(46 nodes) Integral component of mitochondrial inner membrane network (Drosophila melanogaster)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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Your Input:
	CG43327	Uncharacterized protein; It is involved in the biological process described with: cristae formation. (149 aa)
	Tpc2	Thiamine pyrophosphate carrier protein 2; Thiamine transmembrane transporter activity; antiporter activity. It is involved in the biological process described with: mitochondrial thiamine pyrophosphate transmembrane transport; thiamine pyrophosphate transmembrane transport; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
	Ccdc56	Cytochrome c oxidase assembly factor 3, mitochondrial; Coiled-coil domain containing 56 (Ccdc56) encodes a small mitochondrial protein required for cytochrome c oxidase assembly and function; Belongs to the COA3 family. (87 aa)
	CG41128	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (72 aa)
	Pmi	Transmembrane protein 11 homolog, mitochondrial; Pmi (Pmi) encodes a ubiquitous protein of the mitochondrial inner membrane that negatively controls the biogenesis of cristae membrane. Pmi-dependent cristae alterations are associated with impaired oxidative metabolism, abnormal mitochondrial shape/size, defective mitochondrial transport in neurons, and lead to stress-induced paralysis in adult flies. (182 aa)
	Tim17b	Translocase of the inner mitochondrial membrane 17b (Tim17b) encodes a small subunit of the mitochondrial inner membrane translocase complex. It is strictly required for the delivery of proteins to the mitochondrial matrix. (173 aa)
	Tim23	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix. (206 aa)
	CG14929	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (129 aa)
	Etf-QO	Electron transfer flavoprotein-ubiquinone oxidoreductase (Etf-QO) encodes a mitochondrial membrane bound protein that acts as a hub with the product of wal and fuels electrons from fatty acid oxidation by matrix dehydrogenases into the respiratory chain. (604 aa)
	EMRE	Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. (97 aa)
	Mpcp1	Mitochondrial phosphate carrier protein 1, isoform A; Phosphate ion transmembrane transporter activity; inorganic phosphate transmembrane transporter activity. It is involved in the biological process described with: phosphate ion transport; phosphate ion transmembrane transport; Belongs to the mitochondrial carrier (TC 2.A.29) family. (374 aa)
	Chchd3	Coiled-coil-helix-coiled-coil-helix domain containing 3 (Chchd3) encodes a mitochondrial inner membrane protein that is required for mitochondrial fusion. Loss of Chchd3 leads to inactivation of Hippo activity, decreased tissue growth, cell proliferation defects, oxidative stress and JNK pathway activation. (223 aa)
	Tim17a1	Probable mitochondrial import inner membrane translocase subunit Tim17 3; Tim17a1 (Tim17a1) encodes a subunit of the TIM23 complex, which is a presequence translocase responsible for transporting proteins across the inner mitochondrial membrane. It modulates the gating of the transmembrane channel of TIM23 and plays a role in both matrix translocation as well as lateral membrane sorting. (222 aa)
	Tpc1	Thiamine pyrophosphate carrier protein 1 (Tpc1) encodes an important protein for mitochondrial metabolism located at the inner mitochondrial membrane. Its main role is to import thiamine pyrophosphate (ThPP) into mitochondria. ThPP is an essential coenzyme for the E1 components of pyruvate dehydrogenase and oxoglutarate dehydrogenase, which are located in the mitochondrial matrix. (332 aa)
	CG9396	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (151 aa)
	CG9399	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (154 aa)
	Coq2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family. (392 aa)
	Mics1	Mitochondrial morphology and cristae structure 1. (365 aa)
	CG31913	AT02387p; It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly. (215 aa)
	Sfxn1-3	Sideroflexin-1-3; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family. (321 aa)
	Tim17a2	Probable mitochondrial import inner membrane translocase subunit Tim17 4; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (224 aa)
	Tim17b1	Probable mitochondrial import inner membrane translocase subunit Tim17 1; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (179 aa)
	CG1724	MIP34364p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix; protein targeting to mitochondrion. (185 aa)
	CG4942	LD38503p; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; protein insertion into membrane; mitochondrial cytochrome c oxidase assembly. (351 aa)
	OXA1L	OXA1L mitochondrial inner membrane protein, isoform A; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; mitochondrial cytochrome c oxidase assembly; respiratory chain complex IV assembly; protein insertion into membrane. (441 aa)
	CG15296	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (169 aa)
	CG15653	FI16623p1; It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly. (170 aa)
	CG13564	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (81 aa)
	CG6512	SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. (826 aa)
	CG12479	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (74 aa)
	Sfxn2	Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family. (327 aa)
	QIL1	MICOS complex subunit MIC13 homolog QIL1; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (122 aa)
	CG5903	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (226 aa)
	CG2076	RH72958p; Belongs to the BI1 family. (341 aa)
	Spg7	Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. (819 aa)
	CG14483	GEO10187p1; Unfolded protein binding. It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly. (82 aa)
	Tim17b2	Translocase inner membrane 17, isoform A; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix; protein targeting to mitochondrion. (176 aa)
	CG32832	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (140 aa)
	Mitofilin	MICOS complex subunit Mic60; Mitofilin (Mitofilin) encodes a major component of the mitochondrial contact site (MICOS) complex, which is located at the mitochondrial crista junctions. It maintains crista structure and contact sites, and regulates mitochondrial motility. Mitofilin product functions downstream of the kinase encoded by Pink1, to maintain mitochondrial structure and cellular homeostasis. (746 aa)
	l(3)neo43	Lethal (3) neo43, isoform B. (81 aa)
	Mpc1	Mitochondrial pyruvate carrier (Mpc1) encodes an obligate subunit of the mitochondrial pyruvate carrier, which transports pyruvate across the mitochondrial inner membrane. (107 aa)
	Mpcp2	Mitochondrial phosphate carrier protein 2, isoform A; Inorganic phosphate transmembrane transporter activity; phosphate ion transmembrane transporter activity. It is involved in the biological process described with: phosphate ion transmembrane transport; phosphate ion transport; wing disc dorsal/ventral pattern formation; Belongs to the mitochondrial carrier (TC 2.A.29) family. (356 aa)
	MCU	Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. (457 aa)
	CG43321	Uncharacterized protein; It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport; mitochondrial calcium ion homeostasis; calcium import into the mitochondrion. (65 aa)
	CG43328	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (241 aa)
	YME1L	ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] (740 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG12479	CG13564	FBpp0073691	FBpp0072155	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.409
CG12479	CG15296	FBpp0073691	FBpp0071441	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.528
CG12479	CG1724	FBpp0073691	FBpp0076949	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MIP34364p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix; protein targeting to mitochondrion.	0.456
CG12479	CG43327	FBpp0073691	FBpp0297766	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Uncharacterized protein; It is involved in the biological process described with: cristae formation.	0.482
CG12479	CG43328	FBpp0073691	FBpp0297767	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.482
CG12479	CG5903	FBpp0073691	FBpp0312504	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.572
CG12479	Chchd3	FBpp0073691	FBpp0085107	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Coiled-coil-helix-coiled-coil-helix domain containing 3 (Chchd3) encodes a mitochondrial inner membrane protein that is required for mitochondrial fusion. Loss of Chchd3 leads to inactivation of Hippo activity, decreased tissue growth, cell proliferation defects, oxidative stress and JNK pathway activation.	0.687
CG12479	Mitofilin	FBpp0073691	FBpp0307187	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit Mic60; Mitofilin (Mitofilin) encodes a major component of the mitochondrial contact site (MICOS) complex, which is located at the mitochondrial crista junctions. It maintains crista structure and contact sites, and regulates mitochondrial motility. Mitofilin product functions downstream of the kinase encoded by Pink1, to maintain mitochondrial structure and cellular homeostasis.	0.885
CG12479	QIL1	FBpp0073691	FBpp0074982	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13 homolog QIL1; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.459
CG13564	CG12479	FBpp0072155	FBpp0073691	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.409
CG13564	CG15296	FBpp0072155	FBpp0071441	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.455
CG13564	CG43327	FBpp0072155	FBpp0297766	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Uncharacterized protein; It is involved in the biological process described with: cristae formation.	0.455
CG13564	CG43328	FBpp0072155	FBpp0297767	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.455
CG13564	CG5903	FBpp0072155	FBpp0312504	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.572
CG13564	Chchd3	FBpp0072155	FBpp0085107	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Coiled-coil-helix-coiled-coil-helix domain containing 3 (Chchd3) encodes a mitochondrial inner membrane protein that is required for mitochondrial fusion. Loss of Chchd3 leads to inactivation of Hippo activity, decreased tissue growth, cell proliferation defects, oxidative stress and JNK pathway activation.	0.580
CG13564	Mitofilin	FBpp0072155	FBpp0307187	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit Mic60; Mitofilin (Mitofilin) encodes a major component of the mitochondrial contact site (MICOS) complex, which is located at the mitochondrial crista junctions. It maintains crista structure and contact sites, and regulates mitochondrial motility. Mitofilin product functions downstream of the kinase encoded by Pink1, to maintain mitochondrial structure and cellular homeostasis.	0.871
CG13564	QIL1	FBpp0072155	FBpp0074982	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13 homolog QIL1; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.421
CG14483	CG4942	FBpp0311629	FBpp0076251	GEO10187p1; Unfolded protein binding. It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly.	LD38503p; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; protein insertion into membrane; mitochondrial cytochrome c oxidase assembly.	0.497
CG14929	CG15296	FBpp0099880	FBpp0071441	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.579
CG14929	CG43327	FBpp0099880	FBpp0297766	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Uncharacterized protein; It is involved in the biological process described with: cristae formation.	0.566