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| | Zwilch | Protein zwilch; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments ; Belongs to the ZWILCH family. (641 aa) |
| | dgt6 | Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family. (654 aa) |
| | l(3)mbt | Lethal (3) malignant brain tumor (l(3)mbt) encodes a tumor suppressor protein regulating proliferation in the brain, particularly the optic lobes. The proposed functions of the product of l(3)mbt include histone compaction, establishment of chromatin insulators, regulation of the Hippo pathway and repression of the germ line program in somatic cells. (1477 aa) |
| | CG13599 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. (295 aa) |
| | CG10177 | Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: Golgi organization; protein phosphorylation; mitotic DNA damage checkpoint; negative regulation of cell size; signal transduction in response to DNA damage. (411 aa) |
| | Cdc16 | Cell division cycle 16 (Cdc16) encodes an essential subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (718 aa) |
| | Fancd2 | Fanconi anemia complementation group D2 protein; DNA polymerase binding. It is involved in the biological process described with: synapsis; interstrand cross-link repair; intra-S DNA damage checkpoint; double-strand break repair involved in meiotic recombination; DNA repair. (1478 aa) |
| | Dl | Neurogenic locus protein delta; Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. (833 aa) |
| | gwl | Greatwall, isoform A; Greatwall (gwl) encodes a kinase required for mitosis and female meiosis. It phosphorylates the product of endos, which then acts as a stoichiometric inhibitor of the PP2A B-type adaptor subunit encoded by tws. (846 aa) |
| | 14-3-3epsilon | 14-3-3epsilon (14-3-3epsilon) encodes an acidic protein that preferentially heterodimerizes with other members of the family but also can homodimerize. It functions in multiple signaling pathways, most prominently in the Ras/MAPK cascade. It is involved in embryonic hatching, germ cell migration, gonad formation, wing venation and eye development; Belongs to the 14-3-3 family. (262 aa) |
| | asun | Protein asunder; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Plays a role as a regulator of spermatogenesis. Crucial regulator of the mitotic cell cycle and development. Required for the correct dynein-dynactin perinuclear localization important for nucleus- centrosome coupling that occur upon meiotic progression of primary spermatocytes. Plays a role in sperm motility and fertility. May hav [...] (689 aa) |
| | mor | Brahma associated protein 155 kDa; Moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex. (1209 aa) |
| | Rbf2 | Retinoblastoma protein homolog RBF2; It is involved in the biological process described with: cell differentiation; regulation of mitotic cell cycle; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of transcription by RNA polymerase II. (783 aa) |
| | Caf1-55 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] (430 aa) |
| | Rad17 | Rad17; Chromatin binding. It is involved in the biological process described with: DNA repair; DNA damage checkpoint; mitotic DNA replication checkpoint. (535 aa) |
| | Aos1 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. (337 aa) |
| | CG14739 | AT28509p; Ubiquitin conjugating enzyme activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination. (206 aa) |
| | Invadolysin | Leishmanolysin-like peptidase; Invadolysin (Invadolysin) encodes a metalloprotease that is required for mitosis, cell migration and mitochondrial function. (683 aa) |
| | puc | Puckered, isoform A; Puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. (476 aa) |
| | Mcm10 | Protein MCM10 homolog; Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation. (776 aa) |
| | Cdc23 | Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (678 aa) |
| | lok | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. (476 aa) |
| | grp | Serine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] (512 aa) |
| | twe | Twine (twe) encodes a putative tyrosine phosphatase. It regulates the meiotic cell cycle and contributes to spermatogenesis. (426 aa) |
| | Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) |
| | Sos | Protein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (620 aa) |
| | aurB | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. (329 aa) |
| | Cdk1 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. (297 aa) |
| | Cks30A | Cyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. (74 aa) |
| | Rca1 | Regulator of cyclin A1 (Rca1) encodes an anaphase-promoting complex/cyclosome inhibitor. It contributes to mitotic G1/S transition and cyclin degradation. (411 aa) |
| | Mms19 | GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer. (959 aa) |
| | PEK | Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa) |
| | pzg | Putzig, isoform A; Putzig (pzg) encodes a nuclear protein that is involved in chromatin activation of replication related genes and signalling pathways including Notch, Ecdysone and JAK/STAT. It regulates growth, cell death and various developmental processes. (996 aa) |
| | Pitslre | Serine/threonine-protein kinase PITSLRE; Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (952 aa) |
| | trbl | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] (484 aa) |
| | knrl | Knirps-related protein; Knirps-like (knrl) encodes an orphan nuclear hormone receptor with a C4 zinc finger motif, without ligand-binding domain. It is a target gene of the Hedgehog, Wingless and Notch signaling pathways. It controls endoreduplication domains and epithelial morphogenesis in the fore- and hindgut. (647 aa) |
| | smo | Protein smoothened; Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which a [...] (1036 aa) |
| | ex | Protein expanded; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signa [...] (1427 aa) |
| | PNUTS | PNUTS, isoform D; Phosphatase 1 nuclear targeting subunit (PNUTS) encodes a protein phosphatase 1 binding protein involved in developmental growth and gene expression. (1135 aa) |
| | CG14339 | FI19356p1; It is involved in the biological process described with: metaphase/anaphase transition of mitotic cell cycle; cell division; anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; protein ubiquitination. (1017 aa) |
| | Myt1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr- 15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr [...] (533 aa) |
| | mad2 | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. (207 aa) |
| | Rcc1 | Regulator of chromosome condensation 1 (Rcc1) encodes the guanine-nucleotide exchange factor for the product of Ran. It promotes the nucleo-cytoplasmic shuttling of specific proteins and regulates chromatin condensation. The roles of Rcc1 product include cell proliferation, cell survival, apoptosis, epigenetic regulation, and neuronal specification. (547 aa) |
| | RecQ4 | RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair. (1579 aa) |
| | Cdc6 | Cell division control protein; Cdc6 (Cdc6) encodes an essential component of the pre-Replication complex (preRC) together with the origin recognition complex, the product of dup and MCM2-7 proteins. The preRC is present at all chromosomal origins of replication and is required for the initiation of DNA replication. The product of Cdc6 also functions in the co-ordination of DNA replication with mitosis, and may contribute to apoptosis and transcription; Belongs to the CDC6/cdc18 family. (662 aa) |
| | CycA | G2/mitotic-specific cyclin-A; Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. (491 aa) |
| | vih | Ubiquitin-conjugating enzyme E2 C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Belongs to the ubiquitin-conjugating enzyme family. (178 aa) |
| | caup | Homeobox protein caupolican; Caupolican (caup) encodes a homeodomain-containing protein of the TALE subfamily and one of the three components of the Iroquois gene complex. caup product acts as a transcriptional regulator to control territorial and cell fate specification, cell sorting behaviour and pattern formation. It also plays a transcription independent cell-autonomous role in cell proliferation control. (693 aa) |
| | RecQ5 | RecQ5 helicase, isoform B; RecQ5 helicase (RecQ5) encodes a DNA helicase that maintains genome stability via participation in many nuclear DNA metabolic processes including DNA repair, DNA resolution, and RNA transcription. (1058 aa) |
| | gnu | CG5272 protein; Giant nuclei (gnu) encodes a regulatory subunit of the PNG kinase complex, which regulates the levels of the protein encoded by CycB. Members of this complex are required maternally for the normal nuclear divisions of the syncytial embryo. (240 aa) |
| | Z600 | Protein Z600; Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell poliferation allowing cell fate specification and morphogenesis [...] (90 aa) |
| | mus304 | ATR-interacting protein mus304; DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development. Belongs to the ATRIP family. (846 aa) |
| | bora | Aurora borealis (bora) encodes a binding partner of the product of aurA. It is required for spindle orientation and asymmetric cell division; Belongs to the BORA family. (539 aa) |
| | Rad9 | Cell cycle checkpoint control protein; Rad9 (Rad9) encodes a protein that, together with the Rad1 and Hus1-like products, forms the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response. (456 aa) |
| | CG8173 | RE25723p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mitotic cell cycle. (398 aa) |
| | Nprl2 | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] (412 aa) |
| | mei-41 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. [...] (2517 aa) |
| | mus101 | Mutagen-sensitive 101 (mus101) encodes a protein involved in the DNA replication checkpoint during mitosis. (1425 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | ago | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium. (1326 aa) |
| | ida | Imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. (777 aa) |
| | Mfap1 | Microfibrillar-associated protein 1; Required for pre-mRNA splicing. (478 aa) |
| | Iml1 | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] (1544 aa) |
| | l(2)dtl | Protein lethal(2)denticleless; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex; Belongs to the WD repeat cdt2 family. (769 aa) |
| | mi | LD45221p; Minus (mi) encodes a protein that can bind to the product of CycE and the SCF-ago ubiquitin-ligase complex. Minus regulates the turnover of the product of CycE and cell proliferation. (941 aa) |
| | Rae1 | Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation. (346 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | Xpd | Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. (769 aa) |
| | CG30291 | CDK5RAP3-like protein; Probable regulator of cell proliferation. May regulate CDK5, NF-kappa-B-mediated gene transcription and p53/TP53 activation. Belongs to the CDK5RAP3 family. (509 aa) |
| | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (396 aa) |
| | APC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (775 aa) |
| | Nek2 | LD04361p; Nek2 (Nek2) encodes a Ser/Thr kinase belonging to the NIMA family of kinases. It regulates centrosome disjunction, bipolar spindle formation, and kinetochore microtubule dynamics during mitosis. It also participates in meiosis by regulating chromatin condensation events. (735 aa) |
| | APC7 | Anaphase Promoting Complex subunit 7 (APC7) encodes a protein that associates with the anaphase promoting complex/cyclosome (APC/C). It shows synergistic genetic interaction with the essential APC/C subunit encoded by Cdc23. The association of the product of APC7 and APC/C may be either transient or occurs only in certain forms of the APC/C complex. (615 aa) |
| | rux | Cell cycle negative regulator roughex; Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye. (335 aa) |
| | fzr | Fizzy-related, isoform A; Fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. (478 aa) |
| | N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) |
| | Klp3A | Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1212 aa) |
| | Zw10 | Centromere/kinetochore protein zw10; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure [...] (721 aa) |
| | png | Pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu. (291 aa) |
| | mus81 | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. (426 aa) |
| | Rbf | Retinoblastoma-family protein (Rbf) encodes a protein that binds to members of the E2F transcription factors and forms the DREAM complex, which regulates genes with diverse biological functions including cell cycle regulators, apoptosis regulators, and DNA replication/repair factors. The product of Rbf can also bind chromosomal proteins and modulate genome stability. It is negatively regulated by CycE-Cdk2 and CycD-Cdk4 cyclin-dependent kinase complexes. (845 aa) |
| | ase | Achaete-scute complex protein T8; Asense (ase) encodes a transcription factor in the achaete-scute complex. It acts together with other proneural genes in nervous system development, which involves N-mediated lateral inhibition. ase is expressed in the CNS type-I neuroblasts and the PNS sensory organ precursors (SOPs) but not in the proneural clusters that give rise to the SOP via lateral inhibition. (486 aa) |
| | sc | Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation. (345 aa) |
| | ac | Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development. (201 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | ben | Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. (151 aa) |
| | Abi | Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. (477 aa) |
| | CG43295 | Uncharacterized protein. (167 aa) |
| | nbs | Nibrin; Nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. (818 aa) |
| | CycE | G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex. (712 aa) |
| | crol | Crooked legs (crol) encodes a zinc finger transcription factor induced by 20-hydroxyecdysone at the onset of metamorphosis. It regulates wg transcription and cell cycle progression in the wing. Its over-expression in the eye accelerates the cell cycle and de-represses silenced genes. (962 aa) |
| | CG11839 | Uncharacterized protein; Zinc ion binding; nucleic acid binding. It is involved in the biological process described with: mitotic cell cycle; replication fork protection; mitotic DNA replication checkpoint; nuclear DNA replication; mitotic DNA damage checkpoint. (254 aa) |
| | Sin3A | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. (2066 aa) |
| | nej | Nejire, isoform C; Nejire (nej) encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including the histone encoded by His3 on K18, K27, and H4 on K8. By regulating gene expression, the product of nej has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning. (3282 aa) |
| | CG10738 | Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa) |
| | Spindly | Spindly (Spindly) encodes a key regulator of dynein recruitment to kinetochores and is involved in the spindle assembly checkpoint during the cell cycle. It also contributes to cell morphology and migration. (781 aa) |
| | PhKgamma | Phosphorylase kinase gamma (PhKgamma) encodes a protein involved in gastrulation, embryonic mesoderm formation and adult leg musculature development. (560 aa) |
| | Cdk2 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (314 aa) |
| | CycD | Cyclin D (CycD) encodes a protein that binds to the product of Cdk4, thereby promoting its kinase activity. The CycD-Cdk4 complex promotes cell growth and progression through the G1 phase - it phosphorylates and thereby inhibits the product of Rbf, the ortholog of the human tumor suppressor retinoblastoma protein. (477 aa) |
| | dgt3 | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. (565 aa) |
| | CG10336 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). (307 aa) |
| | CHES-1-like | Checkpoint suppressor 1-like (CHES-1-like) encodes a transcription factor that regulates the division of cardiac progenitor cells and dpp transcription in testis. (1268 aa) |
| | Mnn1 | Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like. (763 aa) |
| | tefu | Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...] (2767 aa) |
| | SkpA | SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa) |
| | hh | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa) |
| | Myb | Myb protein; DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. (657 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | ptc | Protein patched; Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU). (1286 aa) |
| | ci | Transcriptional activator cubitus interruptus; Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; requ [...] (1397 aa) |
| | Nup44A | Nucleoporin seh1; Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells. It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC ; Belongs to the WD repeat SEC13 family. (354 aa) |
| | dpn | Protein deadpan; Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self- renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma- HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom [...] (435 aa) |
| | Mad1 | Mitotic arrest-deficient 1 (Mad1) encodes a conserved, essential component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the product of mad2 and promotes the assembly of the products of mad2 and fzy into the mitotic checkpoint complex. During interphase, Mad1 is intranuclear, bound to the product of mad2, and associated primarily with the nuclear pore complex. (730 aa) |
| | Prp38 | Pre-mRNA-splicing factor 38; Required for pre-mRNA splicing; Belongs to the PRP38 family. (330 aa) |
| | dap | RE12958p; Dacapo (dap) encodes a Cyclin-dependent kinase inhibitor in the CIP/KIP family. It binds to CycE-Cdk2 complexes and thereby inhibits their protein kinase activity. Upregulation of dap is required after the last mitosis for arresting cells in G1/G0 before terminal differentiation in many post-mitotic cell types. (245 aa) |
| | Cdc2rk | Cdc2-related kinase (Cdc2rk) encodes a kinase that might be involved in cell cycle regulation; Belongs to the protein kinase superfamily. (387 aa) |
| | mms4 | Methyl methanesulfonate sensitivity 4 (mms4) encodes the non-catalytic subunit of the mus81-mms4 structure-selective endonuclease that functions in DNA repair. (309 aa) |
| | dgt5 | Augmin complex subunit dgt5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. (685 aa) |
| | vg | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] (453 aa) |
| | Rif1 | Telomere-associated protein RIF1; Regulates the timing of initiation of DNA replication. Functions in copy number control by promoting the underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes. Promotes underreplication by localizing to active DNA replication forks in a partially SuUR-dependent manner, and inhibiting replication fork progression. Might also work as an adapter to recruit Pp1-87B to multiple sites on the chromosome and may function with Pp1-87B to mediate underreplication. Plays an essential role in em [...] (1416 aa) |
| | nopo | No poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa) |
| | plu | DNA replication inhibitor plutonium; Plutonium (plu) encodes a protein that binds to and activates the kinase encoded by png. plu mutants are female sterile, and they result in embryos with giant nuclei due to failure to translate CycB mRNA resulting in DNA replication in the absence of mitosis. (174 aa) |
| | CG15237 | GEO10730p1; It is involved in the biological process described with: regulation of mitotic cell cycle spindle assembly checkpoint. (118 aa) |
| | B52 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (355 aa) |
| | Tctp | Translationally controlled tumor protein (Tctp) encodes a protein that belongs to the TCTP family. It interacts with the GTPase encoded by Rheb to regulate organ growth. It is required for DNA damage response and genome stability. (172 aa) |
| | Pp4-19C | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes. The probable PP4 complex Pp4- 19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase- induced cell death (in vitro). (307 aa) |
| | Claspin | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. (1465 aa) |
| | E2f2 | Transcription factor E2F2; Transcriptional repressor that binds to E2f sites and represses E2f-regulated target genes. Binding to E2f sites requires transcription factor Dp. Acts synergistically with Rbf2 to antagonize E2f1-mediated transcriptional activation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. The DREAM complex is required for recruiting E2f2 at differentiation-specific promoters and for stabilizing E2f2-Rbf complexes during S phase. During development, the complex represses trans [...] (370 aa) |
| | Aven | Apoptosis and caspase activation inhibitor, isoform A; It is involved in the biological process described with: negative regulation of G2/M transition of mitotic cell cycle. (294 aa) |
| | Chro | Chromator, isoform A; Chromator (Chro) encodes a chromodomain protein that is required for proper microtubule spindle formation. It is important for normal cell cycle progression, functioning as a spatial regulator of cell cycle factors. (926 aa) |
| | Capr | Caprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs. (961 aa) |
| | tws | Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment. (499 aa) |
| | mars | Mars (mars) encodes a microtubule-associated protein that shuttles between the mitotic spindle and the nucleus. It is required for mitotic spindle attachment to the centrosome; Belongs to the SAPAP family. (921 aa) |
| | kni | Zygotic gap protein knirps; Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression. (434 aa) |
| | Sap30 | Histone deacetylase complex subunit SAP30 homolog; Component of the class 1 Sin3A-histone deacetylase (Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle; Belongs to the SAP30 family. (173 aa) |
| | cdc14 | Cell division cycle 14, isoform A; Protein tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity. (1052 aa) |
| | Bub1 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. (1099 aa) |
| | p115 | General vesicular transport factor p115; Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae. Belongs to the VDP/USO1/EDE1 family. (836 aa) |
| | CG15602 | IP09819p; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: mitotic cytokinesis checkpoint; abscission. (342 aa) |
| | Bub3 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. (326 aa) |
| | Cks85A | Cyclin-dependent kinase subunit 85A (Cks85A) encodes a small protein that interacts with the products of Cdk1 and Cdk2. It also functions with the product of Skp2 to target specific substrates for destruction, including the product of dap. It is required for larval growth and to maintain diploidy in imaginal tissues. (96 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | Hus1-like | Checkpoint protein; Hus1-like (Hus1-like) encodes a protein that together with proteins encoded by Rad1 and Rad9 form the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response. (278 aa) |
| | stg | M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity. (479 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | CycB3 | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Probably functions redundantly with other cyclins in regulation of cell cycle. Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation. Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression. Required with CycB for female fertility. (575 aa) |
| | Smr | Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development. (3607 aa) |
| | lmgA | Putative APC11 anaphase-promoting complex subunit; Lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by Apc2, it forms the minimal ubiquitin ligase module of the APC/C. (85 aa) |
| | Cdc27 | Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1. (900 aa) |
| | CycG | Cyclin G; Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism. Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium. Involved in the transcriptional repression of the homeotic genes Scr and Ubx. Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation follow [...] (566 aa) |
| | dgt4 | Augmin complex subunit dgt4; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. (188 aa) |
| | endos | Endosulfine, isoform A; Endosulfine (endos) encodes a protein that, after its phosphorylation by the kinase encoded by gwl, inhibits the phosphatase encoded by tws. This inhibition is important for the entry of cells into M phase during the cell cycle. (119 aa) |
| | Wdr62 | WD repeat domain 62 (Wdr62) encodes a protein involved in mitosis regulation. (2397 aa) |
| | CG31687 | Uncharacterized protein, isoform B; It is involved in the biological process described with: metaphase/anaphase transition of mitotic cell cycle; cell division; anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; protein ubiquitination. (351 aa) |
| | Dhc64C | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. (4661 aa) |
| | Mtor | Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...] (2346 aa) |
| | Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) |
| | Wee1 | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (609 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | Mps1 | Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. (672 aa) |
| | brm | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] (1658 aa) |
| | slmb | Supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa) |
| | Asciz | ASCIZ zinc finger protein (Asciz) encodes a transcription factor that regulates the expression of ctp, which encodes a LC8 dynein light chain. The product of Asciz is involved in dynein motor functions, including mitotic chromosome segregation, and dynein-independent functions, such as patterning of cell cycles and apoptosis during development. (388 aa) |
| | BuGZ | Bub3 interacting GLEBS and Zinc finger domain protein (BuGZ) encodes a protein involved in dendrite morphogenesis. (622 aa) |
| | REG | Proteasome regulator dREG; REG (REG) encodes an endopeptidase regulator involved in the regulation of the mitotic G1/S transition and proteasomal protein catabolism. (245 aa) |
| | geminin | Geminin, isoform A; Geminin (geminin) encodes a protein that interacts with the replication factor encoded by dup and regulates the Egfr pathway, DNA replication and chromosome ploidy. (192 aa) |
| | BubR1 | Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. (1460 aa) |
| | rod | Rough deal (rod) encodes the major subunit of the Rod-Zw10-Zwilch (RZZ) complex. RZZ is an essential component of the outer kinetochore during mitosis. RZZ helps monitor and correct kinetochore-microtubule attachments during prometaphase, and consequently it regulates mitotic progression. (2089 aa) |
