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Mlp84B Mlp84B TpnC25D TpnC25D Mlp60A Mlp60A cher cher mbl mbl l(2)efl l(2)efl robo3 robo3 Pgk Pgk Gpdh1 Gpdh1 rhea rhea CG43897 CG43897 fln fln sls sls zormin zormin Smn Smn CG43707 CG43707 Zasp67 Zasp67 up up CG1674 CG1674 tmod tmod Dg Dg dia dia mask mask RyR RyR Msp300 Msp300 DAAM DAAM Lmpt Lmpt Mhc Mhc bt bt kon kon CG42319 CG42319 tn tn Unc-89 Unc-89 stv stv Dys Dys Zasp52 Zasp52 Lasp Lasp Tm1 Tm1 TBPH TBPH Zasp66 Zasp66 Gapdh1 Gapdh1 Arc1 Arc1 Tpi Tpi Pglym78 Pglym78 ball ball Ald1 Ald1 Mhcl Mhcl Act88F Act88F Mf Mf sals sals mib2 mib2 bsf bsf Psn Psn fliI fliI Prm Prm rols rols CG14207 CG14207 wupA wupA Chd64 Chd64 CG2113 CG2113 cpa cpa CG3630 CG3630 Actn Actn
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene fusions
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Mlp84BMuscle LIM protein at 84B (Mlp84B) encodes a muscle cytoskeletal protein found primarily at the Z-line boundary. It maintains muscle structural integrity and regulates actin bundling. (495 aa)
TpnC25DEnzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (149 aa)
Mlp60AMuscle LIM protein at 60A (Mlp60A) encodes a Zinc-ion binding protein, expressed strongly in the Z-band region of the sarcomere. It is involved in development and maintenance of the embryonic and flight muscles. (486 aa)
cherFilamin-A; Cheerio (cher) encodes a dimeric F-actin crosslinking protein of the filamin protein family. It functions to organize the F-actin cytoskeleton in multiple contexts including ovarian germline ring canals, migrating somatic cells, and neuronal growth cones. (2429 aa)
mblMuscleblind (mbl) encodes an RNA binding protein that regulates RNA metabolism at the levels of alternative splicing, transcript localization and miRNA and circRNA biogenesis. It contributes to terminal muscle, eye and neural differentiation. (956 aa)
l(2)eflProtein lethal(2)essential for life; Vital role in embryonic development; Belongs to the small heat shock protein (HSP20) family. (187 aa)
robo3Roundabout 3, isoform A. (1342 aa)
PgkPhosphoglycerate kinase (Pgk) encodes an enzyme involved in myoblast fusion; Belongs to the phosphoglycerate kinase family. (415 aa)
Gpdh1Glycerol-3-phosphate dehydrogenase 1 (Gpdh1) encodes a glycerol-3-phosphate dehydrogenase that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate. It is involved in triglyceride metabolism, response to hyperoxia and flight behavior. (360 aa)
rheaRhea, isoform B; Rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells. (2836 aa)
CG43897Uncharacterized protein, isoform M; Actin binding; muscle alpha-actinin binding. It is involved in the biological process described with: mesoderm development; muscle structure development; actin cytoskeleton organization. (1385 aa)
flnFlightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction. (182 aa)
slsTitin; Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. (18468 aa)
zorminZormin, isoform J; Zormin (zormin) encodes a protein found in the Z-disc and the M-line of muscles. It probably has a structural function. (3664 aa)
SmnSurvival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa)
CG43707Uncharacterized protein, isoform E. (2021 aa)
Zasp67Z band alternatively spliced PDZ-motif protein 67 (Zasp67) encodes a member of the Zasp protein family. It is expressed during pupal development and plays a role in adult muscle development, especially in myofibril assembly. (730 aa)
upTroponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere. (397 aa)
CG1674Uncharacterized protein, isoform L; Actin binding. It is involved in the biological process described with: positive regulation of actin filament bundle assembly. (905 aa)
tmodTropomodulin, isoform N; Tropomodulin (tmod) encodes an actin/tropomyosin-associated protein involved in Notch signaling regulation. (567 aa)
DgDystroglycan, isoform D; Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity. (1262 aa)
diaProtein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa)
maskAnkyrin repeat and KH domain-containing protein mask; Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. (4010 aa)
RyRRyanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa)
Msp300Muscle-specific protein 300 kDa (Msp300) encodes a Nesprin-like protein that is required for proper positioning of muscle nuclei, mitochondria, and neuromuscular junction. (13540 aa)
DAAMDishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons. (1463 aa)
LmptLimpet, isoform K; Zinc ion binding. It is involved in the biological process described with: defense response to fungus. (2147 aa)
MhcMyosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains. (1962 aa)
btBent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle. (8933 aa)
konKon-tiki, isoform B; Kon-tiki (kon) (also known as perdido) encodes a single transmembrane protein required to initiate muscle-tendon attachment in a group of embryonic and adult body muscles. kon mutants are embryonic lethal with rounded ventral longitudinal muscles. It concentrates at muscle attachment sites and genetically interacts with integrins. (2381 aa)
CG42319Uncharacterized protein, isoform E; Actin binding; muscle alpha-actinin binding. It is involved in the biological process described with: actin cytoskeleton organization; muscle structure development. (452 aa)
tnThin, isoform C; Thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. (1517 aa)
Unc-89Obscurin; Structural component of the muscle M line which is involved in assembly and organization of sarcomere. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable). (4218 aa)
stvStarvin, isoform E; Starvin (stv) encodes a BAG family member that binds heat shock proteins. It plays roles in somatic muscles and is involved in the chaperone pathway essential for muscle maintenance. It also acts as co-chaperone of Hsp70 proteins during recovery from stress, including cold stress. (635 aa)
DysDystrophin, isoforms A/C/F/G/H; Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane. (3598 aa)
Zasp52Z band alternatively spliced PDZ-motif protein 52 (Zasp52) encodes a member of the Zasp protein family. It is a scaffold protein that binds the product of Actn and localizes to muscle attachment sites and Z-discs in muscle cells, as well as localizing cortically in non-muscle cells. It plays a role in muscle development, especially in myofibril assembly. (2194 aa)
LaspLIM and SH3 domain protein Lasp; Lasp (Lasp) encodes a member of the nebulin family. It plays subtle roles in modulating the actin cytoskeleton in ovaries, testes, and muscles, by serving as a scaffold protein binding multiple partners, especially actin and myosin. In indirect flight muscles, it contributes to I-band and A-band architecture. (657 aa)
Tm1Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family. (711 aa)
TBPHTAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa)
Zasp66Z band alternatively spliced PDZ-motif protein 66 (Zasp66) encodes a scaffold protein that binds the product of Actn and localizes to Z-discs in muscle cells. It plays a role in muscle development, especially in myofibril assembly. (430 aa)
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa)
Arc1Activity-regulated cytoskeleton associated protein 1; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles. Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation. Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction. May play a role in energy balance: required for regulation of body fat b [...] (254 aa)
TpiTriose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production. (348 aa)
Pglym78Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa)
ballNucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] (599 aa)
Ald1Fructose-bisphosphate aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases). (363 aa)
MhclMyosin heavy chain-like, isoform B; Myosin heavy chain-like (Mhcl) encodes a protein that interacts with the product of rols during myoblast fusion; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
Act88FActin, indirect flight muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils; Belongs to the actin family. (376 aa)
MfMyofilin, isoform B; Myofilin (Mf) encodes a structural protein of muscular thick filaments, which may be needed for filament assembly. Alternative splicing of the gene, controlled by the product of salm, produces isoforms of varying size in thoracic muscles. (365 aa)
salsSarcomere length short (sals) encodes an actin binding protein that promotes sarcomeric actin filament elongation from pointed ends during muscle growth. (935 aa)
mib2Mind bomb 2 (mib2) encodes a protein required for regulating synaptic plasticity and memory formation and maintaining muscle integrity. (1049 aa)
bsfBicoid stability factor (bsf) encodes a member of the family of proteins containing the pentatricopeptide motif, an RNA binding domain. It is found in the cytoplasm, where it functions in mRNA stability and post-transcriptional control of gene expression, and in mitochondria, where it has multiple roles in gene expression. It acts at many stages of development, and is required for progression through oogenesis and viability. (1412 aa)
PsnPresenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa)
fliIProtein flightless-1; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development; Belongs to the villin/gelsolin family. (1256 aa)
PrmParamyosin, long form; Paramyosin (Prm) encodes a muscle protein found only in invertebrates. It dimerizes into a coiled-coil that occupies the interior of the thick filament. Its role is thought to be structural, although it can be phosphorylated and this is important for muscle function. (879 aa)
rolsRolling pebbles (rols) encodes a protein required for myoblast fusion in founder cells. it interacts with the membrane spanning Immunoglobulin superfamily protein encoded by kirre and with the product of Mhcl. (1900 aa)
CG14207RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. (192 aa)
wupAWings up A (wupA) encodes a cytoskeletal protein of the troponin complex of the muscle thin filament. It is involved in calcium-dependent regulation of muscle contraction, and in development of the embryonic heart, skeletal muscle and flight muscle It also contributes to non-muscle functions such as apico-basal polarity formation, nuclear division and maintenance of nuclear integrity. (269 aa)
Chd64Transgelin; Chd64 (Chd64) encodes a protein involved in the juvenile hormone mediated signaling pathway; Belongs to the calponin family. (188 aa)
CG2113LP16467p; Actin binding. It is involved in the biological process described with: positive regulation of DNA-binding transcription factor activity; positive regulation of Rho protein signal transduction; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II. (183 aa)
cpaCapping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis. (286 aa)
CG3630EG:152A3.3 protein; Actin binding. It is involved in the biological process described with: positive regulation of Rho protein signal transduction; positive regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated. (371 aa)
ActnAlpha-actinin, sarcomeric; Alpha actinin (Actn) encodes an actin cross-linking protein with muscle and non-muscle specific isoforms, which are produced by alternative spicing. The muscle isoform has a role in muscle development while the non-muscle isoform localizes to ovarian ring canals and has a role in cytoskeletal remodeling of follicle cells; Belongs to the alpha-actinin family. (917 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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