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| | blw | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (552 aa) |
| | ras | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa) |
| | CG34357 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa) |
| | mt:ATPase6 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (224 aa) |
| | CG10097 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (501 aa) |
| | CG10096 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (502 aa) |
| | Adk2 | Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (345 aa) |
| | Aprt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | Mvd | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (388 aa) |
| | ATPsynD | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (178 aa) |
| | CG31183 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | CG10932 | LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa) |
| | CG34342 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (572 aa) |
| | Pde8 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death. (1050 aa) |
| | ATPsyndelta | ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (157 aa) |
| | bur | Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. (683 aa) |
| | Pde11 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. (1451 aa) |
| | Ppcdc | Phosphopantothenoylcysteine decarboxylase activity. It is involved in the biological process described with: coenzyme A biosynthetic process. (191 aa) |
| | AMPdeam | AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa) |
| | veil | Veil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (599 aa) |
| | CG8303 | Putative fatty acyl-CoA reductase CG8303; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (543 aa) |
| | CG12866 | Uncharacterized protein, isoform D; Monocarboxylic acid transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport. (859 aa) |
| | Gart | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. (1353 aa) |
| | Ak3 | GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (216 aa) |
| | Pgk | Phosphoglycerate kinase (Pgk) encodes an enzyme involved in myoblast fusion; Belongs to the phosphoglycerate kinase family. (415 aa) |
| | Pde1c | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1; Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Required for male fertility and male mating behavior. (1173 aa) |
| | CG4020 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (494 aa) |
| | ATPsynbeta | ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (511 aa) |
| | Sgp | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (523 aa) |
| | Acsl | Acyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa) |
| | CG42249 | Uncharacterized protein, isoform C; Nucleotide binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; metal ion binding. It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (558 aa) |
| | CG7362 | Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (793 aa) |
| | Fign | Fidgetin-like protein 1; ATP binding; magnesium ion binding; ATPase activity; microtubule-severing ATPase activity; hydrolase activity. (523 aa) |
| | Pde9 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. (1623 aa) |
| | Ac78C | Adenylyl cyclase 78C; [Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E- cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases. (1727 aa) |
| | Pde6 | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. (1124 aa) |
| | Ppcs | Phosphopantothenoylcysteine synthetase, isoform C; Phosphopantothenate--cysteine ligase activity. (373 aa) |
| | CG5828 | Uncharacterized protein, isoform A; Pantothenate kinase activity. It is involved in the biological process described with: coenzyme A biosynthetic process. (361 aa) |
| | ACXE | Adenylyl cyclase X E; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1123 aa) |
| | CG12268 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (531 aa) |
| | CG43373 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process. (1854 aa) |
| | Parg | Poly(ADP-ribose) glycohydrolase (Parg) encodes a nuclear enzyme that degrades poly(ADP-ribose) to mono(ADP-ribose) from the acceptor proteins after their modification by the product of Parp. It performs several vital roles, including regulation of developmental patterning and germ-line stem cell fate. (723 aa) |
| | ATPsynG | ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (99 aa) |
| | ATPsynCF6 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] (106 aa) |
| | Ac76E | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1312 aa) |
| | ATPsynE | ATP synthase, subunit E, isoform A; Proton transmembrane transporter activity. It is involved in the biological process described with: proton transmembrane transport; ATP synthesis coupled proton transport. (81 aa) |
| | pdgy | Pudgy, isoform A; Pudgy (pdgy) encodes an acyl-CoA synthetase that activates fatty acids by conjugating them to CoA. It is a FOXO transcriptional target that preferentially activates fatty acids destined for beta-oxidation. (597 aa) |
| | CG10738 | Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa) |
| | Gyc76C | Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. (1525 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | CG5065 | Putative fatty acyl-CoA reductase CG5065; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (625 aa) |
| | ScsbetaA | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (503 aa) |
| | CG32305 | Uncharacterized protein; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1164 aa) |
| | CG32301 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; chaeta development; notum development; cyclic nucleotide biosynthetic process. (1111 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | CG18586 | IP13241p; CoA-ligase activity. (545 aa) |
| | CG14893 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (510 aa) |
| | ATPCL | ATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1112 aa) |
| | CG3216 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa) |
| | ATPsynepsilonL | ATP synthase, epsilon subunit-like, isoform A; Proton-transporting ATP synthase activity, rotational mechanism; ATPase activity. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (64 aa) |
| | CG1638 | Uncharacterized protein; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (443 aa) |
| | Gyc32E | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation. (1191 aa) |
| | sdt | Stardust, isoform G; Stardust (sdt) encodes membrane-associated guanylate kinase (MAGUK) protein involved in the maintenance of apico-basal cell polarity and the organization of zonula adherens; Belongs to the MAGUK family. (2020 aa) |
| | Gyc89Da | Soluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (667 aa) |
| | Gyc88E | Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (1097 aa) |
| | mt:ATPase8 | ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (53 aa) |
| | CG33958 | FI12009p; Peptide receptor activity; guanylate cyclase activity. It is involved in the biological process described with: receptor guanylyl cyclase signaling pathway; cGMP biosynthetic process; signal transduction; intracellular signal transduction. (710 aa) |
| | Adk3 | GM02629p; Adenosine kinase activity. (366 aa) |
| | Gapdh1 | Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa) |
| | Pgi | Phosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis. (558 aa) |
| | CG1441 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (517 aa) |
| | Pfk | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (950 aa) |
| | CG8834 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (535 aa) |
| | CG33671 | Mevalonate kinase activity; ATP binding. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; cholesterol biosynthetic process. (390 aa) |
| | Hex-C | Phosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa) |
| | Hmgs | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (465 aa) |
| | knon | Knotted onions; Proton transmembrane transporter activity. It is involved in the biological process described with: Nebenkern assembly; ATP synthesis coupled proton transport. (734 aa) |
| | CG8306 | Putative fatty acyl-CoA reductase CG8306; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (516 aa) |
| | CG9010 | Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process. (343 aa) |
| | CG30103 | Uncharacterized protein; It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (584 aa) |
| | NT5E-2 | Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family. (585 aa) |
| | Mccc2 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival. (578 aa) |
| | Ac3 | Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. (1167 aa) |
| | CG1774 | GH08048p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (472 aa) |
| | CG1635 | LD44914p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (448 aa) |
| | ATPsynC | ATP synthase, subunit C, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (138 aa) |
| | Gycbeta100B | Guanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (787 aa) |
| | Tpi | Triose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production. (348 aa) |
| | ATPsyngamma | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (297 aa) |
| | Gycalpha99B | Head-specific guanylate cyclase; Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. (676 aa) |
| | Mesh1 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; Metazoan SpoT homolog-1 (Mesh1) encodes a structural and functional ortholog of bacterial protein SpoT. It hydrolyzes ppGpp to GDP. Its mutants show retarded growth in amino acid-starved media, suggesting the conserved role in stringent responses. (179 aa) |
| | Pglym78 | Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa) |
| | Pdhb | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (365 aa) |
| | wat | Fatty acyl-CoA reductase wat; Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea. (517 aa) |
| | Hex-t2 | Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa) |
| | Hex-t1 | Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa) |
| | Ald2 | Fructose-bisphosphate aldolase activity. It is involved in the biological process described with: fructose 1,6-bisphosphate metabolic process; glycolytic process. (364 aa) |
| | Ald1 | Fructose-bisphosphate aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases). (363 aa) |
| | CLS | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. (322 aa) |
| | CG11089 | RE29555p; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity. It is involved in the biological process described with: wound healing; 'de novo' IMP biosynthetic process. (590 aa) |
| | CG6178 | GM05240p; CoA-ligase activity; long-chain fatty acid-CoA ligase activity; fatty acid ligase activity; fatty-acyl-CoA synthase activity. It is involved in the biological process described with: long-chain fatty acid metabolic process; fatty-acyl-CoA biosynthetic process; fatty acid biosynthetic process; acyl-CoA metabolic process. (544 aa) |
| | Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. (920 aa) |
| | CG7059 | Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (267 aa) |
| | CG7069 | Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (744 aa) |
| | PyK | Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family. (533 aa) |
| | AdSS | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. (447 aa) |
| | CG4770 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (490 aa) |
| | CG6300 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | CG11659 | RE32325p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (546 aa) |
| | CG11453 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (539 aa) |
| | CG11407 | GH20840p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (538 aa) |
| | CG11391 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (542 aa) |
| | AdSL | Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | CG17560 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (499 aa) |
| | CG17562 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (499 aa) |
| | Gyc89Db | Soluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa) |
| | ATPsynO | ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (209 aa) |
| | Vha55 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (490 aa) |
| | CG4830 | RE54693p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (534 aa) |
| | Pglym87 | Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (292 aa) |
| | Adk1 | AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (396 aa) |
| | nmdyn-D7 | FI21821p1; ATP binding; nucleoside diphosphate kinase activity. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; UTP biosynthetic process; CTP biosynthetic process; GTP biosynthetic process; nucleoside triphosphate biosynthetic process; Belongs to the NDK family. (387 aa) |
| | Dpck | dephospho-CoA kinase activity; ATP binding. It is involved in the biological process described with: coenzyme A biosynthetic process. (236 aa) |
| | CG10268 | Phosphomevalonate kinase activity. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; cholesterol biosynthetic process; isoprenoid biosynthetic process. (189 aa) |
| | Vha68-1 | V-type proton ATPase catalytic subunit A isoform 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (614 aa) |
| | Vha68-3 | Vacuolar H[+] ATPase 68kD subunit 3; ATP binding; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: proton transmembrane transport; ATP metabolic process. (743 aa) |
| | Vha68-2 | Vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) encodes a component of the V1 subunit of the vacuolar ATPase, which acidifies endosomal compartments including the lysosome and influences the activity of several signaling pathways. (614 aa) |
| | ACXA | Adenylyl cyclase X A, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; cyclic nucleotide biosynthetic process; spermatogenesis. (1112 aa) |
| | ACXB | Adenylyl cyclase X B; Adenylate cyclase activity. It is involved in the biological process described with: spermatogenesis; cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1114 aa) |
| | ACXC | Adenylyl cyclase X C, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; spermatogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1130 aa) |
| | ATPsynGL | ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (107 aa) |
| | muc | Midline uncoordinated, isoform B; Pyruvate dehydrogenase (NAD+) activity; dihydrolipoyllysine-residue acetyltransferase activity. It is involved in the biological process described with: grooming behavior; acetyl-CoA biosynthetic process from pyruvate. (512 aa) |
| | CG13771 | Uncharacterized protein, isoform A; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (451 aa) |
| | CG9547 | GH06693p; glutaryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; fatty-acyl-CoA binding. It is involved in the biological process described with: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lysine catabolic process; hydroxylysine catabolic process; fatty-acyl-CoA biosynthetic process; tryptophan metabolic process. (419 aa) |
| | Pfas | Phosphoribosylformylglycinamidine synthase (Pfas) encodes a phosphoribosylformylglycinamidine synthase, which is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the FGAMS family. (1354 aa) |
| | CG11249 | Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (642 aa) |
| | AcCoAS | Acetyl-coenzyme A synthetase; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa) |
| | fbl | Fumble, isoform E; Fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway. (512 aa) |
| | Eno | Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family. (500 aa) |
| | CG9961 | Phosphoglycerate kinase activity; ADP binding; ATP binding. It is involved in the biological process described with: positive regulation of oxidative phosphorylation; gluconeogenesis; glycolytic process. (448 aa) |
| | CG2964 | Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (554 aa) |
| | HINT1 | RH02823p; Hydrolase activity. It is involved in the biological process described with: purine ribonucleotide catabolic process. (150 aa) |
| | Fitm | Fat storage-inducing transmembrane protein; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing. (480 aa) |
| | ScsbetaG | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa) |
| | Ppat-Dpck | Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA. (518 aa) |
| | CG5568 | LD47944p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | ATPsynB | ATP synthase subunit b, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (243 aa) |
| | CG11811 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. (233 aa) |
| | Aps | Aps, isoform A; Aps (Aps) encodes a diphosphoinositol-polyphosphate diphosphatase that hydrolyses a range of (di)nucleoside polyphosphates. It is involved in glucose and lipid homeostasis. (177 aa) |
| | Ak1 | ATP binding; adenylate kinase activity; uridylate kinase activity; Belongs to the adenylate kinase family. (229 aa) |
| | CG17300 | GEO09554p1; Proton transmembrane transporter activity. It is involved in the biological process described with: ATP synthesis coupled proton transport. (152 aa) |
| | CG13474 | GEO02333p1. (148 aa) |
| | ATPsynbetaL | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (622 aa) |
| | CG12229 | AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process. (571 aa) |
| | Papss | PAPS synthetase (Papss) encodes an enzyme that catalyzes the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the sulfate donor compound in all sulfotransferase reactions. Maternally provided Papss product is required for the formation of the embryonic dorsal-ventral axis mediated by the sulfotransferase encoded by pip. (657 aa) |
| | Pfrx | 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form; ATP binding; 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity. It is involved in the biological process described with: glycolytic process; fructose metabolic process; fructose 2,6-bisphosphate metabolic process; carbohydrate phosphorylation. (716 aa) |
| | scu | 3-hydroxyacyl-CoA dehydrogenase type-2; May function in mitochondrial tRNA maturation. Catalyzes the beta-oxidation at position 17 of androgens and estrogens, and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-beta-hydroxylated bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. Required for cell survival during embryonic development. May play a role in germline formation; Belongs to the short-chain dehydrogenases/reductases [...] (255 aa) |
| | sun | Protein stunted; Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels. (61 aa) |
| | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | rut | Ca(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa) |
| | nmdyn-D6 | Nucleoside diphosphate kinase activity. It is involved in the biological process described with: GTP biosynthetic process; nucleoside triphosphate biosynthetic process; CTP biosynthetic process; UTP biosynthetic process; nucleoside diphosphate phosphorylation. (151 aa) |
| | Paics | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the SAICAR synthetase family. (429 aa) |
| | v | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway. (379 aa) |
| | ACXD | Adenylyl cyclase X D, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1162 aa) |
| | FarO | Fatty acyl-CoA reductase in oenocytes (FarO) encodes a long-chain-fatty-acyl-CoA reductase involved in the regulation of cell growth and lipid storage. (504 aa) |
| | Pdha | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (443 aa) |
| | CG7024 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (479 aa) |
| | Hex-A | Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa) |
| | CG9993 | Uncharacterized protein; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (543 aa) |
| | CG17999 | GH16244p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | ATPsynCF6L | ATP synthase, coupling factor 6-like; ATPase activity; proton transmembrane transporter activity. It is involved in the biological process described with: ATP metabolic process; ATP synthesis coupled proton transport. (147 aa) |
| | DIP2 | DISCO Interacting Protein 2 (DIP2) encodes a member of DIP2 family. It interacts physically with the product of disco in vitro and participates in axonal bifurcation and guidance downstream of the JNK pathway. (1773 aa) |
| | CG30427 | CG30427 encodes a fatty-acyl-CoA reductase involved in production of NADPH, sensory perception of pain, phagocytosis and determination of lifespan. (506 aa) |
| | CG4563 | RE01528p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | ATPsynF | Putative ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of [...] (107 aa) |
| | Ak2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily. (240 aa) |
