Your Input: | |
| | l(2)10685 | Lethal (2) 10685; Methyltransferase activity. It is involved in the biological process described with: rRNA methylation; RNA methylation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (503 aa) |
| | CG3008 | Serine/threonine-protein kinase RIO3; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (603 aa) |
| | CG3294 | Uncharacterized protein, isoform A; pre-mRNA 3'-splice site binding; metal ion binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; wound healing. (456 aa) |
| | CG32409 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (349 aa) |
| | Rexo5 | RNA exonuclease 5, isoform A; Nucleic acid binding; 3'-5'-exoribonuclease activity; exonuclease activity. It is involved in the biological process described with: snoRNA 3'-end processing; rRNA 3'-end processing. (681 aa) |
| | CG8549 | Uncharacterized protein, isoform A; It is involved in the biological process described with: mature ribosome assembly. (252 aa) |
| | Pop4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (206 aa) |
| | mRpL36 | Ribosomal protein; Structural constituent of ribosome. It is involved in the biological process described with: ribosome biogenesis; mitochondrial translation; Belongs to the bacterial ribosomal protein bL36 family. (128 aa) |
| | mus301 | Mutagen-sensitive 301 (mus301) encodes a member of the Mus308 subfamily of ATP-dependent helicases. It is involved in the repair of double-strand DNA breaks during recombination and in somatic cells, and in chromosome segregation. It contributes to dorsal-ventral patterning during oogenesis and posterior oocyte positioning. (1051 aa) |
| | RpL14 | Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (166 aa) |
| | pix | Pixie, isoform A; Pixie (pix) encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth. (611 aa) |
| | CG18178 | GH03795p; Nucleic acid binding. It is involved in the biological process described with: maturation of 5.8S rRNA; maturation of LSU-rRNA. (374 aa) |
| | CG8336 | GH06403p; Peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; protein folding. (383 aa) |
| | CG32075 | LD47413p; It is involved in the biological process described with: maturation of 5.8S rRNA; maturation of LSU-rRNA. (541 aa) |
| | CG11726 | IP09423p; Nucleic acid binding; mRNA binding. (291 aa) |
| | RIOK1 | Serine/threonine-protein kinase RIO1; ATP binding; protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of glial cell proliferation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (585 aa) |
| | CG5906 | FI08002p; It is involved in the biological process described with: mitochondrial ribosome assembly; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa) |
| | RpL10Ab | Ribosomal protein L10Ab (RpL10Ab) is an essential gene during oogenesis that encodes a ribosomal protein of the large ribosome subunit; Belongs to the universal ribosomal protein uL1 family. (217 aa) |
| | CG5645 | Protein KRI1 homolog; It is involved in the biological process described with: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); Belongs to the KRI1 family. (855 aa) |
| | eIF2beta | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family. (312 aa) |
| | SmD1 | Small ribonucleoprotein particle protein SmD1 (SmD1) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (124 aa) |
| | Sf3a2 | Splicing factor 3a subunit 2; RNA binding; zinc ion binding. It is involved in the biological process described with: positive regulation of gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome. (264 aa) |
| | mRpL20 | Mitochondrial ribosomal protein L20; rRNA binding; structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation; ribosomal large subunit assembly; Belongs to the bacterial ribosomal protein bL20 family. (150 aa) |
| | CG6833 | GH21710p; Nucleic acid binding; 3'-5' exonuclease activity; exonuclease activity. It is involved in the biological process described with: rRNA processing. (290 aa) |
| | Prp31 | Pre-mRNA processing factor 31 (Prp31) encodes a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development. (501 aa) |
| | Ran-like | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. (217 aa) |
| | CG12301 | LD31322p; It is involved in the biological process described with: rRNA processing; mushroom body development. (771 aa) |
| | CG7275 | LD28275p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (446 aa) |
| | l(3)72Ab | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2142 aa) |
| | CG33158 | Tr-type G domain-containing protein; GTPase activity; ribosome binding; GTP binding. It is involved in the biological process described with: mature ribosome assembly. (1033 aa) |
| | Pop5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (145 aa) |
| | CG7728 | LD38375p; GTP binding; U3 snoRNA binding; GTPase activity. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (1159 aa) |
| | CG5589 | Uncharacterized protein; RNA helicase activity; RNA binding; ATP binding. It is involved in the biological process described with: maturation of SSU-rRNA; Belongs to the DEAD box helicase family. (594 aa) |
| | Nufip | Nufip (Nufip) encodes an adaptor protein for the assembly of RiboNucleo-Particles (RNPs) such as the small nuclear RNP U4 (snRNP U4; part of the spliceosome) and the mRNPs encoding seleno-proteins. It is necessary for the biogenesis of the small nucleolar RNPs (snoRNPs). (511 aa) |
| | Gem2 | Protein Gemin2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. (245 aa) |
| | rept | RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (481 aa) |
| | CG9300 | LD21924p. (673 aa) |
| | Usp39 | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. (494 aa) |
| | CG5800 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. (826 aa) |
| | CG8611 | Probable ATP-dependent RNA helicase CG8611; Probable ATP-dependent RNA helicase. (975 aa) |
| | SNRPG | Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly. Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). (76 aa) |
| | DENR | Density-regulated protein homolog; Regulates translation as part of a complex with MCTS1. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR. (189 aa) |
| | mRpL22 | 39S ribosomal protein L22, mitochondrial; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; ribosome assembly; translation; Belongs to the universal ribosomal protein uL22 family. (233 aa) |
| | CG8939 | Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (817 aa) |
| | CG15916 | RH08992p; It is involved in the biological process described with: rRNA processing. (271 aa) |
| | CG8565 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. (790 aa) |
| | CG9123 | FI12409p; It is involved in the biological process described with: ribosome biogenesis; cell population proliferation. (434 aa) |
| | CG12608 | LD30439p; It is involved in the biological process described with: ribosomal large subunit biogenesis. (443 aa) |
| | CG10993 | GH23064p; RNA binding. It is involved in the biological process described with: small-subunit processome assembly; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (210 aa) |
| | Rtc1 | Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (384 aa) |
| | CG1463 | RE61595p; It is involved in the biological process described with: box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); snoRNA localization. (336 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | CG11583 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (356 aa) |
| | CG32262 | GH12661p; It is involved in the biological process described with: mitochondrial ribosome assembly; Belongs to the peroxisomal membrane protein PXMP2/4 family. (273 aa) |
| | CG32263 | Uncharacterized protein; It is involved in the biological process described with: mitochondrial ribosome assembly; Belongs to the peroxisomal membrane protein PXMP2/4 family. (206 aa) |
| | eIF1 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. (110 aa) |
| | CG16753 | LD46404p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (177 aa) |
| | CG9004 | Nucleolar MIF4G domain-containing protein 1 homolog; RNA binding. It is involved in the biological process described with: ribosomal small subunit biogenesis. (854 aa) |
| | CG13807 | IP04067p; RNA binding. It is involved in the biological process described with: RNA 5'-cap (guanine-N7)-methylation. (170 aa) |
| | hfp | Poly(U)-binding-splicing factor half pint; Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq. Belongs to the RRM half pint family. (637 aa) |
| | CG32344 | Helicase activity; RNA helicase activity; RNA binding; ATP binding. It is involved in the biological process described with: rRNA processing; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (827 aa) |
| | CG3594 | FI01540p; Nucleic acid binding; mRNA binding. (250 aa) |
| | Zfrp8 | Zinc finger protein RP-8 (Zfrp8) encodes a highly conserved protein essential for stem cell maintenance and fast proliferating cells such as cancer cells. It functions in the formation of mRNA ribonucleoprotein (mRNP) complexes. It may regulate the binding of specific mRNPs to the small ribosomal subunit, ultimately controlling their cytoplasmic localization and translation. (347 aa) |
| | eIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa) |
| | Rrp4 | Rrp4, isoform A; Rrp4 (Rrp4) encodes a protein involved in gene expression regulation. (298 aa) |
| | Fib | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gl [...] (344 aa) |
| | CG4038 | Probable H/ACA ribonucleoprotein complex subunit 1; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (237 aa) |
| | CG9344 | RE43665p; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (79 aa) |
| | CG7246 | RE67794p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (602 aa) |
| | CG6999 | CG6999; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (233 aa) |
| | CG32706 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly; defense response to bacterium; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (230 aa) |
| | CG32708 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (239 aa) |
| | l(1)G0020 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the tr [...] (1008 aa) |
| | CG1789 | Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (237 aa) |
| | CG1785 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit. Belongs to the NOP53 family. (478 aa) |
| | CG2260 | LD41718p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (609 aa) |
| | RpS14b | mRNA 5'-UTR binding; structural constituent of ribosome; small ribosomal subunit rRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation; ribosomal small subunit assembly; translation. (151 aa) |
| | RpS14a | 40S ribosomal protein S14a; Small ribosomal subunit rRNA binding; structural constituent of ribosome; mRNA 5'-UTR binding. It is involved in the biological process described with: cytoplasmic translation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation; ribosomal small subunit assembly; Belongs to the universal ribosomal protein uS11 family. (151 aa) |
| | bys | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. (436 aa) |
| | CG3198 | RH42690p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome; positive regulation of gene expression. (438 aa) |
| | MCTS1 | Malignant T-cell-amplified sequence 1 homolog; Regulates translation as part of a complex with DENR. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR. Belongs to the MCTS1 family. (182 aa) |
| | RpL35 | Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation. (123 aa) |
| | Pop1 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. (857 aa) |
| | Sas10 | Something about silencing 10 (Sas10) encodes a protein belonging to the SAS10 family. It might be a substrate of the RNA deaminase encoded by Adar, which shows an adenosine to inosine (A-to-I) deaminase activity in pre-mRNA transcripts. The noncoding strand of the adjacent gene, Rnp4F, reads through to form a duplex with Sas10 transcripts at their 3'-end to target both transcripts for promiscuous A-to-I editing and degradation. (428 aa) |
| | CG3527 | Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfamil [...] (252 aa) |
| | CG2875 | LD21615p; It is involved in the biological process described with: ribosome biogenesis. (497 aa) |
| | Nmd3 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (521 aa) |
| | kz | Probable ATP-dependent RNA helicase kurz; Helicase activity; RNA binding; ATP binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (1192 aa) |
| | crn | Crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis; Belongs to the crooked-neck family. (702 aa) |
| | CG3071 | LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I. (535 aa) |
| | CG14805 | FI20216p1; It is involved in the biological process described with: regulation of DNA-dependent DNA replication initiation; rRNA processing. (506 aa) |
| | sta | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development. Belongs to the universal ribosomal protein uS2 family. (270 aa) |
| | CG11417 | EG:8D8.4 protein; RNA binding. It is involved in the biological process described with: rRNA processing. (771 aa) |
| | su(w[a]) | Protein suppressor of white apricot; Regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). Regulates its own expression at the level of RNA processing. (963 aa) |
| | CG33217 | RE15216p. (699 aa) |
| | AGO2 | Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily. (1217 aa) |
| | RpL23A | Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. (277 aa) |
| | CG4901 | RE48269p; CG4901 encodes an ATP-dependent RNA helicase involved in neurogenesis and spliceosomal complex disassembly. (694 aa) |
| | RpL26 | Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. (149 aa) |
| | l(3)07882 | Nucleolar protein 14 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (852 aa) |
| | CG12320 | Uncharacterized protein, isoform A; It is involved in the biological process described with: spliceosomal tri-snRNP complex assembly. (379 aa) |
| | CG6841 | LD04472p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; regulation of alternative mRNA splicing, via spliceosome. (931 aa) |
| | CG40813 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (213 aa) |
| | eIF3a | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1140 aa) |
| | pit | Probable ATP-dependent RNA helicase pitchoune; Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis. (680 aa) |
| | Rbm13 | Protein MAK16 homolog; It is involved in the biological process described with: maturation of LSU-rRNA; maturation of 5.8S rRNA; Belongs to the MAK16 family. (343 aa) |
| | Rrp6 | Rrp6, isoform B; Rrp6 (Rrp6) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion and mRNA surveillance. (900 aa) |
| | Rpp20 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity). (167 aa) |
| | CG12325 | LD10780p; It is involved in the biological process described with: ribosomal small subunit assembly; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (949 aa) |
| | Rrp40 | Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. (232 aa) |
| | CG7564 | LD04387p; mRNA binding. It is involved in the biological process described with: mRNA splice site selection; mRNA splicing, via spliceosome. (420 aa) |
| | RpL5 | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa) |
| | CG9666 | LD25448p2; Methyltransferase activity; nucleic acid binding. It is involved in the biological process described with: methylation. (213 aa) |
| | Rrp45 | Rrp45, isoform A; AU-rich element binding. (412 aa) |
| | RpL7 | 60S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (252 aa) |
| | eIF4H1 | Nucleic acid binding; translation initiation factor activity; mRNA binding. It is involved in the biological process described with: translational initiation. (388 aa) |
| | CG13096 | Ribosomal L1 domain-containing protein CG13096; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA; Belongs to the universal ribosomal protein uL1 family. Highly divergent. (681 aa) |
| | CG7102 | LD40565p; It is involved in the biological process described with: spliceosomal snRNP assembly. (515 aa) |
| | RpS28b | 40S ribosomal protein S28; Structural constituent of ribosome. It is involved in the biological process described with: ribosomal small subunit assembly; translation; maturation of SSU-rRNA; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS28 family. (65 aa) |
| | RpL7A | Ribosomal protein L7A (RpL7A) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL8 family. (271 aa) |
| | CG6379 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. (788 aa) |
| | RpS5a | Ribosomal protein S5a (RpS5a) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS7 family. (228 aa) |
| | CG3735 | Uncharacterized protein, isoform A; U3 snoRNA binding; rRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (700 aa) |
| | RpS16 | 40S ribosomal protein S16; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation; translation; Belongs to the universal ribosomal protein uS9 family. (148 aa) |
| | Rrp47 | Ribosomal RNA processing 47, isoform A; RNA binding; DNA binding. It is involved in the biological process described with: maturation of 5.8S rRNA; regulation of gene expression. (159 aa) |
| | CG1662 | GH06679p; It is involved in the biological process described with: mitochondrial ribosome assembly; Belongs to the peroxisomal membrane protein PXMP2/4 family. (245 aa) |
| | CG2972 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (472 aa) |
| | RpS19a | Ribosomal protein S19a (RpS19a) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS19 family. (156 aa) |
| | Ns3 | Large subunit GTPase 1 homolog; GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control. (606 aa) |
| | LTV1 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor (LTV1) encodes a protein involved in pre-rRNA processing that is required for the proper biogenesis of the 40S ribosome. LTV1 product is a direct transcriptional target of Myc, thus it is critical for cell growth and survival. (493 aa) |
| | CG44249 | RRM domain-containing protein; mRNA binding; nucleic acid binding; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: DNA metabolic process; DNA catabolic process, exonucleolytic; mRNA splicing, via spliceosome; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (407 aa) |
| | Snp | Snipper, isoform D; Snipper (Snp) encodes a non-essential exonuclease in the DnaQ-H family. (281 aa) |
| | eIF2gamma | Eukaryotic translation initiation factor 2 subunit 3; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cataly [...] (475 aa) |
| | hoip | NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa) |
| | l(2)09851 | Lethal (2) 09851, isoform A. (456 aa) |
| | RpS21 | 40S ribosomal protein S21; May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva. (83 aa) |
| | RpL38 | Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (70 aa) |
| | FBXO11 | F-box protein 11 (FBXO11) encodes a subunit of a SCF-like E3 ubiquitin ligase involved in gene silencing mediated by both siRNAs and miRNAs.s. (1182 aa) |
| | RpLP0 | 60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (317 aa) |
| | Gem3 | Gemin3, isoform A; Gemin 3 (Gem3) encodes an RNA helicase and a member of the SMN-Gemins complex. It is a component of the cytoplasmic U snRNP body and nuclear gems. It is required in the motor system for viability, neuromuscular junction development and motor behaviour. (1028 aa) |
| | CG6769 | LD10434p; Nucleic acid binding; zinc ion binding. It is involved in the biological process described with: ribosomal large subunit biogenesis. (409 aa) |
| | RpL10 | 60S ribosomal protein L10; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal large subunit assembly; cytoplasmic translation. (218 aa) |
| | l(3)72Dn | Lethal (3) 72Dn, isoform B; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (699 aa) |
| | NHP2 | H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (160 aa) |
| | Hsp83 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] (717 aa) |
| | Nopp140 | Nopp140, isoform E; Nopp140 (Nopp140) encodes a nucleolar and Cajal body protein. It is predicted to function as a chaperone in the assembly of small nucleolar ribonucleoprotein particles within Cajal bodies, their transit to nucleoli, and their association with pre-ribosomal RNA within nucleolar dense fibrillar regions. (773 aa) |
| | CG11030 | FI04466p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (332 aa) |
| | Sf3b1 | Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome. (1340 aa) |
| | mRpS7 | 28S ribosomal protein S7, mitochondrial; Structural constituent of ribosome; rRNA binding; mRNA binding. It is involved in the biological process described with: mitochondrial translation; translation; ribosomal small subunit assembly; Belongs to the universal ribosomal protein uS7 family. (218 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | Ip259 | Intronic protein 259, isoform A; It is involved in the biological process described with: maturation of LSU-rRNA; maturation of 5.8S rRNA. (259 aa) |
| | SRPK | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa) |
| | bru3 | Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. (422 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | CG10903 | RE22146p; rRNA (guanine) methyltransferase activity. It is involved in the biological process described with: rRNA (guanine-N7)-methylation. (276 aa) |
| | Rpb4 | DNA-directed RNA polymerase II subunit Rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G. (139 aa) |
| | CG13185 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5526 aa) |
| | armi | Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...] (1188 aa) |
| | CG4022 | LD09868p; It is involved in the biological process described with: rRNA processing; box C/D snoRNP assembly. (531 aa) |
| | Srpk79D | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. (1018 aa) |
| | AGO1 | Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa) |
| | bru2 | Bruno 2, isoform E; RNA binding; mRNA binding. It is involved in the biological process described with: negative regulation of translation; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome. (893 aa) |
| | l(2)k09848 | Lethal (2) k09848, isoform A; It is involved in the biological process described with: muscle cell cellular homeostasis; ribosomal large subunit biogenesis. (419 aa) |
| | mtTFB1 | Dimethyladenosine transferase 1, mitochondrial; Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. In contrast to mtTFB2, it does not have a critical role in either transcription or regulation of the copy number of mitochondrial DNA. (330 aa) |
| | Nop60B | H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis; Belongs to the pseudouridine synthase TruB family. (508 aa) |
| | Non1 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (652 aa) |
| | hyx | Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. (538 aa) |
| | CG7544 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA). Belongs to the methyltransferase superfamily. METTL16/RlmF family. (305 aa) |
| | Nsun5 | Nop2/Sun-like domain containing protein 5 (Nsun5) encodes a protein predicted to catalyze the m5C-methylation of 28S ribosomal RNA. Nsun5 loss leads to increased lifespan and heat shock resistance; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (433 aa) |
| | CG41562 | MIP26132p1; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (213 aa) |
| | RpL7-like | Ribosomal protein L7-like, isoform A; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation. (257 aa) |
| | RpS28-like | Ribosomal protein S28-like; Structural constituent of ribosome. It is involved in the biological process described with: ribosomal small subunit assembly; translation; maturation of SSU-rRNA; cytoplasmic translation. (76 aa) |
| | RpS8 | Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa) |
| | CG17768 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. (154 aa) |
| | U3-55K | U3 small nuclear riboprotein factor 55K; RNA binding; snoRNA binding; U3 snoRNA binding. It is involved in the biological process described with: rRNA processing. (484 aa) |
| | smid | Smallminded, isoform A; Preribosome binding; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of telomerase activity; ribosome biogenesis. (944 aa) |
| | eIF5 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). (464 aa) |
| | tra2 | Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] (264 aa) |
| | mRpS11 | Mitochondrial ribosomal protein S11; mRNA 5'-UTR binding; structural constituent of ribosome; small ribosomal subunit rRNA binding. It is involved in the biological process described with: ribosomal small subunit assembly; translation; mitochondrial translation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (200 aa) |
| | CG6686 | RE11167p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; positive regulation of gene expression; maturation of 5S rRNA. (970 aa) |
| | CG5033 | Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (784 aa) |
| | RpS7 | 40S ribosomal protein S7; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal small subunit biogenesis; cytoplasmic translation; rRNA processing; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa) |
| | CG11123 | RH42110p; RNA binding. (665 aa) |
| | drosha | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa) |
| | CG30349 | FI03455p. (620 aa) |
| | Mys45A | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (712 aa) |
| | Dbp45A | Probable ATP-dependent RNA helicase Dbp45A; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (521 aa) |
| | RpLP0-like | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (256 aa) |
| | CG1671 | LD47550p; U3 snoRNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (787 aa) |
| | CG12909 | CG12909 protein; DNA binding. It is involved in the biological process described with: rRNA processing; negative regulation of transcription by RNA polymerase II. (281 aa) |
| | CG7637 | H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the NOP10 family. (64 aa) |
| | nclb | Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I- elongation factor TFIIH. Acts as regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients. Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts. Not required for female germline stem cell [...] (459 aa) |
| | Prp8 | pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome. (2396 aa) |
| | SmF | Small ribonucleoprotein particle protein SmF (SmF) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmE and SNRPG. (88 aa) |
| | SmD3 | Small ribonucleoprotein particle protein SmD3 (SmD3) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. The product of SmD3 also has a function in germline specification, as it is required for localization of the product of osk to the posterior pole of the oocyte. (151 aa) |
| | CG8545 | LD11307p; RNA binding; rRNA (cytosine-C5-)-methyltransferase activity. It is involved in the biological process described with: maturation of LSU-rRNA; RNA methylation; rRNA base methylation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (891 aa) |
| | CG6220 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. (359 aa) |
| | fand | Pre-mRNA-splicing factor syf1 homolog; Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of it [...] (883 aa) |
| | CG12863 | Uncharacterized protein; Zinc ion binding; nucleic acid binding; rRNA (adenine-N6-)-methyltransferase activity. It is involved in the biological process described with: rRNA methylation. (437 aa) |
| | CG8204 | FI21960p1; It is involved in the biological process described with: snoRNA localization; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); box C/D snoRNP assembly. (143 aa) |
| | CG8414 | Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (995 aa) |
| | Rrp42 | IP10364p; AU-rich element binding. (296 aa) |
| | wcd | U3 small nucleolar RNA-associated protein 18 homolog; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function; Belongs to the WD repeat UTP18 family. (506 aa) |
| | RpS15 | Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation; Belongs to the universal ribosomal protein uS19 family. (148 aa) |
| | CG4866 | RE57564p; snoRNA binding; rRNA binding. It is involved in the biological process described with: rRNA processing. (181 aa) |
| | Ns2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (674 aa) |
| | Dcr-2 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa) |
| | P32 | CG6459 protein; P32 (P32) encodes an evolutionarily conserved mitochondrial protein that functions in presynaptic calcium signaling and neurotransmitter release as well as chromatin metabolism. (263 aa) |
| | HPS4 | Hermansky-Pudlak Syndrome 4 (HPS4) encodes a tethering factor that regulates gene silencing by small RNAs via endosomal trafficking. (858 aa) |
| | icln | Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...] (215 aa) |
| | rig | Rigor mortis (rig) encodes a component of the cytoplasmic U snRNP body and a member of the SMN-Gemins complex. It is required in the motor system for viability and motor behaviour. It also works as a nuclear receptor interacting protein required for ecdysone signalling during larval development. (1235 aa) |
| | CG11563 | MIP13505p1; RNA binding. It is involved in the biological process described with: ribosomal large subunit biogenesis. (207 aa) |
| | RpL6 | Ribosomal protein L6, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit assembly. (262 aa) |
| | CG1542 | Probable rRNA-processing protein EBP2 homolog; Required for the processing of the 27S pre-rRNA. Belongs to the EBP2 family. (307 aa) |
| | eIF4H2 | Translation initiation factor activity; nucleic acid binding; mRNA binding. It is involved in the biological process described with: translational initiation. (459 aa) |
| | RpS28a | Ribosomal protein S28a; Structural constituent of ribosome. It is involved in the biological process described with: ribosomal small subunit assembly; translation; wing disc development; maturation of SSU-rRNA; cytoplasmic translation. (64 aa) |
| | Slu7 | Pre-mRNA-splicing factor Slu7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (574 aa) |
| | eIF2D | Translation initiation factor activity. It is involved in the biological process described with: formation of translation preinitiation complex; ribosome disassembly; translational initiation. (563 aa) |
| | CG11837 | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. (306 aa) |
| | CG1646 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. (1066 aa) |
| | RpL34a | Ribosomal protein L34a, isoform A; Structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; ribosome biogenesis; cytoplasmic translation. (162 aa) |
| | CG14543 | RE68515p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (195 aa) |
| | RpS27 | 40S ribosomal protein S27; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation. (84 aa) |
| | RIOK2 | RIO kinase 2; Protein kinase activity; protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: positive regulation of glial cell proliferation; maturation of SSU-rRNA; protein phosphorylation. (538 aa) |
| | CG11858 | Peptidyl-prolyl cis-trans isomerase activity. (130 aa) |
| | CG11920 | FI08810p; snoRNA binding. It is involved in the biological process described with: rRNA processing. (298 aa) |
| | CG7006 | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa) |
| | CG5728 | LD41803p; RNA binding. It is involved in the biological process described with: mRNA processing; regulation of alternative mRNA splicing, via spliceosome. (1430 aa) |
| | RpS19b | 40S ribosomal protein S19b; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the eukaryotic ribosomal protein eS19 family. (155 aa) |
| | Dcr-1 | Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa) |
| | CG12499 | Uncharacterized protein; It is involved in the biological process described with: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (2059 aa) |
| | CG6937 | RRM domain-containing protein; mRNA binding; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (356 aa) |
| | Nop56 | Nucleolar KKE/D repeat protein; snoRNA binding. (496 aa) |
| | ppan | Protein Peter pan; Required for initiation of larval growth and normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Required for progression of normal oogenesis and maturation of some imaginal tissues into adult structures. (460 aa) |
| | Surf6 | Surfeit locus protein 6 homolog; Involved in a nucleolar function; Belongs to the SURF6 family. (324 aa) |
| | CG11447 | rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. (250 aa) |
| | snRNP-U1-C | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulat [...] (145 aa) |
| | Prp18 | Putative mRNA splicing factor; It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA splicing, via spliceosome; nuclear retention of unspliced pre-mRNA at the site of transcription. (340 aa) |
| | CG8064 | GH01043p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA. (922 aa) |
| | Non3 | Ribosome production factor 2 homolog; Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs; Belongs to the RPF2 family. (320 aa) |
| | Ns1 | Guanine nucleotide-binding protein-like 3 homolog; Nucleostemin 1 (Ns1) encodes a GTPase that is enriched in the peripheral granular components of nucleoli of most larval and adult cells. It is required for nucleolar release of the large ribosomal subunit. Depletion of the Ns1 product reduces viability of midgut imaginal island cells and ribosome abundance in polyploid cells; Belongs to the TRAFAC class YlqF/YawG GTPase family. (581 aa) |
| | Mat89Ba | Nucleolar protein 6; RNA binding. It is involved in the biological process described with: tRNA export from nucleus; rRNA processing; Belongs to the NRAP family. (1193 aa) |
| | CG10185 | WD_REPEATS_REGION domain-containing protein; It is involved in the biological process described with: rRNA processing; regulation of DNA-dependent DNA replication initiation. (1732 aa) |
| | CG4338 | Probable ribosome biogenesis protein CG4338; Probable pre-rRNA processing protein involved in ribosome biogenesis. (274 aa) |
| | Hsc70-4 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa) |
| | RpL10Aa | Ribosomal protein L10Aa (RpL10Aa) encodes a component of the large ribosomal subunit. It is likely a retrogene derived from RpL10Ab and, unlike RpL10Ab, the expression of RpL10Aa is low in most tissues/developmental stages but enriched in the adult testis. (216 aa) |
| | RpS5b | 40S ribosomal protein S5b; rRNA binding; structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the universal ribosomal protein uS7 family. (230 aa) |
| | CG3817 | RRP15-like protein; It is involved in the biological process described with: maturation of 5.8S rRNA; maturation of LSU-rRNA; Belongs to the RRP15 family. (276 aa) |
| | CG8461 | LD29276p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cleavage involved in rRNA processing. (244 aa) |
| | CG9799 | LD47749p; It is involved in the biological process described with: rRNA processing. (922 aa) |
| | CG7488 | GH26602p; rRNA binding; GTP binding; ribosomal small subunit binding. It is involved in the biological process described with: ribosomal small subunit assembly. (373 aa) |
| | CG10909 | IP10714p; rRNA methyltransferase activity; histone-glutamine methyltransferase activity; RNA binding. It is involved in the biological process described with: rRNA methylation; box C/D snoRNA 3'-end processing; histone glutamine methylation. (349 aa) |
| | mbo | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex. Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. (702 aa) |
| | RpL24-like | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity). (191 aa) |
| | CG14683 | Probable methyltransferase-like protein 15 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase. (356 aa) |
| | pont | RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (456 aa) |
| | mtTFB2 | Dimethyladenosine transferase 2, mitochondrial; Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Also regulates mitochondrial DNA copy number. Stimulates transcription independently of the methyltransferase activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. (452 aa) |
| | p23 | Uncharacterized protein CG16817; prostaglandin-E synthase activity; Hsp90 protein binding; chaperone binding. It is involved in the biological process described with: protein folding; positive regulation of small RNA loading onto RISC; chaperone-mediated protein complex assembly; Belongs to the p23/wos2 family. (184 aa) |
| | Rlb1 | Rlb1 protein; It is involved in the biological process described with: maturation of SSU-rRNA. (463 aa) |
| | RpL34b | Ribosomal protein L34b (RpL34b) encodes a ribosomal structural constituent. (168 aa) |
| | mRpL1 | Mitochondrial ribosomal protein L1; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA; translation; mRNA splicing, via spliceosome; maturation of SSU-rRNA; mitochondrial translation. (354 aa) |
| | CG9667 | RE31520p; RNA binding. It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA 3'-splice site recognition; mRNA splicing, via spliceosome. (272 aa) |
| | SmD2 | Small ribonucleoprotein particle protein SmD2 (SmD2) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD1. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (119 aa) |
| | CG10286 | GH12023p; Unfolded protein binding. It is involved in the biological process described with: ribosomal large subunit biogenesis; protein import into nucleus. (625 aa) |
| | CG10055 | Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs). (608 aa) |
| | CG9246 | Nucleolar complex protein 2 homolog; Histone binding; repressing transcription factor binding; transcription corepressor activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; ribosomal large subunit biogenesis; negative regulation of histone acetylation. (766 aa) |
| | Mpp6 | M-phase phosphoprotein 6, isoform A; It is involved in the biological process described with: maturation of 5.8S rRNA. (162 aa) |
| | CG9253 | FI20110p1; RNA binding; RNA helicase activity; ATP binding. It is involved in the biological process described with: rRNA processing; Belongs to the DEAD box helicase family. (507 aa) |
| | CG10341 | H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1/CG4038 to yield mature H/ACA snoRNPs complex (By similarity). (564 aa) |
| | Mtr4 | Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response. (1055 aa) |
| | l(2)34Fd | Lethal (2) 34Fd; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (721 aa) |
| | loqs | Loquacious, isoform B; Loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA. (465 aa) |
| | Nnp-1 | Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA; Belongs to the RRP1 family. (687 aa) |
| | CG6712 | Probable ribosome production factor 1; May be required for ribosome biogenesis. (394 aa) |
| | CG6724 | Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (420 aa) |
| | RluA-1 | RluA pseudouridine synthase 1 (RluA-1) encodes a pseudouridine synthase, an enzyme catalyzing the formation of the most abundant nucleoside modification of RNA, pseudouridine. (739 aa) |
| | RluA-2 | Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: defense response to Gram-negative bacterium; positive regulation of innate immune response; enzyme-directed rRNA pseudouridine synthesis. (547 aa) |
| | me31B | ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa) |
| | CG4364 | Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (627 aa) |
| | CG13097 | U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. (662 aa) |
| | emb | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. (1063 aa) |
| | SmE | Small ribonucleoprotein particle protein SmE (SmE) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmF and SNRPG. (94 aa) |
| | r2d2 | R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC. (311 aa) |
| | nop5 | CG10206-PA; snoRNA binding. It is involved in the biological process described with: rRNA processing. (511 aa) |
| | l(2)k09022 | HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (2096 aa) |
| | CG9107 | LD29822p; Nucleic acid binding. It is involved in the biological process described with: ribosomal small subunit assembly; rRNA processing. (266 aa) |
| | RpL35A | Ribosomal protein L35A; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit biogenesis. (157 aa) |
| | mRpL44 | Mitochondrial ribosomal protein L44; Ribonuclease III activity; double-stranded RNA binding; structural constituent of ribosome. It is involved in the biological process described with: RNA processing; primary miRNA processing; production of siRNA involved in RNA interference; mitochondrial translation; pre-miRNA processing. (321 aa) |
| | Tsr1 | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. (814 aa) |
| | CG12975 | Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both RNA and protein methyltransferases. (124 aa) |
| | mTerf3 | Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription (By similarity). Regulator of mitochondrial ribosome biogenesis and translation that is essential for development. Required for normal mitochondrial transcription and translation. Required for assembly of mitochondrial respiratory complexes and normal mitochondrial function. Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit. (354 aa) |
| | mbm | Mushroom body miniature (mbm) encodes a zinc finger containing protein that localizes in the nucleolus. It plays a role in ribosome biogenesis. (539 aa) |
| | Nle | Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family. (488 aa) |
| | dbe | KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development. (345 aa) |
| | Dbp21E2 | DEAD box protein 21E2 (Dbp21E2) encodes an essential protein and a member of a family of DEAD box RNA helicases. Photoreceptors lacking Dbp21E2 function show defects in rhodopsin biogenesis and the maintenance of photoreceptors, leading to cell degeneration. (536 aa) |
| | Secp43 | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. (336 aa) |
