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| | Vps11 | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. (830 aa) |
| | dor | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route. Required for the biogenesis of eye pigment granules. Required to maintain normal levels of rush, which functions in endosome formation [...] (1002 aa) |
| | Vps26 | Vacuolar protein sorting-associated protein 26; Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis. Belongs to the VPS26 family. (478 aa) |
| | Grip | Glutamate receptor binding protein (Grip) encodes a protein involved in muscle attachment and synapse organization. (1058 aa) |
| | Sara | Zinc finger FYVE domain-containing protein; Smad anchor for receptor activation (Sara) encodes an endosomal protein involved in asymmetric stem cell division, intestinal stem cell homeostasis and stem cell fate determination. (1343 aa) |
| | Vps35 | Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles. (822 aa) |
| | Eps-15 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. (1253 aa) |
| | Vti1a | Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. (230 aa) |
| | Vta1 | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. (316 aa) |
| | Ccz1 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. (485 aa) |
| | g | AP-3 complex subunit delta; Garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color. (1034 aa) |
| | Mvb12 | Multivesicular body subunit 12, isoform A; Ubiquitin binding. It is involved in the biological process described with: virus maturation; viral budding; receptor catabolic process; endosome to lysosome transport via multivesicular body sorting pathway; regulation of epidermal growth factor receptor signaling pathway. (352 aa) |
| | CG14184 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. (180 aa) |
| | Rab8 | Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. (207 aa) |
| | Dysb | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes ; Belongs to the dysbindin family. (288 aa) |
| | fwe | Calcium channel flower; Flower (fwe) encodes a transmembrane protein with different isoforms expressed in 'loser' and in 'winner' cells to mediate win/lose decisions in cell competition and neuronal culling during development and ageing. (194 aa) |
| | mop | Myopic (mop) encodes an endocytic protein that is required for normal Egfr signaling and for the progression of the product of Egfr through the endocytic pathway. It also controls the endosomal localization and signaling activity of the product of yki. (1833 aa) |
| | Vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...] (399 aa) |
| | Blos2 | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. Belongs to the BLOC1S2 family. (159 aa) |
| | SH3PX1 | Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family. (565 aa) |
| | Arl5 | ADP-ribosylation factor-like 5 (Arl5) encodes a protein involved in endosome-to-Golgi trafficking; Belongs to the small GTPase superfamily. Arf family. (179 aa) |
| | Ist1 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. (417 aa) |
| | Vps8 | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. (1229 aa) |
| | CHMP2B | Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation. (212 aa) |
| | Mon1 | Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes. (528 aa) |
| | Vps53 | Vacuolar protein sorting 53; It is involved in the biological process described with: retrograde transport, endosome to Golgi; endocytic recycling. (887 aa) |
| | Snx1 | Sorting nexin 1, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol binding. It is involved in the biological process described with: intracellular protein transport; endocytosis; retrograde transport, endosome to Golgi; early endosome to Golgi transport. (458 aa) |
| | Sec5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa) |
| | Syt1 | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa) |
| | Rab5 | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. (219 aa) |
| | CG17660 | GH17801p; It is involved in the biological process described with: retrograde transport, endosome to Golgi. (536 aa) |
| | TBC1D23 | Uncharacterized protein; GTPase activator activity. It is involved in the biological process described with: positive regulation of intracellular transport; retrograde transport, endosome to Golgi; regulation of GTPase activity. (689 aa) |
| | Vps29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | ex | Protein expanded; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signa [...] (1427 aa) |
| | CG5498 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. (448 aa) |
| | Als2 | Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form. (1486 aa) |
| | Rich | Guanine nucleotide exchange factor subunit Rich; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses. (1429 aa) |
| | Ubc6 | Ubiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK ; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | Vps52 | Vacuolar protein sorting 52; Rab GTPase binding; syntaxin binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; lysosomal transport; Golgi to vacuole transport; endocytic recycling. (662 aa) |
| | IPIP | Uncharacterized protein, isoform A; Protein homodimerization activity. It is involved in the biological process described with: endosome organization; receptor recycling; retrograde transport, endosome to Golgi. (296 aa) |
| | scat | Vacuolar protein sorting-associated protein 54; May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization; Belongs to the VPS54 family. (940 aa) |
| | Stam | Signal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. (689 aa) |
| | Reps | RALBP1 associated Eps domain containing, isoform A; Calcium ion binding; protein binding. It is involved in the biological process described with: endosomal transport; endocytosis. (907 aa) |
| | Vha68-2 | Vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) encodes a component of the V1 subunit of the vacuolar ATPase, which acidifies endosomal compartments including the lysosome and influences the activity of several signaling pathways. (614 aa) |
| | Rab14 | Rab14, isoform B; Rab14 (Rab14) encodes a protein involved in phagocytosis, phagolysosome assembly and phagosome acidification. (239 aa) |
| | Rab9 | RE17845p; Rab9 (Rab9) encodes a member of the Rab subfamily of small GTPases associated with late endosomes. It promotes membrane budding and retrograde recycling of endocytosed materials to the Golgi apparatus. Its roles include recycling of tracheal luminal proteins and tracheal tube length control. (256 aa) |
| | gzl | Godzilla E3 ubiquitin protein ligase (gzl) encodes a protein that ubiquitylates the SNARE protein encoded by Syb. It also promotes apico-basal transcytosis of the product of wg in the wing imaginal disc. (536 aa) |
| | CG8202 | VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. (942 aa) |
| | ATP6AP2 | ATPase H(+)-transporting accessory protein 2 C-terminal fragment; Multifunctional protein which functions as transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump. As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan. Also mediates Wnt/beta-cat signaling through interaction with fz/fz2. Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal sys [...] (320 aa) |
| | Vps16A | Vacuolar protein sorting 16A (Vps16A) encodes a subunit of a heterohexameric tethering complex known as homotypic fusion and protein sorting (HOPS). HOPS roles include promoting the fusion of late endosomes, autophagosomes, biosynthetic vesicles, and lysosomes, and the biogenesis of lysosome-related eye pigment granules. The product of Vps16A is also part of miniCORVET (class C core vacuole/endosome tethering), a tethering complex involved in endosome maturation in nephrocytes and blood cells. (833 aa) |
| | Sbf | SET domain binding factor, isoform A. (1993 aa) |
| | Snx3 | Sorting nexin 3 (Snx3) encodes a protein involved in the secretion of the morphogen encoded by wg. It regulates the retromer-dependent recycling of the transmembrane cargo encoded by wls. (167 aa) |
| | Past1 | Putative Achaete Scute Target 1 (Past1) encodes a protein that associates predominantly with the plasma membrane and genetically interacts with N. It contributes to endocytosis, male sterility, temperature sensitivity, life span and differentiation of photoreceptors R1/R6/R7 and cone cells; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | SIDL | Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Has a role in one of the several mechanisms underlying dendritic localization of Shal channels. (1145 aa) |
| | ema | Protein CLEC16A homolog; Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways. Required for endosome trafficking and maturation. Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes. In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy. Essential for the recruitment of lva-positive Golgi elements to autophagosomes. Likely to function by promoting membrane traffic from [...] (1067 aa) |
| | Rab11 | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa) |
| | Sec15 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (766 aa) |
| | lsn | Vacuolar-sorting protein SNF8; Larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization. (254 aa) |
| | Rab7 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. (207 aa) |
| | Vps33B | Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes; Belongs to the STXBP/unc-18/SEC1 family. (640 aa) |
| | Vps2 | Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. (256 aa) |
| | Exo84 | Exocyst 84, isoform B; Exocyst 84 (Exo84) encodes an exocyst component involved in epithelial polarity. It mediates the apical localization of the transmembrane protein encoded by crb. (672 aa) |
| | Vps16B | Vacuolar protein sorting 16B (Vps16B) encodes a protein that, together with its binding partner encoded by Vps33B, forms a distinct complex necessary for fusions between phagosomes and lysosomes. (447 aa) |
| | FAM21 | WASH complex subunit 2; Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. Belongs to the FAM21 family. (1469 aa) |
| | Vps51 | Vacuolar protein sorting-associated protein 51 homolog; May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans- Golgi network (TGN); Belongs to the VPS51 family. (740 aa) |
| | Sec6 | Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC6 family. (738 aa) |
| | Vps50 | Vacuolar protein sorting 50; It is involved in the biological process described with: endocytic recycling; retrograde transport, endosome to Golgi. (966 aa) |
| | Rho1 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa) |
| | Syx6 | Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity. (339 aa) |
| | shrb | GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling. (226 aa) |
| | CG18659 | Uncharacterized protein, isoform A; Rab GTPase binding; phosphatidylinositol phosphate binding; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rab protein signal transduction; endocytic recycling; endocytosis. (908 aa) |
| | Vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be invo [...] (174 aa) |
| | Hrs | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (760 aa) |
| | CG33635 | Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. (199 aa) |
| | CG32576 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. (140 aa) |
| | GCC185 | GRIP and coiled-coil domain containing 185 kDa; Identical protein binding; ADP-ribosylation factor binding; Rab GTPase binding. (1135 aa) |
| | kst | Karst, isoform E; Karst (kst) encodes a protein that, together with the product of alpha-Spec, crosslinks F-actin and acts as a molecular scaffold. It is recruited to the apical membrane of epithelial cells by the apical determinant encoded by crb. The roles of the product of kst include endosomal trafficking, cell adhesion, cell signaling and growth control. (4337 aa) |
| | Pldn | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, plays a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes. (167 aa) |
| | CG15012 | GEO04055p1; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway. (152 aa) |
| | Blos1 | Biogenesis of lysosome-related organelles complex 1 subunit 1; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes. (147 aa) |
| | lap | Phosphatidylinositol-binding clathrin assembly protein LAP; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction; Belongs to the PICALM/SNAP91 family. (788 aa) |
| | Dap160 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. (1190 aa) |
| | l(2)gd1 | Coiled-coil and C2 domain-containing protein 1-like; Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling; Belongs to the CC2D1 family. (834 aa) |
| | Snx6 | Sorting nexin 6, isoform B; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; phagosome-lysosome fusion involved in apoptotic cell clearance. (455 aa) |
| | nuf | Nuclear fallout, isoform J; Nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes. (541 aa) |
| | Synj | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. (1218 aa) |
| | Vps20 | Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis. (212 aa) |
| | scrib | Protein lap4; Scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. (2585 aa) |
| | Vps28 | Vacuolar protein sorting 28 (Vps28) encodes a member of the ESCRT-I complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. (210 aa) |
| | CG13784 | Uncharacterized protein, isoform F; It is involved in the biological process described with: phospholipid translocation; retrograde transport, endosome to Golgi. (969 aa) |
| | sky | GTPase-activating protein skywalker; GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads [...] (607 aa) |
| | car | Vacuolar protein sorting-associated protein 33A; Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. (639 aa) |
| | Vps60 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] (226 aa) |
| | CG9297 | RE20510p; It is involved in the biological process described with: endocytosis; endosomal transport. (952 aa) |
| | Rab35 | Rab35, isoform A; Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system. (201 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Vti1b | Vesicle transport through interaction with t-SNAREs 1b, isoform A; SNAP receptor activity; SNARE binding. (122 aa) |
| | EndoA | Endophilin-A; Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes. (369 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | CG1116 | Uncharacterized protein, isoform D; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; positive regulation of GTPase activity. (443 aa) |
| | CG2747 | Uncharacterized protein, isoform F; It is involved in the biological process described with: protein localization; endocytosis; retrograde transport, endosome to Golgi. (2172 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | AnxB9 | Annexin B9; Calcium-dependent phospholipid binding; calcium ion binding; protein binding; spectrin binding. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; maintenance of cell polarity; wing disc dorsal/ventral pattern formation. (324 aa) |
| | IKKepsilon | I-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. (720 aa) |
| | SWIP | WASH complex subunit 4; Strumpellin and WASH-interacting protein (SWIP) encodes a protein that is part of the multi-subunit WASH regulatory complex (SHRC) to activate Arp2/3-mediated actin nucleation in a context-dependent manner. The product of SWIP, along with the SHRC, has been found to play a role in actin architecture and ooplasmic streaming during oogenesis, in endosome recycling, and in integrin-mediated cell spreading of hemocytes. (1102 aa) |
| | wash | WASH complex subunit 1; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migrat [...] (499 aa) |
| | Vps4 | Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. (442 aa) |
| | mtm | Myotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. (619 aa) |
| | Chmp1 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. (203 aa) |
| | CG4074 | IP10134p. (295 aa) |
| | Mer | Moesin/ezrin/radixin homolog 2; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate t [...] (635 aa) |
| | Rab6 | Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] (208 aa) |
| | CG30423 | RH04491p; Signaling receptor binding. It is involved in the biological process described with: negative regulation of receptor signaling pathway via JAK-STAT; late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface. (126 aa) |
| | Vps24 | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. (223 aa) |
