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swm swm Rbp1-like Rbp1-like Nab2 Nab2 Rbp1 Rbp1 Srp54 Srp54 x16 x16 Cpsf6 Cpsf6 ZC3H3 ZC3H3 SF2 SF2 SC35 SC35 elav elav Fmr1 Fmr1 B52 B52 Rsf1 Rsf1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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swmZinc finger protein swm; Negatively regulates Hedgehog (hh) protein signal in wing development. Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells. (1063 aa)
Rbp1-likeRbp1-like, isoform B; Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism. (247 aa)
Nab2Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. (1004 aa)
Rbp1RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. (144 aa)
Srp54LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (513 aa)
x16X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. (258 aa)
Cpsf6Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa)
ZC3H3Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleu; binds to polyadenylated mRNA, and is involved in the regulation of mRNA polyadenylation. (597 aa)
SF2Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. (255 aa)
SC35SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (195 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
Fmr1Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa)
B52Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (355 aa)
Rsf1RNA-binding protein Rsf1; May control important aspects of development. (200 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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