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CheB42a CheB42a CheB93b CheB93b CheB93a CheB93a CheB38a CheB38a CheB38c CheB38c CheA29a CheA29a Orco Orco Or67d Or67d Gr68a Gr68a Obp69a Obp69a lush lush Obp99a Obp99a Obp56h Obp56h CheB42b CheB42b ppk25 ppk25 Obp56a Obp56a CheB53b CheB53b CheB53a CheB53a CheB74a CheB74a CheB38b CheB38b ppk23 ppk23 Obp19a Obp19a CheB42c CheB42c Obp99b Obp99b Snmp1 Snmp1 Snmp2 Snmp2 Tk Tk CheB98a CheB98a CG9304 CG9304 Obp56d Obp56d
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CheB42aChemosensory protein B 42a (CheB42a) encodes a member of a family of small secreted proteins associated with the chemosensory system and is involved in male courtship behavior. (198 aa)
CheB93bChemosensory protein B 93b; Lipid binding. It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (203 aa)
CheB93aChemosensory protein B 93a; Lipid binding. It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (200 aa)
CheB38aChemosensory protein B 38a; Lipid binding. It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (197 aa)
CheB38cChemosensory protein B 38c; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (198 aa)
CheA29aPutative pheromone response factor; It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (180 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
Or67dOdorant receptor 67d; Plays a role in detection and sensitivity to pheromones and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to othe [...] (391 aa)
Gr68aGustatory receptor 68a; Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the rele [...] (389 aa)
Obp69aGeneral odorant-binding protein 69a; Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male- specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively. (148 aa)
lushGeneral odorant-binding protein lush; Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by [...] (153 aa)
Obp99aGeneral odorant-binding protein 99a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (142 aa)
Obp56hGeneral odorant-binding protein 56h; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid (By similarity). May function in both olfactory and gustatory systems. (134 aa)
CheB42bChemosensory protein B 42b; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (196 aa)
ppk25Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (451 aa)
Obp56aGeneral odorant-binding protein 56a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (139 aa)
CheB53bChemosensory protein B 53b; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (204 aa)
CheB53aChemosensory protein B 53a; Lipid binding. It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (226 aa)
CheB74aChemosensory protein B 74a; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (202 aa)
CheB38bChemosensory protein B 38b; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (197 aa)
ppk23Pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. (591 aa)
Obp19aGeneral odorant-binding protein 19a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (146 aa)
CheB42cChemosensory protein B 42c; Lipid binding. It is involved in the biological process described with: detection of pheromone; sensory perception of chemical stimulus. (196 aa)
Obp99bGeneral odorant-binding protein 99b; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (149 aa)
Snmp1Sensory neuron membrane protein 1; Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the developmen [...] (551 aa)
Snmp2Sensory neuron membrane protein 2; Plays an olfactory role that is not restricted to pheromone sensitivity; Belongs to the CD36 family. (556 aa)
TkTachykinin-associated peptide 1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which le [...] (297 aa)
CheB98aChemosensory protein A 98a; Lipid binding. It is involved in the biological process described with: sensory perception of chemical stimulus; detection of pheromone. (197 aa)
CG9304Uncharacterized protein, isoform A; It is involved in the biological process described with: G protein-coupled receptor signaling pathway; response to pheromone. (637 aa)
Obp56dGeneral odorant-binding protein 56d; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (131 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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