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| | w | White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker. (687 aa) |
| | Syx4 | Syntaxin-4; Syntaxin 4 (Syx4) encodes a member of the superfamily of SNARE genes, which mediate membrane fusion. The product of Syx4 is associated with Golgi to plasma membrane transport as well as acting as a plasma membrane t-SNARE to regulate synaptic growth at the neuromuscular junction. (333 aa) |
| | CanB | Calcineurin subunit B type 1; Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase. (170 aa) |
| | NAAT1 | Sodium-dependent nutrient amino acid transporter 1; Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine. (641 aa) |
| | Rph | Rabphilin, isoform A; Rab GTPase binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: synaptic vesicle exocytosis; exocytosis; intracellular protein transport; neurotransmitter secretion; vesicle-mediated transport. (638 aa) |
| | bw | Brown (bw) encodes a member of the traffic ATPase (or ABC) family of membrane transporters. It is believed to heterodimerize with the product of w. bw and w are necessary to import guanine, a precursor for the red pteridine pigments, into pigment cells of the eyes, Malpighian tubules and testis sheath. (675 aa) |
| | gammaSnap1 | Gamma Soluble NSF attachment protein 1 (gammaSnap1) encodes a protein involved in the dorsal/ventral pattern formation of the wing disc. (302 aa) |
| | Snap29 | Synaptosomal-associated protein 29kDa (Snap29) encodes a member of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family. It is involved in regulation of autophagy, endocytic recycling and cell division. (284 aa) |
| | Letm1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. (1013 aa) |
| | mth | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (522 aa) |
| | comt | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. (745 aa) |
| | Scamp | Secretory carrier-associated membrane protein; It is involved in the biological process described with: neuromuscular synaptic transmission; synaptic vesicle exocytosis; protein transport; long-term memory. (343 aa) |
| | alphaSnap | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome. (292 aa) |
| | blot | Bloated tubules (blot) encodes a member of the sodium- and chloride-dependent neurotransmitter symporter family. It is required for cortical actin organisation and contributes to embryonic cellularization and renal tubule development in larvae. (976 aa) |
| | rogdi | Rogdi (rogdi) encodes a protein that plays a role in promoting sleep by controlling GABA transmission in GABA neurons; Belongs to the rogdi family. (343 aa) |
| | Syx8 | Syntaxin 8; SNAP receptor activity; SNARE binding. It is involved in the biological process described with: intracellular protein transport; synaptic vesicle docking; vesicle fusion; vesicle docking. (232 aa) |
| | st | Protein scarlet; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules. (666 aa) |
| | Arl1 | ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (180 aa) |
| | DCTN1-p150 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa) |
| | CG4476 | Transporter; CG4476 encodes an orphan member of the SLC6 family of transporters that includes the plasma membrane serotonin and dopamine transporters. CG4476 mutants show a decreased behavioral response to light; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa) |
| | Exo70 | Exocyst complex component 7; Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation. Belongs to the EXO70 family. (693 aa) |
| | Syx16 | Syntaxin 16 (Syx16) encodes a member of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. It is localized to late Golgi compartments and is part of a trans-SNARE complex responsible for endosome-to-Golgi/trans Golgi network retrograde transport. (352 aa) |
| | ine | Sodium- and chloride-dependent GABA transporter ine; Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osm [...] (943 aa) |
| | Sec5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa) |
| | Syt1 | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa) |
| | Snapin | SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity). (134 aa) |
| | Arf79F | ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa) |
| | Sec8 | Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Involved in regulation of synaptic microtubule formation, and also regulation of synaptic growth and glutamate receptor trafficking. Does not appear to be required for basal neurotransmission. (985 aa) |
| | Ntl | Transporter; Neurotransmitter transporter-like (Ntl) encodes a glycine transporter of the SLC6 class, closely related to neurotransmitter transporters and other amino acid transporters. Ntl expression is testes-specific and its mutants are male-sterile, producing sperm with a significant reduction in glycylated tubulin; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (590 aa) |
| | CG31904 | GH01326p; Neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport. (403 aa) |
| | CG13796 | FI18149p1; Neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport. (641 aa) |
| | CG13794 | IP11961p; Neurotransmitter:sodium symporter activity; neurotransmitter transmembrane transporter activity. It is involved in the biological process described with: neurotransmitter transport. (595 aa) |
| | Rab3-GAP | Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1341 aa) |
| | CG15279 | Transporter; L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; amino acid:cation symporter activity; neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: amino acid transmembrane transport; neurotransmitter transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (639 aa) |
| | CarT | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (674 aa) |
| | Syt4 | Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. (474 aa) |
| | Arl2 | ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts. (184 aa) |
| | Vps45 | Vacuolar protein sorting 45 (Vps45) encodes an SM protein that is activated by the product of Rab5 and binds to the product of Rbsn-5 to control entry of endocytosed cargo into the early endosome; Belongs to the STXBP/unc-18/SEC1 family. (574 aa) |
| | Snap24 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. (212 aa) |
| | gammaSnap2 | Soluble NSF attachment protein activity; syntaxin binding. It is involved in the biological process described with: synaptic vesicle priming; neurotransmitter secretion; intracellular protein transport. (283 aa) |
| | Hsc70-4 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa) |
| | VAChT | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa) |
| | Sec10 | Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC10 family. (710 aa) |
| | Exo84 | Exocyst 84, isoform B; Exocyst 84 (Exo84) encodes an exocyst component involved in epithelial polarity. It mediates the apical localization of the transmembrane protein encoded by crb. (672 aa) |
| | CDase | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. (704 aa) |
| | Rep | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). (511 aa) |
| | Sec6 | Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC6 family. (738 aa) |
| | bdg | Bedraggled, isoform A; Bedraggled (bdg) encodes a putative transporter involved in the fate commitment of the R3/R4 pair of photoreceptor cells. (1331 aa) |
| | Arf51F | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation. (175 aa) |
| | VGAT | Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. (549 aa) |
| | Syngr | Synaptogyrin (Syngr) encodes a synaptic vesicle protein implicated in vesicle endocytosis during the bulk endocytosis process. It is the sole Drosopohila homolog of the synaptophysin/synaptogryin synaptic vesicle family of proteins. (241 aa) |
| | CG8850 | Transporter; L-amino acid transmembrane transporter activity; amino acid:cation symporter activity; amino acid:sodium symporter activity; neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport; amino acid transmembrane transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa) |
| | Syx6 | Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity. (339 aa) |
| | Rab3 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. (220 aa) |
| | CG1698 | Transporter; Neurotransmitter:sodium symporter activity; neurotransmitter transmembrane transporter activity; amino acid:cation symporter activity; amino acid:sodium symporter activity; L-amino acid transmembrane transporter activity. It is involved in the biological process described with: neurotransmitter transport; amino acid transmembrane transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (654 aa) |
| | Chc | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa) |
| | Vmat | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa) |
| | Frq1 | Frequenin-1; Ca(2+)-dependent modulation of synaptic efficacy. (187 aa) |
| | Syn | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa) |
| | stmA | Protein EFR3 homolog cmp44E; An essential gene required for embryogenesis; required for cell viability; Belongs to the EFR3 family. (834 aa) |
| | Snap25 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. (212 aa) |
| | prt | Portabella (prt) encodes an orphan vesicular transporter expressed in a discrete number of cells in larvae and adults, including Kenyon cells of the mushroom bodies. prt depletion produces male mating behavior defects and a modest learning deficit. (602 aa) |
| | CG10804 | Transporter; Neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (726 aa) |
| | Syb | Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release. (152 aa) |
| | mfr | Misfire, isoform F; Misfire (mfr) is a ferlin gene that encodes a protein involved in gamete generation. (1647 aa) |
| | Sytbeta | Synaptotagmin beta, isoform D. (602 aa) |
| | List | Transporter; Neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity; L-amino acid transmembrane transporter activity; amino acid:cation symporter activity; amino acid:sodium symporter activity. It is involved in the biological process described with: amino acid transmembrane transport; neurotransmitter transport; response to lithium ion; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (564 aa) |
| | GlyT | Transporter; It is involved in the biological process described with: regulation of circadian rhythm; glycine import across plasma membrane; neurotransmitter transport; glycine transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (1188 aa) |
| | veli | Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (246 aa) |
| | CG13793 | Uncharacterized protein; Neurotransmitter:sodium symporter activity; neurotransmitter transmembrane transporter activity. It is involved in the biological process described with: neurotransmitter transport. (583 aa) |
| | nej | Nejire, isoform C; Nejire (nej) encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including the histone encoded by His3 on K18, K27, and H4 on K8. By regulating gene expression, the product of nej has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning. (3282 aa) |
| | stac | Protein unc-13 homolog 4B; Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membra [...] (1153 aa) |
| | Syx1A | Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Required for coordinated peristaltic contractions. Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens [...] (296 aa) |
| | Sytalpha | Synaptotagmin alpha, isoform B. (504 aa) |
| | CG43066 | Transporter; Neurotransmitter:sodium symporter activity; neurotransmitter transmembrane transporter activity. It is involved in the biological process described with: neurotransmitter transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (721 aa) |
| | Rim | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. (2798 aa) |
| | brp | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa) |
| | Esyt2 | Extended synaptotagmin-like protein 2 (Esyt2) encodes a member of the Synaptotagmin family that localizes to the endoplasmic reticculum (ER). In axonal ER of motorneurons, it may be involved in coordinating intracellular calcium dynamics and constitutive membrane trafficking. (853 aa) |
| | Cadps | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. (1534 aa) |
| | unc-13 | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa) |
| | CanB2 | Calcineurin subunit B type 2; Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase. (170 aa) |
| | Rop | Protein ROP; May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein. (597 aa) |
| | DAT | Sodium-dependent dopamine transporter; Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin. Plays a role in the regulation of the rest/activity cycle. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (644 aa) |
| | Hip14 | Palmitoyltransferase Hip14; Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25. Probably palmitoylates Csp. Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form. Required for synaptic vesicle exocytosis. (655 aa) |
| | Syx17 | Syntaxin 17, isoform B; Syntaxin 17 (Syx17) encodes a Qa type SNARE protein localizing to ER, mitochondria and autophagosomes. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Snap29 and Vamp7. The product of Syx17 roles include autophagosome clearance and neuromuscular function. (346 aa) |
| | CASK | Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa) |
| | Rab3-GEF | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. (2154 aa) |
| | HDAC6 | Histone deacetylase 6, isoform G; Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. (1179 aa) |
| | VGlut | Vesicular glutamate transporter, isoform A. (632 aa) |
| | nSyb | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa) |
| | Syx13 | Syntaxin 13 (Syx13) encodes a member of the syntaxin family of t-SNAREs that mediate vesicle fusion within cells. It localizes to endosomes and is involved in autophagosome maturation. (284 aa) |
| | Frq2 | Frequenin 2 (Frq2) encodes s protein that binds calcium and interacts with the guanyl exchange factor encoded by ric8a to regulate the number of synapses and the probability of neurotransmitter release per synapse. (187 aa) |
| | unc-13-4A | Unc-13-4A, isoform B; It is involved in the biological process described with: synaptic vesicle priming; neurotransmitter secretion. (1371 aa) |
| | Fife | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. (1314 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. (459 aa) |
| | Tk | Tachykinin-associated peptide 1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which le [...] (297 aa) |
| | cpx | Complexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release; Belongs to the complexin/synaphin family. (157 aa) |
| | Arl8 | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. (186 aa) |
| | Vap33 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. (269 aa) |
| | SerT | Sodium-dependent serotonin transporter; Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (622 aa) |
| | CG13795 | FI17140p1; Neurotransmitter transmembrane transporter activity; neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport. (594 aa) |
| | CG33296 | Uncharacterized protein, isoform B; Neurotransmitter:sodium symporter activity. It is involved in the biological process described with: neurotransmitter transport. (585 aa) |
| | Syt7 | Synaptotagmin 7, isoform A; Calcium ion binding; phosphatidylserine binding; SNARE binding; clathrin binding; calcium-dependent phospholipid binding. (416 aa) |
| | Nsf2 | Vesicle-fusing ATPase 2; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity). (752 aa) |
| | Csp | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa) |
| | Gdi | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa) |
| | cac | Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. (2110 aa) |
