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| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | AkhR | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa) |
| | Cpsf160 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa) |
| | AP-2alpha | AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter. (952 aa) |
| | Actbeta | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. (946 aa) |
| | gw | Protein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family. (1384 aa) |
| | Nup44A | Nucleoporin seh1; Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells. It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC ; Belongs to the WD repeat SEC13 family. (354 aa) |
| | Cul1 | Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa) |
| | Pabp2 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, [...] (224 aa) |
| | babo | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1241 aa) |
| | Fbl6 | F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa) |
| | Buffy | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. (299 aa) |
| | PI31 | Proteasome inhibitor PI31 subunit; Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (270 aa) |
| | muskelin | Muskelin, isoform A; It is involved in the biological process described with: regulation of cell-matrix adhesion; oocyte maturation. (853 aa) |
| | phyl | Protein phyllopod; Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch s [...] (400 aa) |
| | Rrp42 | IP10364p; AU-rich element binding. (296 aa) |
| | Dlish | Dachs ligand with SH3s (Dlish) encodes an adapter protein that can bind to the products of d, ds, and ft. It is required for the normal growth of wings and legs via Dachsous-Fat signaling. (355 aa) |
| | POSH | Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway. (838 aa) |
| | Atg7 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa) |
| | Toll-7 | Toll-like receptor 7; Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting [...] (1446 aa) |
| | Debcl | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. (300 aa) |
| | Cul2 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. (753 aa) |
| | wts | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] (1105 aa) |
| | Axn | Axin (Axn) encodes the key scaffolding protein for the canonical Wnt signalling pathway. In the absence of signal, it targets the product of arm for proteolysis inhibiting Wnt signalling. In the presence of signal, it forms a part of the membrane activation complex, disrupting the product of arm degradation. This pathway play roles in cell proliferation (imaginal disc), differentiation (embryonic patterning), death and stemness. (745 aa) |
| | pll | Serine/threonine-protein kinase pelle; Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. (501 aa) |
| | Ythdf | YTH domain-containing family protein; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability. (700 aa) |
| | twin | Twin, isoform C; Twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs. (567 aa) |
| | Tsc1 | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. (1100 aa) |
| | Lsd-1 | Lipid storage droplet-1 (Lsd-1) encodes a protein associated with lipid droplets. It protects lipid droplets from lipase mediated remobilization and facilitates lipolysis by serving as an anchoring point for lipases such as the one encoded by Hsl. It is involved in lipid storage amount regulation and energy homeostasis in concert with the product of Lsd-2. (431 aa) |
| | p53 | P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. (495 aa) |
| | EloB | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. (118 aa) |
| | CstF64 | Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa) |
| | spn-E | Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] (1434 aa) |
| | Rpb7 | IP02321p; Single-stranded DNA binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; single-stranded RNA binding; translation initiation factor binding. It is involved in the biological process described with: positive regulation of translational initiation; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; transcription initiation from RNA polymerase II promoter; nuclear-transcribed mRNA catabolic process, exonucleolytic; transcription by RNA polymerase II. (173 aa) |
| | GlyS | Glycogen synthase (GlyS) encodes a glycosyltransferase that catalyzes linkage of glucose monomers into glycogen. Regulation of the product of GlyS activity by glucose 6-phosphate and phosphorylation helps control cellular glycogen levels. (709 aa) |
| | CycC | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase Cdk8 that phosphoryla [...] (267 aa) |
| | Sbf | SET domain binding factor, isoform A. (1993 aa) |
| | Aduk | Another drosophila Unc-51-like kinase, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of autophagosome assembly; autophagy. (520 aa) |
| | Pomp | GEO05038p1; It is involved in the biological process described with: proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteolysis. (134 aa) |
| | fzy | FI02843p; Fizzy (fzy) encodes WD40 domain protein required for the full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) in mitosis and meiosis. The product of fzy functions to target substrates for destruction and drive metaphase and anaphase transition. (526 aa) |
| | CG15262 | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. (438 aa) |
| | Ge-1 | Enhancer of mRNA-decapping protein 4 homolog; In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets. (1354 aa) |
| | abo | Abnormal oocyte (abo) encodes a negative regulator of histone transcription genes by its binding to their regulatory regions. abo mutations cause a maternal-effect lethality that can be rescued by specific regions of heterochromatin during early embryogenesis. (539 aa) |
| | piwi | Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] (843 aa) |
| | aub | Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...] (866 aa) |
| | Utx | Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa) |
| | Ufd4 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (2727 aa) |
| | me31B | ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa) |
| | poe | Protein purity of essence; Has a role in growth of the perineurial glial layer of the larval peripheral nerve. May have a role in male fertility and eye development or function. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (5322 aa) |
| | cort | Protein cortex; Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Required for the completion of meiosis in oocytes. Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis. Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation. Promotes degradation of mtrm at the oocyte-to-embryo transition. Belongs to the WD repeat CORT family. (483 aa) |
| | Ubc6 | Ubiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK ; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | PEK | Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa) |
| | Rga | Regulator of gene activity; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Essential for viability. Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes. (585 aa) |
| | CG2091 | GH04919p; RNA 7-methylguanosine cap binding; m7G(5')pppN diphosphatase activity. It is involved in the biological process described with: deadenylation-dependent decapping of nuclear-transcribed mRNA. (374 aa) |
| | park | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa) |
| | trbl | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] (484 aa) |
| | ex | Protein expanded; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signa [...] (1427 aa) |
| | ebi | F-box-like/WD repeat-containing protein ebi; F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral [...] (700 aa) |
| | mio | GATOR complex protein MIOS; An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte [...] (867 aa) |
| | GlyP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle. (844 aa) |
| | CG9962 | IP11482p; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-serine phosphorylation; negative regulation of canonical Wnt signaling pathway; protein phosphorylation. (319 aa) |
| | Cpsf6 | Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa) |
| | Cdk8 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...] (454 aa) |
| | CG12362 | RBR-type E3 ubiquitin transferase; Ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; protein polyubiquitination. (511 aa) |
| | Ufd1-like | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (316 aa) |
| | Nprl3 | GATOR complex protein NPRL3; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] (610 aa) |
| | CG9951 | Coiled-coil domain-containing protein 22 homolog; Cullin family protein binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; Belongs to the CCDC22 family. (555 aa) |
| | sina | E3 ubiquitin-protein ligase sina; E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cel [...] (314 aa) |
| | hid | Cell death protein hid; Activator of apoptosis, with grim and rpr, that acts on the effector Dredd. Seems to act genetically upstream of baculoviral anti-apoptotic p35. Blocks Diap2 from binding and inactivating the effector caspase Drice. (410 aa) |
| | rpr | Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1. (65 aa) |
| | gig | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. (1847 aa) |
| | AP-1-2beta | Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. (921 aa) |
| | Atg101 | Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. (218 aa) |
| | Nprl2 | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] (412 aa) |
| | Traf-like | TNF-receptor-associated factor-like, isoform A; Protein binding. It is involved in the biological process described with: positive regulation of lipophagy. (474 aa) |
| | CG8974 | GH14055p; Ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; ER-associated misfolded protein catabolic process. (277 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | CkIalpha | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling. Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling. Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh. Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F [...] (337 aa) |
| | Upf1 | Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity). (1180 aa) |
| | Akh | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa) |
| | ntc | Protein nutcracker; Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability. (314 aa) |
| | Usp5 | Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. (827 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (790 aa) |
| | CG13928 | GH11843p; It is involved in the biological process described with: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation. (245 aa) |
| | Iml1 | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] (1544 aa) |
| | DCP1 | Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing. (372 aa) |
| | fzr2 | Fizzy-related 2 (fzr2) is exclusively expressed in testis and encodes a protein that binds to the anaphase-promoting complex/cyclosome (APC/C). As for the related proteins encoded by fzr, fzy and cort, it activates the ubiquitin ligase activity of the APC/C and allows the recruitment of target proteins such as those encoded by CycA, CycB, CycB3 and pim. (451 aa) |
| | Rrp4 | Rrp4, isoform A; Rrp4 (Rrp4) encodes a protein involved in gene expression regulation. (298 aa) |
| | Dcp-1 | Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. (323 aa) |
| | ari-2 | Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates; Belongs to the RBR family. Ariadne subfamily. (509 aa) |
| | LSm1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (137 aa) |
| | CG3295 | GH10162p; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (432 aa) |
| | Traf6 | TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa) |
| | UbcE2H | Ubiquitin conjugating enzyme E2H (UbcE2H)encodes an E2 enzyme involved in protein ubiquitylation. It is involved in response to viral infection; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | fzr | Fizzy-related, isoform A; Fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. (478 aa) |
| | AMPKalpha | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. (582 aa) |
| | CG31759 | Uncharacterized protein, isoform C; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. (564 aa) |
| | Doa | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa) |
| | AGO3 | Protein argonaute-3; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at [...] (867 aa) |
| | Rab21 | Rab21, isoform C; GTP binding; GTPase activity; phosphatidylinositol 3-kinase catalytic subunit binding; protein binding. It is involved in the biological process described with: Rab protein signal transduction; intracellular protein transport; vesicle-mediated transport; positive regulation of autophagosome maturation; cortical actin cytoskeleton organization. (222 aa) |
| | Atg1 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa) |
| | Kcmf1 | E3 ubiquitin-protein ligase Kcmf1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (599 aa) |
| | TER94 | Transitional endoplasmic reticulum ATPase TER94; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/ [...] (826 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | CG33144 | Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (1102 aa) |
| | CG1677 | MIP35121p1; Metal ion binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (1000 aa) |
| | DCP2 | Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly. (792 aa) |
| | foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) |
| | AGO1 | Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa) |
| | ari-1 | E3 ubiquitin-protein ligase ariadne-1; Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family mem [...] (503 aa) |
| | Marf1 | Meiosis regulator and mRNA stability factor 1, isoform D; mRNA binding involved in posttranscriptional gene silencing; CCR4-NOT complex binding. It is involved in the biological process described with: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; posttranscriptional gene silencing. (1305 aa) |
| | eIF4A | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa) |
| | Mitf | Mitf, isoform C; Mitf (Mitf) encodes a b-HLH-Zip transcription factor that regulates basic cellular processes in part by controlling the expression of the vacuolar (H[+])-ATPase subunits. (837 aa) |
| | Synj | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. (1218 aa) |
| | wds | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa) |
| | Roc1a | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa) |
| | Rpb4 | DNA-directed RNA polymerase II subunit Rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G. (139 aa) |
| | slmb | Supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa) |
| | sip3 | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] (626 aa) |
| | put | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa) |
| | Wdr24 | GATOR complex protein WDR24; An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyt [...] (777 aa) |
| | Tnks | Tankyrase (Tnks) encodes an ADP-ribose polymerase that regulates Wnt signalling by contributing to the degradation of Axn. (1520 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | Rnf146 | MIP02988p; Zinc ion binding; ubiquitin-protein transferase activity; poly-ADP-D-ribose binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein destabilization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (448 aa) |
| | Not3 | CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (844 aa) |
| | S6k | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa) |
| | roq | Roquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (819 aa) |
| | Tailor | Tailor (Tailor) encodes a cytoplasmic RNA-specific terminal uridylyltransferase. It acts as part of the terminal RNA uridylation-mediated processing (TRUMP) complex, marking RNA species for 3'-to-5' exoribonucleolytic decay by the product of Dis3l2. The product of Tailor regulates microRNA biogenesis by targeting precursor-microRNAs (predominantly mirtron hairpins) and targets unprocessed RNA polymerase III transcripts for degradation in a cytoplasmic RNA surveillance pathway. (563 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Tis11 | Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets. (436 aa) |
| | Lerp | Lysosomal enzyme receptor protein (Lerp) encodes a protein involved in lysosome function and autophagy. (918 aa) |
| | dco | Discs overgrown protein kinase; Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin- protein ligase. (440 aa) |
| | Patr-1 | Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions. (968 aa) |
| | Not1 | Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development. (2511 aa) |
| | Smox | Mothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa) |
| | Fer2 | 48 related 2 (Fer2) encodes a bHLH-transcription factor required for the development of a subset of circadian pacemaker neurons and dopaminergic neurons in the protocerebral anterior medial (PAM) and the protocerebral anterior lateral clusters. It is also required for the survival of the PAM cluster dopaminergic neurons in adulthood. (283 aa) |
| | Rrp45 | Rrp45, isoform A; AU-rich element binding. (412 aa) |
| | sima | Protein similar; Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (1593 aa) |
| | Pop2 | Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (361 aa) |
| | Sting | Sting, isoform B; cyclic-di-GMP binding; cyclic-GMP-AMP binding. (343 aa) |
| | Rrp40 | Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. (232 aa) |
| | CG32039 | Uncharacterized protein, isoform A. (82 aa) |
| | RanBPM | Ran-binding proteins 9/10 homolog; May be involved in JAK/STAT signaling. Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche. The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC). Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity [...] (1127 aa) |
| | Apc2 | Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. (1067 aa) |
| | CG34401 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. (2371 aa) |
| | Sesn | Sestrin (Sesn) encodes a stress-inducible protein that suppresses accumulation of reactive oxygen species and inhibits the TORC1 signaling pathway, which allows it to regulate oxidative damage. (497 aa) |
| | tn | Thin, isoform C; Thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. (1517 aa) |
| | CG31855 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (109 aa) |
| | smg | Smaug (smg) encodes the founding member of the SMAUG family of sequence-specific RNA-binding proteins. During the maternal-to-zygotic transition in early embryos, the smg product inhibits the translation and induces the degradation of hundreds of maternal mRNAs by recruitment of the CCR4-NOT deadenylase complex, thereby controlling embryonic patterning, activation of zygotic transcription, and early embryonic cell cycles. (1109 aa) |
| | SkpA | SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa) |
| | Pink1 | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. (721 aa) |
| | Chc | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa) |
