STRINGSTRING
Sar1 Sar1 AP-1mu AP-1mu Syt1 Syt1 Membrin Membrin wls wls fwe fwe BORCS5 BORCS5 Mctp Mctp Dop1R2 Dop1R2 VGlut VGlut nSyb nSyb Vti1b Vti1b Sec24AB Sec24AB Sec16 Sec16 p115 p115 Sec31 Sec31 Sec13 Sec13 Afti Afti Rph Rph AP-1gamma AP-1gamma Vti1a Vti1a Sec24CD Sec24CD Sec22 Sec22 Sec23 Sec23 unc-13 unc-13 AP-1sigma AP-1sigma Clc Clc prt prt Atet Atet Syn Syn Vmat Vmat Chc Chc Syx6 Syx6 Syngr Syngr VGAT VGAT VAChT VAChT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Sar1Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. (193 aa)
AP-1muAdaptor Protein complex 1, mu subunit (AP-1mu) encodes a clathrin adaptor involved in intracellular transport. It controls the trafficking of proteins, including the products of N and spdo. (426 aa)
Syt1Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa)
MembrinProbable Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa)
wlsProtein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa)
fweCalcium channel flower; Flower (fwe) encodes a transmembrane protein with different isoforms expressed in 'loser' and in 'winner' cells to mediate win/lose decisions in cell competition and neuronal culling during development and ageing. (194 aa)
BORCS5LD30509p; It is involved in the biological process described with: lysosome localization; organelle transport along microtubule; positive regulation of anterograde synaptic vesicle transport. (349 aa)
MctpMultiple C2 and transmembrane domain-containing protein; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. (982 aa)
Dop1R2Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa)
VGlutVesicular glutamate transporter, isoform A. (632 aa)
nSybNeuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa)
Vti1bVesicle transport through interaction with t-SNAREs 1b, isoform A; SNAP receptor activity; SNARE binding. (122 aa)
Sec24ABSecretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. (1184 aa)
Sec16Secretory 16 (Sec16) encodes a protein involved in the organization of endoplasmic reticulum exit sites. It contributes to stress response to amino-acid starvation, during which it mediates the formation of both Sec bodies and stress granules. (2326 aa)
p115General vesicular transport factor p115; Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae. Belongs to the VDP/USO1/EDE1 family. (836 aa)
Sec31Secretory 31 (Sec31) encodes a protein involved in the innate immune response. (1260 aa)
Sec13Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] (356 aa)
AftiAftiphilin, isoform E; Aftiphilin (Afti) encodes an AP-1 adaptor complex binding protein involved in eye photoreceptor development and intracellular transport. (1161 aa)
RphRabphilin, isoform A; Rab GTPase binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: synaptic vesicle exocytosis; exocytosis; intracellular protein transport; neurotransmitter secretion; vesicle-mediated transport. (638 aa)
AP-1gammaAdaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking. (982 aa)
Vti1aVesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. (230 aa)
Sec24CDSecretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. (1231 aa)
Sec22Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family. (213 aa)
Sec23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (781 aa)
unc-13Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa)
AP-1sigmaAP complex subunit sigma; Clathrin adaptor activity; clathrin binding; Belongs to the adaptor complexes small subunit family. (157 aa)
ClcClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (219 aa)
prtPortabella (prt) encodes an orphan vesicular transporter expressed in a discrete number of cells in larvae and adults, including Kenyon cells of the mushroom bodies. prt depletion produces male mating behavior defects and a modest learning deficit. (602 aa)
AtetABC transporter expressed in trachea (Atet) encodes a protein that is involved in transmembrane transport. (832 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
VmatVesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa)
ChcClathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa)
Syx6Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity. (339 aa)
SyngrSynaptogyrin (Syngr) encodes a synaptic vesicle protein implicated in vesicle endocytosis during the bulk endocytosis process. It is the sole Drosopohila homolog of the synaptophysin/synaptogryin synaptic vesicle family of proteins. (241 aa)
VGATVesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. (549 aa)
VAChTVesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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