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Mdr50 Mdr50 Cyp12d1-p Cyp12d1-p Cyp6w1 Cyp6w1 Cyp6g1 Cyp6g1 LRR LRR mtt mtt nAChRalpha1 nAChRalpha1 Gr66a Gr66a Cyp12d1-d Cyp12d1-d Cyp6g2 Cyp6g2 Cyp6t3 Cyp6t3 Mdr49 Mdr49 Cyp6a8 Cyp6a8 Cyp6a2 Cyp6a2 nAChRbeta2 nAChRbeta2 Cyp12a4 Cyp12a4 nAChRalpha6 nAChRalpha6 Cyp6v1 Cyp6v1 Cyp6t1 Cyp6t1 Mdr65 Mdr65 Gr8a Gr8a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Mdr50Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion. (1313 aa)
Cyp12d1-pProbable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)
Cyp6w1Probable cytochrome P450 6w1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (514 aa)
Cyp6g1Cytochrome P450 6g1; Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones. (524 aa)
LRRLeucine-rich repeat, isoform F; Leucine-rich repeat (LRR) encodes a protein that contributes to the response to insecticides. It regulates the immune response and NIK/NF-kappaB signaling. (1486 aa)
mttMangetout, isoform G; G protein-coupled receptor activity. It is involved in the biological process described with: adult feeding behavior; response to insecticide; phospholipase C-activating G protein-coupled receptor signaling pathway. (1472 aa)
nAChRalpha1Acetylcholine receptor subunit alpha-like 1; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (597 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
Cyp12d1-dProbable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)
Cyp6g2Probable cytochrome P450 6g2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides; Belongs to the cytochrome P450 family. (519 aa)
Cyp6t3Probable cytochrome P450 6t3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (501 aa)
Mdr49Multidrug resistance protein homolog 49; Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. (1302 aa)
Cyp6a8Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (506 aa)
Cyp6a2Cytochrome P450 6a2; Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones. (506 aa)
nAChRbeta2Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. (519 aa)
Cyp12a4Probable cytochrome P450 12a4, mitochondrial; Has a role in resistance to insecticide lufenuron, but no other insecticides. (536 aa)
nAChRalpha6Nicotinic Acetylcholine Receptor alpha6 (nAChRalpha6) encodes a postsynaptic receptor involved in cation transport, synaptic transmission, muscle homeostasis and sensitivity to insecticides. (523 aa)
Cyp6v1Probable cytochrome P450 6v1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (520 aa)
Cyp6t1Probable cytochrome P450 6t1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (529 aa)
Mdr65Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1302 aa)
Gr8aGustatory receptor 8a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing and avoiding L-canavanine, a plant-derived insecticide. (385 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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