9 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nSyb	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa)
	Sec5	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa)
	Syt1	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa)
	Syt4	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. (474 aa)
	Rab3	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. (220 aa)
	Pld	Phospholipase; Phosphatidylinositol binding; phospholipase D activity. (1364 aa)
	Syb	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release. (152 aa)
	CG6454	Uncharacterized protein, isoform C; Calcium ion binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: intracellular protein transmembrane transport; protein localization to plasma membrane; positive regulation of protein targeting to membrane; positive regulation of glucose transmembrane transport; positive regulation of vesicle fusion. (1569 aa)
	GABA-B-R2	Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. (1224 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GABA-B-R2	nSyb	FBpp0308298	FBpp0303878	Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.404
Pld	Syb	FBpp0112984	FBpp0271782	Phospholipase; Phosphatidylinositol binding; phospholipase D activity.	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	0.426
Pld	nSyb	FBpp0112984	FBpp0303878	Phospholipase; Phosphatidylinositol binding; phospholipase D activity.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.426
Rab3	Syb	FBpp0087352	FBpp0271782	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	0.939
Rab3	Syt1	FBpp0087352	FBpp0077410	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	0.984
Rab3	Syt4	FBpp0087352	FBpp0081097	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	0.926
Rab3	nSyb	FBpp0087352	FBpp0303878	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.771
Syb	Pld	FBpp0271782	FBpp0112984	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	Phospholipase; Phosphatidylinositol binding; phospholipase D activity.	0.426
Syb	Rab3	FBpp0271782	FBpp0087352	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.939
Syb	Syt1	FBpp0271782	FBpp0077410	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	0.985
Syb	Syt4	FBpp0271782	FBpp0081097	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	0.860
Syb	nSyb	FBpp0271782	FBpp0303878	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.928
Syt1	Rab3	FBpp0077410	FBpp0087352	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.984
Syt1	Syb	FBpp0077410	FBpp0271782	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	0.985
Syt1	Syt4	FBpp0077410	FBpp0081097	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	0.924
Syt1	nSyb	FBpp0077410	FBpp0303878	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.979
Syt4	Rab3	FBpp0081097	FBpp0087352	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.926
Syt4	Syb	FBpp0081097	FBpp0271782	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.	0.860
Syt4	Syt1	FBpp0081097	FBpp0077410	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.	0.924
Syt4	nSyb	FBpp0081097	FBpp0303878	Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.	Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion.	0.879