(12 nodes) Autophagy of nucleus network (Drosophila melanogaster)

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	CG11975	LD32381p; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. It is involved in the biological process described with: autophagy of nucleus; protein lipidation; autophagy of mitochondrion; protein localization to phagophore assembly site; autophagosome assembly. (340 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (269 aa)
	Atg3	Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. (330 aa)
	Atg13	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa)
	Atg7	Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa)
	Atg12	Autophagy protein 12-like; Required for autophagy. (111 aa)
	Atg1	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
	Atg18a	Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes. (447 aa)
	Atg9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
	Atg18b	Autophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. (471 aa)
	Atg2	Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. (1906 aa)
	Atg17	Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg1	Atg12	FBpp0289788	FBpp0289288	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy protein 12-like; Required for autophagy.	0.998
Atg1	Atg13	FBpp0289788	FBpp0081333	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.	0.999
Atg1	Atg17	FBpp0289788	FBpp0306962	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan.	0.999
Atg1	Atg18a	FBpp0289788	FBpp0302863	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes.	0.996
Atg1	Atg18b	FBpp0289788	FBpp0304068	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding.	0.995
Atg1	Atg2	FBpp0289788	FBpp0305632	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy.	0.999
Atg1	Atg3	FBpp0289788	FBpp0074822	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy.	0.998
Atg1	Atg5	FBpp0289788	FBpp0071023	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).	0.998
Atg1	Atg7	FBpp0289788	FBpp0085891	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan.	0.973
Atg1	Atg9	FBpp0289788	FBpp0302990	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.995
Atg1	CG11975	FBpp0289788	FBpp0307729	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	LD32381p; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. It is involved in the biological process described with: autophagy of nucleus; protein lipidation; autophagy of mitochondrion; protein localization to phagophore assembly site; autophagosome assembly.	0.551
Atg12	Atg1	FBpp0289288	FBpp0289788	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	0.998
Atg12	Atg13	FBpp0289288	FBpp0081333	Autophagy protein 12-like; Required for autophagy.	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.	0.970
Atg12	Atg17	FBpp0289288	FBpp0306962	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan.	0.973
Atg12	Atg18a	FBpp0289288	FBpp0302863	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes.	0.990
Atg12	Atg18b	FBpp0289288	FBpp0304068	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding.	0.983
Atg12	Atg2	FBpp0289288	FBpp0305632	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy.	0.940
Atg12	Atg3	FBpp0289288	FBpp0074822	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy.	0.999
Atg12	Atg5	FBpp0289288	FBpp0071023	Autophagy protein 12-like; Required for autophagy.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).	0.999
Atg12	Atg7	FBpp0289288	FBpp0085891	Autophagy protein 12-like; Required for autophagy.	Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan.	0.999