STRINGSTRING
CG4714 CG4714 CG3062 CG3062 CG17122 CG17122 CCDC151 CCDC151 CG5964 CG5964 IFT57 IFT57 BBS8 BBS8 rempA rempA CG13693 CG13693 asl asl BBS5 BBS5 CG3769 CG3769 Bug22 Bug22 CG17118 CG17118 Fam92 Fam92 Ttc26 Ttc26 CG5614 CG5614 CG7131 CG7131 DZIP1 DZIP1 Sas-6 Sas-6 CG13436 CG13436 CG30069 CG30069 CG4712 CG4712 ana3 ana3 BBS4 BBS4 ana2 ana2 CG42231 CG42231 kat-60L1 kat-60L1 Cep135 Cep135 Plp Plp dila dila cnn cnn Poc1 Poc1 Rilpl Rilpl Oseg2 Oseg2 cep290 cep290 ana1 ana1 unc unc nompB nompB cdc14 cdc14 CG7218 CG7218 Cby Cby Grip71 Grip71 CG7886 CG7886 IFT54 IFT54
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CG4714DUF4201 domain-containing protein. (732 aa)
CG3062Protein Flattop homolog; It is involved in the biological process described with: cilium organization; Belongs to the Flattop family. (252 aa)
CG17122MIP04749p. (598 aa)
CCDC151Coiled-coil domain containing protein 151; It is involved in the biological process described with: axonemal dynein complex assembly; cilium movement; negative gravitaxis. (614 aa)
CG5964Uncharacterized protein; It is involved in the biological process described with: cilium assembly; establishment of epithelial cell polarity. (928 aa)
IFT57Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family. (405 aa)
BBS8Bardet-Biedl syndrome 8; It is involved in the biological process described with: cilium assembly; non-motile cilium assembly. (549 aa)
rempAReduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface. (1503 aa)
CG13693DUF4201 domain-containing protein. (443 aa)
aslAsterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. (994 aa)
BBS5Bardet-Biedl syndrome 5; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: cilium assembly; intracellular transport. (381 aa)
CG3769IP11319p; Dynein heavy chain binding; ATP-dependent microtubule motor activity, minus-end-directed. It is involved in the biological process described with: intraciliary retrograde transport; intraciliary transport involved in cilium assembly. (368 aa)
Bug22Cilia- and flagella-associated protein 20; Basal body up regulated gene 22 (Bug22) encodes a ciliary protein involved in cilium organization and assembly. It contributes to multiple processes during spermatogenesis including tubulin polyglycylation, axoneme assembly, sperm individualization and motility. It also contributes to locomotion, dendrite morphogenesis and neuron and muscle development; Belongs to the CFAP20 family. (199 aa)
CG17118DUF667 domain-containing protein; It is involved in the biological process described with: positive regulation of cell motility; cilium assembly; regulation of cilium beat frequency involved in ciliary motility. (281 aa)
Fam92GH04442p; It is involved in the biological process described with: negative regulation of protein secretion. (395 aa)
Ttc26Tetratricopeptide repeat domain 26; Intraciliary transport particle B binding. It is involved in the biological process described with: cilium assembly; intraciliary anterograde transport; intraciliary transport involved in cilium assembly. (570 aa)
CG5614FI08029p; It is involved in the biological process described with: cilium assembly. (358 aa)
CG7131GH14048p; Microtubule binding. It is involved in the biological process described with: microtubule anchoring. (494 aa)
DZIP1Uncharacterized protein, isoform A; Nucleic acid binding. It is involved in the biological process described with: cilium assembly. (737 aa)
Sas-6Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2. (472 aa)
CG13436FI06007p. (576 aa)
CG30069CG30069 encodes a large protein conserved in other insects with up to 80 copies of a tandem array of a 29 amino acid repeat. Ubiquitous CG30069 RNAi causes lethality and wing-specific RNAi causes wing adhesion defects. (4012 aa)
CG4712FI19336p1. (674 aa)
ana3Anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles. (1977 aa)
BBS4Bardet-Biedl syndrome 4 protein homolog; May be required for microtubule anchoring at the centrosome. Required for ciliogenesis (By similarity); Belongs to the BBS4 family. (486 aa)
ana2Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. (420 aa)
CG42231Uncharacterized protein; It is involved in the biological process described with: cilium assembly. (242 aa)
kat-60L1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (673 aa)
Cep135Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. (1065 aa)
PlpPericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. (2895 aa)
dilaCentrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme. (1155 aa)
cnnCentrosomin (cnn) encodes an essential mitotic centrosome component. During early embryogenesis it is required to organize the mitotic spindle, the actin cytoskeleton and centriole replication. It is also required for mitotic and meiotic divisions during spermatogenesis, as well as organization of the sperm axoneme. The product of cnn can interact with microtubules, actin and the kinase encoded by polo. (1378 aa)
Poc1Proteome of centrioles 1 (Poc1) encodes a cytoplasmic protein located in the sperm giant centriole and proximal centriole-like structure (PCL), which assists in the elongation of the giant centrioles and recruitment of centriolar proteins to the PCL. It contributes to sperm motility and fertility. (403 aa)
RilplRILP-like protein homolog; May have a role in lysosome distribution by interacting with Arl8; Belongs to the RILPL family. (486 aa)
Oseg2Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Belongs to the IFT172 family. (1754 aa)
cep290Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane. (1978 aa)
ana1Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility. (1729 aa)
uncUncoordinated, isoform A; Uncoordinated (unc) encodes a basal body-associated protein that is required for normal ciliogenesis. unc depletion results in spermatids with defective flagella and truncated cilia in mechanosensory and chemosensory neurons. Its name arises from the severe uncoordination phenotype due to a lack of proprioceptive sensory feedback. (1386 aa)
nompBNo mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits. (857 aa)
cdc14Cell division cycle 14, isoform A; Protein tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity. (1052 aa)
CG7218Protein TAPT1 homolog; It is involved in the biological process described with: positive regulation of cilium assembly; maintenance of protein localization in endoplasmic reticulum. (676 aa)
CbyChibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation. (132 aa)
Grip71Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa)
CG7886Protein Cep78 homolog; May play a role in cilium biogenesis. Belongs to the CEP78 family. (818 aa)
IFT54Intraflagellar transport 54; Microtubule binding. It is involved in the biological process described with: regulation of microtubule cytoskeleton organization; intraciliary transport; cilium assembly. (588 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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