STRINGSTRING
trr trr Lpt Lpt Dpy-30L2 Dpy-30L2 Pa1 Pa1 Ptip Ptip Rbbp5 Rbbp5 Utx Utx Dpy-30L1 Dpy-30L1 CG14282 CG14282 ash2 ash2 wds wds Ncoa6 Ncoa6 Hcf Hcf
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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trrHistone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...] (2431 aa)
LptLost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. (1482 aa)
Dpy-30L2Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. (98 aa)
Pa1PTIP associated 1; It is involved in the biological process described with: histone H3-K4 methylation. (122 aa)
PtipPAX transcription activation domain interacting protein (Ptip) encodes a component of a Histone H3K4 methyltransferase complex that contributes to Trithorax-mediated epigenetic imprinting during development. (2294 aa)
Rbbp5Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. (489 aa)
UtxUtx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa)
Dpy-30L1Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. (134 aa)
CG14282IP09474p; It is involved in the biological process described with: histone H3-K4 methylation. (293 aa)
ash2Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] (556 aa)
wdsProtein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa)
Ncoa6Nuclear receptor coactivator 6 (Ncoa6) encodes a subunit of the Trithorax-related (Trr) complex, a COMPASS-like complex that mediates the methylation of histone H3K4. The product of Ncoa6 is required for transcriptional output of the Hippo pathway by directly interacting with the protein encoded by yki and recruiting the Trr complex to Hippo target genes. (2467 aa)
HcfHCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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