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Smox Smox Gbs-70E Gbs-70E Myc Myc Lztr1 Lztr1 Rack1 Rack1 put put Sik3 Sik3 Atg1 Atg1 Ide Ide Pdk Pdk AkhR AkhR Actbeta Actbeta babo babo Hr96 Hr96 GlyS GlyS Gnmt Gnmt sNPF sNPF GlyP GlyP Ilp2 Ilp2 CG12289 CG12289 CG7551 CG7551 CG7335 CG7335 CG7328 CG7328 Akh Akh Pask Pask Gbs-76A Gbs-76A
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SmoxMothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa)
Gbs-70EProtein phosphatase 1 regulatory subunit; Glycogen binding subunit 70E (Gbs-70E) is one of the glycogen binding subunits of protein phosphatase 1 (Pp1) that interacts with all of the known Pp1 catalytic subunits (encoded by Pp1-87B, flw, Pp1alpha-96A, and Pp1-13C). The product of Gbs-70E is involved in the regulation of glycogen metabolism, and plays a role in the egg development. (384 aa)
MycMyc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa)
Lztr1Leucine-zipper-like transcriptional regulator 1 homolog; Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complex that mediates ubiquitination of Ras (By similarity); Belongs to the LZTR1 family. (998 aa)
Rack1Guanine nucleotide-binding protein subunit beta-like protein; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). (318 aa)
putSerine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa)
Sik3ATP binding; protein serine/threonine kinase activity. (1471 aa)
Atg1Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
IdeInsulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. (990 aa)
Pdk[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism; Belongs to the PDK/BCKDK protein kinase family. (422 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
ActbetaInhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. (946 aa)
baboReceptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa)
Hr96Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. (723 aa)
GlySGlycogen synthase (GlyS) encodes a glycosyltransferase that catalyzes linkage of glucose monomers into glycogen. Regulation of the product of GlyS activity by glucose 6-phosphate and phosphorylation helps control cellular glycogen levels. (709 aa)
GnmtGlycine N-methyltransferase (Gnmt) encodes an enzyme that catalyzes the methylation reaction of glycine to generate sarcosine (N-methylglycine). It is abundantly expressed in the fat body and controls the amount of methyl donor S-adenosylmethionine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. (289 aa)
sNPFShort neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa)
GlyPGlycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle. (844 aa)
Ilp2Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa)
CG12289MIP04348p; Fructokinase activity; carbohydrate kinase activity; ketohexokinase activity. (378 aa)
CG7551AT07524p; Ketohexokinase activity; fructokinase activity; carbohydrate kinase activity. (322 aa)
CG7335PfkB domain-containing protein; Carbohydrate kinase activity; fructokinase activity; ketohexokinase activity. (372 aa)
CG7328RE49431p; Carbohydrate kinase activity; fructokinase activity; ketohexokinase activity. (306 aa)
AkhAdipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa)
PaskPAS kinase; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; negative regulation of glycogen biosynthetic process. (985 aa)
Gbs-76AGlycogen-binding subunit 76A; Protein phosphatase 1 binding; glycogen binding. It is involved in the biological process described with: regulation of glycogen biosynthetic process. (681 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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