STRINGSTRING
up up Actn Actn wupA wupA flr flr rols rols rt rt Bsg Bsg ball ball Lasp Lasp Unc-89 Unc-89 kon kon C3G C3G bt bt if if Mhc Mhc mask mask dia dia Dg Dg Mical Mical CG14964 CG14964 hts hts CanB2 CanB2 bru1 bru1 sls sls fln fln rhea rhea how how tw tw l(2)efl l(2)efl cher cher CG13366 CG13366 mys mys Scgdelta Scgdelta Mlp84B Mlp84B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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upTroponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere. (397 aa)
ActnAlpha-actinin, sarcomeric; Alpha actinin (Actn) encodes an actin cross-linking protein with muscle and non-muscle specific isoforms, which are produced by alternative spicing. The muscle isoform has a role in muscle development while the non-muscle isoform localizes to ovarian ring canals and has a role in cytoskeletal remodeling of follicle cells; Belongs to the alpha-actinin family. (917 aa)
wupAWings up A (wupA) encodes a cytoskeletal protein of the troponin complex of the muscle thin filament. It is involved in calcium-dependent regulation of muscle contraction, and in development of the embryonic heart, skeletal muscle and flight muscle It also contributes to non-muscle functions such as apico-basal polarity formation, nuclear division and maintenance of nuclear integrity. (269 aa)
flrActin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Essential for organismal and cell viability. Required for the development of normal wing cell planar polarity. (608 aa)
rolsRolling pebbles (rols) encodes a protein required for myoblast fusion in founder cells. it interacts with the membrane spanning Immunoglobulin superfamily protein encoded by kirre and with the product of Mhcl. (1900 aa)
rtProtein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa)
BsgBasigin, isoform G; Basigin (Bsg) encodes an IgG family glycoprotein that promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. It contributes to photoreceptor cell morphogenesis, sarcomere organization and spermatid development. (648 aa)
ballNucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] (599 aa)
LaspLIM and SH3 domain protein Lasp; Lasp (Lasp) encodes a member of the nebulin family. It plays subtle roles in modulating the actin cytoskeleton in ovaries, testes, and muscles, by serving as a scaffold protein binding multiple partners, especially actin and myosin. In indirect flight muscles, it contributes to I-band and A-band architecture. (657 aa)
Unc-89Obscurin; Structural component of the muscle M line which is involved in assembly and organization of sarcomere. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable). (4218 aa)
konKon-tiki, isoform B; Kon-tiki (kon) (also known as perdido) encodes a single transmembrane protein required to initiate muscle-tendon attachment in a group of embryonic and adult body muscles. kon mutants are embryonic lethal with rounded ventral longitudinal muscles. It concentrates at muscle attachment sites and genetically interacts with integrins. (2381 aa)
C3GGuanine nucleotide-releasing factor 2; C3G guanyl-nucleotide exchange factor (C3G) is expressed in the developing embryonic muscles and its product plays a role in body wall muscle development during larval stages. (1571 aa)
btBent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle. (8933 aa)
ifIntegrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. (1396 aa)
MhcMyosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains. (1962 aa)
maskAnkyrin repeat and KH domain-containing protein mask; Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. (4010 aa)
diaProtein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa)
DgDystroglycan, isoform D; Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity. (1262 aa)
Mical[F-actin]-monooxygenase Mical; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin. Belongs to the Mical family. (4743 aa)
CG14964Uncharacterized protein. (1443 aa)
htsHu li tai shao (hts) encodes an adducin homolog that is associated with the plasma membrane cytoskeleton, fusome and oocyte ring canals. It has essential functions in muscle, nerve and other tissues, and is required for fertility in males and females; Belongs to the aldolase class II family. Adducin subfamily. (1833 aa)
CanB2Calcineurin subunit B type 2; Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase. (170 aa)
bru1Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa)
slsTitin; Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. (18468 aa)
flnFlightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction. (182 aa)
rheaRhea, isoform B; Rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells. (2836 aa)
howProtein held out wings; Required for integrin-mediated cell-adhesion in wing blade. Vital role in steroid regulation of muscle development and to control heart rate. Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. (418 aa)
twProtein O-mannosyl-transferase 2; Twisted (tw) encodes a protein that transfers a mannose to the Ser/Thr residues of dystroglycan, via forming an heterodimer with the product of rt. Its roles include myogenesis, muscle architecture and cell adhesion. (765 aa)
l(2)eflProtein lethal(2)essential for life; Vital role in embryonic development; Belongs to the small heat shock protein (HSP20) family. (187 aa)
cherFilamin-A; Cheerio (cher) encodes a dimeric F-actin crosslinking protein of the filamin protein family. It functions to organize the F-actin cytoskeleton in multiple contexts including ovarian germline ring canals, migrating somatic cells, and neuronal growth cones. (2429 aa)
CG13366FI18193p1. (1094 aa)
mysIntegrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] (846 aa)
ScgdeltaGamma/delta-sarcoglycan-like protein SCG-GAMMA/DELTA; Sarcoglycan delta (Scgdelta) encodes a transmembrane protein that is required for normal muscle structure and function. It contributes to sarcomere organization and heart contraction. (404 aa)
Mlp84BMuscle LIM protein at 84B (Mlp84B) encodes a muscle cytoskeletal protein found primarily at the Z-line boundary. It maintains muscle structural integrity and regulates actin bundling. (495 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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