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Ir8a Ir8a Ir76b Ir76b ine ine Ir76a Ir76a NaCP60E NaCP60E para para Ir25a Ir25a axo axo Ca-alpha1T Ca-alpha1T Ir84a Ir84a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Ir8aIonotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa)
Ir76bIonotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa)
ineSodium- and chloride-dependent GABA transporter ine; Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osm [...] (943 aa)
Ir76aIonotropic receptor 76a, isoform E; Olfactory receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: transmission of nerve impulse; detection of chemical stimulus involved in sensory perception of smell; detection of chemical stimulus involved in sensory perception. (646 aa)
NaCP60ENa channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses; Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily. (2896 aa)
paraSodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily. (2145 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
axoAxotactin, isoform C; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: transmission of nerve impulse. (2179 aa)
Ca-alpha1TCa[2+]-channel protein alpha[[1]] subunit T (Ca-alpha1T) encodes an alpha 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride. (3218 aa)
Ir84aIonotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior. (644 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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