked (su(f)) is an essential gene that encodes a protein involved in mRNA 3'-end processing (the nuclear cleavage/polyadenylation reaction) and alternative poly(A) site utilization. su(f) product accumulates in dividing cells where it is required for mitosis progression. (765 aa) |
| | Srpk79D | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. (1018 aa) |
| | heph | Hephaestus, isoform Y; Hephaestus (heph) encodes a nucleo-cytoplasmic shuttling protein that regulates osk mRNA translation. It is involved in spermatid individualization and Notch signalling regulation. (898 aa) |
| | U2af50 | U2 small nuclear riboprotein auxiliary factor 50 (U2af50) encodes the large subunit of the heterodimeric complex U2AF. U2AF binds to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site early in spliceosome assembly. (427 aa) |
| | B52 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (355 aa) |
| | sm | Smooth, isoform T; Smooth (sm) encodes an RNA binding, heterogeneous nuclear ribonucleoprotein involved in axon guidance, mRNA processing, chemosensation, determination of lifespan and feeding behavior. (552 aa) |
| | Gld2 | GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory. (1364 aa) |
| | CG4887 | FI21118p1; mRNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1004 aa) |
| | snRNP-U1-70K | Small ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome. (448 aa) |
| | CG16865 | UPF0428 protein CG16865; It is involved in the biological process described with: mRNA splicing, via spliceosome; Belongs to the UPF0428 family. (247 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | CG10466 | Uncharacterized protein, isoform A; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (154 aa) |
| | Sf3b1 | Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome. (1340 aa) |
| | Rox8 | Rox8, isoform D; Rox8 (Rox8) encodes a protein involved in the regulation of alternative mRNA splicing. (470 aa) |
| | Zn72D | Zinc-finger protein at 72D (Zn72D) encodes a protein involved in the splicing of the mle transcript. (884 aa) |
| | Tailor | Tailor (Tailor) encodes a cytoplasmic RNA-specific terminal uridylyltransferase. It acts as part of the terminal RNA uridylation-mediated processing (TRUMP) complex, marking RNA species for 3'-to-5' exoribonucleolytic decay by the product of Dis3l2. The product of Tailor regulates microRNA biogenesis by targeting precursor-microRNAs (predominantly mirtron hairpins) and targets unprocessed RNA polymerase III transcripts for degradation in a cytoplasmic RNA surveillance pathway. (563 aa) |
| | Cdc27 | Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1. (900 aa) |
| | U2af38 | U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. (264 aa) |
| | Rsf1 | RNA-binding protein Rsf1; May control important aspects of development. (200 aa) |
| | Bx42 | Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway. (547 aa) |
| | CG7974 | GM02612p; It is involved in the biological process described with: regulation of mRNA splicing, via spliceosome. (294 aa) |
| | Gem3 | Gemin3, isoform A; Gemin 3 (Gem3) encodes an RNA helicase and a member of the SMN-Gemins complex. It is a component of the cytoplasmic U snRNP body and nuclear gems. It is required in the motor system for viability, neuromuscular junction development and motor behaviour. (1028 aa) |
| | ps | Pasilla, isoform R; Pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology. (780 aa) |
| | orb | Oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. (915 aa) |
| | Syp | Syncrip, isoform J; Syncrip (Syp) encodes an RNA-binding protein that regulates the localization and translation of mRNAs involved in multiple processes. It is required for synapse morphology and synaptic transmission at the neuromuscular junction as well as being involved in oocyte axis specification and control of neuronal cell fates in the mushroom body. (761 aa) |
| | CG4291 | FI17537p1; RNA binding; zinc ion binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; RNA splicing. (338 aa) |
| | Sf3b2 | Splicing factor 3b subunit 2, isoform A; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (749 aa) |
| | hoip | NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa) |
| | Acn | Acinus, isoform A; Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy. (739 aa) |
| | CG44249 | RRM domain-containing protein; mRNA binding; nucleic acid binding; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: DNA metabolic process; DNA catabolic process, exonucleolytic; mRNA splicing, via spliceosome; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (407 aa) |
| | cactin | Cactin; Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway. Belongs to the CACTIN family. (720 aa) |
| | CG4119 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (998 aa) |
| | CG3436 | GM13767p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mitotic cell cycle. (347 aa) |
| | wisp | Poly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa) |
| | CG6379 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. (788 aa) |
| | CG7102 | LD40565p; It is involved in the biological process described with: spliceosomal snRNP assembly. (515 aa) |
| | CG15160 | Uncharacterized protein, isoform C; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing. (834 aa) |
| | ymp | Yellow-emperor, isoform D; It is involved in the biological process described with: mRNA splicing, via spliceosome. (186 aa) |
| | Prp4k | Uncharacterized protein, isoform C; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mRNA splicing, via spliceosome; positive regulation of hippo signaling. (912 aa) |
| | CG7564 | LD04387p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome. (420 aa) |
| | sip1 | Septin-interacting protein 1; May be involved in pre-mRNA splicing. (839 aa) |
| | mkg-p | Monkey king protein, isoform A; RNA uridylyltransferase activity; nucleotidyltransferase activity. It is involved in the biological process described with: mRNA processing; pre-miRNA processing; RNA 3' uridylation. (659 aa) |
| | CG6841 | LD04472p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; regulation of alternative mRNA splicing, via spliceosome. (931 aa) |
| | Bin1 | Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins. Interacts with bicoid (bcd) to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. Interacts with Trl and binds to Polycomb response elements at the bithorax complex. May contribute to the regulation of other homeotic gene expressions. (150 aa) |
| | tbrd-1 | Testis-specifically expressed bromodomain containing protein-1 (tbrd-1) encodes a protein involved in gene activation that is required for male germ cell differentiation. It interacts with the products of tbrd-2, tbrd-3 and testis-specific TAFs. (513 aa) |
| | CG12320 | Uncharacterized protein, isoform A; It is involved in the biological process described with: spliceosomal tri-snRNP complex assembly. (379 aa) |
| | Suv3 | ATP-dependent RNA helicase SUV3 homolog, mitochondrial; Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts. (763 aa) |
| | Rpb4 | DNA-directed RNA polymerase II subunit Rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G. (139 aa) |
| | REG | Proteasome regulator dREG; REG (REG) encodes an endopeptidase regulator involved in the regulation of the mitotic G1/S transition and proteasomal protein catabolism. (245 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | btz | Barentsz, isoform D; Barentsz (btz) encodes a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. It is required for the posterior localization of osk mRNA. (806 aa) |
| | abs | ATP-dependent RNA helicase abstrakt; ATP-dependent RNA helicase. Is essential for the directed and fasciculated early outgrowth of the bolwig nerves, as well as for its navigation at later stages. Is required during post-transcriptional gene expression. Plays a role during morphogenetic process, apoptosis and the establishment of cell polarity. (619 aa) |
| | CG14641 | LD46870p; pre-mRNA binding; mRNA binding; metal ion binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (418 aa) |
| | Hel25E | ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin. (424 aa) |
| | Phf5a | PHD finger-like domain-containing protein 5A; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; Belongs to the PHF5 family. (111 aa) |
| | x16 | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. (258 aa) |
| | SmE | Small ribonucleoprotein particle protein SmE (SmE) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmF and SNRPG. (94 aa) |
| | Srp54 | LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (513 aa) |
| | Bug22 | Cilia- and flagella-associated protein 20; Basal body up regulated gene 22 (Bug22) encodes a ciliary protein involved in cilium organization and assembly. It contributes to multiple processes during spermatogenesis including tubulin polyglycylation, axoneme assembly, sperm individualization and motility. It also contributes to locomotion, dendrite morphogenesis and neuron and muscle development; Belongs to the CFAP20 family. (199 aa) |
| | aub | Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...] (866 aa) |
| | hrg | Hiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb. (827 aa) |
| | bru3 | Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. (422 aa) |
| | SRPK | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa) |
| | Rnmt | mRNA cap guanine-N7 methyltransferase; mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. (427 aa) |
| | Mtr4 | Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response. (1055 aa) |
| | CG4935 | AT12460p; Molecular adaptor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome. (308 aa) |
| | LSm7 | Like Sm 7, isoform A; RNA binding. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process; mRNA splicing, via spliceosome. (110 aa) |
| | CG10333 | RH55640p; ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of defense response to virus. (822 aa) |
| | bsf | Bicoid stability factor (bsf) encodes a member of the family of proteins containing the pentatricopeptide motif, an RNA binding domain. It is found in the cytoplasm, where it functions in mRNA stability and post-transcriptional control of gene expression, and in mitochondria, where it has multiple roles in gene expression. It acts at many stages of development, and is required for progression through oogenesis and viability. (1412 aa) |
| | ncm | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. (1330 aa) |
| | l(2)37Cb | Lethal (2) 37Cb; RNA binding; RNA helicase activity. It is involved in the biological process described with: mRNA splicing, via spliceosome. (894 aa) |
| | CG1965 | LD29489p; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; negative regulation of transcription by RNA polymerase II. (905 aa) |
| | Ref1 | RNA and export factor binding protein 1; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (266 aa) |
| | SmD2 | Small ribonucleoprotein particle protein SmD2 (SmD2) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD1. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (119 aa) |
| | CG9667 | RE31520p; RNA binding. It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA 3'-splice site recognition; mRNA splicing, via spliceosome. (272 aa) |
| | CG7483 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. Has a role in oskar mRNA localization at the posterior pole of the developing oocyte. (399 aa) |
| | CG9684 | CG9684 encodes a protein belonging to the TDRD1 family that is predicted to have a role in the piRNA pathway. (642 aa) |
| | beag | LD21347p; Beag (beag) encodes a spliceosomal protein required for normal neuromuscular junction development and function. It functions together with the product of Smu1 and can regulate the alternative mRNA splicing of Fas2. (557 aa) |
| | Sf3b5 | Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as component of spliceosome. As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation. When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes ; Belongs to the SF3B5 family. (85 aa) |
| | RnpS1 | RNA-binding protein S1 (RnpS1) encodes a protein involved in RNA splicing and regulation of DNA transposition. (374 aa) |
| | Rbp1 | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. (144 aa) |
| | CG17187 | RE47242p; Nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (299 aa) |
| | CG5641 | Interleukin enhancer-binding factor 2 homolog; May regulate transcription of undefined genes. (396 aa) |
| | Rbp4 | RNA-binding protein 4 (Rbp4) encodes a protein that mediates the translational repression of CycB during meiosis in males. (428 aa) |
| | sqd | RNA-binding protein squid; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues. (344 aa) |
| | Hsc70-4 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa) |
| | obe | Obelus (obe) encodes a Ski2-family helicase that regulates alternative mRNA splicing of crb. It is required for cell polarity and adherens junction organization. (2183 aa) |
| | CG5213 | AT22957p; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome. (251 aa) |
| | CG10324 | FI23980p1. (543 aa) |
| | Sf3a1 | Splicing factor 3a subunit 1; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; mitotic cell cycle; spermatogenesis. (784 aa) |
| | SF1 | Splicing factor 1, isoform A; Zinc ion binding; pre-mRNA branch point binding; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (787 aa) |
| | Cbp20 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa) |
| | CstF64 | Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa) |
| | Cpsf73 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa) |
| | Prp18 | Putative mRNA splicing factor; It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA splicing, via spliceosome; nuclear retention of unspliced pre-mRNA at the site of transcription. (340 aa) |
| | snRNP-U1-C | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulat [...] (145 aa) |
| | nos | Protein nanos; Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal. Acts by forming a complex with pum and brat that regulates translation and mRNA stability. The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Controls posterior development. Rescuing factor for the abdominal defect of posterior group mutants. The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein. (401 aa) |
| | CG5316 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). (662 aa) |
