STRINGSTRING
Grip128 Grip128 Grip84 Grip84 polo polo Grip163 Grip163 CG7716 CG7716 gammaTub23C gammaTub23C Grip75 Grip75 CG18109 CG18109 Grip71 Grip71 asp asp sub sub nudE nudE Mzt1 Mzt1 Plp Plp CG3085 CG3085 Grip91 Grip91 CG32232 CG32232 CG32820 CG32820 CG17450 CG17450 gammaTub37C gammaTub37C CG32819 CG32819 msd1 msd1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Grip128Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division. (1092 aa)
Grip84Gamma-tubulin complex component 2 homolog; Gamma-tubulin binding; microtubule minus-end binding. (926 aa)
poloSerine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (576 aa)
Grip163Grip163 (Grip163) encodes a gamma-tubulin binding protein involved in the mitotic cell cycle. (1351 aa)
CG7716Gamma-tubulin complex component; Microtubule minus-end binding; gamma-tubulin binding. It is involved in the biological process described with: microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization; mitotic cell cycle; spindle assembly. (728 aa)
gammaTub23CTubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (475 aa)
Grip75Gamma-tubulin complex component 4 homolog; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (650 aa)
CG18109GCP_N_terminal domain-containing protein; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: spindle assembly; mitotic cell cycle; microtubule nucleation by interphase microtubule organizing center; cytoplasmic microtubule organization; meiotic cell cycle. (1931 aa)
Grip71Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa)
aspProtein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation. (1954 aa)
subKinesin-like protein subito; Subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa)
nudENuclear distribution protein nudE homolog; nudE (nudE) encodes a conserved protein that localizes to kinetochores and spindle microtubules. It contributes to the spindle checkpoint, spindle orientation, centrosome behavior and dendrite morphogenesis. (377 aa)
Mzt1Mitotic spindle organizing protein 1; Gamma-tubulin binding. It is involved in the biological process described with: gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly. (82 aa)
PlpPericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. (2895 aa)
CG3085CG3085 protein; Structural constituent of cytoskeleton. It is involved in the biological process described with: microtubule nucleation; cilium assembly; cilium movement involved in cell motility. (432 aa)
Grip91Gamma-tubulin complex component 3; Gamma-tubulin ring protein 91 (Grip91) encodes a gamma-tubulin binding protein involved in male meiotic division and the organization of the meiotic spindle; Belongs to the TUBGCP family. (917 aa)
CG32232Gamma-tubulin complex component; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: mitotic cell cycle; spindle assembly; microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization. (975 aa)
CG32820Structural constituent of cytoskeleton. It is involved in the biological process described with: flagellated sperm motility; microtubule nucleation. (601 aa)
CG17450Uncharacterized protein, isoform B; It is involved in the biological process described with: sperm competition. (601 aa)
gammaTub37CTubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle. Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle. (457 aa)
CG32819LD08455p; Structural constituent of cytoskeleton. It is involved in the biological process described with: flagellated sperm motility; microtubule nucleation. (601 aa)
msd1Augmin complex subunit msd1; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle. (138 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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