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| | ens | Ensconsin, isoform F; Ensconsin (ens) encodes a microtubule associated protein required for multiple kinesin-1 functions. It contributes to microtubule motor activity, centrosome separation, nuclear positioning and skeletal muscle development. (1241 aa) |
| | Klp3A | Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1212 aa) |
| | lva | Protein lava lamp; Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization. Under starvation conditions recruited by ema to developing autophagsosomes where it may function in autophagosome growth. (2779 aa) |
| | CG3226 | LD13807p; Ubiquitin protein ligase binding; S100 protein binding; tubulin binding. It is involved in the biological process described with: heart development. (230 aa) |
| | Moe | Moesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa) |
| | Klp59D | Kinesin-like protein at 59D (Klp59D) encodes a kinesin involved in the regulation spindle microtubule dynamics and sperm ciliogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (729 aa) |
| | Klp59C | Kinesin-like protein Klp59C; Required during anaphase to drive sister chromatid separation to actively depolymerize kinetochore microtubules at their kinetochore- associated plus ends, thereby contributing to chromatid mobility through a 'Pac-man' mechanism. (626 aa) |
| | Klp61F | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] (1066 aa) |
| | Girdin | Girdin, isoform A; Microtubule binding; dynein light intermediate chain binding. (1381 aa) |
| | pav | Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. (887 aa) |
| | TTLL1B | Tubulin tyrosine ligase-like 1B; Tubulin binding; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation. (487 aa) |
| | CG32232 | Gamma-tubulin complex component; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: mitotic cell cycle; spindle assembly; microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization. (975 aa) |
| | feo | Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. (671 aa) |
| | Klp10A | Kinesin-like protein Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux'. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara- expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cyto [...] (805 aa) |
| | nod | Kinesin-like protein Nod; No distributive disjunction (nod) encodes a kinesin-like protein that is important for nonexchange chromosome biology. The nod product is necessary for chromosome segregation during meiosis and for proper chromosome alignment along the meiotic spindle. (666 aa) |
| | Grip91 | Gamma-tubulin complex component 3; Gamma-tubulin ring protein 91 (Grip91) encodes a gamma-tubulin binding protein involved in male meiotic division and the organization of the meiotic spindle; Belongs to the TUBGCP family. (917 aa) |
| | CG11584 | RE15373p; Transcription coactivator activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; microtubule binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; dendrite morphogenesis. (662 aa) |
| | CG9072 | Tubulin-specific chaperone A; Tubulin binding; beta-tubulin binding. It is involved in the biological process described with: protein folding; tubulin complex assembly; post-chaperonin tubulin folding pathway; Belongs to the TBCA family. (149 aa) |
| | Grip128 | Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division. (1092 aa) |
| | Efhc1.1 | EF-hand domain containing 1.1; It is involved in the biological process described with: regulation of neuron projection development; regulation of dendrite morphogenesis; synaptic growth at neuromuscular junction. (793 aa) |
| | kat80 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (819 aa) |
| | CG12395 | CG12395-PA; Microtubule binding. It is involved in the biological process described with: regulation of cytoskeleton organization. (254 aa) |
| | TTLL1A | Tubulin tyrosine ligase-like 1A; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (496 aa) |
| | Grip84 | Gamma-tubulin complex component 2 homolog; Gamma-tubulin binding; microtubule minus-end binding. (926 aa) |
| | CG17122 | MIP04749p. (598 aa) |
| | CG9279 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. (1339 aa) |
| | DCTN1-p150 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa) |
| | Klp68D | Kinesin-like protein at 68D (Klp68D) encodes the kinesin-2beta motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp64D and Kap3. It plays an essential role in the sensory cilia assembly, microtubule organization in dendrites, and axonal transport. (784 aa) |
| | Grip163 | Grip163 (Grip163) encodes a gamma-tubulin binding protein involved in the mitotic cell cycle. (1351 aa) |
| | Blos2 | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. Belongs to the BLOC1S2 family. (159 aa) |
| | CG16719 | GH24859p; Microtubule binding. It is involved in the biological process described with: regulation of cytoskeleton organization; mesoderm development. (271 aa) |
| | CG32371 | MIP05284p; Microtubule binding; microtubule plus-end binding. It is involved in the biological process described with: protein localization to microtubule; protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; spindle assembly. (294 aa) |
| | CG7716 | Gamma-tubulin complex component; Microtubule minus-end binding; gamma-tubulin binding. It is involved in the biological process described with: microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization; mitotic cell cycle; spindle assembly. (728 aa) |
| | Klp64D | Kinesin-like protein at 64D (Klp64D) encodes the kinesin-2alpha motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp68D and Kap3. It plays an essential role in sensory cilia assembly and axonal transport; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (677 aa) |
| | CG2955 | GH14206p; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: spindle assembly; regulation of microtubule polymerization or depolymerization; protein localization to microtubule plus-end; protein localization to microtubule. (565 aa) |
| | TBCC | Tubulin-binding cofactor C, isoform A; Tubulin binding. It is involved in the biological process described with: tubulin complex assembly; protein folding; post-chaperonin tubulin folding pathway; cell morphogenesis. (355 aa) |
| | toc | Toucan, isoform A; Toucan (toc) encodes a protein that associates with spindle microtubules being involved in mitotic spindle organization, mitotic sister chromatid segregation and ovarian follicle cell formation. (2162 aa) |
| | TBCD | Tubulin folding cofactor D (TBCD) encodes one of the tubulin folding cofactors, which assist in the formation of tubulin heterodimers. It cooperates with the product of Dscam1 to regulate microtubule organization during neural development. (1189 aa) |
| | CG13251 | CCDC66 domain-containing protein; Microtubule binding. It is involved in the biological process described with: retinal rod cell development. (1088 aa) |
| | Klp31E | Kinesin-like protein at 31E, isoform A; Microtubule binding; ATPase activity; ATP binding; microtubule motor activity. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1048 aa) |
| | Grip75 | Gamma-tubulin complex component 4 homolog; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (650 aa) |
| | cana | CENP-ana, isoform A; CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1931 aa) |
| | CG18109 | GCP_N_terminal domain-containing protein; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: spindle assembly; mitotic cell cycle; microtubule nucleation by interphase microtubule organizing center; cytoplasmic microtubule organization; meiotic cell cycle. (1931 aa) |
| | CLIP-190 | Restin homolog; Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization. (1690 aa) |
| | Grip71 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa) |
| | hook | Protein hook; Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down- regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity. (679 aa) |
| | neb | LP17758p; Nebbish (neb) encodes a microtubule motor protein that interacts with PP1 phosphatases and is involved in chromosome segregation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1121 aa) |
| | spir | Protein spire; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton. (1020 aa) |
| | Sas-4 | Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. (901 aa) |
| | mgr | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl. (194 aa) |
| | Jupiter | Microtubule-associated protein Jupiter; Binds to all microtubule populations. Belongs to the MAP Jupiter family. (208 aa) |
| | IFT54 | Intraflagellar transport 54; Microtubule binding. It is involved in the biological process described with: regulation of microtubule cytoskeleton organization; intraciliary transport; cilium assembly. (588 aa) |
| | Cp190 | Centrosome-associated zinc finger protein CP190; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the [...] (1096 aa) |
| | CG7131 | GH14048p; Microtubule binding. It is involved in the biological process described with: microtubule anchoring. (494 aa) |
| | spas | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa) |
| | asp | Protein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation. (1954 aa) |
| | CG10845 | FI06030p; Microtubule binding. (463 aa) |
| | Mink | Mitotic spindle and nuclear protein; Microtubule binding. It is involved in the biological process described with: mitotic chromosome condensation; establishment of mitotic spindle localization; mitotic cytokinesis. (754 aa) |
| | TTLL5 | Tubulin tyrosine ligase-like 5, isoform A; Protein-glycine ligase activity; tubulin-glutamic acid ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; C-terminal protein amino acid modification; protein polyglycylation; protein polyglutamylation. (917 aa) |
| | TTLL6B | Tubulin tyrosine ligase-like 6B; ATP binding; protein-glycine ligase activity; tubulin-glutamic acid ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; protein polyglycylation; microtubule cytoskeleton organization. (720 aa) |
| | Klp98A | Kinesin-like protein Klp98A; Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa si [...] (1265 aa) |
| | Apc | APC-like, isoform A; APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. (2417 aa) |
| | dgt6 | Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family. (654 aa) |
| | CG1890 | Tubulin-specific chaperone A; Beta-tubulin binding; tubulin binding. It is involved in the biological process described with: post-chaperonin tubulin folding pathway; tubulin complex assembly; protein folding; Belongs to the TBCA family. (110 aa) |
| | Efhc1.2 | EF-hand domain containing 1.2; It is involved in the biological process described with: regulation of neuron projection development; cilium assembly. (765 aa) |
| | sub | Kinesin-like protein subito; Subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa) |
| | unc-104 | Kinesin-like protein unc-104; Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (1739 aa) |
| | Khc | Kinesin heavy chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. (975 aa) |
| | CG30069 | CG30069 encodes a large protein conserved in other insects with up to 80 copies of a tandem array of a 29 amino acid repeat. Ubiquitous CG30069 RNAi causes lethality and wing-specific RNAi causes wing adhesion defects. (4012 aa) |
| | Opa1 | Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (972 aa) |
| | shot | Short stop (shot) encodes a member of the spectraplakin family of large cytoskeletal linker molecules. It binds both actin and microtubules, as well as scaffold proteins, certain signalling factors and calcium. It plays developmental and maintenance roles in the nervous system, the epidermis, at muscle attachments, the foregut, the wing, tracheae and oocytes. (8805 aa) |
| | Map60 | Microtubule-associated protein 60 (Map60) encodes a microtubule binding protein that, together with gamma-tubulin and the product of Cp190, is a component of a centrosomal complex that can interact with microtubules. (440 aa) |
| | CG8800 | Uncharacterized protein; Motor activity; alpha-tubulin binding; dynein heavy chain binding. It is involved in the biological process described with: outer dynein arm assembly. (188 aa) |
| | pnut | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. (539 aa) |
| | scra | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] (1239 aa) |
| | Incenp | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. (755 aa) |
| | cos | Kinesin-like protein costa; Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome- mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation. May negatively regulate a hh- signaling pathway whi [...] (1201 aa) |
| | Kif3C | Kinesin-like protein; It is involved in the biological process described with: microtubule-based movement; cell projection organization; anterograde dendritic transport of neurotransmitter receptor complex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (649 aa) |
| | chb | CLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...] (1491 aa) |
| | CG32318 | RT07324p; ATP-dependent microtubule motor activity, plus-end-directed; microtubule motor activity; ATP binding; microtubule binding. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (164 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | Kif19A | Kinesin family member 19A; ATP binding; ATPase activity; microtubule binding; microtubule motor activity; ATP-dependent microtubule motor activity, plus-end-directed. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (750 aa) |
| | Kank | Kank, isoform D; Kank (Kank) encodes a microtubule plus-end binding protein. (1339 aa) |
| | CG15373 | Uncharacterized protein, isoform B. (1137 aa) |
| | CG4537 | Uncharacterized protein; PDZ domain binding; microtubule binding. It is involved in the biological process described with: cytoplasmic microtubule organization. (97 aa) |
| | nudE | Nuclear distribution protein nudE homolog; nudE (nudE) encodes a conserved protein that localizes to kinetochores and spindle microtubules. It contributes to the spindle checkpoint, spindle orientation, centrosome behavior and dendrite morphogenesis. (377 aa) |
| | CG17816 | Uncharacterized protein, isoform G; Microtubule binding. It is involved in the biological process described with: negative regulation of centriole replication. (882 aa) |
| | CG33286 | AT08232p. (1062 aa) |
| | CG12983 | Uncharacterized protein, isoform D. (1104 aa) |
| | CG18190 | FI16628p1; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: protein localization to microtubule plus-end; protein localization to microtubule; spindle assembly; regulation of microtubule polymerization or depolymerization. (248 aa) |
| | CG33287 | Uncharacterized protein. (1101 aa) |
| | capu | Cappuccino (capu) encodes a formin family protein that nucleates actin filaments and accelerates their elongation. It works with the product of spir to build an actin mesh that fills the oocyte during mid-oogenesis. capu is necessary for polarity establishment and female fertility. (1361 aa) |
| | corn | Cornetto, isoform C; Cornetto (corn) encodes a microtubule binding protein involved in exocytosis regulation. (1107 aa) |
| | kst | Karst, isoform E; Karst (kst) encodes a protein that, together with the product of alpha-Spec, crosslinks F-actin and acts as a molecular scaffold. It is recruited to the apical membrane of epithelial cells by the apical determinant encoded by crb. The roles of the product of kst include endosomal trafficking, cell adhesion, cell signaling and growth control. (4337 aa) |
| | Eb1 | Eb1, isoform F; Eb1 (Eb1) encodes a microtubule end-binding protein that contributes to organization of the microtubule cytoskeleton. It is involved in chromosome segregation, wound healing and flight behavior. (297 aa) |
| | TTLL4A | Tubulin tyrosine ligase-like 4A, isoform D; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation; wound healing. (1071 aa) |
| | kat-60L1 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (673 aa) |
| | TTLL6A | Tubulin tyrosine ligase-like 6A; Tubulin-glutamic acid ligase activity; protein-glycine ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (867 aa) |
| | CG2082 | BcDNA.GH02439. (368 aa) |
| | jar | Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (1268 aa) |
| | CG42399 | Uncharacterized protein, isoform B; Microtubule binding. It is involved in the biological process described with: microtubule cytoskeleton organization. (1655 aa) |
| | tacc | Transforming acidic coiled-coil protein (tacc) encodes a centrosomal protein that helps to stabilize microtubules. It seems to influence microtubules indirectly, primarily through its interaction with the product of msps. It is also phosphorylated by the product of aurA, and this activates its ability to stabilize microtubules. (1322 aa) |
| | ReepA | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. (716 aa) |
| | CG13924 | Uncharacterized protein, isoform C. (494 aa) |
| | Cep135 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. (1065 aa) |
| | Mzt1 | Mitotic spindle organizing protein 1; Gamma-tubulin binding. It is involved in the biological process described with: gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly. (82 aa) |
| | msps | Protein mini spindles; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte micr [...] (2082 aa) |
| | stai | Stathmin, isoform D; Stathmin (stai) encodes a tubulin binding protein involved in axo-dendritic transport, gamete generation and synaptic growth at neuromuscular junction. (381 aa) |
| | CG10839 | IP06404p; Motor activity; dynein heavy chain binding; alpha-tubulin binding. It is involved in the biological process described with: outer dynein arm assembly. (182 aa) |
| | futsch | Microtubule-associated protein futsch; During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by [...] (5495 aa) |
| | pod1 | Coronin; Pod1 (pod1) encodes a microtubule and actin filament binding protein involved in actin cytoskeleton reorganization and axon guidance; Belongs to the WD repeat coronin family. (1266 aa) |
| | Kebab | Kinetochore and Eb1-associated basic protein; Microtubule binding; kinetochore binding. (548 aa) |
| | Bsg25D | Blastoderm-specific gene 25D (Bsg25D) encodes the ortholog of Ninein, a microtubule-anchoring protein in humans. Bsg25D is highly expressed at blastoderm stage embryos and its product localizes to the centrosome periphery. (1118 aa) |
| | BuGZ | Bub3 interacting GLEBS and Zinc finger domain protein (BuGZ) encodes a protein involved in dendrite morphogenesis. (622 aa) |
| | Khc-73 | Kinesin heavy chain 73 (Khc-73) encodes a member of the Kinesin-3 family of microtubule-based transport motors. It facilitates endosomal transport during interphase and modulates cortical polarity during asymmetric neuroblast cell division; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1957 aa) |
| | CG30389 | Uncharacterized protein, isoform E; Microtubule binding; actin filament binding. It is involved in the biological process described with: neuronal signal transduction; chemotaxis. (1037 aa) |
| | CG15306 | Uncharacterized protein, isoform A; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: spindle assembly; regulation of microtubule polymerization or depolymerization; protein localization to microtubule plus-end; protein localization to microtubule. (357 aa) |
| | DCX-EMAP | Echinoderm microtubule-associated protein-like CG42247; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (1118 aa) |
| | mlt | Mulet, isoform A; Mulet (mlt) encodes a tubulin-specific chaperone E-like protein involved in sperm individualization and regulation of microtubule depolymerization. (459 aa) |
| | wac | Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] (163 aa) |
| | cmet | CENP-meta, isoform C; CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2189 aa) |
| | Patronin | Patronin; Involved in mitotic spindle assembly. Regulates microtubule (MT) severing. Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is s [...] (1689 aa) |
| | alpha-Spec | Spectrin alpha chain; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi- derived membrane secretion [...] (2457 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | beta-Spec | Beta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. (2308 aa) |
| | bif | Bifocal, isoform F; Bifocal (bif) encodes an actin and microtubule binding protein involved in axon guidance and regulation of axon extension. (1305 aa) |
| | Efa6 | PH and SEC7 domain-containing protein; Guanine nucleotide exchange factor for Arf6. Regulates axon growth and branching by inhibiting microtubule polymerisation at the cortex. Together with shot, promotes axonal microtubule bundle integrity. Required for normal ethanol-induced tolerance and preference. Probably by activating Arf6, counteracts ethanol-induced sedation. (1601 aa) |
| | apolpp | Apolipophorin-1; Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. Also involved in the transport of hydrophobic ligands like juvenile hormones, pheromone hydrocarbons and carotenoids. Required for morphogens wingless (wg) and hedgehog (hh) function, probably by acting as vehicles for the movement of wg and hh, explaining how covalently lipidated wg and hh can spread over long distances. May also be involved in transport and/or metabolism of heme. (3351 aa) |
| | TTLL4B | Tubulin tyrosine ligase-like 4B, isoform B; ATP binding; protein-glycine ligase activity; tubulin-glutamic acid ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (989 aa) |
| | Kat60 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (605 aa) |
| | Drp1 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | Tbce | Tubulin-specific chaperone E; Tubulin-folding protein which is required for the development of the neuronal microtubule network. Essential for the development and function of neuromuscular synapses. Likely to promote microtubule formation by acting in the negative regulation of the microtubule- severing protein spas; Belongs to the TBCE family. (523 aa) |
| | CG11539 | N-acetyltransferase 9-like protein; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: protein acetylation; histone acetylation; Belongs to the acetyltransferase family. GNAT subfamily. (200 aa) |
| | wash | WASH complex subunit 1; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migrat [...] (499 aa) |
| | Arl8 | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. (186 aa) |
| | dgt2 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. (231 aa) |
| | CG15676 | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (182 aa) |
| | pigs | GAS2-like protein pickled eggs; Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons; Belongs to the GAS2 family. (977 aa) |
| | CG14535 | Kinesin-like protein CG14535; ATP binding; microtubule binding; microtubule motor activity; ATP-dependent microtubule motor activity, plus-end-directed. (1131 aa) |
| | Mst27D | IP12509p; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: protein localization to microtubule plus-end; protein localization to microtubule; spindle assembly; regulation of microtubule polymerization or depolymerization. (424 aa) |
| | tau | Microtubule-associated protein; Microtubule binding. It is involved in the biological process described with: neuron projection development; rhabdomere morphogenesis; negative regulation of neuron death; microtubule cytoskeleton organization. (717 aa) |
| | mars | Mars (mars) encodes a microtubule-associated protein that shuttles between the mitotic spindle and the nucleus. It is required for mitotic spindle attachment to the centrosome; Belongs to the SAPAP family. (921 aa) |
| | Gas8 | Dynein regulatory complex subunit 4; Cytoskeletal linker which probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity); Belongs to the DRC4 family. (479 aa) |
| | ncd | Protein claret segregational; Non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (700 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | sofe | Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization. (607 aa) |
| | Klp67A | Kinesin-like protein at 67A (Klp67A) encodes a microtubule motor protein involved in chromosome congression and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (814 aa) |
| | Klp54D | Kinesin-like protein; Microtubule binding; ATPase activity; ATP binding; microtubule motor activity. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (760 aa) |
| | Apc2 | Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. (1067 aa) |
| | mei-38 | Meiotic 38 (mei-38) encodes a microtubule-associated protein that functions in mitosis and meiosis. (347 aa) |
