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Zasp52 Zasp52 baz baz Fas3 Fas3 sdt sdt mesh mesh dlg1 dlg1 veli veli lft lft moody moody Cad86C Cad86C crb crb Nrg Nrg l(2)gl l(2)gl bark bark bbg bbg scrib scrib smash smash pyd pyd aPKC aPKC CG42748 CG42748 Shrm Shrm CG6398 CG6398 Gli Gli CG45049 CG45049 Zyx Zyx Tsp2A Tsp2A pck pck bou bou Moe Moe shg shg CG3770 CG3770 Patj Patj Girdin Girdin CG13704 CG13704 fw fw par-6 par-6 Ssk Ssk Tsf2 Tsf2 Nrx-IV Nrx-IV crim crim Mdr65 Mdr65 sinu sinu Sec5 Sec5 Cont Cont nrv2 nrv2 Mcr Mcr yrt yrt kune kune cora cora Sec6 Sec6 Lac Lac wun wun Atpalpha Atpalpha vari vari arm arm
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Zasp52Z band alternatively spliced PDZ-motif protein 52 (Zasp52) encodes a member of the Zasp protein family. It is a scaffold protein that binds the product of Actn and localizes to muscle attachment sites and Z-discs in muscle cells, as well as localizing cortically in non-muscle cells. It plays a role in muscle development, especially in myofibril assembly. (2194 aa)
bazBazooka, isoform B; Bazooka (baz) encodes a scaffold protein that forms a complex with the products of par-6 and aPKC and with other cortical, cytoskeletal and regulatory proteins. It functions in cell polarization pathways in epithelial, neuronal and other cell types. (1520 aa)
Fas3Fasciclin-3; Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system. (577 aa)
sdtStardust, isoform G; Stardust (sdt) encodes membrane-associated guanylate kinase (MAGUK) protein involved in the maintenance of apico-basal cell polarity and the organization of zonula adherens; Belongs to the MAGUK family. (2020 aa)
meshProtein mesh; Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction. Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium. Required for maintaining the three-layered structure of the proventriculus. (1454 aa)
dlg1Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa)
veliProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (246 aa)
lftProtein limb expression 1 homolog; Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg. In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds. Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity. (268 aa)
moodyG-protein coupled receptor moody; Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug- related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in tu [...] (670 aa)
Cad86CCadherin-86C; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1949 aa)
crbProtein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] (2253 aa)
NrgNeuroglian; The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. (1309 aa)
l(2)glLethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development. (1161 aa)
barkProtein bark beetle; Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation. Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis. Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions. Required for the accumulation of Gli at tricellular junctions. (3123 aa)
bbgPDZ domain-containing protein BBG-LP12; It is involved in the biological process described with: border follicle cell migration; imaginal disc-derived wing morphogenesis. (2637 aa)
scribProtein lap4; Scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. (2585 aa)
smashUncharacterized protein CG43427. (1541 aa)
pydPolychaetoid, isoform O; Polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two; Belongs to the MAGUK family. (2395 aa)
aPKCAtypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa)
CG42748Uncharacterized protein, isoform K; Protein phosphatase 1 binding. It is involved in the biological process described with: cell-cell junction organization. (2190 aa)
ShrmProtein Shroom; Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction. During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh. May be involved in the assembly of microtubule arrays during cell elongation (By similarity). (1576 aa)
CG6398LD36024p. (290 aa)
GliGliotactin, isoform A; Gliotactin (Gli) encodes a transmembrane protein localized at tricellular junctions that is necessary for septate junction and permeability barrier formation. (956 aa)
CG45049Uncharacterized protein, isoform D. (273 aa)
ZyxZyx102.44 isoform; Zyxin (Zyx) encodes an actin cytoskeleton regulator found at cell-matrix junctions and cell-cell adherens junctions. Its roles include mechanotransduction and regulation of the Hippo signaling pathway. (585 aa)
Tsp2ATetraspanin-2A; Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium; Belongs to the tetraspanin (TM4SF) family. (244 aa)
pckEG:80H7.2 protein; Pickel (pck) encodes a transmembrane protein of the Claudin superfamily. It is part of the septate junction (SJ) core complex and essential for SJ morphogenesis and function. The transepithelial barrier function of epithelial tissues is affected in pck mutants. (256 aa)
bouGEO07593p1; Boudin (bou) encodes a membrane glycoprotein of the Ly6 superfamily that is required for the formation of septate junctions in epithelial tissues. (149 aa)
MoeMoesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa)
shgDE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa)
CG3770FI21252p1. (219 aa)
PatjPatj (Patj) encodes a PDZ domain-protein that forms an apical protein complex with the products of crb and sdt. It plays supporting roles in apico-basal cell polarity and stability of adherens junction. It is also involved in retinal morphogenesis, maintenance, and planar cell polarity; Belongs to the Patj family. (871 aa)
GirdinGirdin, isoform A; Microtubule binding; dynein light intermediate chain binding. (1381 aa)
CG13704GEO07727p1. (136 aa)
fwFurrowed, isoform A; Furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. (1174 aa)
par-6Par-6, isoform A; Par-6 (par-6) encodes a scaffold protein that forms a complex with the products of baz and aPKC and with other cortical, cytoskeletal and regulatory proteins. It is involved in cell polarization, actin-based protrusion formation and tracheal branching. (351 aa)
SskProtein snakeskin; Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A. May be important for barrier function of the midgut epithelium. (162 aa)
Tsf2Transferrin 2 (Tsf2) encodes a protein that requires binding with iron for protein function. It is localised at the paracellular septate junctions in epithelial tissues and is required for junction assembly. Tsf2 mutants show overelongated tracheal tubes. (819 aa)
Nrx-IVNeurexin-4; Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. Belongs to the neurexin family. (1284 aa)
crimGEO04224p1; Crimpled (crim) encodes a protein involved in tracheal system development and the localization of septate junction components. (158 aa)
Mdr65Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1302 aa)
sinuSinuous (sinu) encodes a claudin that contributes to the assembly of septate junctions. It is involved in the development of heart, tracheal tree and the glial blood-brain barrier. (247 aa)
Sec5Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa)
ContContactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. (1390 aa)
nrv2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (323 aa)
McrMacroglobulin complement-related (Mcr) encodes a transmembrane protein of the conserved thioester-containing protein (TEP) superfamily including macroglobulins and complement proteins. It is a core component of septate junctions, which provide an essential paracellular barrier to epithelia. (1760 aa)
yrtYurt, isoform A; Yurt (yrt) encodes a membrane-associated protein. It contributes to apical-basal polarity and permeability of septate junctions. In differentiating epithelial cells, it counteracts apical polarity proteins to sustain lateral membrane stability and apical-basal polarity. In fully differentiated cells, the product of yrt acts as a negative regulatory component of the crb complex and limits apical membrane growth. (972 aa)
kuneKune-kune; It is involved in the biological process described with: establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; septate junction assembly. (264 aa)
coraProtein 4.1 homolog; An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development. (1698 aa)
Sec6Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC6 family. (738 aa)
LacLachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. (359 aa)
wunPutative phosphatidate phosphatase; Wunen (wun) encodes a lipid phosphate phosphatase with 6 transmembrane domains and an active site that is predicted to face extracellularly. It is required for germ cell migration and survival, septate junction function in the tracheal system and for heart formation; Belongs to the PA-phosphatase related phosphoesterase family. (379 aa)
AtpalphaSodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1041 aa)
variVaricose, isoform B; Varicose (vari) encodes a protein involved in tracheal system development and septate junction assembly; Belongs to the MAGUK family. (636 aa)
armArmadillo segment polarity protein; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha- catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. Belongs to the beta-catenin family. (843 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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