node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ArfGAP3 | Sec23 | FBpp0304160 | FBpp0301099 | ADP-ribosylation factor GTPase activating protein 3 (ArfGAP3) a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye. | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | 0.445 |
ArfGAP3 | Sec31 | FBpp0304160 | FBpp0311417 | ADP-ribosylation factor GTPase activating protein 3 (ArfGAP3) a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye. | Secretory 31 (Sec31) encodes a protein involved in the innate immune response. | 0.400 |
CG5498 | Vps20 | FBpp0077896 | FBpp0300826 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. | Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis. | 0.903 |
CG5498 | Vps24 | FBpp0077896 | FBpp0312584 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. | 0.916 |
CG5498 | Vps60 | FBpp0077896 | FBpp0305334 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] | 0.900 |
CG5498 | shrb | FBpp0077896 | FBpp0087704 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. | GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling. | 0.979 |
Sec13 | Sec23 | FBpp0311988 | FBpp0301099 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | 0.999 |
Sec13 | Sec24AB | FBpp0311988 | FBpp0308496 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. | 0.998 |
Sec13 | Sec24CD | FBpp0311988 | FBpp0303000 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. | 0.997 |
Sec13 | Sec31 | FBpp0311988 | FBpp0311417 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | Secretory 31 (Sec31) encodes a protein involved in the innate immune response. | 0.999 |
Sec13 | sau | FBpp0311988 | FBpp0100140 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | Golgi phosphoprotein 3 homolog sauron; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the local [...] | 0.426 |
Sec23 | ArfGAP3 | FBpp0301099 | FBpp0304160 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | ADP-ribosylation factor GTPase activating protein 3 (ArfGAP3) a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye. | 0.445 |
Sec23 | Sec13 | FBpp0301099 | FBpp0311988 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | 0.999 |
Sec23 | Sec24AB | FBpp0301099 | FBpp0308496 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. | 0.999 |
Sec23 | Sec24CD | FBpp0301099 | FBpp0303000 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. | 0.999 |
Sec23 | Sec31 | FBpp0301099 | FBpp0311417 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Secretory 31 (Sec31) encodes a protein involved in the innate immune response. | 0.999 |
Sec23 | sau | FBpp0301099 | FBpp0100140 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Golgi phosphoprotein 3 homolog sauron; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the local [...] | 0.599 |
Sec23 | shi | FBpp0301099 | FBpp0305866 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.520 |
Sec24AB | Sec13 | FBpp0308496 | FBpp0311988 | Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | 0.998 |
Sec24AB | Sec23 | FBpp0308496 | FBpp0301099 | Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. | 0.999 |