Your Input: | |
| | CG11164 | Uncharacterized protein, isoform A; RNA-DNA hybrid ribonuclease activity. It is involved in the biological process described with: ribonucleotide metabolic process; RNA catabolic process. (340 aa) |
| | su(sable) | Protein suppressor of sable; Affects the transcript levels of those alleles that it suppresses. May be involved in influencing complex assembly on cryptic 5'-splice sites or nuclear RNA export; binds RNA preferentially at a sequence that resembles a cryptic 5'-splice site (in vitro). (1325 aa) |
| | mus81 | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. (426 aa) |
| | MTPAP | Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. (612 aa) |
| | CG3857 | Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). (487 aa) |
| | Cbp80 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs [...] (800 aa) |
| | Upf2 | RE04053p; Upf2 (Upf2) encodes a protein required for nonsense-mediated mRNA decay (NMD). It interacts directly with the product of Upf1 to identify and degrade NMD-substrate mRNAs, including mRNAs containing premature termination codons and a number of normal endogenous mRNAs. (1241 aa) |
| | Zpr1 | LD37736p; Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation. (457 aa) |
| | LSm1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (137 aa) |
| | Rrp4 | Rrp4, isoform A; Rrp4 (Rrp4) encodes a protein involved in gene expression regulation. (298 aa) |
| | Not11 | CCR4-NOT transcription complex subunit 11, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process. (247 aa) |
| | Upf3 | Upf3, isoform B; Upf3 (Upf3) encodes a protein that regulates targets of the nonsense-mediated mRNA decay pathway. This pathway participates in homeostatic gene expression regulation and plays a quality control role in the elimination of mRNAs with premature termination codons. The product of Upf3 is involved in cell cycle progression and general developmental rate. (492 aa) |
| | DCP1 | Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing. (372 aa) |
| | Pym | Partner of Y14 and mago; Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit [...] (207 aa) |
| | cN-IIIB | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. Belongs to the pyrimidine 5'-nucleotidase family. (319 aa) |
| | Dis3l2 | Dis3 like 3'-5' exoribonuclease 2 (Dis3l2) encodes a 3'-5'-exoribonuclease involved in catabolism of miRNA and tRNA; Belongs to the RNR ribonuclease family. (1044 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (790 aa) |
| | AhcyL1 | Adenosylhomocysteinase like 1 (AhcyL1) encodes a protein that, together with the product of AhcyL2, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and productio [...] (521 aa) |
| | Upf1 | Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity). (1180 aa) |
| | CG11158 | RH22417p. (344 aa) |
| | CG12177 | RE18811p. (362 aa) |
| | Rai1 | Decapping nuclease DXO homolog; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (375 aa) |
| | Rcd-1 | Required for cell differentiation 1, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process. (304 aa) |
| | CG32533 | LD31543p; RNA binding; helicase activity. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. (1139 aa) |
| | Mtr3 | FI01414p. (326 aa) |
| | CG6839 | Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (430 aa) |
| | Adgf-A | Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. (553 aa) |
| | Adgf-A2 | Adenosine deaminase-related growth factor A2 (Adgf-A2) encodes a growth factor involved in spermatid development. (561 aa) |
| | Adgf-B | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. (520 aa) |
| | Edc3 | Enhancer of mRNA-decapping protein 3; In the process of mRNA degradation, may play a role in mRNA decapping. (680 aa) |
| | Zcchc7 | Zinc finger CCHC-type containing 7; Nucleic acid binding; zinc ion binding. It is involved in the biological process described with: defense response to virus. (1734 aa) |
| | CG14120 | Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (1371 aa) |
| | CG14118 | MIP11263p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (439 aa) |
| | Aps | Aps, isoform A; Aps (Aps) encodes a diphosphoinositol-polyphosphate diphosphatase that hydrolyses a range of (di)nucleoside polyphosphates. It is involved in glucose and lipid homeostasis. (177 aa) |
| | pix | Pixie, isoform A; Pixie (pix) encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth. (611 aa) |
| | RNaseX25 | Endoribonuclease activity; RNA binding; ribonuclease T2 activity; ribonuclease activity. It is involved in the biological process described with: RNA catabolic process; multicellular organism reproduction; Belongs to the RNase T2 family. (325 aa) |
| | Gen | Flap endonuclease GEN; Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'- overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'- exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates. (726 aa) |
| | Fitm | Fat storage-inducing transmembrane protein; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing. (480 aa) |
| | DIP1 | DsRBD-containing protein dip1-c splice isoform; DISCO Interacting Protein 1 (DIP1) encodes a protein that binds to double-stranded RNA and pre-miRNA. It is involved in the defense response to virus. (410 aa) |
| | CG3165 | LD40940p; Nucleic acid binding; 3'-5'-exodeoxyribonuclease activity. (351 aa) |
| | CG17224 | FI09636p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleotide catabolic process; nucleoside metabolic process. (300 aa) |
| | HINT1 | RH02823p; Hydrolase activity. It is involved in the biological process described with: purine ribonucleotide catabolic process. (150 aa) |
| | Tengl1 | Testis EndoG-Like 1; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (319 aa) |
| | Tengl2 | Endonuclease; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (318 aa) |
| | Tengl3 | Testis EndoG-Like 3; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (337 aa) |
| | CG13690 | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (347 aa) |
| | CG2091 | GH04919p; RNA 7-methylguanosine cap binding; m7G(5')pppN diphosphatase activity. It is involved in the biological process described with: deadenylation-dependent decapping of nuclear-transcribed mRNA. (374 aa) |
| | Rga | Regulator of gene activity; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Essential for viability. Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes. (585 aa) |
| | CG8891 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa) |
| | Rat1 | Rat1 5'-3' exoribonuclease (Rat1) encodes a member of the 5'-3' exonuclease family. It is required for mRNA processing and mutations cause phenotypes in various cell types, including the nervous system. (908 aa) |
| | CG8349 | CMP/dCMP-type deaminase domain-containing protein; Cytidine deaminase activity; zinc ion binding. It is involved in the biological process described with: cytidine deamination. (264 aa) |
| | Wdr82 | WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. (317 aa) |
| | Rcd-1r | Rcd-1 related; It is involved in the biological process described with: negative regulation of translation; spermatogenesis; mRNA catabolic process; reproductive process. (290 aa) |
| | pelo | Protein pelota; Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. It is also required for normal eye patterning and for mitotic divisions in the ovary. Required for ovarian germ line stem cell self-renewal. May play a role in regulating translation. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). (395 aa) |
| | me31B | ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa) |
| | CG6729 | Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). (944 aa) |
| | dUTPase | Deoxyuridine triphosphatase, isoform A; dUTP diphosphatase activity; magnesium ion binding. It is involved in the biological process described with: dUMP biosynthetic process; dUTP metabolic process; dUTP catabolic process. (188 aa) |
| | Ge-1 | Enhancer of mRNA-decapping protein 4 homolog; In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets. (1354 aa) |
| | CG5418 | IU_nuc_hydro domain-containing protein. (355 aa) |
| | Drep4 | DNA fragmentation factor-related protein 4 (Drep4) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep3 and Drep1 via CIDE-CIDE interaction. It is the ortholog of human DFFB, which has a nuclease activity. The Drep4 product might function in apoptotic DNA fragmentation. (450 aa) |
| | Ski6 | Ski6, isoform A; Ski6 (Ski6) encodes a protein involved in gene expression regulation. (246 aa) |
| | Smg5 | Smg5, isoform A; Smg5 (Smg5) encodes a protein involved in mRNA catabolism. (1177 aa) |
| | CG15262 | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. (438 aa) |
| | Mtr4 | Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response. (1055 aa) |
| | LSm7 | Like Sm 7, isoform A; RNA binding. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process; mRNA splicing, via spliceosome. (110 aa) |
| | Ada | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (337 aa) |
| | Son | Son DNA binding protein, isoform A; Double-stranded RNA binding; RNA binding. (874 aa) |
| | Rrp46 | FI06805p; Rrp46 (Rrp46) encodes a protein involved in gene expression regulation. (233 aa) |
| | Tengl4 | Testis EndoG-Like 4; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (378 aa) |
| | Adgf-C | Adenosine deaminase-related growth factor C; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. (506 aa) |
| | Adgf-D | Adenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation. (502 aa) |
| | sqd | RNA-binding protein squid; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues. (344 aa) |
| | Rpb7 | IP02321p; Single-stranded DNA binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; single-stranded RNA binding; translation initiation factor binding. It is involved in the biological process described with: positive regulation of translational initiation; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; transcription initiation from RNA polymerase II promoter; nuclear-transcribed mRNA catabolic process, exonucleolytic; transcription by RNA polymerase II. (173 aa) |
| | DNaseII | Deoxyribonuclease II (DNaseII) encodes an ubiquitous endonuclease that hydrolyzes DNA without sequence specificity, generating nucleotides with 3'-phosphate. It is localized in lysosomes, and essential for degrading nuclear DNA of the engulfed apoptotic cells. DNase II is also responsible to digest mitochondrial DNA during autophagy. (366 aa) |
| | Dcr-1 | Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa) |
| | tst | Twister, isoform A; Twister (tst) encodes a protein that regulates mRNA alternative splicing. (1197 aa) |
| | twin | Twin, isoform C; Twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs. (567 aa) |
| | Dis3 | Dis3, isoform A; Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance; Belongs to the RNR ribonuclease family. (982 aa) |
| | Trf4-2 | Inactive non-canonical poly(A) RNA polymerase protein Trf4-2; Polynucleotide adenylyltransferase activity. It is involved in the biological process described with: histone mRNA catabolic process; nuclear polyadenylation-dependent ncRNA catabolic process; snoRNA polyadenylation; Belongs to the DNA polymerase type-B-like family. (407 aa) |
| | Smg6 | GH14566p; Smg6 (Smg6) encodes an RNA endonuclease that is required for nonsense mediated mRNA decay (NMD). Upon recognition of an NMD-targeted transcript, it cleaves the mRNA in the vicinity of the termination codon, exposing free 5' and 3' ends leading to the complete exonucleolytic degradation of the target. (948 aa) |
| | CG6330 | GH09623p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process; gravitaxis; nucleotide catabolic process. (368 aa) |
| | Sid | Stress induced DNase (Sid) encodes a protein belonging to an evolutionarily conserved enzyme family that degrades both single and double stranded nucleic acids. Sid expression is highly induced by bacterial infection and oxidative stress. Its apparent role is to protect from the toxic effects of excess DNA/RNA released by a vigorous immune response. (370 aa) |
| | CG14062 | LP23408p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (346 aa) |
| | Mesh1 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; Metazoan SpoT homolog-1 (Mesh1) encodes a structural and functional ortholog of bacterial protein SpoT. It hydrolyzes ppGpp to GDP. Its mutants show retarded growth in amino acid-starved media, suggesting the conserved role in stringent responses. (179 aa) |
| | CG30105 | Uncharacterized protein; It is involved in the biological process described with: RNA catabolic process. (155 aa) |
| | Dcr-2 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa) |
| | NT5E-2 | Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family. (585 aa) |
| | CG30103 | Uncharacterized protein; It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (584 aa) |
| | Rrp42 | IP10364p; AU-rich element binding. (296 aa) |
| | Dera | Deoxyribose-phosphate aldolase activity. It is involved in the biological process described with: carbohydrate catabolic process; deoxyribonucleotide catabolic process. (347 aa) |
| | EndoG | Endonuclease G (EndoG) encodes an enzyme with endodeoxyribonuclease and endoribonuclease activity. It is involved in germ cell programmed cell death, mitochondrion inheritance and spermatid development. (310 aa) |
| | cuff | Cutoff (cuff) encodes a protein that interacts with the products of rhi and del in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. The product of cuff is therefore an integral part of the piRNA response to transposon activity in the germline. In its absence, a DNA damage checkpoint is activated leading to ventralization of the egg and embryo. (384 aa) |
| | RpLP0-like | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (256 aa) |
| | CG8777 | LP07472p; It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process. (1233 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1241 aa) |
| | Pabp2 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, [...] (224 aa) |
| | rnh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (333 aa) |
| | gw | Protein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family. (1384 aa) |
| | nompA | No mechanoreceptor potential A (nompA) encodes an apical extracellular matrix protein involved in mechanotransduction. In mechanosensory sensilla, the product of nompAis transported to and incorporated into an apical extracellular cap, which encloses the tips of sensory cilia and connects them to force-transmitting structures. nompA loss causes sensory defects including deafness, touch-insensitivity, and lack of coordination due to loss of proprioception. (1557 aa) |
| | CG7206 | FI16522p1. (404 aa) |
| | CG17768 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. (154 aa) |
| | CG6171 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. (255 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | CG7907 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. (753 aa) |
| | smg | Smaug (smg) encodes the founding member of the SMAUG family of sequence-specific RNA-binding proteins. During the maternal-to-zygotic transition in early embryos, the smg product inhibits the translation and induces the degradation of hundreds of maternal mRNAs by recruitment of the CCR4-NOT deadenylase complex, thereby controlling embryonic patterning, activation of zygotic transcription, and early embryonic cell cycles. (1109 aa) |
| | CG31759 | Uncharacterized protein, isoform C; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. (564 aa) |
| | CG12917 | IP10440p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (356 aa) |
| | PNPase | Polynucleotide phosphorylase (PNPase) encodes an enzyme involved in the regulation of mitochondrial mRNA stability. (771 aa) |
| | pcm | 5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control. (1613 aa) |
| | WRNexo | Werner Syndrome-like exonuclease; WRN exonuclease (WRNexo) encodes a 3'-5' exonuclease that cleaves 3' ends of both single-stranded and duplex DNA substrates that resemble DNA structures present during DNA replication. It may act in concert with RecQ family helicases to resolve Holliday junctions or other unusual DNA structures. It is likely to be involved in DNA replication, recombination and repair, and is essential for early embryonic development. (354 aa) |
| | CG33346 | Endonuclease; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (364 aa) |
| | CG3788 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (378 aa) |
| | DCP2 | Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly. (792 aa) |
| | Sarm | NAD(+) hydrolase sarm1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) c [...] (1730 aa) |
| | AGO1 | Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa) |
| | armi | Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...] (1188 aa) |
| | Rpb4 | DNA-directed RNA polymerase II subunit Rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G. (139 aa) |
| | fal | Falten, isoform B; Falten (fal) encodes a protein with potential GTPase activity. It is expressed in the mesoderm and is elevated in embryos lacking how function. (368 aa) |
| | Pde9 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. (1623 aa) |
| | Drep1 | DNAation factor-related protein 1, isoform B; DNA fragmentation factor-related protein 1 (Drep1) encodes a protein that regulates apoptosis. (306 aa) |
| | Trf4-1 | Non-canonical poly(A) RNA polymerase protein Trf4-1; Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs. (1001 aa) |
| | Not3 | CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (844 aa) |
| | Tudor-SN | Staphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. (926 aa) |
| | CG42249 | Uncharacterized protein, isoform C; Nucleotide binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; metal ion binding. It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (558 aa) |
| | CG8360 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (158 aa) |
| | CG8353 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa) |
| | NTPase | NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family. (524 aa) |
| | roq | Roquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (819 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | CG3819 | RE59221p; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (423 aa) |
| | Patr-1 | Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions. (968 aa) |
| | Not1 | Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development. (2511 aa) |
| | CG11883 | Uncharacterized protein, isoform C; Hydrolase activity. It is involved in the biological process described with: nucleotide catabolic process. (792 aa) |
| | CG8915 | FI18001p1; ATP binding; RNA binding; helicase activity; N6-methyladenosine-containing RNA binding. (976 aa) |
| | veil | Veil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (599 aa) |
| | nonC | Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1. (3218 aa) |
| | Rrp45 | Rrp45, isoform A; AU-rich element binding. (412 aa) |
| | Pop2 | Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (361 aa) |
| | Ude | Uracil-DNA degrading factor, isoform B; Uracil-DNA degrading factor (Ude) encodes a DNA-processing enzyme with uracil-DNA-degrading activity. (316 aa) |
| | Rrp40 | Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. (232 aa) |
| | Rrp6 | Rrp6, isoform B; Rrp6 (Rrp6) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion and mRNA surveillance. (900 aa) |
| | Ahcy | Adenosylhomocysteinase (Ahcy) encodes S-adenosyl-L-homocysteine hydrolase, the rate-limiting enzyme in methionine metabolism. This tetrameric enzyme catalyzes the reversible hydrolysis of S-Adenosylhomocysteine (SAH) to adenosine and L-homocysteine. The function of Ahcy product is required to maintain proper concentrations of SAH, which serves as an inhibitor of S-adenosylmethionine-dependent methylation reactions. (432 aa) |
| | Suv3 | ATP-dependent RNA helicase SUV3 homolog, mitochondrial; Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts. (763 aa) |
| | Not10 | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). (635 aa) |
