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Plap Plap Hrs Hrs Rpn13 Rpn13 Vps13D Vps13D CG42383 CG42383 Tab2 Tab2 CG10508 CG10508 LUBEL LUBEL CG8892 CG8892 CG14322 CG14322 p47 p47 CG9062 CG9062 Rad23 Rad23 casp casp Npl4 Npl4 bam bam CG10694 CG10694 CG10435 CG10435 Stam Stam CG4968 CG4968 Cks30A Cks30A CG3529 CG3529 Vps36 Vps36 TSG101 TSG101 Wdr92 Wdr92 Mvb12 Mvb12 CG12024 CG12024 CG12782 CG12782 Rae1 Rae1 Gga Gga Rpn13R Rpn13R CG2701 CG2701 Cks85A Cks85A Bub3 Bub3 hyd hyd CG5445 CG5445 Faf2 Faf2 rngo rngo
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PlapPhospholipase A2 activator protein, isoform A; Ubiquitin binding. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin recycling. (787 aa)
HrsHepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (760 aa)
Rpn13Proteasomal ubiquitin receptor ADRM1 homolog; May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome (By similarity). (424 aa)
Vps13DVacuolar protein sorting-associated protein 13D; Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. (3919 aa)
CG42383Uncharacterized protein; Ubiquitin binding. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; nuclear envelope reassembly; autophagosome assembly; membrane fusion; Golgi organization. (353 aa)
Tab2TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways. (831 aa)
CG10508Uncharacterized protein, isoform K. (733 aa)
LUBELE3 ubiquitin-protein ligase lubel; E3 ubiquitin-protein ligase which conjugates linear 'Met- 1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response. Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains. Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin- conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-l [...] (2892 aa)
CG8892UBX domain-containing protein 7. (496 aa)
CG14322Uncharacterized protein, isoform B; Ubiquitin binding. It is involved in the biological process described with: protein polyubiquitination. (1597 aa)
p47GH01724p; P47 (p47) encodes a protein involved in nuclear envelope reassembly and rhabdomere development. (407 aa)
CG9062WD repeat-containing protein 48 homolog; Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). (680 aa)
Rad23DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. (414 aa)
caspCaspar, isoform A; Caspar (casp) encodes a protein that inhibits the immune deficiency pathway, but not the Toll pathway, by blocking cleavage and nuclear translocation of the product of Rel. (695 aa)
Npl4Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. (652 aa)
bamBag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway. (442 aa)
CG10694AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. (290 aa)
CG10435LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. (495 aa)
StamSignal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. (689 aa)
CG4968Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. (262 aa)
Cks30ACyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. (74 aa)
CG3529GH05942p; It is involved in the biological process described with: intracellular protein transport. (543 aa)
Vps36Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...] (399 aa)
TSG101Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles. (408 aa)
Wdr92WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade. (375 aa)
Mvb12Multivesicular body subunit 12, isoform A; Ubiquitin binding. It is involved in the biological process described with: virus maturation; viral budding; receptor catabolic process; endosome to lysosome transport via multivesicular body sorting pathway; regulation of epidermal growth factor receptor signaling pathway. (352 aa)
CG12024GH08896p. (292 aa)
CG12782WD_REPEATS_REGION domain-containing protein; Ubiquitin binding; RNA binding. It is involved in the biological process described with: RNA export from nucleus; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; mRNA export from nucleus. (336 aa)
Rae1Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation. (346 aa)
GgaGolgi-localized, gamma-adaptin ear containing, ARF binding protein (Gga) encodes a clathrin binding protein involved in post-Golgi vesicle-mediated transport. (660 aa)
Rpn13RRegulatory particle non-ATPase 13-related; Endopeptidase activator activity; proteasome binding; ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (324 aa)
CG2701EG:95B7.9 protein; Ubiquitin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. (735 aa)
Cks85ACyclin-dependent kinase subunit 85A (Cks85A) encodes a small protein that interacts with the products of Cdk1 and Cdk2. It also functions with the product of Skp2 to target specific substrates for destruction, including the product of dap. It is required for larval growth and to maintain diploidy in imaginal tissues. (96 aa)
Bub3Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. (326 aa)
hydE3 ubiquitin-protein ligase hyd; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk. (2887 aa)
CG5445MIP08896p; Ubiquitin binding. It is involved in the biological process described with: macroautophagy. (303 aa)
Faf2Fas-associated factor 2 (Faf2) encodes a putative ubiquitin ligase with a proteosome dependent function. (464 aa)
rngoRings lost (rngo) encodes a ubiquitin receptor that binds to ubiquitinated proteins via its ubiquitin-associated domain. It is an essential protein that is required for proper development of ring canals in the female germ line. (458 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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