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osk osk Fdh Fdh Pp1-87B Pp1-87B ninaE ninaE Sema2a Sema2a VGAT VGAT Ih Ih Syn Syn Ekar Ekar mnb mnb nAChRalpha7 nAChRalpha7 b b tay tay Dop1R1 Dop1R1 ogre ogre verm verm cac cac Galphas Galphas nonA nonA CG4476 CG4476 Surf1 Surf1 mbm mbm Fic Fic Ttc19 Ttc19
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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oskMaternal effect protein oskar; Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole. (606 aa)
FdhAlcohol dehydrogenase class-3; Formaldehyde dehydrogenase (Fdh) encodes a medium-chain alcohol dehydrogenase. This enzyme also functions as S-nitrosoglutathione reductase during the nitric oxide metabolism, contributing to visual memory. (379 aa)
Pp1-87BSerine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily. (302 aa)
ninaEOpsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa)
Sema2aSemaphorin-2A; Semaphorin 2a (Sema2a) encodes a secreted member of the semaphorin protein family. It utilizes the receptor encoded by PlexB to mediate both repulsive and attractive axon guidance. It also utilizes the transmembrane semaphorin encoded by Sema1a as a receptor for dendrite process guidance. (724 aa)
VGATVesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. (549 aa)
IhI[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration. (1327 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
EkarEye-enriched kainate receptor, isoform B; Eye-enriched kainate receptor (Ekar) encodes an ionotropic receptor that responds to the neurotransmitter glutamate. (899 aa)
mnbMinibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa)
nAChRalpha7Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. (564 aa)
bBlack (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa)
tayTay bridge (tay) encodes a nuclear protein acting in the MAP kinase pathway by preventing the product of rl activation. It is present in most cell types, and accumulates strongly in differentiated neurons. (2486 aa)
Dop1R1Dopamine receptor 1; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role i [...] (560 aa)
ogreInnexin inx1; Optic ganglion reduced (ogre) encodes one of the innexin subunits spanning the membrane 4 times. Together with the products of Inx2 and Inx3, it forms homo or hetero oligomers forming gap junctions, which allow the transfer of small solute between cells. (362 aa)
vermVermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control. (555 aa)
cacVoltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. (2110 aa)
GalphasG protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa)
nonAProtein no-on-transient A; Required for normal vision and courtship behavior in Drosophila. (742 aa)
CG4476Transporter; CG4476 encodes an orphan member of the SLC6 family of transporters that includes the plasma membrane serotonin and dopamine transporters. CG4476 mutants show a decreased behavioral response to light; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa)
Surf1SURF1-like protein; Surfeit 1 (Surf1) encodes a nuclear gene encoding a protein that might be involved in the assembly of the mitochondrial respiratory chain Cytochrome Oxidase (COX or Complex IV). Mutations in its human ortholog Surf1 are related to Leigh Syndrome with COX deficiency (LScox). Surf1 RNAi knockdown produces many of the hallmark signs of LScox, albeit with a more complex biochemical profile. (300 aa)
mbmMushroom body miniature (mbm) encodes a zinc finger containing protein that localizes in the nucleolus. It plays a role in ribosome biogenesis. (539 aa)
FicProtein adenylyltransferase Fic; Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-247 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AM [...] (492 aa)
Ttc19Tetratricopeptide repeat protein 19 homolog, mitochondrial; Required for mitochondrial complex III formation. (369 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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