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| | CG3328 | Uncharacterized protein, isoform C; Sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (1423 aa) |
| | CG46339 | Uncharacterized protein, isoform D; Peptide binding; aminopeptidase activity; zinc ion binding; metalloaminopeptidase activity. (1194 aa) |
| | frma | Fra mauro, isoform F; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis; negative regulation of female receptivity, post-mating. (611 aa) |
| | Spg7 | Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. (819 aa) |
| | CG3107 | Presequence protease, mitochondrial; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity); Belongs to the peptidase M16 family. PreP subfamily. (1034 aa) |
| | Nep1 | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. (849 aa) |
| | CalpA | Calpain-A catalytic subunit; Calpain-A (CalpA) encodes a calcium-dependent modulatory protease that cleaves its substrates in a limited fashion. During patterning and division in the blastoderm embryo, CalpA product cleaves the NF-kappaB inhibitor and the cell cycle regulator encoded by cact and CycB, respectively. CalpA product also regulates dendritic prunning of sensory neurons. (843 aa) |
| | pen-2 | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. (101 aa) |
| | Spase25 | Signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (199 aa) |
| | rho-7 | Rhomboid-7, isoform A; Rhomboid-7 (rho-7) encodes an intramembrane serine protease of the rhomboid family present in the inner membrane of mitochondria. It regulates mitochondrial fusion during spermatogenesis and muscle development. rho-7 genetically interacts with fog, Opa1 and Pink1. (351 aa) |
| | ste24c | Ste24c prenyl protease type I (ste24c) encodes a protein that, along with the products of ste24a and ste24b, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24c plays an essential role in the male germline; Belongs to the peptidase M48A family. (456 aa) |
| | Fur1 | Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (1478 aa) |
| | Nepl21 | Neprilysin-like 21; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (707 aa) |
| | aph-1 | Gamma-secretase subunit Aph-1; Anterior pharynx defective 1 (aph-1) encodes a scaffolding subunit of the gamma-secretase complex together with the products of Psn, Nct and pen-2. It is involved in several Notch related processes such as differentiation, cellular organization and developmental patterning via gamma-secretase proteolitic function. (238 aa) |
| | Nct | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (699 aa) |
| | Tasp1 | Taspase 1 (Tasp1) encodes a threonine-type endopeptidase involved in spermatogenesis and the defense response to Gram-negative bacteria. (365 aa) |
| | rho | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa) |
| | gd | Serine protease gd; Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. (531 aa) |
| | hpo | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] (669 aa) |
| | Nep5 | Neprilysin 5, isoform D; Metallopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (882 aa) |
| | Nep3 | Neprilysin-3; Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle- term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation; Belongs to the peptidase M13 family. (786 aa) |
| | Nep2 | Neprilysin-2, soluble form; Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues. Functions in female fertility, embryogenesis and memory formation. Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates. Also required for normal patterns of hatching due to its important role in early embryonic development. Required in the dorsal paired medial neurons for the proper formation of middle-term memory. Also required in the mus [...] (774 aa) |
| | Spase22-23 | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (179 aa) |
| | YME1L | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] (740 aa) |
| | SppL | Signal peptide peptidase-like, isoform D; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: membrane protein proteolysis; signal peptide processing. (422 aa) |
| | CG4678 | Uncharacterized protein, isoform E; Metallocarboxypeptidase activity; zinc ion binding; serine-type carboxypeptidase activity. It is involved in the biological process described with: peptide metabolic process; protein processing. (527 aa) |
| | Nepl6 | Neprilysin-like 6; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (655 aa) |
| | Dredd | Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family. (494 aa) |
| | Nepl16 | Neprilysin-like 16; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (752 aa) |
| | snk | Serine protease snake; Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. (435 aa) |
| | hh | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa) |
| | svr | Carboxypeptidase D; Required for the proper melanization and sclerotization of the cuticle; Belongs to the peptidase M14 family. (1439 aa) |
| | CG8728 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. (556 aa) |
| | Mmp2 | Matrix metalloproteinase-2; Has metalloproteinase activity. Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue. Required for growth of the dorsal air sac primordium and development of the dorsal air sacs. Promotes embryonic motor axon fasciculation. Cleaves and activates frac to promote motor axon bundling during outgrowth. Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites g [...] (758 aa) |
| | S2P | Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity. (508 aa) |
| | Nepl10 | Neprilysin-like 10; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (633 aa) |
| | eIF3m | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). (387 aa) |
| | CG8320 | FI07302p; It is involved in the biological process described with: vacuolar protein processing. (174 aa) |
| | ste24b | Ste24b prenyl protease type I (ste24b) encodes a protein that, along with the products of ste24a and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24b plays an essential role in the male germline; Belongs to the peptidase M48A family. (447 aa) |
| | ste24a | Prenyl protease type I (ste24a) encodes a protein that, along with the products of ste24b and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases; Belongs to the peptidase M48A family. (451 aa) |
| | CG11110 | IP06605p; Serine-type peptidase activity. It is involved in the biological process described with: signal peptide processing; protein processing involved in protein targeting to mitochondrion; mitochondrial respiratory chain complex assembly. (171 aa) |
| | CG7791 | Peptidase_M3 domain-containing protein; Metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing; proteolysis; peptide metabolic process. (699 aa) |
| | SCAP | SREBP cleavage activating protein; Sterol binding. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; protein processing; SREBP signaling pathway. (1276 aa) |
| | Drice | Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family. (339 aa) |
| | Spase12 | Signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (98 aa) |
| | Nepl19 | Neprilysin-like 19; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (671 aa) |
| | Nepl20 | Neprilysin-like 20; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (700 aa) |
| | Nepl18 | Neprilysin-like 18; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (682 aa) |
| | Nepl17 | Neprilysin-like 17; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (681 aa) |
| | Nep7 | Neprilysin 7; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (717 aa) |
| | amon | Amontillado (amon) encodes a member of the Prohormone Convertase (PC) family of proteolytic enzymes. PCs generally recognize conserved basic amino acid sequences within protein precursors to direct catalysis of specific cleavage. amon product directly cleaves sli protein and may also target the propeptide encoded by Akh. It is also required for the production of bioactive neuropeptide hormones (e.g. those encoded by Hug, Crz, Ms, Capa and sNPF); Belongs to the peptidase S8 family. (654 aa) |
| | CG13630 | Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (374 aa) |
| | tld | Dorsal-ventral patterning protein tolloid; Tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa. (1067 aa) |
| | tok | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. (1464 aa) |
| | Nepl13 | Neprilysin-like 13; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (741 aa) |
| | Nepl14 | Neprilysin-like 14; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (696 aa) |
| | Nepl15 | Neprilysin-like 15; Metalloendopeptidase activity. It is involved in the biological process described with: compound eye morphogenesis; proteolysis. (686 aa) |
| | Nep4 | Neprilysin-4; Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5. Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake. Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins [...] (1040 aa) |
| | UQCR-C1 | Metalloendopeptidase activity; ubiquinol-cytochrome-c reductase activity; metal ion binding; endopeptidase activity. It is involved in the biological process described with: protein processing; protein processing involved in protein targeting to mitochondrion; mitochondrial electron transport, ubiquinol to cytochrome c. (470 aa) |
| | Nepl12 | Neprilysin-like 12; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (702 aa) |
| | twr | Signal peptidase complex catalytic subunit SEC11; Serine-type peptidase activity; peptidase activity. It is involved in the biological process described with: signal peptide processing. (185 aa) |
| | CG5131 | Mitochondrial inner membrane protease ATP23; Metalloendopeptidase activity. It is involved in the biological process described with: mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial protein processing. (283 aa) |
| | Nepl9 | Neprilysin-like 9; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (652 aa) |
| | Nepl8 | Neprilysin-like 8; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (619 aa) |
| | Semp1 | Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female. (251 aa) |
| | Ance | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. (615 aa) |
| | Nepl7 | Neprilysin-like 7, isoform A; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (669 aa) |
| | und | Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (448 aa) |
| | Nepl5 | Neprilysin-like 5; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (684 aa) |
| | Nepl4 | Neprilysin-like 4; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (652 aa) |
| | Nepl11 | Neprilysin-like 11; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (592 aa) |
| | disp | Dispatched (disp) encodes a multipass transmembrane protein and a member of the RND transporter family. It is required for the release and long-range activity of the lipid-modified product of hh from producing cells. The products of hh and disp control cell growth, survival, fate, and patterning. (1218 aa) |
| | S1P | Serine-type endopeptidase activity. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; proteolysis. (1012 aa) |
| | Sems | Seminase (Sems) encodes a serine protease produced in male's accessory glands and transferred to females during mating. It is an essential component in the pathway for proteolytic processing of different seminal proteins. It cleaves the metalloprotease encoded by Semp1, which in turn also cleaves the seminal proteins encoded by Acp26Aa and Acp36DE. It is also required for sperm release from storage via regulation of the product of SP. (275 aa) |
| | Psn | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa) |
| | Spp | Signal peptide peptidase; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: signal peptide processing; cellular response to unfolded protein; membrane protein proteolysis. (389 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | Sras | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family. (302 aa) |
| | ndl | Serine protease nudel; Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo. Belongs to the peptidase S1 family. (2616 aa) |
| | Dronc | Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. (450 aa) |
| | CalpB | Calpain-B catalytic subunit 1; Calcium-regulated non-lysosomal thiol-protease. (925 aa) |
| | CG7573 | LP11230p; Metalloendopeptidase activity. It is involved in the biological process described with: CAAX-box protein processing. (477 aa) |
| | 26-29-p | Homologue of Sarcophaga 26,29kDa proteinase; Cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; Belongs to the peptidase C1 family. (549 aa) |
| | CG6512 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. (826 aa) |
| | goe | Protein gone early; Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, ma [...] (879 aa) |
| | Fur2 | Furin-like protease 2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (1682 aa) |
| | CG9240 | Mitochondrial inner membrane protease subunit; Serine-type peptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion. (166 aa) |
| | Nep6 | Neprilysin 6, isoform A; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (655 aa) |
| | rho-4 | Rhomboid-4, isoform A; Rhomboid-4 (rho-4) encodes a member of the rhomboid superfamily of intramembrane serine proteases, which cleave to release proteins from the membrane. It processes the transmembrane EGF ligands encoded by spi, Krn, and grk. Its activity is directly and dramatically stimulated by calcium; Belongs to the peptidase S54 family. (417 aa) |
| | rasp | Protein-cysteine N-palmitoyltransferase Rasp; Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling. (500 aa) |
| | stet | Stem cell tumor, isoform B; Stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr; Belongs to the peptidase S54 family. (485 aa) |
| | ru | Roughoid/rhomboid-3; Roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye; Belongs to the peptidase S54 family. (341 aa) |
| | CG3589 | LD11031p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein processing; regulation of fatty acid beta-oxidation. (509 aa) |
