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| | Hmt4-20 | Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. (1300 aa) |
| | Naa30A | N-alpha-acetyltransferase 30A; Probable catalytic component of a complex displaying alpha (N-terminal) acetyltransferase activity. (377 aa) |
| | trr | Histone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...] (2431 aa) |
| | Smyd3 | SET and MYND domain containing, class 3; Histone-lysine N-methyltransferase activity; protein-lysine N-methyltransferase activity. It is involved in the biological process described with: histone lysine methylation. (468 aa) |
| | vilya | Vilya (vilya) encodes a meiosis-specific ring-domain-containing protein that is required for programmed meiotic double-strand break formation. It also functions as a component of the recombination nodule. (237 aa) |
| | CG2652 | GH07966p; It is involved in the biological process described with: regulation of transcription, DNA-templated. (235 aa) |
| | Tip60 | Histone acetyltransferase Tip60; Tat interactive protein 60kDa (Tip60) encodes a lysine acetyltransferase that acetylates histone proteins to regulate chromatin packaging and epigenetic gene control. It also acetylates non-histone proteins, and plays a role in apoptosis, DNA repair and various neural processes. (541 aa) |
| | mof | Males-absent on the first protein; Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positivel [...] (827 aa) |
| | Setd3 | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-74'. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. (537 aa) |
| | l(1)G0020 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the tr [...] (1008 aa) |
| | Cfp1 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. (663 aa) |
| | CG17440 | AT26187p; It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (366 aa) |
| | Loxl2 | Lysyl oxidase-like 2; Scavenger receptor activity; protein-lysine 6-oxidase activity; copper ion binding. It is involved in the biological process described with: cell adhesion; cellular protein modification process; oxidation-reduction process. (511 aa) |
| | Lpt | Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. (1482 aa) |
| | CG33230 | MIP03820p; Protein-lysine N-methyltransferase activity. It is involved in the biological process described with: peptidyl-lysine monomethylation. (446 aa) |
| | Dpy-30L2 | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. (98 aa) |
| | Pa1 | PTIP associated 1; It is involved in the biological process described with: histone H3-K4 methylation. (122 aa) |
| | Set2 | Probable histone-lysine N-methyltransferase CG1716; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (2362 aa) |
| | e(y)1 | Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. (278 aa) |
| | Spt7 | LD38742p; Spt7 (Spt7) encodes a subunit of the SAGA chromatin modifying complex. (359 aa) |
| | Ing3 | Inhibitor of growth protein; Histone acetyltransferase activity. It is involved in the biological process described with: histone acetylation; histone exchange. (686 aa) |
| | CG7889 | FI07229p; Protein-lysine N-methyltransferase activity; methyltransferase activity. It is involved in the biological process described with: methylation; peptidyl-lysine trimethylation; peptidyl-lysine methylation. (319 aa) |
| | Ulp1 | GH15225p; Ulp1 (Ulp1) encodes a cysteine protease that catalyzes both SUMO maturation and SUMO deconjugation. It localizes to the nucleoplasmic face of the nuclear pore complex. Ulp1 knockdown in S2 cells results in relocalization of SUMO from the nucleus to the cytoplasm. (1513 aa) |
| | narya | RING finger protein narya; Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process. Plays a role in DSBs processing into crossovers. Plays a redundant role with nenya in chromosome segregation during female meiosis. (211 aa) |
| | rept | RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (481 aa) |
| | qjt | Quijote, isoform A; Quijote (qjt) encodes a SUMO E3 ligase and a highly conserved subunit of the Smc5/6 complex. It is enriched in heterochromatin and recruited to heterochromatic double-strand break repair sites. (233 aa) |
| | EAChm | Enhancer of Acetyltransferase Chameau (EAChm) encodes a protein that regulates gene transcription in embryos by enhancing the activity of the histone H3 acetyltransferase encoded by chm. (211 aa) |
| | CG12316 | GH22749p; Chromatin binding. It is involved in the biological process described with: histone H4-K16 acetylation. (1188 aa) |
| | Ptip | PAX transcription activation domain interacting protein (Ptip) encodes a component of a Histone H3K4 methyltransferase complex that contributes to Trithorax-mediated epigenetic imprinting during development. (2294 aa) |
| | Spt20 | Spt20, isoform A; Transcription coregulator activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; histone acetylation. (1873 aa) |
| | CG32110 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. (411 aa) |
| | Gcn5 | Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. (813 aa) |
| | Plod | Procollagen-lysine,2-oxoglutarate 5-dioxygenase; Procollagen lysyl hydroxylase (Plod) encodes a lysyl dehydrogenase with roles in Collagen IV biosynthesis. It localizes to the endoplasmic reticulum and is required for the secretion Collagen IV from haemocytes and fat body. (721 aa) |
| | vnc | Variable nurse cells (vnc) encodes a protein involved in histone acetylation and oogenesis. (196 aa) |
| | Tat | Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (461 aa) |
| | CG17003 | Alpha-tubulin N-acetyltransferase 2; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (287 aa) |
| | CG8005 | Probable deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (368 aa) |
| | Uba2 | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. (700 aa) |
| | eco | N-acetyltransferase eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. (1052 aa) |
| | msl-3 | Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable. (512 aa) |
| | velo | Veloren, isoform A; Veloren (velo) encodes a SUMO protease that is required for dendrite and axon targeting of olfactory projection neurons. (1833 aa) |
| | Eaf6 | Esa1-associated factor 6; Histone acetyltransferase activity (H3-K23 specific). (225 aa) |
| | Elp3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (552 aa) |
| | msl-2 | E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. (773 aa) |
| | Taf10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (167 aa) |
| | Taf10b | Transcription initiation factor TFIID subunit 10b; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (146 aa) |
| | CG3515 | FI19335p1; Chromatin binding; histone methyltransferase activity (H3-K4 specific). It is involved in the biological process described with: histone H3-K4 trimethylation. (395 aa) |
| | Rbbp5 | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. (489 aa) |
| | ppl | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity); Belongs to the GcvH family. (165 aa) |
| | Hat1 | Histone acetyltransferase 1 (Hat1) encodes a B-type histone acetyltransferase that localizes to both the cytoplasm and the nucleus. It is involved in the escort machinery of newly synthesized histones encoded by His3 and His4 to chromatin and acetylates the product of His4 at lysines 5 and 12. It also forms a complex with centromeric histone encoded by cid and is involved in cid chromatin assembly. (405 aa) |
| | CG9804 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). (234 aa) |
| | smt3 | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. (90 aa) |
| | Atac1 | Ada2a-containing complex component 1 (Atac1) encodes a protein involved in chromatin remodeling and histone acetylation. (356 aa) |
| | Gas41 | LD16161p; Gas41 (Gas41) encodes a protein that contributes to histone acetylation and is involved in chromatin organization and RNA interference. (227 aa) |
| | Su(var)205 | Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. (206 aa) |
| | Wdr82 | WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. (317 aa) |
| | D12 | D12 (D12) encodes a protein involved in chromatin remodeling and histone acetylation. (969 aa) |
| | Utx | Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa) |
| | Dpy-30L1 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. (134 aa) |
| | Ada1-2 | Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex. (308 aa) |
| | Ada1-1 | Transcriptional Adaptor 1-1 (Ada1-1) encodes a subunit of the SAGA chromatin modifying complex. (308 aa) |
| | Sirt1 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa) |
| | Ing5 | Inhibitor of growth family member 5 (Ing5) encodes a histone acetyltransferase that forms part of the Enok complex, which interacts with the product of elg1 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading. (285 aa) |
| | NC2beta | Protein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family. (183 aa) |
| | chif | Chiffon (chif) encodes a protein associated with the origin recognition complex that binds to chromosomal origins of replication and is required for the initiation of cellular DNA replication. It is involved in DNA replication, chorion production, muscle homeostasis, and axon guidance. (1711 aa) |
| | Atac2 | Ada2a-containing complex component 2 (Atac2) encodes a protein involved in chromatin organization, intestinal stem cell homeostasis, and histone acetylation. (774 aa) |
| | msl-1 | Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. (1039 aa) |
| | CG3909 | WD_REPEATS_REGION domain-containing protein. (331 aa) |
| | pont | RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (456 aa) |
| | Taf12 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. (196 aa) |
| | Sbf | SET domain binding factor, isoform A. (1993 aa) |
| | Spt3 | FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex. (384 aa) |
| | Aos1 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. (337 aa) |
| | MBD-R2 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. (1169 aa) |
| | PR-Set7 | Histone-lysine N-methyltransferase PR-Set7; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis; Belongs to the class V-like SAM-binding methyltransferase superfa [...] (691 aa) |
| | trx | Histone-lysine N-methyltransferase trithorax; Histone methyltransferase that trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. (3726 aa) |
| | Caf1-55 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] (430 aa) |
| | CG5013 | RE16487p; Methyltransferase activity; protein-lysine N-methyltransferase activity. It is involved in the biological process described with: methylation; peptidyl-lysine trimethylation. (247 aa) |
| | CG14282 | IP09474p; It is involved in the biological process described with: histone H3-K4 methylation. (293 aa) |
| | CG5466 | GH15831p; Histone methyltransferase activity (H3-K79 specific). It is involved in the biological process described with: regulation of cell cycle; histone H3-K79 methylation. (594 aa) |
| | Oga | O-GlcNAcase (Oga) encodes a protein that, together with the product of sxc, is responsible for O-GlcNAcylation. O-GlcNAcylation is a dynamic post-translational modification that modifies serine and threonine residues of proteins, and plays important roles in biological functions such as metabolism and neurodegeneration. (1019 aa) |
| | Smyd5 | SET and MYND domain containing, class 5; S-adenosylmethionine-dependent methyltransferase activity. It is involved in the biological process described with: histone lysine methylation. (393 aa) |
| | wda | Will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5. (743 aa) |
| | ash2 | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] (556 aa) |
| | vig2 | Vig2, isoform B; Vig2 (vig2) encodes a protein involved in heterochromatin organization, histone H3-K9 methylation and chromatin silencing regulation. (443 aa) |
| | Mocs2B | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. (367 aa) |
| | NSD | Probable histone-lysine N-methyltransferase Mes-4; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (1427 aa) |
| | nenya | RING finger protein nenya; Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process. Plays a redundant role with narya in chromosome segregation during female meiosis. (219 aa) |
| | CG1894 | Histone acetyltransferase activity; histone binding; H4 histone acetyltransferase activity. It is involved in the biological process described with: histone acetylation; positive regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Belongs to the MYST (SAS/MOZ) family. (421 aa) |
| | Brd8 | Bromodomain containing 8; It is involved in the biological process described with: negative regulation of gene expression; histone exchange; histone acetylation. (872 aa) |
| | Naa40 | N(Alpha)-acetyltransferase 40; peptide-serine-N-acetyltransferase activity; H4 histone acetyltransferase activity; peptide alpha-N-acetyltransferase activity; H2A histone acetyltransferase activity. It is involved in the biological process described with: regulation of ribosomal DNA heterochromatin assembly; N-terminal protein amino acid acetylation. (202 aa) |
| | Loxl1 | Lysyl oxidase-like 1 (Loxl1) encodes a protein-lysine 6-oxidase that might be involved in euchromatinization and gene regulation. (360 aa) |
| | nero | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control; Belongs to the deoxyhypusine hydroxylase family. (302 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses. Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel. Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling. (433 aa) |
| | Bap55 | Brahma associated protein 55kD (Bap55) encodes a member of two chromatin remodeling complexes. As part of the Brahma complex, it is needed for cell growth and survival in the wing imaginal disc; as a member of the TIP60 complex, it is thought to regulate dendrite wiring specificity in olfactory projection neurons; Belongs to the actin family. (425 aa) |
| | BEAF-32 | Boundary element-associated factor of 32kD (BEAF-32) encodes a DNA-binding protein with binding sites near transcription start sites. Its roles include chromatin domain insulator function, gene regulation and genome organization. (283 aa) |
| | san | Probable N-acetyltransferase san; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (By similarity). Also displays N-epsilon- acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates. Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired togethe [...] (184 aa) |
| | Su(var)2-10 | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. (640 aa) |
| | MrgBP | MRG/MORF4L binding protein; It is involved in the biological process described with: histone exchange; histone acetylation; regulation of transcription by RNA polymerase II. (201 aa) |
| | CG10931 | IP10415p; Histone methyltransferase activity (H3-K4 specific). It is involved in the biological process described with: histone H3-K4 methylation; histone H3 acetylation. (345 aa) |
| | Naa60 | N-alpha-acetyltransferase 60; Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. [Isoform B]: Does not show histone acetyltransferase activity toward free histones; Belongs to the acetyltransferase family. NAA60 subfamily. (276 aa) |
| | Chrac-14 | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf. Has a role in DNA damage response by preventing cid mislocalization to chromatin [...] (128 aa) |
| | Ada2b | Transcriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (555 aa) |
| | Mnn1 | Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like. (763 aa) |
| | egg | Histone-lysine N-methyltransferase eggless; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (1262 aa) |
| | CG4565 | Uncharacterized protein; Histone methyltransferase activity (H3-K36 specific); zinc ion binding. It is involved in the biological process described with: histone methylation; histone lysine methylation. (269 aa) |
| | Set1 | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. (1641 aa) |
| | CG42299 | IP07325p; SUMO transferase activity; zinc ion binding. It is involved in the biological process described with: double-strand break repair via homologous recombination. (182 aa) |
| | CG42300 | MIP26115p; Zinc ion binding; SUMO transferase activity. It is involved in the biological process described with: double-strand break repair via homologous recombination. (181 aa) |
| | CG12560 | IP09231p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: histone acetylation. (278 aa) |
| | CG3347 | FI16849p1; It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (538 aa) |
| | Den1 | Deneddylase 1, isoform C; NEDD8-specific protease activity. It is involved in the biological process described with: positive regulation of apoptotic process; protein deneddylation. (249 aa) |
| | nej | Nejire, isoform C; Nejire (nej) encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including the histone encoded by His3 on K18, K27, and H4 on K8. By regulating gene expression, the product of nej has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning. (3282 aa) |
| | Nipped-A | Transcription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes. (3790 aa) |
| | gpp | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity. (2137 aa) |
| | Nup358 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] (2718 aa) |
| | Taf1 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. (2172 aa) |
| | CG33060 | Uncharacterized protein; It is involved in the biological process described with: histone H3-K4 methylation. (121 aa) |
| | ash1 | Histone-lysine N-methyltransferase ash1; Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active. Belongs to t [...] (2226 aa) |
| | wds | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa) |
| | Atac3 | Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. (583 aa) |
| | lwr | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. (159 aa) |
| | Ada2a | Transcriptional adapter 2A; GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II- dependent transcription. (562 aa) |
| | Su(var)3-9 | Histone-lysine N-methyltransferase Su(var)3-9; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation. Belongs to the cl [...] (635 aa) |
| | Rcd1 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. (1131 aa) |
| | Ncoa6 | Nuclear receptor coactivator 6 (Ncoa6) encodes a subunit of the Trithorax-related (Trr) complex, a COMPASS-like complex that mediates the methylation of histone H3K4. The product of Ncoa6 is required for transcriptional output of the Hippo pathway by directly interacting with the protein encoded by yki and recruiting the Trr complex to Hippo target genes. (2467 aa) |
| | ear | ENL/AF9-related, isoform B; ENL/AF9-related (ear) encodes a transcription factor that is a component of the super elongation complex (SEC), which regulates transcription by RNA Polymerase II. It also interacts with the histone methyltransferase encoded by gpp in the Dot1 complex (DotCom), which modifies chromatin structure by methylating histone H3 on lysine 79. (945 aa) |
| | sr | Stripe, isoform D; Stripe (sr) encodes a transcription factor that induces the fate of tendon cells in the embryo as well as in the adult fly. It works upstream of tendon specific genes including Tsp, slow and Lrt. (1271 aa) |
| | brm | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] (1658 aa) |
| | PSR | Bifunctional arginine demethylase and lysyl-hydroxylase PSR; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (441 aa) |
| | E(Pc) | Enhancer of Polycomb (E(Pc)) encodes a chromatin protein that functions as a suppressor of position-effect variegation. An unusual member of the Polycomb group; it does not exhibit homeotic transformations on its own, but rather enhances mutations in other Polycomb group genes. It forms part of the TIP60 histone acetyltransferase complex, which has been involved in many processes, including both transcriptional activation and repression. (2097 aa) |
| | ND-ACP | Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity); Belongs to the acyl carrier protein (ACP) family. (181 aa) |
| | Topors | E3 ubiquitin-protein ligase Topors; Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effec [...] (1038 aa) |
| | Naa20A | N(Alpha)-acetyltransferase 20 A, isoform B; Peptide alpha-N-acetyltransferase activity. It is involved in the biological process described with: negative regulation of neuron apoptotic process; histone acetylation; N-terminal peptidyl-methionine acetylation. (180 aa) |
| | chm | Chameau (chm) encodes a histone acetyl transferase involved in epigenetic mechanisms of transcriptional control and regulation of replication origin activity. Its functions include modulation of JNK activity and gene regulation by Polycomb group genes; Belongs to the MYST (SAS/MOZ) family. (811 aa) |
| | G9a | G9a, isoform B; G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory. (1657 aa) |
| | HDAC4 | Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. (1269 aa) |
| | MRG15 | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. (429 aa) |
| | E(z) | Histone-lysine N-methyltransferase E(z); Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting [...] (765 aa) |
| | CG11539 | N-acetyltransferase 9-like protein; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: protein acetylation; histone acetylation; Belongs to the acetyltransferase family. GNAT subfamily. (200 aa) |
| | CG44243 | LD05679p; Lipoyltransferase activity. It is involved in the biological process described with: protein lipoylation. (396 aa) |
| | Ada3 | Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. (588 aa) |
| | dgt1 | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. (589 aa) |
| | YL-1 | Vacuolar protein sorting-associated protein 72 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. (351 aa) |
| | Sgf29 | SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. (289 aa) |
| | dom | Helicase domino; Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (3233 aa) |
| | enok | Histone acetyltransferase; Enoki mushroom (enok) encodes a MYST family histone acetyltransferase that acetylates lysine residues on histones, including H3K23, to regulate gene transcription. It contributes to stem cell self-renewal, oogenesis and neural development; Belongs to the MYST (SAS/MOZ) family. (2291 aa) |
| | CG9643 | Protein-lysine N-methyltransferase CG9643; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (219 aa) |
| | Hcf | HCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa) |
| | lid | Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry. (1838 aa) |
| | Br140 | Bromodomain-containing protein, 140kD (Br140) encodes a histone acetyltransferase that is a component of the Enok complex, which interacts with the product of elg1 via Br140 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading. (1430 aa) |
| | SmydA-8 | SET domain-containing protein SmydA-8, isoform A; Histone deacetylase binding; S-adenosylmethionine-dependent methyltransferase activity. It is involved in the biological process described with: histone lysine methylation; negative regulation of gene expression. (462 aa) |
| | CG12717 | FI06413p; SUMO-specific isopeptidase activity; SUMO-specific endopeptidase activity. It is involved in the biological process described with: dendritic spine morphogenesis; central nervous system projection neuron axonogenesis; protein desumoylation. (681 aa) |
| | cerv | Cervantes, isoform A; Zinc ion binding; SUMO transferase activity. It is involved in the biological process described with: DNA repair; double-strand break repair via homologous recombination. (230 aa) |
| | Act87E | Actin-87E; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa) |
| | CG3337 | FI06469p; Protein-lysine N-methyltransferase activity. (204 aa) |
| | tna | Tonalli, isoform B; Tonalli (tna) is an essential gene that encodes several isoforms, including Tna-A, which physically associates with subunits of the Brahma chromatin remodeling complex and is involved in transcriptional activation. (1186 aa) |
