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CanA1 CanA1 Wdr92 Wdr92 Galphai Galphai CG31960 CG31960 Itpr Itpr Orco Orco GluRIIA GluRIIA Nos Nos Gyc89Db Gyc89Db GluRIID GluRIID KaiR1D KaiR1D Gycalpha99B Gycalpha99B Cad99C Cad99C Capa Capa Gycbeta100B Gycbeta100B inaC inaC trpl trpl GluRIIB GluRIIB Ca-alpha1D Ca-alpha1D Galphao Galphao Pka-C1 Pka-C1 capt capt GluRIIE GluRIIE Gyc88E Gyc88E Gyc89Da Gyc89Da Gyc32E Gyc32E CG3216 CG3216 5PtaseI 5PtaseI zyd zyd norpA norpA Acam Acam CG42637 CG42637 CG42638 CG42638 CG10738 CG10738 Pka-R1 Pka-R1 CngA CngA RyR RyR Spn Spn Cam Cam CanA-14F CanA-14F Cngl Cngl Pp2B-14D Pp2B-14D CanB2 CanB2 up up Pde9 Pde9 SPoCk SPoCk Trpml Trpml GluRIIC GluRIIC rdgC rdgC sra sra CG31183 CG31183 CG34357 CG34357 CG42260 CG42260 cac cac CanB CanB CG16721 CG16721 CngB CngB Stim Stim amn amn
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CanA1Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. (622 aa)
Wdr92WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade. (375 aa)
GalphaiG protein alpha i subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
CG31960GEO02651p1; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization; Belongs to the calmodulin family. (148 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
NosNitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. (1349 aa)
Gyc89DbSoluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa)
GluRIIDGlutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (902 aa)
KaiR1DKainate-type ionotropic glutamate receptor subunit 1D; It is involved in the biological process described with: calcium ion import across plasma membrane; regulation of synaptic activity; synaptic transmission, glutamatergic; positive regulation of neuromuscular synaptic transmission; modulation of chemical synaptic transmission. (853 aa)
Gycalpha99BHead-specific guanylate cyclase; Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. (676 aa)
Cad99CCadherin-99C; Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response. Essential for female fertility. Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands. Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane. Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli. Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulat [...] (1706 aa)
CapaCardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. (151 aa)
Gycbeta100BGuanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (787 aa)
inaCProtein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa)
trplTransient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa)
GluRIIBGlutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (913 aa)
Ca-alpha1DVoltage-dependent calcium channel type D subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Encodes a dihydropyridine- and diltiazem- sensitive current in larval body wall muscle. Vital for embryonic development; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2552 aa)
GalphaoG protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa)
Pka-C1cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa)
captAdenylyl cyclase-associated protein; Capulet (capt) encodes a conserved actin binding protein that functions across eukaryotes to negatively regulate actin filament assembly. Different types of actin filament formation are differentially affected by the loss of capt. (783 aa)
GluRIIEGlutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. (897 aa)
Gyc88ESoluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (1097 aa)
Gyc89DaSoluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (667 aa)
Gyc32EATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation. (1191 aa)
CG3216Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa)
5PtaseI5PtaseI, isoform C; Inositol-polyphosphate 5-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; phosphatidylinositol dephosphorylation. (699 aa)
zydZydeco, isoform F; Zydeco (zyd) encodes a potassium-dependent sodium/calcium exchanger found in cortex glia. It is thought to serve as a key calcium export pathway to control calcium oscillations that occur in membrane microdomains of the glial cell; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (542 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
AcamCalmodulin-related protein 97A; May be involved in calcium-mediated signal transduction. (148 aa)
CG42637Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa)
CG42638Cation channel activity. (652 aa)
CG10738Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa)
Pka-R1Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa)
CngACyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. (840 aa)
RyRRyanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa)
SpnSpinophilin, isoform J; Spinophilin (Spn) encodes a scaffold protein protein that regulates the neurexin/neuroligin signalling at the presynaptic active zone. (2148 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
CanA-14FSerine/threonine-protein phosphatase 2B catalytic subunit 3; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. (584 aa)
CnglIntracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport. (1970 aa)
Pp2B-14DSerine/threonine-protein phosphatase 2B catalytic subunit 2; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. (570 aa)
CanB2Calcineurin subunit B type 2; Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase. (170 aa)
upTroponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere. (397 aa)
Pde9High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. (1623 aa)
SPoCkSecretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1062 aa)
TrpmlTransient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa)
GluRIICGlutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)
rdgCRetinal degeneration C (rdgC) encodes a serine/threonine phosphatase that binds Ca2+/calmodulin and contains 2 Ca2+-binding EF-hand motifs. It promotes the dephosphorylation of the product of ninaE, which prevents its internalization. It also promotes the dephosphorylation of the product of trp at specific site affecting the frequency response to modulated light. (746 aa)
sraProtein sarah; Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte. Belongs to the RCAN family. (292 aa)
CG31183ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa)
CG34357Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa)
CG42260Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl. (1269 aa)
cacVoltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. (2110 aa)
CanBCalcineurin subunit B type 1; Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase. (170 aa)
CG16721LD23868p; It is involved in the biological process described with: cAMP-mediated signaling; signal transduction. (494 aa)
CngBCyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling. (1040 aa)
StimStromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. (570 aa)
amnAmnesiac neuropeptides; Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve. (180 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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