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| | AsnS | Asparagine synthase (glutamine-hydrolyzing) activity. It is involved in the biological process described with: asparagine biosynthetic process. (558 aa) |
| | y | Yellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts; Belongs to the major royal jelly protein family. (541 aa) |
| | arg | Arginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay. (351 aa) |
| | CG17896 | Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). (520 aa) |
| | CG10802 | LD13611p; Ser-tRNA(Ala) hydrolase activity; ATP binding; nucleic acid binding; alanine-tRNA ligase activity. It is involved in the biological process described with: alanyl-tRNA aminoacylation; regulation of translational fidelity. (436 aa) |
| | CG6428 | SD20009p; Asparaginase activity. It is involved in the biological process described with: asparagine catabolic process. (631 aa) |
| | Shmt | Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa) |
| | Spat | Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. (394 aa) |
| | alpha-PheRS | Phenylalanyl-tRNA synthetase, alpha-subunit (alpha-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the beta-subunit it forms a tetrameric enzyme complex. This subunit provides the catalytic core. (498 aa) |
| | LysRS | Lysine--tRNA ligase; tRNA binding; ATP binding; lysine-tRNA ligase activity. It is involved in the biological process described with: lysyl-tRNA aminoacylation. (607 aa) |
| | T3dh | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (464 aa) |
| | TyrRS-m | Tyrosine--tRNA ligase, mitochondrial; Tyrosyl-tRNA synthetase, mitochondrial (TyrRS-m) encodes an enzyme that catalyzes the ligation of tyrosine to the mitochondrial-encoded tRNA-Tyr. The TyrRS-m protein is encoded by a nuclear gene and imported to the mitochondria where it functions in mitochondrial protein synthesis; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa) |
| | Trh | Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. (555 aa) |
| | ProRS-m | Prolyl-tRNA synthetase, mitochondrial, isoform A; proline-tRNA ligase activity; ATP binding; glycine-tRNA ligase activity. It is involved in the biological process described with: glycyl-tRNA aminoacylation; prolyl-tRNA aminoacylation. (458 aa) |
| | AhcyL1 | Adenosylhomocysteinase like 1 (AhcyL1) encodes a protein that, together with the product of AhcyL2, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and productio [...] (521 aa) |
| | Gad1 | Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family. (510 aa) |
| | Faa | Fumarylacetoacetase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; homogentisate catabolic process; tyrosine catabolic process. (417 aa) |
| | LeuRS-m | Leucyl-tRNA synthetase, mitochondrial; aminoacyl-tRNA editing activity; leucine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: leucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (869 aa) |
| | v | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway. (379 aa) |
| | CG1673 | Branched-chain-amino-acid transaminase activity. It is involved in the biological process described with: valine biosynthetic process; branched-chain amino acid biosynthetic process; leucine biosynthetic process; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (443 aa) |
| | CG5599 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Acetyltransferase activity; lipoic acid binding. (462 aa) |
| | CG7860 | Probable isoaspartyl peptidase/L-asparaginase CG7860 alpha chain; Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. (332 aa) |
| | ArgRS | Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (665 aa) |
| | Oat | Ornithine aminotransferase, mitochondrial; Ornithine-oxo-acid transaminase activity; identical protein binding; pyridoxal phosphate binding. It is involved in the biological process described with: arginine catabolic process to proline via ornithine; ornithine metabolic process; arginine catabolic process to glutamate. (431 aa) |
| | CG7430 | Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa) |
| | TrpRS-m | Tryptophanyl-tRNA synthetase, mitochondrial (TrpRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of tryptophan to its cognate tRNA to form tryptophanyl-tRNA. (665 aa) |
| | TyrRS | tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation. (525 aa) |
| | GluRS-m | Glutamyl-tRNA synthetase, mitochondrial; glutamate-tRNA ligase activity; tRNA binding; ATP binding; zinc ion binding. It is involved in the biological process described with: glutamyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (511 aa) |
| | GlyRS | Glycyl-tRNA synthetase, isoform B; Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis. (765 aa) |
| | CG6661 | GH20963p; 1-pyrroline-5-carboxylate dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: proline metabolic process; proline catabolic process to glutamate; oxidation-reduction process. (581 aa) |
| | CG32099 | GH12334p; Holo-[acyl-carrier-protein] synthase activity; magnesium ion binding. It is involved in the biological process described with: lysine biosynthetic process via aminoadipic acid. (290 aa) |
| | CG10361 | FI03238p; Pyridoxal phosphate binding; glycine C-acetyltransferase activity. It is involved in the biological process described with: biosynthetic process; threonine catabolic process; cellular amino acid metabolic process. (417 aa) |
| | CG7560 | GH04035p; FAD binding; methylenetetrahydrofolate reductase (NAD(P)H) activity. It is involved in the biological process described with: methionine biosynthetic process; tetrahydrofolate interconversion; one-carbon metabolic process; oxidation-reduction process. (349 aa) |
| | aay | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (270 aa) |
| | Dhpr | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. (235 aa) |
| | CG6638 | RE62833p; isovaleryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process; leucine catabolic process. (420 aa) |
| | Hn | Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis. (452 aa) |
| | AlaRS-m | Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1012 aa) |
| | slgA | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. (681 aa) |
| | Cbs | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. (522 aa) |
| | SerRS | Seryl-tRNA synthetase (SerRS) encodes a protein that aminoacylates transfer RNAs (tRNA) for their use by the ribosome during protein synthesis. (501 aa) |
| | Got2 | Aspartate aminotransferase; Glutamate oxaloacetate transaminase 2 (Got2) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis, which in turn regulates postsynaptic receptor field size. (431 aa) |
| | Gs1 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. (399 aa) |
| | CG5955 | GH18546p; L-threonine 3-dehydrogenase activity; coenzyme binding. It is involved in the biological process described with: threonine catabolic process. (367 aa) |
| | Hpd | 4-hydroxyphenylpyruvate dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; tyrosine catabolic process. (380 aa) |
| | ppl | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity); Belongs to the GcvH family. (165 aa) |
| | IleRS | Isoleucyl-tRNA synthetase, isoform A; isoleucine-tRNA ligase activity; tRNA binding; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1229 aa) |
| | CG12173 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (256 aa) |
| | CG11236 | GH12548p; FAD binding; D-amino-acid oxidase activity. It is involved in the biological process described with: D-amino acid metabolic process; oxidation-reduction process. (341 aa) |
| | Sps2 | Selenide, water dikinase 2; Selenophosphate synthetase 2 (Sps2) is essential for selenoprotein biosynthesis. It encodes an enzyme that catalyzes the synthesis of selenophosphate from selenide and/or other selenium metabolites. Selenophosphate is an active selenium donor for the formation of selenocysteine. (370 aa) |
| | CG6415 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (405 aa) |
| | Nos | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. (1349 aa) |
| | hgo | Homogentisate 1,2-dioxygenase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; oxidation-reduction process; cellular amino acid metabolic process; tyrosine metabolic process. (439 aa) |
| | amd | 3,4-dihydroxyphenylacetaldehyde synthase; Catalyzes both the decarboxylation and deamination of L-dopa to 3,4-dihydroxylphenylacetaldehyde (DHPAA). Probably responsible for the protein cross-linking during the development of flexible cuticles. Participates in catecholamine catabolism. (510 aa) |
| | Ddc | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. (510 aa) |
| | pyd3 | Pyd3 (pyd3) encodes a beta-alanine synthase involved in pyrimidine catabolism, beta-alanine biosynthesis and cuticle pigmentation. (386 aa) |
| | TrpRS | Tryptophanyl-tRNA synthetase (TrpRS) is expressed to high levels in the salivary gland. This could be incidental due to proximity to the salivary gland transcription factor encoded by sage; Belongs to the class-I aminoacyl-tRNA synthetase family. (430 aa) |
| | Srr | Serine racemase, isoform B; Serine racemase activity; L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity. It is involved in the biological process described with: threonine catabolic process; L-serine catabolic process. (469 aa) |
| | CG8132 | LD31229p; Omega-amidase activity. It is involved in the biological process described with: glutamine metabolic process; asparagine metabolic process; oxaloacetate metabolic process. (283 aa) |
| | GstZ2 | Probable maleylacetoacetate isomerase 2; Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). Belongs to the GST superfamily. Zeta family. (227 aa) |
| | GstZ1 | Probable maleylacetoacetate isomerase 1; Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). (246 aa) |
| | CG8199 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (439 aa) |
| | CG8526 | AT09114p; Asparaginase activity. It is involved in the biological process described with: asparagine catabolic process. (605 aa) |
| | CG3999 | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (985 aa) |
| | pug | C-1-tetrahydrofolate synthase, cytoplasmic; Pugilist (pug) encodes the trifunctional enzyme methylenetetrahydrofolate dehydrogenase involved in the pigmentation of pteridines and ommochromes; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. (968 aa) |
| | CG6465 | GH04054p; Metallopeptidase activity; aminoacylase activity. It is involved in the biological process described with: proteolysis; cellular amino acid metabolic process. (401 aa) |
| | Kyat | Kynurenine aminotransferase, isoform A; Pyridoxal phosphate binding; cysteine-S-conjugate beta-lyase activity; kynurenine-oxoglutarate transaminase activity. It is involved in the biological process described with: biosynthetic process; kynurenine metabolic process. (450 aa) |
| | Gnmt | Glycine N-methyltransferase (Gnmt) encodes an enzyme that catalyzes the methylation reaction of glycine to generate sarcosine (N-methylglycine). It is abundantly expressed in the fat body and controls the amount of methyl donor S-adenosylmethionine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. (289 aa) |
| | ry | Xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (1335 aa) |
| | yellow-f2 | L-dopachrome tautomerase yellow-f2; Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. Belongs to the major royal jelly protein family. (452 aa) |
| | yellow-f | L-dopachrome tautomerase yellow-f; Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages. Belongs to the major royal jelly protein family. (429 aa) |
| | CG5044 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | P5cr-2 | Pyrroline-5-carboxylate reductase activity. It is involved in the biological process described with: oxidation-reduction process; L-proline biosynthetic process. (273 aa) |
| | P5cr | Pyrroline-5-carboxylate reductase activity. It is involved in the biological process described with: oxidation-reduction process; L-proline biosynthetic process. (280 aa) |
| | GatA | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (508 aa) |
| | e | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. (879 aa) |
| | P5CDh2 | delta-1-Pyrroline-5-carboxylate dehydrogenase 2 (P5CDh2) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation. (614 aa) |
| | cd | Cardinal (cd) encodes a phenoxazinone synthetase involved in the kynurenine pathway. It contributes to ommochrome biosynthesis, neuron death and siRNA-mediated gene silencing. (830 aa) |
| | CG6733 | RE20374p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa) |
| | CG6738 | FI02833p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa) |
| | bb8 | Big bubble 8 (bb8) encodes a glutamate dehydrogenase involved in the development of the spermatid mitochondria; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (535 aa) |
| | CG10184 | LD34157p; L-allo-threonine aldolase activity. It is involved in the biological process described with: threonine catabolic process; glycine biosynthetic process. (383 aa) |
| | GluProRS | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family. (1714 aa) |
| | Slimp | Serine--tRNA synthetase-like protein Slimp; Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP. (464 aa) |
| | GatB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (516 aa) |
| | beta-PheRS | Phenylalanyl-tRNA synthetase, beta-subunit (beta-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the alpha-subunit it forms a tetrameric enzyme complex. This subunit plays a role in recognition and binding of tRNAPhe and it provides the editing site that hydrolyzes wrongfully activated or ligated compounds. (589 aa) |
| | GlnRS | Probable glutamine--tRNA ligase; glutamine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: dendrite morphogenesis; glutaminyl-tRNA aminoacylation. (778 aa) |
| | Ssadh | Succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity. It is involved in the biological process described with: oxidation-reduction process; gamma-aminobutyric acid catabolic process. (509 aa) |
| | CG11899 | Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (364 aa) |
| | CG11334 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (364 aa) |
| | Mccc2 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival. (578 aa) |
| | Tdc2 | Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior. (637 aa) |
| | Tdc1 | Tyrosine decarboxylase 1 (Tdc1) encodes a protein involved in behavioral response to ethanol. (587 aa) |
| | CG13423 | Bleomycin hydrolase; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: homocysteine catabolic process; response to toxic substance; proteolysis. (476 aa) |
| | MetRS | Methionyl-tRNA synthetase (MetRS) encodes an enzyme that catalyzes the covalent attachment of methionine to methionyl-tRNA, an essential first step of protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1022 aa) |
| | CG15093 | Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; 3-hydroxyisobutyrate dehydrogenase activity; NADP binding; NAD binding. It is involved in the biological process described with: cellular amino acid metabolic process; oxidation-reduction process; valine catabolic process. (324 aa) |
| | CG5493 | Cysteine dioxygenase activity; ferrous iron binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. It is involved in the biological process described with: oxidation-reduction process; L-cysteine catabolic process. (238 aa) |
| | Dark | Death-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. (1440 aa) |
| | AsnRS-m | Asparaginyl-tRNA synthetase, mitochondrial; ATP binding; nucleic acid binding; asparagine-tRNA ligase activity. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (460 aa) |
| | Got1 | Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis. (437 aa) |
| | CysRS | Cysteine--tRNA ligase, cytoplasmic; ATP binding; cysteine-tRNA ligase activity; tRNA binding. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (741 aa) |
| | PheRS-m | Probable phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. (453 aa) |
| | Odc1 | Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (394 aa) |
| | Odc2 | Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (393 aa) |
| | yellow-h | Yellow-h. (463 aa) |
| | Sardh | Oxidoreductase activity; sarcosine dehydrogenase activity. It is involved in the biological process described with: sarcosine catabolic process; oxidation-reduction process; S-adenosylmethionine cycle. (894 aa) |
| | Aasdh | Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post- translational protein modification or for post-transcriptional modification of an RNA. (1012 aa) |
| | MetRS-m | Methionine--tRNA ligase, mitochondrial; ATP binding; methionine-tRNA ligase activity. It is involved in the biological process described with: methionyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa) |
| | CG11241 | IP18034p; Pyridoxal phosphate binding; alanine-glyoxylate transaminase activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (518 aa) |
| | ValRS-m | Valyl-tRNA synthetase, mitochondrial, isoform A; valine-tRNA ligase activity; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (994 aa) |
| | ThrRS | Threonyl-tRNA synthetase, isoform A; threonine-tRNA ligase activity; aminoacyl-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; threonyl-tRNA aminoacylation. (747 aa) |
| | Ahcy | Adenosylhomocysteinase (Ahcy) encodes S-adenosyl-L-homocysteine hydrolase, the rate-limiting enzyme in methionine metabolism. This tetrameric enzyme catalyzes the reversible hydrolysis of S-Adenosylhomocysteine (SAH) to adenosine and L-homocysteine. The function of Ahcy product is required to maintain proper concentrations of SAH, which serves as an inhibitor of S-adenosylmethionine-dependent methylation reactions. (432 aa) |
| | CG12338 | RE49860p; D-amino-acid oxidase activity; FAD binding. It is involved in the biological process described with: oxidation-reduction process; D-amino acid metabolic process. (335 aa) |
| | LeuRS | Leucyl-tRNA synthetase, isoform A; leucine-tRNA ligase activity; ATP binding; aminoacyl-tRNA editing activity. It is involved in the biological process described with: leucyl-tRNA aminoacylation; wound healing; Belongs to the class-I aminoacyl-tRNA synthetase family. (1182 aa) |
| | ple | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. (579 aa) |
| | Hdc | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. (847 aa) |
| | Eip55E | Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. (393 aa) |
| | CG10623 | CG10623 protein; Zinc ion binding; betaine-homocysteine S-methyltransferase activity; S-adenosylmethionine-homocysteine S-methyltransferase activity. It is involved in the biological process described with: S-methylmethionine cycle; methionine biosynthetic process. (331 aa) |
| | cn | Kynurenine 3-monooxygenase; Cinnabar (cn) encodes the enzyme that synthesizes 3-hydroxykynurenine (3-HK) as part of the kynurenine pathway of tryptophan degradation. 3-HK is an intermediate product in the formation of ommochromes, the brown pigments in the fly eye, and thus cn loss of function mutant flies exhibit altered eye color. Several kynurenine pathway metabolites are neuroactive and have been linked to the pathogenesis of neurodegenerative disorders. (465 aa) |
| | CG17110 | AT09807p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (402 aa) |
| | CG6726 | Uncharacterized protein, isoform A; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa) |
| | Hmgcl | 3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A; hydroxymethylglutaryl-CoA lyase activity. It is involved in the biological process described with: leucine metabolic process; leucine catabolic process; lipid metabolic process; ketone body biosynthetic process. (323 aa) |
| | Gs2 | Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. (373 aa) |
| | LKRSDH | Lysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway. (928 aa) |
| | CG10621 | FI01821p; S-adenosylmethionine-homocysteine S-methyltransferase activity. It is involved in the biological process described with: S-methylmethionine cycle; methionine biosynthetic process. (331 aa) |
| | CG8097 | RE16047p; arginine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: arginyl-tRNA aminoacylation. (446 aa) |
| | CysRS-m | Cysteinyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; cysteine-tRNA ligase activity. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (558 aa) |
| | CG1764 | GM09012p; Amino acid binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; dimethylargininase activity. It is involved in the biological process described with: positive regulation of nitric oxide biosynthetic process; citrulline metabolic process; arginine metabolic process. (268 aa) |
| | CG1461 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (501 aa) |
| | CG1440 | Uncharacterized protein, isoform D; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: homocysteine catabolic process; response to toxic substance; proteolysis. (551 aa) |
| | AlaRS | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (966 aa) |
| | Dhfr | Dihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth. (182 aa) |
| | Adi1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (186 aa) |
| | CG17691 | Uncharacterized protein, isoform C; Alpha-ketoacid dehydrogenase activity. It is involved in the biological process described with: response to nutrient; fatty-acyl-CoA biosynthetic process; branched-chain amino acid catabolic process. (364 aa) |
| | CG31115 | Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (290 aa) |
| | Argl | Argininosuccinate lyase activity. It is involved in the biological process described with: arginine biosynthetic process via ornithine. (469 aa) |
| | CG17486 | Asparagine synthetase domain-containing protein CG17486; Asparagine synthase (glutamine-hydrolyzing) activity. It is involved in the biological process described with: asparagine biosynthetic process. (564 aa) |
| | Gabat | Gamma-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter gamma-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (486 aa) |
| | IleRS-m | Isoleucyl-tRNA synthetase, mitochondrial; tRNA binding; aminoacyl-tRNA editing activity; ATP binding; isoleucine-tRNA ligase activity. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (941 aa) |
| | GLS | Glutaminase, isoform H; Glutaminase activity. It is involved in the biological process described with: glutamine catabolic process; glutamine metabolic process; glutamate biosynthetic process. (775 aa) |
| | CG9674 | Uncharacterized protein, isoform F; It is involved in the biological process described with: glutamate biosynthetic process; ammonia assimilation cycle; oxidation-reduction process. (2115 aa) |
| | P5CS | Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (776 aa) |
| | b | Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa) |
| | Mtap | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (360 aa) |
| | AspRS-m | Aspartyl-tRNA synthetase, mitochondrial (AspRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of aspartate to its cognate tRNA to form aspartyl-tRNA. (1082 aa) |
| | CG11134 | Probable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (227 aa) |
| | AsnRS | Asparaginyl-tRNA synthetase, isoform A; Nucleic acid binding; asparagine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (558 aa) |
| | P5CDh1 | delta-1-Pyrroline-5-carboxylate dehydrogenase 1 (P5CDh1) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation. (574 aa) |
| | AspRS | Aspartyl-tRNA synthetase (AspRS) is an essential gene that is predicted to encode an aspartate-tRNA ligase. It functions as a Sxl dosage-sensitive maternal modifier. (531 aa) |
| | ValRS | Valyl-tRNA synthetase, isoform C; aminoacyl-tRNA editing activity; ATP binding; valine-tRNA ligase activity. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1055 aa) |
| | HisRS | Histidyl-tRNA synthetase, isoform D; histidine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: histidyl-tRNA aminoacylation; mitochondrial translation. (564 aa) |
| | ArgRS-m | Arginyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; arginine-tRNA ligase activity. It is involved in the biological process described with: arginyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (594 aa) |
| | SerRS-m | Seryl-tRNA synthetase, mitochondrial (SerRS-m) encodes an enzyme that catalyses the aminoacylation of tRNAser with serine, to be used for gene translation during protein synthesis. (417 aa) |
| | CG14882 | Uncharacterized protein, isoform A; [methionine synthase] reductase activity. It is involved in the biological process described with: oxidation-reduction process; methionine biosynthetic process. (454 aa) |
| | Ass | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa) |
| | CG17109 | Uncharacterized protein, isoform A; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (400 aa) |
| | CG5805 | GH22160p; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; Belongs to the mitochondrial carrier (TC 2.A.29) family. (339 aa) |
| | r | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. (2224 aa) |
| | GatC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (148 aa) |
| | Gdh | Glutamate dehydrogenase, mitochondrial; Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism. (562 aa) |
