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| | tutl | Turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control; Belongs to the immunoglobulin superfamily. Turtle family. (1536 aa) |
| | armi | Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...] (1188 aa) |
| | Cdc42 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa) |
| | Calx | Na/Ca-exchange protein (Calx) encodes a Na-Ca exchanger involved in phototransduction and response to endoplasmic reticulum stress; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa) |
| | unc-13 | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa) |
| | Synj | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. (1218 aa) |
| | pod1 | Coronin; Pod1 (pod1) encodes a microtubule and actin filament binding protein involved in actin cytoskeleton reorganization and axon guidance; Belongs to the WD repeat coronin family. (1266 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | Shawl | Shaw-like, isoform C; Delayed rectifier potassium channel activity; voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; potassium ion transport; protein homooligomerization. (937 aa) |
| | futsch | Microtubule-associated protein futsch; During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by [...] (5495 aa) |
| | Appl | Amyloid-beta-like protein; During development, plays a role in the regulation of the neddylation pathway. Appl and APP-BP1 interact antagonistically during development; Belongs to the APP family. (890 aa) |
| | Mob4 | MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family. (227 aa) |
| | Dscam1 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. (2038 aa) |
| | Mical | [F-actin]-monooxygenase Mical; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin. Belongs to the Mical family. (4743 aa) |
| | Srpk79D | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. (1018 aa) |
| | fry | Protein furry; Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity. (3544 aa) |
| | Nrg | Neuroglian; The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. (1309 aa) |
| | rpk | Ripped pocket, isoform B; Ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. (568 aa) |
| | Imp | IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs. (638 aa) |
| | brp | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa) |
| | plum | Plum, isoform B; Plum (plum) encodes an Ig-superfamily transmembrane protein. It is required for developmental pruning of both mushroom body neurons and motor neurons via TGF-beta signaling. plum genetically interacts with myo and babo. (1298 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra. Belongs to the TRIM/RBCC family. (740 aa) |
| | Tao | Serine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa) |
| | DAAM | Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons. (1463 aa) |
| | Syx1A | Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Required for coordinated peristaltic contractions. Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens [...] (296 aa) |
| | Ptp99A | Protein tyrosine phosphatase 99A (Ptp99A) encodes a transmembrane receptor tyrosine phosphatase. Its single mutants have no known phenotypes, but Ptp99A synergizes with Ptp69D to increase the penetrance of the Ptp69D motor axon defects. Ptp99A mutations also suppress the 'bypass' motor axon phenotype produced by Lar mutations; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (1397 aa) |
| | Ank2 | Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. (13559 aa) |
| | CG42674 | Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of Rho protein signal transduction; imaginal disc-derived leg morphogenesis. (1661 aa) |
| | ReepB | Receptor expression-enhancing protein; It is involved in the biological process described with: regulation of intracellular transport; endoplasmic reticulum tubular network organization; endoplasmic reticulum organization. (178 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | NetB | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. (793 aa) |
| | Ptp4E | Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. (1767 aa) |
| | Rtnl1 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. (607 aa) |
| | jar | Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (1268 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | CG7166 | IP11255p; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (467 aa) |
| | Nedd4 | E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa) |
| | mnb | Minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa) |
| | CaMKII | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. (531 aa) |
| | Eb1 | Eb1, isoform F; Eb1 (Eb1) encodes a microtubule end-binding protein that contributes to organization of the microtubule cytoskeleton. It is involved in chromosome segregation, wound healing and flight behavior. (297 aa) |
| | Gr66a | Gustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa) |
| | Gr2a | Putative gustatory receptor 2a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (428 aa) |
| | Pldn | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, plays a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes. (167 aa) |
| | Gr93b | Putative gustatory receptor 93b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (395 aa) |
| | Shaw | Shaker cognate w (Shaw) encodes a voltage-gated potassium channel (Kv3.1) that mediates a non-inactivating potassium current open at resting membrane potential. It is important for controlling excitability of motor neurons and clock neurons. It regulates circadian rhythms and is in a pathway with the product of qsm and Na[+] K[+] Ca[2+] Co-transporter. (619 aa) |
| | ena | Enabled (ena) encodes the sole Drosophila member of the Ena/VASP family. It acts as a processive actin polymerase, stimulating actin addition at the barbed end. It has roles in both epithelial morphogenesis and CNS pathfinding. (980 aa) |
| | Fak | Focal adhesion kinase (Fak) encodes a non-Receptor Tyrosine kinase (nRTK) that is involved in signaling and cytoskeletal dynamics integrating signals from RTKs and integrins. Its function has been described in multiple contexts including embryonic muscle attachement, morphogensis of the optic stalk, synaptic growth and transmission, and in the regulation of RTK-MAP kinase signaling in epithelia. (1500 aa) |
| | Gr63a | Gustatory and odorant receptor 63a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. (489 aa) |
| | prt | Portabella (prt) encodes an orphan vesicular transporter expressed in a discrete number of cells in larvae and adults, including Kenyon cells of the mushroom bodies. prt depletion produces male mating behavior defects and a modest learning deficit. (602 aa) |
| | nudE | Nuclear distribution protein nudE homolog; nudE (nudE) encodes a conserved protein that localizes to kinetochores and spindle microtubules. It contributes to the spindle checkpoint, spindle orientation, centrosome behavior and dendrite morphogenesis. (377 aa) |
| | Snap25 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. (212 aa) |
| | Syn | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa) |
| | CadN | Neural-cadherin; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information. (3101 aa) |
| | Gr22b | Putative gustatory receptor 22b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds. (386 aa) |
| | Vmat | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa) |
| | cact | NF-kappa-B inhibitor cactus; Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation. (500 aa) |
| | Gr28b | Putative gustatory receptor 28b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (470 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | arm | Armadillo segment polarity protein; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha- catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. Belongs to the beta-catenin family. (843 aa) |
| | gukh | GUK-holder, isoform A; GUK-holder (gukh) encodes a protein that regulates spindle orientation in neuroblasts via direct interaction with microtubules and the tumor suppressors encoded by dlg1 and scrib. It also plays a role in polarizing fate determinants, such as the product of mira. (1788 aa) |
| | Gr89a | Putative gustatory receptor 89a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr77a subfamily. (362 aa) |
| | chb | CLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...] (1491 aa) |
| | ChAT | Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. (721 aa) |
| | metro | Menage a trois (metro) encodes controls the expansion of larval neuromuscular junctions (NMJs) and the proper establishment of synaptic boutons. At NMJs Metro associates with the adaptor protein encoded by veli to stabilize the product of dlg1 in a trimeric scaffold complex that limits the size of active zones and glutamate receptor fields; Belongs to the MAGUK family. (595 aa) |
| | Gr47b | Putative gustatory receptor 47b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (414 aa) |
| | otk | Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (1033 aa) |
| | fra | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. (1526 aa) |
| | shot | Short stop (shot) encodes a member of the spectraplakin family of large cytoskeletal linker molecules. It binds both actin and microtubules, as well as scaffold proteins, certain signalling factors and calcium. It plays developmental and maintenance roles in the nervous system, the epidermis, at muscle attachments, the foregut, the wing, tracheae and oocytes. (8805 aa) |
| | Prosap | Prosap, isoform A; Prosap (Prosap) encodes a member of SH3 and multiple ankyrin repeat domain (SHANK) family of genes that encode synaptic scaffolding proteins. It regulates synaptic growth and development, including the structure of the neuromuscular junction and synapses of the calyx, and olfactory acuity. (1871 aa) |
| | Khc | Kinesin heavy chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. (975 aa) |
| | unc-104 | Kinesin-like protein unc-104; Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (1739 aa) |
| | Cbp53E | Calbindin-32; Calbindin 53E (Cbp53E) encodes a 6 EF-hand domain-containing protein that regulates neuronal development. (310 aa) |
| | CG6805 | LD06095p; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. It is involved in the biological process described with: positive regulation of flagellated sperm motility; phosphatidylinositol dephosphorylation; inositol phosphate dephosphorylation. (357 aa) |
| | stau | Maternal effect protein staufen; RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis. In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior- posterior patterning of the developing embryo. Association with osk or bcd at their respective poles, appears to promote the formation and stabilization o [...] (1026 aa) |
| | Gr57a | Putative gustatory receptor 57a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (416 aa) |
| | Rab2 | Rab2, isoform A; Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. (213 aa) |
| | hdc | Headcase short protein; Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function. (1080 aa) |
| | Apc | APC-like, isoform A; APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. (2417 aa) |
| | Gr98d | Putative gustatory receptor 98d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (412 aa) |
| | Gr98c | Putative gustatory receptor 98c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (408 aa) |
| | Gr98b | Putative gustatory receptor 98b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (403 aa) |
| | Gr98a | Putative gustatory receptor 98a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (391 aa) |
| | spas | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa) |
| | CG33111 | FI03658p. (515 aa) |
| | Gr94a | Putative gustatory receptor 94a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (404 aa) |
| | klg | LD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. (545 aa) |
| | Gr93c | Putative gustatory receptor 93c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (397 aa) |
| | Gr93d | Gustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (381 aa) |
| | Gr93a | Gustatory receptor for bitter taste 93a; Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (419 aa) |
| | Burs | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. (173 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | Sec15 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (766 aa) |
| | Rab11 | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa) |
| | Gr92a | Putative gustatory receptor 92a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (386 aa) |
| | psidin | Phagocyte signaling-impaired protein; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body. Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response. (948 aa) |
| | VAChT | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa) |
| | Past1 | Putative Achaete Scute Target 1 (Past1) encodes a protein that associates predominantly with the plasma membrane and genetically interacts with N. It contributes to endocytosis, male sterility, temperature sensitivity, life span and differentiation of photoreceptors R1/R6/R7 and cone cells; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | Cpn | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. (864 aa) |
| | Syt4 | Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. (474 aa) |
| | Gr39b | Putative gustatory receptor 39b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Has also atypical sensory function in organ not limited to conventional taste sensing like abdominal ganglions. (369 aa) |
| | Gr39a | Gustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa) |
| | Ret | Ret oncogene (Ret) encodes a cell surface receptor mediating dendrite development of class IV dendritic arborization sensory neurons. It interacts with integrins and mediates rac1 signaling to promote dendrite adhesion to the extracellular matrix; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1235 aa) |
| | CarT | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (674 aa) |
| | sNPF | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa) |
| | Catsup | Protein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (449 aa) |
| | dl | Embryonic polarity protein dorsal; Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage. A morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'- GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in larvae. Part of a signaling pathway involving NF- kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition [...] (999 aa) |
| | CLIP-190 | Restin homolog; Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization. (1690 aa) |
| | Gr36c | Putative gustatory receptor 36c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa) |
| | Gr36b | Putative gustatory receptor 36b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (391 aa) |
| | Gr36a | Putative gustatory receptor 36a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily. (391 aa) |
| | Gr33a | Gustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa) |
| | Gr32a | Gustatory and pheromone receptor 32a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily. (461 aa) |
| | Eaat1 | Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. (479 aa) |
| | Bsg | Basigin, isoform G; Basigin (Bsg) encodes an IgG family glycoprotein that promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. It contributes to photoreceptor cell morphogenesis, sarcomere organization and spermatid development. (648 aa) |
| | Gr28a | Putative gustatory receptor 28a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands. (450 aa) |
| | wg | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa) |
| | nrv2 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (323 aa) |
| | ihog | Interference hedgehog (ihog) encodes a type 1 membrane protein that acts as a co-receptor for the product of hh upstream or at the level of the receptor encoded by ptc. It interacts with the products of disp, dlp, dally and shf. It is involved in imaginal pattern formation and embryonic cuticle pattern formation. (886 aa) |
| | Cont | Contactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. (1390 aa) |
| | spartin | Protein spartin; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival. (553 aa) |
| | kra | Krasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2beta. It is involved in axon guidance, long-term memory, and alcohol addiction. (422 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | Sec8 | Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Involved in regulation of synaptic microtubule formation, and also regulation of synaptic growth and glutamate receptor trafficking. Does not appear to be required for basal neurotransmission. (985 aa) |
| | Gr77a | Putative gustatory receptor 77a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (449 aa) |
| | Psn | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa) |
| | Gr21a | Gustatory and odorant receptor 21a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr [...] (447 aa) |
| | Gr22f | Putative gustatory receptor 22f; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (378 aa) |
| | Gr22c | Putative gustatory receptor 22c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (383 aa) |
| | Gr22a | Putative gustatory receptor 22a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (394 aa) |
| | Gr22e | Gustatory receptor for bitter taste 22e; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons. (389 aa) |
| | Syt1 | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa) |
| | Gr23a | Gustatory receptor 23a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (374 aa) |
| | bdl | Borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection; Belongs to the immunoglobulin superfamily. (719 aa) |
| | Exo70 | Exocyst complex component 7; Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation. Belongs to the EXO70 family. (693 aa) |
| | SH3PX1 | Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family. (565 aa) |
| | Gr68a | Gustatory receptor 68a; Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the rele [...] (389 aa) |
| | Ptp69D | Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (1462 aa) |
| | Abp1 | Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family. (531 aa) |
| | DCTN1-p150 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa) |
| | dlp | Dally-like, isoform A; Dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg; Belongs to the glypican family. (765 aa) |
| | Nrt | Neurotactin; May mediate or modulate cell adhesion between embryonic cells during development; In the C-terminal section; belongs to the type-B carboxylesterase/lipase family. (846 aa) |
| | CG9279 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. (1339 aa) |
| | wnd | Wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons. (977 aa) |
| | gogo | Golden goal (gogo) encodes a transmembrane protein involved in axonal pathfinding, especially in axon-axon and axon-target interactions. (1272 aa) |
| | alphaSnap | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome. (292 aa) |
| | par-6 | Par-6, isoform A; Par-6 (par-6) encodes a scaffold protein that forms a complex with the products of baz and aPKC and with other cortical, cytoskeletal and regulatory proteins. It is involved in cell polarization, actin-based protrusion formation and tracheal branching. (351 aa) |
| | Efhc1.1 | EF-hand domain containing 1.1; It is involved in the biological process described with: regulation of neuron projection development; regulation of dendrite morphogenesis; synaptic growth at neuromuscular junction. (793 aa) |
| | Lrp4 | LDL receptor related protein 4 (Lrp4) encodes a type I transmembrane protein that is enriched in presynaptic terminals and regulates synaptic organization in the olfactory circuit. (2009 aa) |
| | Scamp | Secretory carrier-associated membrane protein; It is involved in the biological process described with: neuromuscular synaptic transmission; synaptic vesicle exocytosis; protein transport; long-term memory. (343 aa) |
| | g | AP-3 complex subunit delta; Garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color. (1034 aa) |
| | comt | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. (745 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | Gr10b | Putative gustatory receptor 10b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily. (373 aa) |
| | mas | Protein masquerade; In embryogenesis, has a role in somatic muscle attachment and in the development of axonal pathways probably by stabilizing cell- matrix adhesion and/or by acting as a competitive antagonist of serine proteases. (1047 aa) |
| | Sac1 | Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance. (592 aa) |
| | trio | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. (2263 aa) |
| | Aplip1 | JNK-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). (490 aa) |
| | gek | Serine/threonine-protein kinase Genghis Khan; Acts as a downstream effector for the regulation of actin polymerization by Cdc42. (1637 aa) |
| | Gr59e | Putative gustatory receptor 59e; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (399 aa) |
| | Gr59f | Putative gustatory receptor 59f; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (406 aa) |
| | Gr59c | Putative gustatory receptor 59c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (397 aa) |
| | Gr59d | Putative gustatory receptor 59d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa) |
| | Gr59b | Gustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (366 aa) |
| | Gr59a | Gustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (367 aa) |
| | wrapper | GH03113p; Wrapper (wrapper) encodes a protein involved in axon ensheathment and glial apoptosis. (500 aa) |
| | Vps35 | Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles. (822 aa) |
| | Gr58b | Putative gustatory receptor 58b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (408 aa) |
| | Gr58a | Putative gustatory receptor 58a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (395 aa) |
| | Magi | Magi, isoform A; Magi (Magi) encodes a molecular scaffolding protein that is involved in adherens junction (AJ) organization. Magi is ubiquitously expressed and its product localizes at AJ with the Par polarity complex. (1202 aa) |
| | Atg8a | Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan. (121 aa) |
| | Gr9a | Putative gustatory receptor 9a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (341 aa) |
| | Gr8a | Gustatory receptor 8a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing and avoiding L-canavanine, a plant-derived insecticide. (385 aa) |
| | Grip | Glutamate receptor binding protein (Grip) encodes a protein involved in muscle attachment and synapse organization. (1058 aa) |
| | fzr | Fizzy-related, isoform A; Fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. (478 aa) |
| | Con | Connectin; Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion. (691 aa) |
| | mtg | Mind the gap (mtg) encodes a protein involved in synapse assembly. (556 aa) |
| | Gr22d | Gustatory receptor 22d (Gr22d) encodes a transmembrane domain protein unrelated to GPCRs that is predicted to mediate response to non-volatile compounds. (387 aa) |
| | pyd | Polychaetoid, isoform O; Polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two; Belongs to the MAGUK family. (2395 aa) |
| | Rop | Protein ROP; May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein. (597 aa) |
| | robo2 | Roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts. (1519 aa) |
| | kek6 | Kekkon 6, isoform B; Neurotrophin binding; neurotrophin receptor activity. It is involved in the biological process described with: regulation of synaptic plasticity. (843 aa) |
| | unc80 | Protein unc-80 homolog; Component of the na (narrow abdomen) sodium channel complex. In the circadian clock neurons it functions with na and unc79 to promote circadian rhythmicity; Belongs to the unc-80 family. (3332 aa) |
| | Abl | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. (1723 aa) |
| | Dab | Disabled (Dab) encodes an adaptor protein that is a core component of the Abl tyrosine kinase signaling pathway. It associates with transmembrane receptors including those encoded by N and Appl. It is involved in axon patterning, embryo morphogenesis and trafficking in endocytosis, exocytosis and Golgi organization. (2360 aa) |
| | erm | Fez family zinc finger protein erm; Zinc-finger transcriptional repressor. In larval brain, involved in the maintenance of cell fate of intermediate neural progenitors (INPs) that derive from type II neuroblasts. Restricts INP developmental potential and dedifferentiation by interacting with HDAC3 and the chromatin remodeling Brahma-associated protein (BAP) complex. Restricts INP proliferation by regulating neuroblast specific factors such as prospero, pnt and grh, and by antagonizing the function of self-renewal factors, such as klu, dpn and E(spl)mgamma-HLH. In the optic lobe, essent [...] (698 aa) |
| | drl | Tyrosine-protein kinase Drl; Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non- vital for development. May be part of a signal transduction cascade involved in learning and possibly memory. (645 aa) |
| | Dscam3 | Down syndrome cell adhesion molecule 3 (Dscam3) encodes a large transmembrane protein that functions in homophilic cell adhesion. It may also function as an axon guidance receptor. (2087 aa) |
| | par-1 | Par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. (1170 aa) |
| | sky | GTPase-activating protein skywalker; GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads [...] (607 aa) |
| | Dscam2 | Down syndrome cell adhesion molecule 2 (Dscam2) encodes a transmembrane protein. Its alternative splicing produces two biochemically distinct homophilic binding proteins expressed in different cells. It can mediate both repulsion and adhesion between neurons and contributes to boundary formation, neurite targeting and synapse formation in the brain. (2101 aa) |
| | CASK | Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa) |
| | Ptp10D | Protein tyrosine phosphatase 10D (Ptp10D) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp10D regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. It also binds to the product of sas to regulate its signaling in glia. (1990 aa) |
| | Rab3-GEF | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. (2154 aa) |
| | CG9784 | Uncharacterized protein, isoform C; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. It is involved in the biological process described with: positive regulation of flagellated sperm motility; phosphatidylinositol dephosphorylation; inositol phosphate dephosphorylation. (519 aa) |
| | sli | Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. (2157 aa) |
| | Lar | Tyrosine-protein phosphatase Lar; Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl. Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function. (2032 aa) |
| | nSyb | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa) |
| | Cdk5alpha | Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration. (472 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | Alk | Anaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb. (1701 aa) |
| | trc | Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...] (463 aa) |
| | Dhc64C | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. (4661 aa) |
| | Acsl | Acyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa) |
| | jeb | Jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. (560 aa) |
| | PsGEF | Protostome-specific GEF, isoform E. (2777 aa) |
| | Dscam4 | Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system. (1935 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | Unc-76 | Unc-76, isoform A; Unc-76 (Unc-76) encodes a kinesin binding protein involved in axo-dendritic transport. (474 aa) |
| | Rdl | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. (608 aa) |
| | path | Proton-coupled amino acid transporter-like protein pathetic; Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in a cell- autonomous manner for dendrite growth in neurons with large dendrite arbors. (471 aa) |
| | drpr | Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] (1042 aa) |
| | Mkk4 | MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. (424 aa) |
| | beta-Spec | Beta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. (2308 aa) |
| | EndoA | Endophilin-A; Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes. (369 aa) |
| | Efa6 | PH and SEC7 domain-containing protein; Guanine nucleotide exchange factor for Arf6. Regulates axon growth and branching by inhibiting microtubule polymerisation at the cortex. Together with shot, promotes axonal microtubule bundle integrity. Required for normal ethanol-induced tolerance and preference. Probably by activating Arf6, counteracts ethanol-induced sedation. (1601 aa) |
| | Nrx-1 | Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function. (1847 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | Synd | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa) |
| | boi | Brother of ihog (boi) encodes a transmembrane protein that binds to the product of hh. The products of boi and ihog promote Hh signaling in receiving cells by acting as a co-receptor for the effector protein encoded by ptc. The product of boi also can suppress Hh signaling through a sequestration and release mechanism in cells producing the product of hh. It regulates many hh-dependent processes including proliferation, cell fate specification, and patterning. (1105 aa) |
| | robo3 | Roundabout 3, isoform A. (1342 aa) |
| | CG44153 | Uncharacterized protein, isoform A; G protein-coupled receptor activity; cell-cell adhesion mediator activity. It is involved in the biological process described with: axon guidance; dendrite self-avoidance; homophilic cell adhesion via plasma membrane adhesion molecules. (1946 aa) |
| | cpx | Complexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release; Belongs to the complexin/synaphin family. (157 aa) |
| | CG34353 | Uncharacterized protein, isoform C; Axon guidance receptor activity. It is involved in the biological process described with: gravitaxis; synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (581 aa) |
| | Arl8 | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. (186 aa) |
| | Nak | Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization. (1488 aa) |
| | rad | Radish, isoform I; Radish (rad) encodes a protein involved in anesthesia-resistant memory and heart contraction regulation. (1799 aa) |
| | X11L | X11L, isoform F; X11L (X11L) encodes a scaffolding protein that is important for eye development. It interacts with the products of rst and Appl and is required for targeting several proteins to cell membranes. (1170 aa) |
| | Sdc | Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction. (495 aa) |
| | CG13506 | FI23916p1; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (503 aa) |
| | robo1 | Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development. (1395 aa) |
| | CG13531 | Uncharacterized protein, isoform B; It is involved in the biological process described with: synaptic vesicle transport; chemical synaptic transmission; axo-dendritic transport; axon extension. (1815 aa) |
| | fusl | Fuseless, isoform A; Fuseless (fusl) encodes a protein involved in the clustering of voltage-gated calcium channels and the exocytosis of calcium-dependent synaptic vesicles. (453 aa) |
| | kcc | Kazachoc, isoform G; Kazachoc (kcc) encodes a potassium:chloride symporter that contributes to seizure susceptibility. (1077 aa) |
| | SerT | Sodium-dependent serotonin transporter; Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (622 aa) |
| | Bace | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. (372 aa) |
| | Fas2 | Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa) |
| | Ser | Protein serrate; Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues. (1407 aa) |
| | ringer | Tubulin polymerization-promoting protein homolog; Regulator of microtubule required for axonal extension during embryonic development. Promotes microtubule bundling and polymerization. Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules ; Belongs to the TPPP family. (192 aa) |
| | tau | Microtubule-associated protein; Microtubule binding. It is involved in the biological process described with: neuron projection development; rhabdomere morphogenesis; negative regulation of neuron death; microtubule cytoskeleton organization. (717 aa) |
| | na | Narrow abdomen, isoform F; Narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. (2233 aa) |
| | Gr43a | Gustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa) |
| | Csp | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa) |
| | Gr97a | Putative gustatory receptor 97a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (425 aa) |
| | ple | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. (579 aa) |
| | ckn | Caskin, isoform B; Caskin (ckn) encodes a cytoplasmic adaptor protein that intreacts with the products of Lar and dock. It is required for axon growth and guidance. (924 aa) |
| | NetA | Netrin-A; Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. (726 aa) |
| | cup | Protein cup; Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localizat [...] (1117 aa) |
| | Ptth | Prothoracicotropic hormone, isoform F; Prothoracicotropic hormone (Ptth) encodes a secreted neuropeptide that regulates ecdysone production contributing to larval to pupal transition. It signals through Torso/RAS/Erk pathway. It also modulates larval light avoidance independently of ecdysone. (218 aa) |
| | Gr10a | Gustatory receptor 10a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (408 aa) |
| | orb2 | Translational regulator orb2; Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'- UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid- like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Isoform A is required for initial memory acquisition and, following subsequent late dopaminerg [...] (769 aa) |
