STRINGSTRING
cher cher Shmt Shmt Egfr Egfr rut rut amn amn lush lush geko geko rogdi rogdi aay aay Tat Tat S S aru aru AcCoAS AcCoAS Itpr Itpr kra kra Nmdar1 Nmdar1 Orco Orco Akap200 Akap200 Aldh Aldh Sirt1 Sirt1 Ku80 Ku80 spi spi mura mura Arfip Arfip Crz Crz klg klg Pkc98E Pkc98E Tdc1 Tdc1 hppy hppy inaC inaC Jhe Jhe scb scb Arf51F Arf51F Pka-R2 Pka-R2 Drat Drat Tbh Tbh Pka-C1 Pka-C1 DopEcR DopEcR Syn Syn Adh Adh Vrp1 Vrp1 hang hang dlg1 dlg1 Agpat2 Agpat2 Pka-R1 Pka-R1 moody moody slpr slpr Tao Tao Cam Cam CG17734 CG17734 homer homer CrzR CrzR vsg vsg CASK CASK apt apt Gbs-70E Gbs-70E rho rho dnc dnc Spn27A Spn27A pum pum pxb pxb Gclm Gclm Bacc Bacc vap vap Jwa Jwa Fas2 Fas2 rl rl dpr9 dpr9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cherFilamin-A; Cheerio (cher) encodes a dimeric F-actin crosslinking protein of the filamin protein family. It functions to organize the F-actin cytoskeleton in multiple contexts including ovarian germline ring canals, migrating somatic cells, and neuronal growth cones. (2429 aa)
ShmtSerine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa)
EgfrEpidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa)
rutCa(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa)
amnAmnesiac neuropeptides; Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve. (180 aa)
lushGeneral odorant-binding protein lush; Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by [...] (153 aa)
gekoGeko (Gk) protein; It is involved in the biological process described with: sensory perception of smell; behavioral response to ethanol. (206 aa)
rogdiRogdi (rogdi) encodes a protein that plays a role in promoting sleep by controlling GABA transmission in GABA neurons; Belongs to the rogdi family. (343 aa)
aayPhosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (270 aa)
TatAlpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (461 aa)
SStar (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa)
aruArouser, isoform A; Arouser (aru) encodes an SH3 adaptor protein that interacts with Egfr and PI3K pathways. Its roles include regulation of synapse number, memory formation and ethanol sedation sensitivity. (805 aa)
AcCoASAcetyl-coenzyme A synthetase; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
kraKrasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2beta. It is involved in axon guidance, long-term memory, and alcohol addiction. (422 aa)
Nmdar1Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
Akap200A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...] (837 aa)
AldhAldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. (520 aa)
Sirt1NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
Ku80ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. (699 aa)
spiProtein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination. (234 aa)
muraMurashka, isoform C; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: long-term memory; protein ubiquitination; behavioral response to ethanol. (1173 aa)
ArfipArfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development. (355 aa)
CrzCorazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa)
klgLD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. (545 aa)
Pkc98EProtein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn. (739 aa)
Tdc1Tyrosine decarboxylase 1 (Tdc1) encodes a protein involved in behavioral response to ethanol. (587 aa)
hppyHappyhour, isoform A; Happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. (1218 aa)
inaCProtein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa)
JheCarboxylic ester hydrolase; Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior; Belongs to the type-B carboxylesterase/lipase family. (579 aa)
scbIntegrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...] (1115 aa)
Arf51FADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation. (175 aa)
Pka-R2cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain. (377 aa)
DratDeath resistor Adh domain containing target (Drat) encodes a member of the zinc-dependent ADH-like family that is an effector of ethanol-induced apoptosis. (434 aa)
TbhTyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (670 aa)
Pka-C1cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa)
DopEcRDopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. (322 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
AdhAlcohol dehydrogenase (Adh) encodes an alcohol and acetaldehyde dehydrogenase involved in alcohol and acetaldehyde metabolism. (256 aa)
Vrp1Verprolin 1, isoform G; Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. (852 aa)
hangHangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. (2223 aa)
dlg1Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa)
Agpat21-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: behavioral response to ethanol; phosphatidic acid biosynthetic process. (271 aa)
Pka-R1Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa)
moodyG-protein coupled receptor moody; Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug- related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in tu [...] (670 aa)
slprMitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure. (1155 aa)
TaoSerine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
CG17734Uncharacterized protein, isoform C; It is involved in the biological process described with: mitochondrial respirasome assembly; behavioral response to ethanol. (106 aa)
homerHomer, isoform E; Homer (homer) encodes a protein that acts as an adaptor protein binding to group I metabotropic glutamate receptors and other intracellular signaling proteins. It contributes to regulation of sleep, locomotor activity and ethanol tolerance. (531 aa)
CrzRCorazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. (644 aa)
vsgVisgun, isoform E; Visgun (vsg) encodes a protein involved in cell proliferation regulation, response to ethanol and long-term memory. (262 aa)
CASKPeripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa)
aptApontic, isoform F; Apontic (apt) encodes a DNA-binding protein that acts as a transcriptional regulator and can function in translational repression. It plays roles in cell migration, cell fate specification, and morphogenesis via STAT signaling pathway inhibition. (499 aa)
Gbs-70EProtein phosphatase 1 regulatory subunit; Glycogen binding subunit 70E (Gbs-70E) is one of the glycogen binding subunits of protein phosphatase 1 (Pp1) that interacts with all of the known Pp1 catalytic subunits (encoded by Pp1-87B, flw, Pp1alpha-96A, and Pp1-13C). The product of Gbs-70E is involved in the regulation of glycogen metabolism, and plays a role in the egg development. (384 aa)
rhoProtein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa)
dncDunce (dnc) encodes a cAMP-specific phosphodiesterase, responsible for cAMP degradation. dnc product plays a pivotal role in neurological and behavioral plasticity including synaptic development and function, learning and courtship. The product of dnc is also known to affect regulation of several developmental processes such as oogenesis; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. (1209 aa)
Spn27ASerine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] (447 aa)
pumMaternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa)
pxbPxb (pxb) encodes a protein involved in response to ethanol, long-term memory and regulation of hemocyte proliferation. (636 aa)
GclmGlutamate-cysteine ligase modifier subunit (Gclm) encodes a protein that regulates the ligase activity of the product of Gclc. It is involved in glutathione biosynthesis, arsenic detoxification and response to ethanol. (285 aa)
BaccBacchus; Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA. (152 aa)
vapVacuolar peduncle (vap) encodes a GTPase-activating protein for Ras-family small GTPases that functions in the intracellular Ras-MAP kinase pathway. vap loss produces age-dependent neurodegeneration in the adult brain. The product of vap function in neuronal survival is mediated through the EGF receptor pathway and Rab5-dependent endocytosis. (954 aa)
JwaPRA1 family protein; It is involved in the biological process described with: response to ethanol. (249 aa)
Fas2Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa)
rlMitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa)
dpr9Defective proboscis extension response 9, isoform A; It is involved in the biological process described with: behavioral response to ethanol; synapse organization; sensory perception of chemical stimulus. (602 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.