STRINGSTRING
ntc ntc CG12402 CG12402 RYBP RYBP CG4911 CG4911 CG13766 CG13766 CG43089 CG43089 CG30466 CG30466 Kdm2 Kdm2 FBXO11 FBXO11 CG15412 CG15412 Ppa Ppa CG8272 CG8272 slmb slmb CG4042 CG4042 dmpd dmpd Cul4 Cul4 CG32221 CG32221 CG34025 CG34025 CG12520 CG12520 CG9003 CG9003 SkpA SkpA CG33969 CG33969 Cul1 Cul1 Fbl6 Fbl6 SkpB SkpB Fsn Fsn fsd fsd CG11044 CG11044 Cul2 Cul2 FipoQ FipoQ CG5003 CG5003 CG14317 CG14317 CG14891 CG14891 Fbxl7 Fbxl7 CG5961 CG5961 CG9316 CG9316 CG13085 CG13085 CG14937 CG14937 CG13088 CG13088 Rca1 Rca1 CG31633 CG31633 Fbw5 Fbw5 jet jet Skp2 Skp2 CG7148 CG7148 morgue morgue pall pall CG32085 CG32085 CG11658 CG11658 Cul6 Cul6 CG7707 CG7707 SkpE SkpE SkpC SkpC SkpD SkpD Fbxl4 Fbxl4 CG2247 CG2247 ago ago CG15800 CG15800 mi mi SkpF SkpF CG6758 CG6758
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ntcProtein nutcracker; Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability. (314 aa)
CG12402Uncharacterized protein, isoform C; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (671 aa)
RYBPRing and YY1 Binding Protein (RYBP) encodes a ubiquitin interacting protein. It interacts with epigenetic regulators of the Polycomb and trithorax groups to control post-translational histone modifications. The product of RYBP is involved in regulation of the innate immune response and cell death/cell survival, and the control of morphogenesis. (150 aa)
CG4911LD04326p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (450 aa)
CG13766Uncharacterized protein, isoform A; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (315 aa)
CG43089GEO10396p1; Cullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (144 aa)
CG30466Uncharacterized protein, isoform B; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (405 aa)
Kdm2JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (1345 aa)
FBXO11F-box protein 11 (FBXO11) encodes a subunit of a SCF-like E3 ubiquitin ligase involved in gene silencing mediated by both siRNAs and miRNAs.s. (1182 aa)
CG15412Uncharacterized protein, isoform C. (486 aa)
PpaPartner of paired, isoform B; Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. (562 aa)
CG8272Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (710 aa)
slmbSupernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa)
CG4042FI07223p. (284 aa)
dmpdDampened, isoform A; Dampened (dmpd) encodes a nuclear F-box protein that acts as a co-activator of the product of bcd in modulating the expression level of its target gene hb. (603 aa)
Cul4Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. (821 aa)
CG32221GM18426p; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (432 aa)
CG34025F-box domain-containing protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (325 aa)
CG12520Uncharacterized protein, isoform B; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (371 aa)
CG9003Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to endoplasmic reticulum stress. (651 aa)
SkpASKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa)
CG33969RE11703p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (410 aa)
Cul1Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa)
Fbl6F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa)
SkpBCullin family protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (161 aa)
FsnF-box/SPRY domain-containing protein 1; Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation; Belongs to the FBXO45/Fsn family. (255 aa)
fsdFates-shifted (fsd) encodes an F-box protein with a role in the gradient formation of the product of bcd and fatemap specification through targeting bcd protein for ubiquitination and degradation. (312 aa)
CG11044F-box domain-containing protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (511 aa)
Cul2Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. (753 aa)
FipoQUncharacterized protein, isoform A; It is involved in the biological process described with: positive regulation of protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (515 aa)
CG5003FI05230p; It is involved in the biological process described with: regulation of cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle. (713 aa)
CG14317MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (448 aa)
CG14891GH16156p; Nucleic acid binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (495 aa)
Fbxl7F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. (772 aa)
CG5961LD45245p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (442 aa)
CG9316Uncharacterized protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (448 aa)
CG13085Uncharacterized protein, isoform A; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (240 aa)
CG14937RE59904p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (445 aa)
CG13088AT02038p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (401 aa)
Rca1Regulator of cyclin A1 (Rca1) encodes an anaphase-promoting complex/cyclosome inhibitor. It contributes to mitotic G1/S transition and cyclin degradation. (411 aa)
CG31633LD20162p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (408 aa)
Fbw5F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway. (656 aa)
jetJetlag, isoform A; Jetlag (jet) encodes an F-box protein that is a component of an SCF E3 ubiquitin ligase complex. It targets the product of tim for degradation upon light exposure, and is essential for photic entrainment of the circadian clock. (319 aa)
Skp2S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. (559 aa)
CG7148GH10766p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (454 aa)
morgueModifier of rpr and grim, ubiquitously expressed (morgue) encodes an F box/ubiquitin conjugase domain protein. It regulates cell death by controlling the levels of the apoptosis inhibitor encoded by Diap1. (491 aa)
pallPallbearer (pall) encodes an F-Box protein. In response to apoptosis, it translocates from the nucleus to the cytoplasm of macrophages to promote apoptotic cell clearance by degrading the product of RpS6, and promote actin remodeling through activation of the product of Rac2. (314 aa)
CG32085FI04525p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (666 aa)
CG11658LD30288p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (351 aa)
Cul6Cullin 6; Ubiquitin-protein transferase activity; ubiquitin protein ligase binding; Belongs to the cullin family. (670 aa)
CG7707AT02411p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (320 aa)
SkpECullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (167 aa)
SkpCCullin family protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (158 aa)
SkpDCullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (158 aa)
Fbxl4F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa)
CG2247LD23158p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; defense response to bacterium. (1048 aa)
agoF-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium. (1326 aa)
CG15800Skp1_POZ domain-containing protein; Cullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (157 aa)
miLD45221p; Minus (mi) encodes a protein that can bind to the product of CycE and the SCF-ago ubiquitin-ligase complex. Minus regulates the turnover of the product of CycE and cell proliferation. (941 aa)
SkpFCullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (171 aa)
CG6758GH02866p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (667 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (40%) [HD]