A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...]

Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family.

TM2 domain-containing protein CG10795.

TM2 domain-containing protein CG11103.

TM2 domain-containing protein CG10795.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

TM2 domain-containing protein CG10795.

TM2 domain-containing protein almondex; Involved in the control of cell fates in the neurectoderm. Acts as a positive regulator of Notch pathway and is required at different levels during development; Belongs to the TM2 family.

TM2 domain-containing protein CG11103.

TM2 domain-containing protein CG10795.

TM2 domain-containing protein CG11103.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

FI12101p; UDP-xylosyltransferase activity; glucosyltransferase activity; UDP-glucosyltransferase activity. It is involved in the biological process described with: protein O-linked glycosylation; positive regulation of Notch signaling pathway.

GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that c [...]

FI12101p; UDP-xylosyltransferase activity; glucosyltransferase activity; UDP-glucosyltransferase activity. It is involved in the biological process described with: protein O-linked glycosylation; positive regulation of Notch signaling pathway.

O-glucosyltransferase rumi; Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.

Eps15 homology domain containing protein-binding protein 1 (Ehbp1) encodes a protein that mediates asymmetric protein secretion. It regulates the trafficking and secretion of distinct Notch signaling components and extracellular membrane proteins.

FI04474p; Sanpodo (spdo) encodes a four-pass transmembrane domain containing protein that interacts with both the product of numb and the Notch signaling pathway to enable precursor cells to divide asymmetrically to produce daughter cells of distinct fates. Its roles include cell fate specification in the nervous system, mesoderm, and endoderm.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

TM2 domain-containing protein CG10795.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

TM2 domain-containing protein CG11103.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that c [...]

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

TM2 domain-containing protein almondex; Involved in the control of cell fates in the neurectoderm. Acts as a positive regulator of Notch pathway and is required at different levels during development; Belongs to the TM2 family.

GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.

Fringe glycosyltransferase; Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta- 1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.

Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization.

Liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways.

Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization.

FI04474p; Sanpodo (spdo) encodes a four-pass transmembrane domain containing protein that interacts with both the product of numb and the Notch signaling pathway to enable precursor cells to divide asymmetrically to produce daughter cells of distinct fates. Its roles include cell fate specification in the nervous system, mesoderm, and endoderm.

Nedd4 family interacting protein (Ndfip) encodes a protein that interacts with the ubiquitin ligases encoded by Nedd4 and Su(dx) and regulates Notch signaling.

Protein deltex; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Belongs to the Deltex family.

Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family.

A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...]

Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family.

E3 ubiquitin-protein ligase mind-bomb; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl- dependent signalin [...]

GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that c [...]

FI12101p; UDP-xylosyltransferase activity; glucosyltransferase activity; UDP-glucosyltransferase activity. It is involved in the biological process described with: protein O-linked glycosylation; positive regulation of Notch signaling pathway.