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| | RhoGAP92B | Rho GTPase-activating protein 92B; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (740 aa) |
| | Svil | Supervillin, isoform AE; Actin filament binding. It is involved in the biological process described with: actin polymerization or depolymerization. (4526 aa) |
| | Naus | Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton. (609 aa) |
| | Arpc2 | Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa) |
| | Btk29A | Btk family kinase at 29A (Btk29A) encodes a non-receptor tyrosine kinase with diverse roles including cellularization, morphogenesis, patterning and germ cell proliferation; Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. (786 aa) |
| | Kank | Kank, isoform D; Kank (Kank) encodes a microtubule plus-end binding protein. (1339 aa) |
| | Vrp1 | Verprolin 1, isoform G; Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. (852 aa) |
| | Cip4 | Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. (665 aa) |
| | Vav | Vav guanine nucleotide exchange factor (Vav) encodes a protein that belongs to the Dbl GEF superfamily. It functions as a GDP/GTP exchange factor for the product of Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation. (1001 aa) |
| | ena | Enabled (ena) encodes the sole Drosophila member of the Ena/VASP family. It acts as a processive actin polymerase, stimulating actin addition at the barbed end. It has roles in both epithelial morphogenesis and CNS pathfinding. (980 aa) |
| | Nedd4 | E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa) |
| | if | Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. (1396 aa) |
| | jar | Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (1268 aa) |
| | Mhc | Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains. (1962 aa) |
| | Strump | WASH complex subunit homolog 5; Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail. (1191 aa) |
| | DAAM | Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons. (1463 aa) |
| | chinmo | Zinc finger protein chinmo; Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye- antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis [...] (840 aa) |
| | smog | Smog, isoform D; Smog (smog) encodes a G-protein-coupled receptor with a key role in gastrulation. It contributes to cell intercalation and apical constriction via myosin II activation. (951 aa) |
| | dia | Protein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa) |
| | qua | Villin-like protein quail; Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments. Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis. (892 aa) |
| | Cortactin | Cortactin, isoform A; Proline-rich region binding; actin filament binding. (559 aa) |
| | tmod | Tropomodulin, isoform N; Tropomodulin (tmod) encodes an actin/tropomyosin-associated protein involved in Notch signaling regulation. (567 aa) |
| | Lam | Lamin Dm0; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle. (622 aa) |
| | Abi | Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. (477 aa) |
| | CG1674 | Uncharacterized protein, isoform L; Actin binding. It is involved in the biological process described with: positive regulation of actin filament bundle assembly. (905 aa) |
| | Cdc42 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa) |
| | CG43658 | Uncharacterized protein, isoform C; Guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rho protein signal transduction; imaginal disc-derived leg morphogenesis; actin cytoskeleton organization; positive regulation of stress fiber assembly; positive regulation of Rho protein signal transduction. (2263 aa) |
| | SCAR | SCAR, isoform D; SCAR (SCAR) encodes a primary regulator of the Arp2/3 complex, which promotes actin polymerization and influences cell shape and motility. It is involved in myoblast fusion, eye morphogenesis and axogenesis. (674 aa) |
| | CG4230 | Uncharacterized protein, isoform C; It is involved in the biological process described with: negative regulation of apoptotic process; regulation of actin filament polymerization. (386 aa) |
| | gish | Gilgamesh, isoform L; Gilgamesh (gish) encodes a plasma membrane-associated kinase that regulates Hedgehog and Wingless signaling activity. It is involved in planar cell polarity via regulation of Rab11-mediated vesicle trafficking. (537 aa) |
| | fz | Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] (612 aa) |
| | Abl | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. (1723 aa) |
| | RhoBTB | Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. (783 aa) |
| | Rack1 | Guanine nucleotide-binding protein subunit beta-like protein; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). (318 aa) |
| | cpb | Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis. (276 aa) |
| | Rac1 | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa) |
| | step | Steppke, isoform C; Steppke (step) encodes a member of the cytohesin family of guanine nucleotide exchange factors, which regulate small GTPases of the ADP-ribosylation factor (ARF) family. It contributes to multiple signaling pathways, such as Egfr, MAPK, PI3K and insulin signaling. It is involved in wing and eye development, germ cell segregation and cell growth. (727 aa) |
| | sti | Non-specific serine/threonine protein kinase; Sticky (sti) encodes a member of the AGC family of kinases that functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing. (1858 aa) |
| | Rac2 | Ras-related protein Rac2; Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes. (192 aa) |
| | LRR | Leucine-rich repeat, isoform F; Leucine-rich repeat (LRR) encodes a protein that contributes to the response to insecticides. It regulates the immune response and NIK/NF-kappaB signaling. (1486 aa) |
| | LamC | Lamin-C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis. (640 aa) |
| | fog | G protein-coupled receptor ligand; Coordinates cell shape changes during formation of the ventral furrow and invagination of the posterior midgut primordium, by inducing apical constriction of cells in spatially and temporally defined manners. Could function as a secreted signal to initiate apical constriction by acting as a ligand for an unidentified G protein- coupled receptor, which in turn activates the G protein alpha subunit encoded by concertina, in neighboring cells. Such an intracellular pathway would ultimately induce contraction of the apical actin-myosin network. In the ven [...] (730 aa) |
| | PsGEF | Protostome-specific GEF, isoform E. (2777 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Fhos | Formin homology 2 domain containing (Fhos) encodes a protein that regulates actin-dependent remodeling of muscle cytoskeleton via induction of actin stress fibers, directs macrophage migration during cellular immune response, and is involved in autophagic programmed cell death. (2528 aa) |
| | Ocrl | Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. (850 aa) |
| | spoon | Spoonbill, isoform C; RNA binding; protein kinase A regulatory subunit binding. (607 aa) |
| | Moe | Moesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa) |
| | Lst8 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. (313 aa) |
| | cpa | Capping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis. (286 aa) |
| | Ssrp | FACT complex subunit Ssrp1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (723 aa) |
| | gek | Serine/threonine-protein kinase Genghis Khan; Acts as a downstream effector for the regulation of actin polymerization by Cdc42. (1637 aa) |
| | dsh | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | Rok | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. (1390 aa) |
| | Arpc3B | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (174 aa) |
| | CG6891 | GEO10539p1; Actin filament binding. It is involved in the biological process described with: regulation of actin filament polymerization. (163 aa) |
| | CG7423 | IP06248p; Sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of cell growth; regulation of barbed-end actin filament capping. (124 aa) |
| | Abp1 | Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family. (531 aa) |
| | flr | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Essential for organismal and cell viability. Required for the development of normal wing cell planar polarity. (608 aa) |
| | IRSp53 | Insulin receptor substrate 53 kDa (IRSp53) encodes a protein required for filopodia formation during the adhesion and fusion of myoblasts. (1076 aa) |
| | CG32066 | GH09096p. (324 aa) |
| | pbl | Pebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. (1311 aa) |
| | RhoGEF4 | Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of stress fiber assembly; positive regulation of Rho protein signal transduction. (647 aa) |
| | fliI | Protein flightless-1; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development; Belongs to the villin/gelsolin family. (1256 aa) |
| | Gel | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed; Belongs to the villin/gelsolin family. (798 aa) |
| | Arpc4 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. (168 aa) |
| | ninaC | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. (1501 aa) |
| | Akap200 | A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...] (837 aa) |
| | CG31715 | RE44624p; It is involved in the biological process described with: regulation of barbed-end actin filament capping. (121 aa) |
| | p38b | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa) |
| | Arpc1 | Actin-related protein 2/3 complex, subunit 1 (Arpc1) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis. (377 aa) |
| | GMF | Glia maturation factor (GMF) encodes a protein belonging to the ADF-H domain family of proteins, which promote dissambly of actin networks. It specifically binds to and promotes disassembly of Arp2/3-nucleated lamellipodial actin networks. It plays a role in promoting protrusion dynamics during cell migration. (138 aa) |
| | Arfip | Arfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development. (355 aa) |
| | sals | Sarcomere length short (sals) encodes an actin binding protein that promotes sarcomeric actin filament elongation from pointed ends during muscle growth. (935 aa) |
| | CG9288 | Protein Abitram; May regulate actin polymerization. (214 aa) |
| | twf | Twinfilin (twf) encodes a ubiquitously expressed actin monomer binding protein that is structurally related to the product of tsr and inhibits actin filament assembly. It is highly conserved and is present in all eukaryotes except plants. Its roles include bristle and neuronal development; Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (343 aa) |
| | Cyfip | Cytoplasmic FMR1-interacting protein; Specifically Rac1-associated protein 1 (Sra-1) encodes an essential protein that is a component of the WAVE actin nucleator complex. It controls actin cytoskeleton remodeling and interacts with the products of Fmr1 and Rac1. It controls morphogenesis and synapse organization. (1291 aa) |
| | Atx2 | Ataxin-2 homolog; RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation. Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B. Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian [...] (1084 aa) |
| | Nup98-96 | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] (1960 aa) |
| | ssh | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. (1193 aa) |
| | WASp | WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis. (527 aa) |
| | CG15236 | FI03272p. (807 aa) |
| | RhoGEF2 | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. (2559 aa) |
| | Rho1 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa) |
| | Ggamma1 | Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. (70 aa) |
| | Crk | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. (271 aa) |
| | Rhp | Rhophilin, isoform A; It is involved in the biological process described with: signal transduction. (718 aa) |
| | svr | Carboxypeptidase D; Required for the proper melanization and sclerotization of the cuticle; Belongs to the peptidase M14 family. (1439 aa) |
| | Gbeta13F | Guanine nucleotide-binding protein subunit beta-1; G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions. (340 aa) |
| | chic | Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance. (126 aa) |
| | Tm2 | Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis. (284 aa) |
| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | seq | Sequoia, isoform A; Sequoia (seq) encodes a pan-neuronally expressed zinc-finger transcription factor that governs dendrite and axon outgrowth. It is necessary for the proper development of tracheal branches and dendritic branches of multidendritic neurons, as well as development of the R8 cell in eye development. (882 aa) |
| | Whamy | WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion. (630 aa) |
| | p120ctn | Adherens junction protein p120 (p120ctn) encodes an important modulator of cell adhesion. It binds to and stabilizes classic cadherin cell adhesion receptors at the cell surface. Unlike its mammalian homologs, it is non-essential but becomes essential if the levels of the product of shg are reduced. (781 aa) |
| | conu | Rho GTPase-activating protein conundrum; GTPase-activating protein (GAP) for Rho1; functions with the ERM protein Moe to regulate Rho1 and control proliferation in the developing epithelium. Recruited by Moe to the cell cortex where it negatively regulates Rho1 activity. Can also promote cell proliferation independently of its GAP activity, perhaps by acting with Arf51F (Arf6) to positively regulate Rac1. (629 aa) |
| | RhoGAP68F | Rho GTPase activating protein at 68F (RhoGAP68F) encodes a GTPase activating protein acting upon small Rho-family GTPases involved in epithelial morphogenesis. It localizes to Rab4 recycling endosomes, forms a complex with the product of Rab4 and modulates the transport of Rab4 recycling endosomes back to the cell surface. (476 aa) |
| | cta | Guanine nucleotide-binding protein subunit alpha homolog; May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes; Belongs to the G-alpha family. G(12) subfamily. (457 aa) |
| | ed | Echinoid, isoform A; Echinoid (ed) encodes a cell adhesion molecule of adherens junctions that mediate cell adhesion/recognition. It participates in multiple signaling pathways including Egfr, Notch and Hippo during organogenesis. It is also required in multiple steps of dorsal closure during embryogenesis. (1332 aa) |
| | dco | Discs overgrown protein kinase; Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin- protein ligase. (440 aa) |
| | Arpc3A | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (177 aa) |
| | Arpc5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development; Belongs to the ARPC5 family. (151 aa) |
| | mwh | Multiple wing hairs (mwh) encodes the most downstream member of the fz/stan planar cell polarity pathway. It binds to the sides of F-actin polymers, inhibits actin polymerization and bundles F-actin. It accumulates on the proximal side of wing cells prior to hair initiation and then in the growing hair. (1069 aa) |
| | sqh | Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. (174 aa) |
| | mys | Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] (846 aa) |
| | mthl1 | Methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. (676 aa) |
| | PICK1 | Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding. (577 aa) |
| | HSPC300 | Haematopoietic stem/progenitor cell protein 300 (HSPC300) encodes a subunit of the Scar/WAVE complex, which activates the Arp2/3 complex at the plasma membrane to generate membrane protrusions that drive cell migration. (76 aa) |
| | Src64B | Tyrosine-protein kinase Src64B; Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. (553 aa) |
| | nwk | Protein nervous wreck; Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation. Required for normal structure and function of synapses at the neuromuscular junction. Plays a role in synaptic vesicle trafficking. Required for the release of a normal number of synaptic vesicles per action potential. (1075 aa) |
