STRINGSTRING
Src42A Src42A alpha-Cat alpha-Cat vanin-like vanin-like Gbeta5 Gbeta5 shg shg Pi3K59F Pi3K59F Galphas Galphas trio trio ImpE2 ImpE2 Ack Ack Coq8 Coq8 dah dah fu fu Gbeta76C Gbeta76C Galphaf Galphaf CG13458 CG13458 Pi3K68D Pi3K68D Galphai Galphai FIG4 FIG4 ninaC ninaC Sos Sos CG5131 CG5131 Atg13 Atg13 Vps15 Vps15 FER FER CG5608 CG5608 CG33331 CG33331 ninaE ninaE klg klg Atg6 Atg6 Wsck Wsck Apc Apc Atg14 Atg14 Vps13B Vps13B trp trp Snx16 Snx16 CG15611 CG15611 inaC inaC clu clu Shark Shark trpl trpl Ggamma1 Ggamma1 gcl gcl Socs44A Socs44A cos cos arm arm Gbeta13F Gbeta13F Galphao Galphao Pink1 Pink1 CG17760 CG17760 Vps13D Vps13D CG9592 CG9592 Pldn Pldn inaF-B inaF-B larp larp norpA norpA lap lap CG30054 CG30054 mbc mbc inaD inaD Esyt2 Esyt2 CG43324 CG43324 mud mud CadN2 CadN2 Vps13 Vps13 Socs16D Socs16D ImpE3 ImpE3 Rop Rop Atg18a Atg18a kmr kmr Socs36E Socs36E Stacl Stacl Abl Abl Ack-like Ack-like Pi3K21B Pi3K21B Lrr47 Lrr47 Atg18b Atg18b Rac1 Rac1 ImpE1 ImpE1 Galphaq Galphaq Atg2 Atg2 cta cta Pi3K92E Pi3K92E Atg17 Atg17 CG11975 CG11975 CG14671 CG14671 Arl8 Arl8 Fkbp59 Fkbp59 Src64B Src64B Ggamma30A Ggamma30A Apc2 Apc2
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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Src42ATyrosine-protein kinase Src42A; Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity. Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduc [...] (1597 aa)
alpha-CatCatenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. (917 aa)
vanin-likeVanin-like protein 1; Probable hydrolase; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. (558 aa)
Gbeta5RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. (358 aa)
shgDE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
GalphasG protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa)
trioTrio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. (2263 aa)
ImpE220-hydroxyecdysone protein; Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates. (466 aa)
AckActivated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa)
Coq8Coenzyme Q8; Protein kinase activity; kinase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; ubiquinone biosynthetic process. (661 aa)
dahDiscontinuous actin hexagon (dah) encodes a protein required for cortical furrows during early embryogenesis that is recruited to the membrane in a process dependent on the product of nuf. (649 aa)
fuSerine/threonine-protein kinase fused; Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. (805 aa)
Gbeta76CGuanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit. (346 aa)
GalphafG protein alpha f subunit (Galphaf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function; Belongs to the G-alpha family. (399 aa)
CG13458GH20023p; Translation regulator activity. It is involved in the biological process described with: positive regulation of mitochondrial translation. (634 aa)
Pi3K68DPhosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway; Belongs to the PI3/PI4-kinase family. (1876 aa)
GalphaiG protein alpha i subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
FIG4FIG4 phosphoinositide 5-phosphatase; Phosphoric ester hydrolase activity. It is involved in the biological process described with: larval locomotory behavior; regulation of lysosome size; compound eye morphogenesis. (858 aa)
ninaCNeither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. (1501 aa)
SosProtein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa)
CG5131Mitochondrial inner membrane protease ATP23; Metalloendopeptidase activity. It is involved in the biological process described with: mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial protein processing. (283 aa)
Atg13Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa)
Vps15Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa)
FERTyrosine-protein kinase Fer; Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm. (1325 aa)
CG5608FI07645p; It is involved in the biological process described with: phosphatidylinositol biosynthetic process; positive regulation of kinase activity. (687 aa)
CG33331Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (342 aa)
ninaEOpsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa)
klgLD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. (545 aa)
Atg6Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. (422 aa)
WsckPutative tyrosine-protein kinase Wsck; Putative receptor with tyrosine-protein kinase activity. (791 aa)
ApcAPC-like, isoform A; APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. (2417 aa)
Atg14Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. (503 aa)
Vps13BVacuolar protein sorting 13B, isoform A; It is involved in the biological process described with: protein targeting to vacuole; protein retention in Golgi apparatus. (3731 aa)
trpTransient receptor potential protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. Bel [...] (1275 aa)
Snx16Sorting nexin 16 (Snx16) encodes a protein that regulates synaptic growth at the neuromuscular junction. (407 aa)
CG15611Uncharacterized protein, isoform A; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: response to endoplasmic reticulum stress; positive regulation of Rho protein signal transduction. (508 aa)
inaCProtein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa)
cluClueless (clu) encodes a cytoplasmic ribonucleoprotein that is required for mitochondrial function. It functions in part with protein complexes at the outer mitochondrial membrane, such as the ribosome, the translocase complex TOM and the mitophagy proteins encoded by park and Pink1. Loss of clu causes mitochondrial oxidative damage, decreased ATP and lethality. (1448 aa)
SharkTyrosine-protein kinase Shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] (939 aa)
trplTransient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa)
Ggamma1Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. (70 aa)
gclGerm cell-less (gcl) encodes a conserved BTB (broad-complex, tramtrack, and bric-a-brac) protein that mediates transcriptional repression in the germline and the degradation of the receptor tyrosine kinase encoded by tor, which in turn allows germ cell formation. (569 aa)
Socs44ASuppressor of Cytokine Signaling at 44A (Socs44A) encodes a protein that promotes the degradation of interacting proteins by recruiting Cullin/Elongin ubiquitin ligase complexes. It activity negatively regulates JAK/STAT signaling and positively impacts RTK signaling in a context specific manner, which can impact developmental patterning. (342 aa)
cosKinesin-like protein costa; Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome- mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation. May negatively regulate a hh- signaling pathway whi [...] (1201 aa)
armArmadillo segment polarity protein; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha- catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. Belongs to the beta-catenin family. (843 aa)
Gbeta13FGuanine nucleotide-binding protein subunit beta-1; G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions. (340 aa)
GalphaoG protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa)
Pink1PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. (721 aa)
CG17760SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa)
Vps13DVacuolar protein sorting-associated protein 13D; Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. (3919 aa)
CG9592IP08778p; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (152 aa)
PldnBiogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, plays a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes. (167 aa)
inaF-BGEO10024p1; inaF-B (inaF-B) encodes a calcium channel regulator involved in response to light and the regulation of photoreceptor cell membrane potential. (81 aa)
larpLa-related protein 1; RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation. (1673 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
lapPhosphatidylinositol-binding clathrin assembly protein LAP; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction; Belongs to the PICALM/SNAP91 family. (788 aa)
CG30054Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa)
mbcMyoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. (2008 aa)
inaDInactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. (686 aa)
Esyt2Extended synaptotagmin-like protein 2 (Esyt2) encodes a member of the Synaptotagmin family that localizes to the endoplasmic reticculum (ER). In axonal ER of motorneurons, it may be involved in coordinating intracellular calcium dynamics and constitutive membrane trafficking. (853 aa)
CG43324Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (66 aa)
mudMushroom body defect (mud) encodes regulates spindle orientation via interactions with the dynein complex. (2567 aa)
CadN2Putative neural-cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1799 aa)
Vps13Vacuolar protein sorting-associated protein 13; Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system. May function as part of a lysosomal degradation pathway. (3321 aa)
Socs16DSuppressor of Cytokine Signaling at 16D (Socs16D) encodes a member of the SOCS family. It binds to the product of Pvr when catalytically active and is required for downstream activation of Target of Rapamycin Complex 1, but not the product of rl. (1021 aa)
ImpE3Ecdysone-inducible gene E3; It is involved in the biological process described with: imaginal disc eversion. (325 aa)
RopProtein ROP; May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein. (597 aa)
Atg18aAutophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes. (447 aa)
kmrUncharacterized protein, isoform I; Phosphatidylinositol bisphosphate binding. It is involved in the biological process described with: regulation of establishment of planar polarity. (3090 aa)
Socs36ESuppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. (737 aa)
StaclStac-like, isoform J; It is involved in the biological process described with: skeletal muscle contraction; intracellular signal transduction; positive regulation of cell size; positive regulation of voltage-gated calcium channel activity; positive regulation of protein localization to plasma membrane. (1970 aa)
AblTyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. (1723 aa)
Ack-likeActivated Cdc42 kinase-like (Ack-like) encodes a non-receptor tyrosine kinase that participates in signaling by the small GTPase encoded by Cdc42. It is involved in embryonic dorsal closure, an epithelial morphogenetic event. (1495 aa)
Pi3K21BPi3K21B, isoform B; Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional cllass IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. (496 aa)
Lrr47Leucine-rich repeat 47, isoform A; It is involved in the biological process described with: Ras protein signal transduction; signal transduction. (428 aa)
Atg18bAutophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. (471 aa)
Rac1Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa)
ImpE1Ecdysone-inducible gene E1 (ImpE1) encodes a protein similar to a low-density lipoprotein (LDL) receptor. It is hypothesized to play a role in the cell rearrangements associated with morphogenesis of the disc epithelium. ImpE1 transcription is upregulated by 20-hydroxyecdysone. (1616 aa)
GalphaqG protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. (396 aa)
Atg2Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. (1906 aa)
ctaGuanine nucleotide-binding protein subunit alpha homolog; May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes; Belongs to the G-alpha family. G(12) subfamily. (457 aa)
Pi3K92EPhosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa)
Atg17Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa)
CG11975LD32381p; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. It is involved in the biological process described with: autophagy of nucleus; protein lipidation; autophagy of mitochondrion; protein localization to phagophore assembly site; autophagosome assembly. (340 aa)
CG14671GEO12035p1; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (155 aa)
Arl8ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. (186 aa)
Fkbp59FK506-binding protein 59kD (Fkbp59) encodes a peptidylprolyl isomerase involved in the regulation of calcium transport and phototransduction. (439 aa)
Src64BTyrosine-protein kinase Src64B; Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. (553 aa)
Ggamma30AGuanine nucleotide-binding protein subunit gamma-e; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye. (238 aa)
Apc2Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. (1067 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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