STRINGSTRING
su(r) su(r) Acox57D-p Acox57D-p Acox57D-d Acox57D-d Sc2 Sc2 CG3902 CG3902 SdhAL SdhAL CG6638 CG6638 Mcad Mcad CG9547 CG9547 CG7840 CG7840 CG10495 CG10495 CG17544 CG17544 CG10463 CG10463 CG9471 CG9471 CG4860 CG4860 Arc42 Arc42 SdhD SdhD Ppox Ppox Coprox Coprox SdhB SdhB CG7461 CG7461 SdhBL SdhBL CG1434 CG1434 CG3645 CG3645 CG6282 CG6282 Dhod Dhod CG9527 CG9527 CG5009 CG5009 Egm Egm CG16935 CG16935 SdhA SdhA CG4586 CG4586
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
su(r)Suppressor of rudimentary (su(r)) encodes a dihydropyrimidine dehydrogenase, the first step of pyrimidine catabolism. su(r) depletion does not produce visible phenotypes, but synergistic effects are exhibited by combining mutants with genes affecting pyrimidine biosynthesis and beta-alanine metabolism. (1031 aa)
Acox57D-pAcyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; acyl-CoA oxidase activity; FAD binding; fatty acid binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Acox57D-dAcyl-coenzyme A oxidase; FAD binding; fatty acid binding; acyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Sc2Sc2; Oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors. It is involved in the biological process described with: very long-chain fatty acid biosynthetic process. (302 aa)
CG3902FI09602p; Flavin adenine dinucleotide binding; acyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process. (414 aa)
SdhALSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (651 aa)
CG6638RE62833p; isovaleryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process; leucine catabolic process. (420 aa)
McadProbable medium-chain specific acyl-CoA dehydrogenase, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (419 aa)
CG9547GH06693p; glutaryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; fatty-acyl-CoA binding. It is involved in the biological process described with: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lysine catabolic process; hydroxylysine catabolic process; fatty-acyl-CoA biosynthetic process; tryptophan metabolic process. (419 aa)
CG7840Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). (326 aa)
CG10495LD05576p; tRNA dihydrouridine synthase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: tRNA processing; oxidation-reduction process. (396 aa)
CG17544acyl-CoA oxidase activity; fatty acid binding; FAD binding; flavin adenine dinucleotide binding; pristanoyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (693 aa)
CG10463tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Metal ion binding; flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity. It is involved in the biological process described with: oxidation-reduction process; tRNA processing. (604 aa)
CG9471TA01656p1; Riboflavin reductase (NADPH) activity; biliverdin reductase activity. It is involved in the biological process described with: multicellular organism reproduction. (204 aa)
CG4860RE05302p; acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: fatty acid beta-oxidation; butyrate catabolic process. (415 aa)
Arc42SD24551p; Flavin adenine dinucleotide binding; butyryl-CoA dehydrogenase activity; acyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; butyrate catabolic process. (405 aa)
SdhDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (182 aa)
PpoxProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (475 aa)
CoproxOxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). (390 aa)
SdhBSuccinate dehydrogenase, subunit B (iron-sulfur) (SdhB) encodes the iron-sulfur cluster-containing subunit of the succinate dehydrogenase complex, which oxidizes succinate to fumarate and passes the electrons to quinones. The redox-active cofactors in this subunit are part of the electron transfer machinery in the complex; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (297 aa)
CG7461Uncharacterized protein, isoform B; very-long-chain-acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; fatty-acyl-CoA binding. It is involved in the biological process described with: oxidation-reduction process. (627 aa)
SdhBLSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (437 aa)
CG1434GH10289p; Flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity. It is involved in the biological process described with: tRNA dihydrouridine synthesis; oxidation-reduction process. (473 aa)
CG3645MIP22167p; Flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity. It is involved in the biological process described with: tRNA processing; oxidation-reduction process. (505 aa)
CG6282Uncharacterized protein, isoform D; Oxidoreductase activity, acting on the CH-CH group of donors. It is involved in the biological process described with: lipid metabolic process. (479 aa)
DhodDihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis. (405 aa)
CG9527Acyl-coenzyme A oxidase; Fatty acid binding; FAD binding; acyl-CoA oxidase activity; pristanoyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation. (724 aa)
CG5009Probable peroxisomal acyl-coenzyme A oxidase 1; Flavin adenine dinucleotide binding; fatty acid binding; FAD binding; acyl-CoA oxidase activity; Belongs to the acyl-CoA oxidase family. (669 aa)
EgmLP02372p; Enigma (Egm) encodes a mitochondrial oxidoreductase involved in oxidative stress response and lipid homeostasis. (639 aa)
CG16935Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (357 aa)
SdhASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders. (661 aa)
CG4586Acyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; FAD binding; fatty acid binding; acyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.