node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ImpL2 | Pten | FBpp0073106 | FBpp0289789 | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | 0.500 |
ImpL2 | foxo | FBpp0073106 | FBpp0293589 | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | 0.675 |
Pten | ImpL2 | FBpp0289789 | FBpp0073106 | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. | 0.500 |
Pten | foxo | FBpp0289789 | FBpp0293589 | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | 0.977 |
Pten | trbl | FBpp0289789 | FBpp0077893 | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] | 0.531 |
Pten | wdb | FBpp0289789 | FBpp0084575 | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | Widerborst (wdb) encodes a B' regulatory subunit of the serine/threonine phosphatase complex PP2A. It regulates Hedgehog, protein kinase B and insulin receptor signaling pathways. | 0.519 |
bmm | foxo | FBpp0289427 | FBpp0293589 | Brummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | 0.671 |
bmm | mdy | FBpp0289427 | FBpp0080474 | Brummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. | O-acyltransferase; Midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults. | 0.842 |
foxo | ImpL2 | FBpp0293589 | FBpp0073106 | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. | 0.675 |
foxo | Pten | FBpp0293589 | FBpp0289789 | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | 0.977 |
foxo | bmm | FBpp0293589 | FBpp0289427 | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | Brummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. | 0.671 |
foxo | trbl | FBpp0293589 | FBpp0077893 | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] | 0.647 |
mdy | bmm | FBpp0080474 | FBpp0289427 | O-acyltransferase; Midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults. | Brummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. | 0.842 |
trbl | Pten | FBpp0077893 | FBpp0289789 | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | 0.531 |
trbl | foxo | FBpp0077893 | FBpp0293589 | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | 0.647 |
wdb | Pten | FBpp0084575 | FBpp0289789 | Widerborst (wdb) encodes a B' regulatory subunit of the serine/threonine phosphatase complex PP2A. It regulates Hedgehog, protein kinase B and insulin receptor signaling pathways. | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | 0.519 |