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| | Sik2 | Salt-inducible kinase 2 (Sik2) encodes a serine/threonine kinase that is activated by the product of Lkb1. It regulates lipid storage and energy homeostasis by controlling the activity of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). (1398 aa) |
| | nmo | Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (439 aa) |
| | CG34357 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa) |
| | CG31145 | Extracellular serine/threonine protein CG31145; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. (982 aa) |
| | Madm | Nuclear receptor-binding protein homolog; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus. (637 aa) |
| | Wnk | Wnk kinase, isoform M; Wnk kinase (Wnk) encodes a chloride-sensitive Ser/Thr kinase that signals through a downstream target Ser/Thr kinase, encoded by fray, which is activated by phosphorylation the product of Wnk. Its roles include regulation of ion transport and cell growth, and differentiation and developmental patterning, including roles in canonical Wnt signaling and induction of the product of Awh. (2462 aa) |
| | CG31183 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | CG5790 | FI19424p1; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: double-strand break repair via break-induced replication; peptidyl-serine phosphorylation; protein phosphorylation. (665 aa) |
| | Gprk1 | G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (700 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | CkIIalpha | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. (336 aa) |
| | Prp4k | Uncharacterized protein, isoform C; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mRNA splicing, via spliceosome; positive regulation of hippo signaling. (912 aa) |
| | Ddr | Discoidin domain receptor, isoform F; Transmembrane receptor protein tyrosine kinase activity; ATP binding; collagen binding; protein tyrosine kinase collagen receptor activity. It is involved in the biological process described with: transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of kinase activity; protein phosphorylation; multicellular organism development. (1054 aa) |
| | ksr | Kinase suppressor of ras (ksr) encodes a MAP-kinase scaffold protein. It mediates the activation of the serine/threonine kinase encoded by Dsor1. (966 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | Src64B | Tyrosine-protein kinase Src64B; Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. (553 aa) |
| | Adck1 | AarF domain-containing kinase 1; Essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L to regulate the mitochondrial structural proteins Opa1 and Mitofilin. This function is likely to be kinase-independent (By similarity). Functions in tracheal development and larval molting probably by acting in sterol modification and/or intracellular lipid trafficking. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). (518 aa) |
| | CG7236 | Uncharacterized protein, isoform C; ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase activity. It is involved in the biological process described with: mitotic cytokinesis; protein phosphorylation. (438 aa) |
| | nonC | Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1. (3218 aa) |
| | Bub1 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. (1099 aa) |
| | Nak | Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization. (1488 aa) |
| | Drl-2 | Derailed 2 (Drl-2) is a member of the RYK gene family encoding a receptor tyrosine kinase that transduces Wnt5 signaling. It regulates salivary gland positioning, muscle attachment site selection and olfactory system development. The products of Drl-2 and drl can play both cooperative and opposing roles, depending on the cells where they are differentially expressed. (648 aa) |
| | meng | Serine/threonine-protein kinase meng-po; Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM). (456 aa) |
| | Nuak | Nuak1 ortholog, isoform I; Protein serine/threonine kinase activity; structural molecule activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. (2556 aa) |
| | Dyrk2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2; In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. (757 aa) |
| | IKKepsilon | I-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. (720 aa) |
| | dnt | Tyrosine-protein kinase Dnt; Doughnut on 2 (dnt) encodes a Ryk family Wnt receptor-tyrosine kinase-related protein. It can form homo- and heterodimers with the other two Ryks (encoded by Drl-2 and drl) via binding the ligand encoded by Wnt5. dnt and drl products act during embryonic muscle attachment site selection. (584 aa) |
| | l(2)efl | Protein lethal(2)essential for life; Vital role in embryonic development; Belongs to the small heat shock protein (HSP20) family. (187 aa) |
| | Strn-Mlck | Stretchin-Mlck, isoform U; Stretchin-Mlck (Strn-Mlck) encodes a complex locus producing many large protein isoforms, which likely regulate cytoskeletal dynamics in muscles. A shorter isoform is specifically expressed in indirect flight muscle, localizes to the thick filament and is required to prevent flight muscle hypercontraction. Strn-Mlck mutants cannot fly and show flight muscle atrophy. (8255 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | CG9886 | Glycerate kinase activity. It is involved in the biological process described with: protein phosphorylation; Belongs to the glycerate kinase type-2 family. (487 aa) |
| | AMPKalpha | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. (582 aa) |
| | Src42A | Tyrosine-protein kinase Src42A; Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity. Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduc [...] (1597 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | Gcn2 | Gcn2, isoform C; Gcn2 (Gcn2) encodes a kinase activated during amino acid starvation to phosphorylate the eIF2 subunit encoded by eIF2alpha. Gcn2 product plays roles in ageing, dpp signalling, dietary choice and response to infection. (1591 aa) |
| | dco | Discs overgrown protein kinase; Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin- protein ligase. (440 aa) |
| | Pak | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. (840 aa) |
| | Mkk4 | MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. (424 aa) |
| | CG17698 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. (694 aa) |
| | yata | Yata, isoform A; ATP binding. It is involved in the biological process described with: protein phosphorylation. (873 aa) |
| | S6kII | Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. (911 aa) |
| | fs(1)h | Homeotic protein female sterile; Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx. (2046 aa) |
| | S6k | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa) |
| | Pdk1 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa) |
| | CycT | Cyclin-T; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (1097 aa) |
| | JIL-1 | Chromosomal serine/threonine-protein kinase JIL-1; Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A. (1207 aa) |
| | sti | Non-specific serine/threonine protein kinase; Sticky (sti) encodes a member of the AGC family of kinases that functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing. (1858 aa) |
| | CG4629 | Uncharacterized protein, isoform E; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. (570 aa) |
| | Wee1 | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (609 aa) |
| | trc | Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...] (463 aa) |
| | dop | Drop out (dop) encodes a microtubule-associated Ser/Thr (MAST) protein kinase. Among its potential substrates is the microtubule motor Dynein. The product of dop is required for membrane growth and polarity during cell formation in the early cleavage stage embryo. (2139 aa) |
| | Alk | Anaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb. (1701 aa) |
| | hpo | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] (669 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | bma | Black match, isoform F. (854 aa) |
| | Mps1 | Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. (672 aa) |
| | SRPK | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa) |
| | CASK | Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa) |
| | Ack-like | Activated Cdc42 kinase-like (Ack-like) encodes a non-receptor tyrosine kinase that participates in signaling by the small GTPase encoded by Cdc42. It is involved in embryonic dorsal closure, an epithelial morphogenetic event. (1495 aa) |
| | PKD | Protein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. (906 aa) |
| | par-1 | Par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. (1170 aa) |
| | put | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa) |
| | drl | Tyrosine-protein kinase Drl; Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non- vital for development. May be part of a signal transduction cascade involved in learning and possibly memory. (645 aa) |
| | Abl | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. (1723 aa) |
| | wit | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] (913 aa) |
| | Eip63E | Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis. (538 aa) |
| | Pak3 | Non-specific serine/threonine protein kinase; Pak3 (Pak3) encodes a Ser/Thr kinase implicated in myoblast fusion, synapse development, wound healing and border cell migration. It functions downstream of the small Rac GTPases to regulate actin cytoskeletal organization. (583 aa) |
| | bon | Bonus, isoform C; Bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. (1207 aa) |
| | gish | Gilgamesh, isoform L; Gilgamesh (gish) encodes a plasma membrane-associated kinase that regulates Hedgehog and Wingless signaling activity. It is involved in planar cell polarity via regulation of Rab11-mediated vesicle trafficking. (537 aa) |
| | aPKC | Atypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa) |
| | sqa | Spaghetti-squash activator (sqa) encodes a myosin light chain kinase-like protein. It is a substrate of the kinase encoded by Atg1 and is required for starvation-induced autophagy. (888 aa) |
| | sax | Receptor protein serine/threonine kinase; Saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (582 aa) |
| | Srpk79D | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. (1018 aa) |
| | Ptpmeg | Protein tyrosine phosphatase Meg (Ptpmeg) encodes a tyrosine phosphatase that interacts with the product of Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (974 aa) |
| | Cam | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa) |
| | Taf1 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. (2172 aa) |
| | IKKbeta | Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response. (717 aa) |
| | Sik3 | ATP binding; protein serine/threonine kinase activity. (1471 aa) |
| | Tao | Serine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa) |
| | slpr | Mitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure. (1155 aa) |
| | MAPk-Ak2 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (359 aa) |
| | CG10738 | Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | Gyc76C | Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. (1525 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | Takl2 | Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays. (281 aa) |
| | Pvr | Receptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. (1577 aa) |
| | SNF4Agamma | SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation. (1400 aa) |
| | PhKgamma | Phosphorylase kinase gamma (PhKgamma) encodes a protein involved in gastrulation, embryonic mesoderm formation and adult leg musculature development. (560 aa) |
| | KP78b | KP78b, isoform A; ATP binding; tau-protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; microtubule cytoskeleton organization; intracellular signal transduction. (604 aa) |
| | KP78a | LP21052p1; Protein serine/threonine kinase activity; ATP binding; tau-protein kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; microtubule cytoskeleton organization. (705 aa) |
| | bt | Bent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle. (8933 aa) |
| | Tfb5 | Transcription factor B5 (Tfb5) encodes a subunit of the basal transcription and DNA repair factor TFIIH, which operates in transcription and DNA repair. (73 aa) |
| | Drak | Death-associated protein kinase related (Drak) encodes a protein serine/threonine kinase belonging to the Death-associated protein kinase family. It promotes phosphorylation of the product of sqh at sites known to stimulate actomyosin contractility. Its main characterized function is to shape epithelial tissues during development. (674 aa) |
| | CG4041 | LD42868p; Rab GTPase binding; GTPase activator activity; ATP binding. It is involved in the biological process described with: activation of GTPase activity; Golgi organization; protein phosphorylation; regulation of GTPase activity; intracellular protein transport. (819 aa) |
| | Atg1 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa) |
| | mnb | Minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa) |
| | Cdk2 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (314 aa) |
| | CaMKII | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. (531 aa) |
| | Asator | Asator (Asator) encodes a tau-tubulin kinase homolog that is localized to the cytoplasm at interphase. It directly interacts with the spindle matrix protein encoded by Mtor and localizes to the spindle region during mitosis. (1349 aa) |
| | Ask1 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. (1363 aa) |
| | CG42366 | Uncharacterized protein, isoform A; Protein kinase activity; MAP kinase activity; ATP binding. It is involved in the biological process described with: cilium assembly; intraciliary transport; intracellular signal transduction; protein phosphorylation; regulation of gene expression. (706 aa) |
| | Doa | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa) |
| | Csk | C-terminal Src kinase (Csk) encodes a cytoplasmic tyrosine kinase that acts as a tumor suppressor through Src pathway inibition as well as a mediator of the activity of the product of Egfr. (1052 aa) |
| | Tlk | Tousled-like kinase, isoform G; Tousled-like kinase (Tlk) encodes a serine/threonine kinase that acts in a cell cycle-dependent manner. It contributes to cell morphogenesis, cell migration and cell death through interactions with chromatin components. (1489 aa) |
| | CG32944 | Uncharacterized protein, isoform F; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; peptidyl-serine phosphorylation. (576 aa) |
| | CG3216 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa) |
| | Fak | Focal adhesion kinase (Fak) encodes a non-Receptor Tyrosine kinase (nRTK) that is involved in signaling and cytoskeletal dynamics integrating signals from RTKs and integrins. Its function has been described in multiple contexts including embryonic muscle attachement, morphogensis of the optic stalk, synaptic growth and transmission, and in the regulation of RTK-MAP kinase signaling in epithelia. (1500 aa) |
| | CG3277 | Transmembrane receptor protein tyrosine kinase activity; ATP binding. It is involved in the biological process described with: transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of kinase activity; protein phosphorylation; multicellular organism development. (789 aa) |
| | Haspin | Putative serine/threonine-protein kinase haspin homolog; Histone kinase activity (H3-T3 specific); ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; mitotic cell cycle; protein phosphorylation. (566 aa) |
| | Unc-89 | Obscurin; Structural component of the muscle M line which is involved in assembly and organization of sarcomere. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable). (4218 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | Pkn | Serine/threonine-protein kinase N; Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis. (1501 aa) |
| | Pdk | [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism; Belongs to the PDK/BCKDK protein kinase family. (422 aa) |
| | Gyc32E | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation. (1191 aa) |
| | Btk29A | Btk family kinase at 29A (Btk29A) encodes a non-receptor tyrosine kinase with diverse roles including cellularization, morphogenesis, patterning and germ cell proliferation; Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. (786 aa) |
| | CG17528 | Serine/threonine-protein kinase CG17528; ATP binding; calmodulin binding; protein serine/threonine kinase activity; calcium-dependent protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation; intracellular signal transduction; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (748 aa) |
| | Stlk | Putative serine/threonine-protein kinase STE20-like; ATP binding. It is involved in the biological process described with: protein phosphorylation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (346 aa) |
| | tefu | Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...] (2767 aa) |
| | Pink1 | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. (721 aa) |
| | Dyrk3 | Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (828 aa) |
| | Ptpmeg2 | Protein tyrosine phosphatase Meg2 (Ptpmeg2) encodes a phosphatase involved in border follicle cell migration. (827 aa) |
| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | CkIIbeta | Casein kinase II beta subunit (CkIIbeta) encodes the regulatory subunit of the CKII holoenzyme, a protein serine/threonine kinase composed of a and b subunits. Interactions have been reported with other kinases (e.g., the products of PIP4K and S6kII), the RNA-binding protein encoded by orb , the Hedgehog signaling pathway and clock proteins such as the products of tim and per. The product of CkIIbeta functions in oogenesis, neurogenesis, development (brain and other tissues) as well as circadian behavior. (235 aa) |
| | CG8878 | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. (1004 aa) |
| | sff | Sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. (861 aa) |
| | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B; Foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. (1088 aa) |
| | Eph | Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. (1096 aa) |
| | CaMKI | Calmodulin binding; ATP binding; calmodulin-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (405 aa) |
| | tor | Tyrosine-protein kinase receptor torso; Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity). (923 aa) |
| | CG8726 | FI05228p; Phosphatidylinositol binding; actin binding; ATP binding. It is involved in the biological process described with: regulation of membrane potential; negative regulation of ATPase activity; protein phosphorylation; negative regulation of ion transport. (646 aa) |
| | babo | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa) |
| | Cdc2rk | Cdc2-related kinase (Cdc2rk) encodes a kinase that might be involved in cell cycle regulation; Belongs to the protein kinase superfamily. (387 aa) |
| | otk | Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (1033 aa) |
| | Mos | Mos oncogene (Mos) encodes a kinase that activates the MAPK cascade during oogenesis; Belongs to the protein kinase superfamily. (364 aa) |
| | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2; Neurospecific receptor kinase (Nrk) encodes a receptor tyrosine kinase that is expressed in the developing nervous system and regulates axon pathfinding and rhabdomere elongation. It interacts genetically with Dys and Dg. (724 aa) |
| | CG8485 | Uncharacterized protein, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (860 aa) |
| | Tfb1 | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (585 aa) |
| | Cdk5 | Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration. (294 aa) |
| | Shark | Tyrosine-protein kinase Shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] (939 aa) |
| | Cdk4 | Cyclin-dependent kinase 4 (Cdk4) encodes a protein that contributes to cell cycle progression and cell growth. It is involved in the regulation of JAK-STAT and TORC1 signalling pathways. (317 aa) |
| | CG4945 | Uncharacterized protein, isoform B; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; mesoderm development. (577 aa) |
| | Pkc53E | Protein kinase C, brain isozyme; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection ; Belongs to the prote [...] (679 aa) |
| | inaC | Protein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa) |
| | fj | Extracellular serine/threonine protein kinase four-jointed; Golgi serine/threonine protein kinase required for intermediate growth in the proximal-distal axis. Phosphorylates specific residues within extracellular cadherin domains of Fat (ft) and Dachsous (ds) as they transit through the Golgi. Acts in ommatidial polarity determination as a secondary signal downstream of Notch, JAK/STAT and wingless. Also necessary for the initiation, up- regulation or maintenance of Notch ligand, Serrate (Ser) expression in legs, thereby participating in a feedback loop with N signaling. Sufficient fo [...] (583 aa) |
| | hppy | Happyhour, isoform A; Happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. (1218 aa) |
| | BubR1 | Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. (1460 aa) |
| | Gprk2 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (714 aa) |
| | gskt | Putative glycogen synthase kinase-3 homolog; Gasket (gskt) is a retro-transposed glycogen synthase kinase 3 gene, derived from sgg, that is required for male fertility. Like many genes retroposed from the X chromosome, it is highly expressed in the testis. (501 aa) |
| | CG12069 | UT01108p; cAMP-dependent protein kinase activity; ATP binding. It is involved in the biological process described with: protein kinase A signaling; protein phosphorylation. (356 aa) |
| | Pka-C2 | ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation. (354 aa) |
| | wts | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] (1105 aa) |
| | Pkc98E | Protein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn. (739 aa) |
| | CG1951 | LD39455p; ATP binding. It is involved in the biological process described with: protein phosphorylation; multicellular organism reproduction. (835 aa) |
| | pll | Serine/threonine-protein kinase pelle; Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. (501 aa) |
| | ball | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] (599 aa) |
| | Cad96Ca | Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. (773 aa) |
| | RIOK2 | RIO kinase 2; Protein kinase activity; protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: positive regulation of glial cell proliferation; maturation of SSU-rRNA; protein phosphorylation. (538 aa) |
| | niki | NimA-like kinase; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: chromosome segregation; protein phosphorylation. (841 aa) |
| | Wsck | Putative tyrosine-protein kinase Wsck; Putative receptor with tyrosine-protein kinase activity. (791 aa) |
| | p38c | Putative mitogen-activated protein kinase 14C; P38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc. (356 aa) |
| | p38a | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. (366 aa) |
| | CG10177 | Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: Golgi organization; protein phosphorylation; mitotic DNA damage checkpoint; negative regulation of cell size; signal transduction in response to DNA damage. (411 aa) |
| | CG6800 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. (302 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | Takl1 | ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity. (393 aa) |
| | cdi | Center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. (1213 aa) |
| | Mekk1 | Mekk1, isoform B; Mekk1 (Mekk1) encodes a MAP kinase kinase kinase that regulates the stress response. It is required for resistance to several stresses, notably osmotic shock, and for the regulation of the activity of the product of Duox. (1571 aa) |
| | gwl | Greatwall, isoform A; Greatwall (gwl) encodes a kinase required for mitosis and female meiosis. It phosphorylates the product of endos, which then acts as a stoichiometric inhibitor of the PP2A B-type adaptor subunit encoded by tws. (846 aa) |
| | fray | Frayed, isoform A; Frayed (fray) encodes a serine/threonine-protein kinase required for axonal ensheathment. It is activated via phosphorylation by the kinase encoded by Wnk. The product of fray contributes to regulating ion transport, canonical Wnt signaling and asymmetric cell division. (552 aa) |
| | CG14305 | AT25266p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (302 aa) |
| | CG7156 | LD24550p; Protein serine/threonine kinase activity; phosphatidylinositol binding; ATP binding. It is involved in the biological process described with: protein phosphorylation. (681 aa) |
| | htl | Fibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa) |
| | GckIII | Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. (642 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
| | CG3631 | Glycosaminoglycan xylosylkinase homolog; Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans. Belongs to the FAM20 family. (421 aa) |
| | Lkb1 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. (567 aa) |
| | Lk6 | Lk6 kinase (Lk6) encodes the single ortholog of MAPK signal integrating kinases, which are phosphorylated and activated by ERK. Lk6 product phosphorylates the protein encoded by eIF4E1 to influence translation initiation via formation of the eIF4F complex. (1142 aa) |
| | aurA | Aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. (411 aa) |
| | Aduk | Another drosophila Unc-51-like kinase, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of autophagosome assembly; autophagy. (520 aa) |
| | FER | Tyrosine-protein kinase Fer; Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm. (1325 aa) |
| | Vps15 | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa) |
| | CG1227 | LD17053p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; positive regulation of cell size. (320 aa) |
| | Ret | Ret oncogene (Ret) encodes a cell surface receptor mediating dendrite development of class IV dendritic arborization sensory neurons. It interacts with integrins and mediates rac1 signaling to promote dendrite adhesion to the extracellular matrix; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1235 aa) |
| | lok | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. (476 aa) |
| | CG7094 | FI08417p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: peptidyl-serine phosphorylation; protein phosphorylation; negative regulation of canonical Wnt signaling pathway. (390 aa) |
| | grp | Serine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] (512 aa) |
| | p38b | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa) |
| | Pk34A | RT06158p; Cyclin binding; ATP binding; cyclin-dependent protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression; G1/S transition of mitotic cell cycle; protein phosphorylation; positive regulation of cell population proliferation; regulation of G2/M transition of mitotic cell cycle. (392 aa) |
| | aurB | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. (329 aa) |
| | Cdk1 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. (297 aa) |
| | Ror | Ror (Ror) encodes a transmembrane receptor tyrosine kinase structurally related to vertebrate neural-specific Wnt-binding Ror receptors. It is primarily expressed in the nervous system and it is likely to signal through the ERK MAP kinase pathway. (685 aa) |
| | CG4839 | LP05330p; ATP binding; cGMP-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (1003 aa) |
| | Dref | DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. (709 aa) |
| | Cks30A | Cyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. (74 aa) |
| | ninaC | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. (1501 aa) |
| | CG9222 | AT03158p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (337 aa) |
| | tkv | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (575 aa) |
| | aux | Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. (1165 aa) |
| | CG12147 | AT15039p; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; positive regulation of canonical Wnt signaling pathway. (477 aa) |
| | PEK | Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa) |
| | CycH | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. (324 aa) |
| | SAK | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...] (769 aa) |
| | Cdk12 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (1157 aa) |
| | Ilk | Integrin linked kinase (Ilk) encodes a pseudokinase that, together with the products of stck and parvin, mediates part of the adhesive functions of integrins. (448 aa) |
| | Pitslre | Serine/threonine-protein kinase PITSLRE; Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (952 aa) |
| | Pkg21D | Protein kinase, cGMP-dependent at 21D (Pkg21D) encodes a Mg[+] dependent-kinase that is activated by cGMP. It contributes to somatic muscle development, salivary gland morphogenesis and epithelial fluid transport. (768 aa) |
| | Tfb4 | Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. (299 aa) |
| | CG9962 | IP11482p; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-serine phosphorylation; negative regulation of canonical Wnt signaling pathway; protein phosphorylation. (319 aa) |
| | CG3008 | Serine/threonine-protein kinase RIO3; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (603 aa) |
| | Tak1 | Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis. (678 aa) |
| | Prpk | P53-related protein kinase (Prpk) encodes an atypical Ser/Thr kinase part of the KEOPS/EKC complex. It phosphorylates the product of p53 and is regulated by the products of Akt1 and Rab35. It is involved in tRNAs modification, telomere and chromatin dynamics. (224 aa) |
| | Myt1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr- 15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr [...] (533 aa) |
| | Hsp67Bc | Heat shock gene 67Bc (Hsp67Bc) encodes a small heat shock protein (hsp) that binds to the product encoded by stv to regulate protein lipidation. The product of Hsp67Bc also induces the phosphorylation of eIF2alpha protein and stimulates autophagy, thereby facilitating the clearance of misfolded proteins. Hsp67Bc expression can be regulated by the product of pcm. (199 aa) |
| | Cdk8 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...] (454 aa) |
| | RIOK1 | Serine/threonine-protein kinase RIO1; ATP binding; protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of glial cell proliferation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (585 aa) |
| | btl | Fibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa) |
| | mrn | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (499 aa) |
| | Pka-C3 | cAMP-dependent protein kinase catalytic subunit 3; Does not have an essential role in development. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (583 aa) |
| | wnd | Wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons. (977 aa) |
| | polo | Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (576 aa) |
| | S6KL | S6 Kinase Like (S6KL) encodes a serine/threonine kinase that inhibits BMP signaling through facilitating degradation of the BMP receptor encoded by tkv. It inhibits neuromuscular junction growth and promotes synaptic endocytosis at the neuromuscular junctions; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (483 aa) |
| | fu | Serine/threonine-protein kinase fused; Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. (805 aa) |
| | CG8173 | RE25723p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mitotic cell cycle. (398 aa) |
| | Rok | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. (1390 aa) |
| | mbt | Serine/threonine-protein kinase PAK mbt; Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42. (639 aa) |
| | mei-41 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. [...] (2517 aa) |
| | CG8565 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. (790 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | CkIalpha | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling. Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling. Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh. Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F [...] (337 aa) |
| | LIMK1 | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. (1257 aa) |
| | CG2577 | CG2577-PA; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: peptidyl-serine phosphorylation; Wnt signaling pathway. (344 aa) |
| | hop | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. (1177 aa) |
| | sev | Protein sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. (2554 aa) |
| | Tie | Tie-like receptor tyrosine kinase (Tie) encodes a predicted transmembrane tyrosine kinase receptor. Its potential ligands for include Pvf protein family members. It may be involved in cell survival and cell migration. (1233 aa) |
| | Ack | Activated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa) |
| | msn | Misshapen, isoform A; Misshapen (msn) encodes a Sterile 20 MAP kinase kinase kinase. (1504 aa) |
| | Ptp61F | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. (548 aa) |
| | Hipk | Homeodomain interacting protein kinase (Hipk) encodes a protein that belongs to the DYRK family kinases. It can modulate signaling pathways including Wingless, Notch, Hippo, Hedgehog, JNK, and cell death. It plays roles in development, proliferation and patterning of many tissues, including the eye, wing, and the embryo. (1340 aa) |
| | Slik | Sterile20-like kinase (Slik) encodes a member of the Sterile-20 kinase family. It acts via Raf to promote cell proliferation in imaginal disc epithelia. Independently, Slik acts via the product of Moe to support epithelial integrity. (1703 aa) |
| | Ssl | Protein kinase regulator activity. It is involved in the biological process described with: protein phosphorylation; Belongs to the casein kinase 2 subunit beta family. (219 aa) |
| | gek | Serine/threonine-protein kinase Genghis Khan; Acts as a downstream effector for the regulation of actin polymerization by Cdc42. (1637 aa) |
| | Pask | PAS kinase; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; negative regulation of glycogen biosynthetic process. (985 aa) |
| | Cdk9 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. (404 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | Erk7 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. (916 aa) |
| | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (396 aa) |
| | Nek2 | LD04361p; Nek2 (Nek2) encodes a Ser/Thr kinase belonging to the NIMA family of kinases. It regulates centrosome disjunction, bipolar spindle formation, and kinetochore microtubule dynamics during mitosis. It also participates in meiosis by regulating chromatin condensation events. (735 aa) |
| | Cdc7 | Cdc7 kinase (Cdc7) encodes a conserved protein kinase that is activated by the regulatory subunit encoded by chif during late G1/S of the cell cycle. The activated product of Cdc7 promotes the initiation of DNA replication through phosphorylation, and thereby activation, of the DNA helicase encoded by Mcm2. (700 aa) |
| | Cdk7 | Cyclin-dependent kinase 7 (Cdk7) encodes a serine/threonine protein kinase whose activity depends on the regulatory subunits encoded by CycH and Mat1. This trimeric Cdk complex activates other Cdks by phosphorylation in their T-loop and is called Cdk activating kinase (CAK). CAK can also be part of TFIIH, where the product of Cdk7 phosphorylates different transcription substrates (e.g. CTD of Pol II). (353 aa) |
| | png | Pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu. (291 aa) |
